If you’ve struggled with stress, anxiety, or other emotional issues, it’s likely no surprise to hear that mental health is intrinsically tied to our digestive health. Scientists continue to study the gut-brain connection and its role in treating mental health conditions, including depression, anxiety, and mood disorders.
You may have heard of colon cleansers before but wondered whether they effectively accomplish anything other than frequent trips to the bathroom. Can they impact your emotional wellbeing? Can cleansing the colon mean cleansing the mind?
Our team investigated zuPOO, an all-natural colon cleanser produced by the company UMZU. In our review below, you’ll learn about this product’s pros, cons, and scientific details, allowing you to decide if zuPOO might help your gut and mind find balance.
- Supports gut health with all-natural herbs and botanicals
- Scientific studies support all product ingredients
- May promote better mental focus and mood
- May assist with temporary weight loss
- 60-day money-back guarantee
- Free shipping on any order over $99
- Subscribe & Save program takes 15% off all orders
- Not as transparent with ingredient labeling as other UMZU products
- Unsafe for long-term use
- Not intended for children
- If you are pregnant or lactating – consult your doctor before taking
We recommend zuPOO for adults looking to improve their overall gastric health, relieve bloating or constipation, and cleanse their colon of unwanted buildup and toxins. UMZU – the company that manufactures zuPOO – is reputable and provides scientifically backed information and education about its ingredients. We found zuPOO to be an effective product that naturally cleanses your digestive tract and promotes overall wellbeing.
zuPOO is a great solution for bloating, constipation, and improving overall gut health.
This all-natural supplement contains herbs and botanicals scientifically proven to support gut health and even boost mood and energy. All purchases are covered by a 60-day money-back guarantee.
Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.
We extensively test each health service or product we review. We try our best to give you, our readers, an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality, the latest medical evidence and health standards, and a simple question: would we buy the product or service ourselves if it weren’t part of our job, and would we recommend it to family and friends?
Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.
zuPOO is an all-natural supplement for gut health. This colon cleanser flushes your gut of waste and toxins, eliminating up to 20 pounds of fecal buildup and reducing stomach bloat. It can also:
- Benefit short-term weight loss
- Help restore natural microbiome
- Enhance mental and physical health
Christopher Walker founded UMZU – the company that manufactures zuPOO – in 2015 after achieving personal success in treating the effects of a pituitary tumor he developed while a neuroscience student at Duke University. Walker’s published findings led others to push him into developing all-natural hormone-balancing treatments.
Since its founding, UMZU has expanded across the health and wellness market. Today, it offers an array of all-natural, scientifically-backed supplements for:
- Gut health
- Weight-loss support
- Bone health
- Improved mood and focus
The science backs up zuPOO’s ingredients, and we found the product to be effective without the bloating, gas, and discomfort we’ve experienced with other colon cleansers.
zuPOO contains powerful, all-natural laxatives that help purge the body of accumulated waste and toxins. In fact, it’s effective enough that we recommend those taking it have constant bathroom access during the cleansing period. zuPOO is most effective when combined with a healthy lifestyle, including diet, exercise, and proper hydration.
Keep in mind: zuPOO is intended for short-term use. Taking this supplement beyond the recommended 15-day regimen is inadvisable due to potential side effects, including liver toxicity.
When you prepare to use an all-natural colon cleanser like zuPOO, you should know what to expect and plan your circumstances upon those expectations. You’ll want ready access to a restroom because you’ll need it for the next two weeks. For instance, those with highly focused, face-to-face jobs like teaching might want to plan their colon cleanse during summer break.
zuPOO contains several botanicals and all-natural compounds that work together to purge your digestive tract of unwanted waste and toxins. These scientifically-backed ingredients include:
Cascara sagrada is a derivative from the dried bark of a species of buckthorn tree native to western North America. It contains natural compounds called anthraquinones. They have several therapeutic uses, including the treatment of constipation, cancer, multiple sclerosis, and arthritis. Cascara sagrada is a natural laxative used historically by Native American people that you can find today on many pharmacy shelves for digestive health. However, you should note that long-term use of cascara sagrada is not advised in high doses, as this can lead to liver toxicity. Medical researchers do not recommend its usage if you are pregnant or nursing.
Senna leaf is another common herbal laxative found in over-the-counter supplements. While researchers consider senna safe in recommended dosages for limited periods, it can lead to liver injury in excess. However, liver injury cases are rare and reverse themselves upon discontinued use.
Fennel seed powder
Fennel seed has a long history as a traditional medicinal treatment for reproductive, endocrine, respiratory, and digestive ailments. This herbal plant shows promise in scientific studies for its antiviral, anti-inflammatory, and anti-tumor properties, among other benefits.
Researchers and scientists have published thousands of studies on bentonite clay’s benefits and potential treatments. This natural clay can benefit the body’s detoxification, relieve skin irritation, and help in treating diarrhea, constipation, colitis, and irritable bowel syndrome (IBS).
Buckthorn bark powder
Buckthorn is a rich source of anthraquinones and a similar laxative to cascara sagrada. It may help treat various health conditions, including cancer, constipation, skin disorders, and hemorrhoids.
Aloe leaf extract
Clinical trials demonstrate the safety and efficacy of aloe vera leaf for the short-term treatment of irritable bowel syndrome (IBS). This common house plant has centuries-long use in traditional Indian medicine for treating infections and digestive issues like constipation. Today, scientists and researchers continue studying aloe vera’s therapeutic uses for diabetes, metastatic cancer, ulcers, and surgical wounds.
Slippery elm extract
Slippery elm, a prebiotic with use dating back centuries as a therapeutic in Ayurvedic medicine, boasts several health benefits, from improving gastrointestinal health to reducing inflammation.
Milk thistle is a common ingredient in wellness supplements supporting digestive and liver health. Some studies have shown milk thistle to be helpful in the treatment of diabetes, but more research is needed in determining its efficacy in this use.
Cayenne pepper extract
Capsaicin, the primary component of cayenne pepper, shows the potential to promote metabolic and vascular health and prevent and heal gastric ulcers.
How to take zuPOO
When you begin your zuPOO regimen, you’ll take two capsules daily over 15 days. UMZU recommends taking zuPOO at bedtime with a full glass of water. Over the next two weeks, you’ll want to maintain a high water intake daily to prevent dehydration through excessive excrement.
Within the first 48 hours of taking zuPOO, you may experience bloat and discomfort as your body prepares to expel waste. And this is where having a nearby restroom at all times is essential. Some consumers expel waste over eight times daily during the cleanse period.
Once your regimen is complete, you should feel lighter and relieved of bloat, gut discomfort, and constipation. While UMZU recommends performing a zuPOO cleanse every 90 days, we feel this is somewhat excessive and potentially unsafe. We suggest consulting with your doctor or dietician if you continue using zuPOO beyond the occasional colon cleanse.
zuPOO is safe when used as directed for the 15-day regimen. Some of the most important factors to consider with zuPOO are the impacts of its ingredients and how they might interact with any current or long-term medications you may take. For instance, several of zuPOO’s main ingredients, including cascara sagrada, can cause liver problems with extended use. Those taking medications or with chronic medical conditions should consult their doctor before use.
UMZU does not recommend this product for those who are pregnant or nursing, and it is unsuitable for children. If you have a history of eating disorders or dietary supplement abuse, avoid zuPOO.
This product is intended to assist with healthy digestion, not long-term weight management. While weight loss may be a short-term benefit, laxatives should not be used for long-term weight loss or as a “quick fix” solution. Doing so is harmful to your body.
Like all supplements from UMZU, you can purchase zuPOO as a single purchase or sign up for a subscription membership which takes 15% off all orders. zuPOO is also sold in UMZU’s Gut Health Bundle, combining this supplement with Floracil50 and zuACV to replenish your digestive system with prebiotics and probiotics for healthy gut maintenance in the long term.
UMZU provides free shipping on any order over $99.
In the chart below, you’ll see the individual, subscription, and bundle prices for zuPOO side by side to help you decide what option may be best for you.
|One-time purchase||Subscription purchase|
|Gut Health Bundle||$109.85||$93.37|
Is zuPOO a good value?
zuPOO is among the higher-end all-natural laxative supplements in terms of price. However, as this is not a product intended for everyday long-term use, we found its primary value in its scientifically backed ingredients and transparency.
For instance, Gaia Herbs sells a Natural Laxative for $19.99, which shares some (but not all) ingredients with zuPOO. Its primary components include organic senna leaf and aloe juice powder, but it lacks the potent cascara sagrada that zuPOO has. Puritan’s Pride sells low-cost Herbal Laxative Tablets for just $8.99, but it is less transparent in its ingredients and provides little scientific research to back them up.
Ultimately, we found zuPOO to be a good value and a cost-effective choice for an all-natural supplement with a blend of potent botanical laxatives. We trust the UMZU brand and recommend enrolling in its subscription plan for the Digestive Health Bundle for the savings that it offers.
HSA, FSA, and health insurance
UMZU does not accept payments from HSAs, FSAs, or health insurance.
At Innerbody Research, we customize our evaluation criteria depending on the type and nature of the health-related service or product. But in general, for health products and services, we have five broad areas that we explore in our evaluations, including:
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