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Finding the Best DNA Health Test

Our experts explain everything you need to know about DNA health testing.

Medically reviewed by: Gerard DiLeo, MD
Last Updated: Mar 26, 2020

23andMe's DNA Test

Health DNA testing has come a long way in recent years, and it is thrilling to imagine the wealth of information we’ll be able to learn about ourselves in another 10 years. Last year, 23andMe became the first company to receive FDA approval to market genetic risk information for certain conditions. Unlike some of the other well-known DNA testing companies like AncestryDNA, 23andMe has focused a lot of its efforts on providing consumers with very useful health-related information. As you will see below, many smaller testing companies focus on one or two niche health areas. 23andMe, however, really shines in a number of areas and offers the most comprehensive DNA-based health test by far. For this reason, 23andMe offers the best all-around tests and remains our top recommended testing provider for most people.

Read on to find out how DNA health tests work, what you can discover about your health from them, and how we determined our recommendations.

What is the best DNA tests for health?

Why you should trust us recently celebrated its 20-year anniversary online. Over the past two decades, we have helped tens of millions of readers make informed decisions involving staying healthy and living healthier lifestyles.

Our testing team has purchased and compared over 300 genetics-based tests to date, and we are constantly updating our reviews based on the latest test advances. We strive to give you, our readers, an unbiased, marketing-jargon-free description of the DNA tests reviewed based on scientific evidence.

The primary author of this guide has a PhD in Genetics and was formally a Population Geneticist for a major DNA testing company. And like all medical-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for medical accuracy.

What can you learn from DNA health tests?

DNA health tests can tell you quite a bit about certain aspects of your genetic health, ranging from serious to fun. Here are some of the specific areas that you can learn about.

General health risk testing

Best DNA Health Test | Innerbody

By analyzing your DNA and looking at what genetic markers are present, DNA testing companies can tell you about your risk of developing a range of conditions. For example, 23andMe covers more than 10 different disease risks, including your likelihood of developing:

  • Breast cancer
  • Early-onset Alzheimer’s disease
  • Celiac disease
  • Age-related macular degeneration
  • Parkinson’s disease

It is always important to remember that these tests do not provide diagnoses. You should interpret the results carefully, ideally with the help of a genetic counselor or healthcare provider.

Best for Health Risks
23andMe: Ancestry + Health

23andMe: Ancestry + Health

By far the best at-home DNA test for general health risks, covering 10+ reports covering breast cancer, Alzheimer’s disease, Parkinson's disease, and more.

23andMe offers the most well-rounded, comprehensive at-home DNA health test on the market. The Ancestry reports included are also top-notch and a fun bonus that complements the health-related information nicely.

Carrier screening testing

Carrier screening is a type of genetic test that can tell you whether you carry a genetic variant associated with certain genetic disorders. Most of the time, these variants will not affect you directly, but you may pass them on to your children. Examples of diseases that can be passed on in this way include cystic fibrosis, sickle cell anemia, and hereditary hearing loss. Most commonly, if both parents are carriers for a certain disease-causing variant, there will be a 25% chance that their child will be affected by the disease. Taking genetic screening tests can allow couples to take steps to minimize the chances that their children will inherit a disorder, or allow them to plan for the future, often with the help of a genetic counselor or their healthcare provider.

Best for Carrier Screening
23andMe: Ancestry + Health

23andMe: Ancestry + Health

This test’s Carrier Status Report covers an outstanding 44 different inherited conditions + Health Risks, Wellness, Traits, and Ancestry reports.

23andMe offers the most well-rounded, comprehensive at-home DNA health test on the market. The Ancestry reports included are also top-notch and a fun bonus that complements the health-related information nicely.

Wellness & traits testing

Wellness and traits reports contain information on other traits that are related to your overall health. These include your natural “genetic weight,” how likely you are to experience deep sleep, and your predisposition for addiction, along with other traits. This information can be useful to guide you in terms of your diet and lifestyle, but don’t read too much into the results! For instance, you may weigh much less than the average person of your sex and age but find that your natural genetic weight is in fact 7% above average. This is because genetics is only a small part of the story; lifestyle and environment are very important factors for most characteristics covered in this test.

Best for Wellness & Traits
23andMe: Ancestry + Health

23andMe: Ancestry + Health

This test’s Wellness & Traits Reports cover 5 different wellness areas and 30+ traits. Test also includes Health Risks, Wellness, Traits, and Ancestry reports.

23andMe offers the most well-rounded, comprehensive at-home DNA health test on the market. The Ancestry reports included are also top-notch and a fun bonus that complements the health-related information nicely.

Nutrition testing

Some “wellness” areas are more popular than others, and nutrition and fitness are the most popular by far. Tests in these two areas aim to go beyond simply giving you nice-to-know information. Instead, they give you actionable recommendations that will enable you to live a more healthy lifestyle. In a nutshell, the tests look at specific gene variants that are thought to be associated with particular traits such as metabolism, muscle tissue type, gluten sensitivity, and nutrient absorption. As long as you: 1) take the resulting recommendations with a grain of salt, 2) keep in mind that lifestyle and environmental factors also weigh heavily in most outcomes, and 3) consult a professional nutritionist before making any drastic diet changes, these tests can be motivating and fun.

Fitness testing

Another very popular “wellness” area that deserves its own section is Fitness. DNA tests in this category analyze different genes related to metabolism, exercise recovery, and muscle strength. Again, we would like to make the same caveat that you must: 1) take the resulting recommendations with a grain of salt, 2) keep in mind that lifestyle and environmental factors weigh heavily in most fitness-related outcomes, and 3) consult a professional physical trainer or medical professional before making any drastic changes to your fitness regime.

Cellular aging testing

Incredibly, it is now possible to learn about how well your cells are aging using DNA testing. The tests are based on telomeres, which are cap structures that protect the ends of our chromosomes from being degraded. Your telomeres naturally wear down and shorten as you age; each time a cell divides and DNA replicates itself, telomeres get a little shorter. But please keep in mind that scientific evidence shows that other factors within our control can affect our telomere length positively and negatively, including stress management, diet, exercise, and sleep quality, to name a few.

By measuring the length of your telomeres and comparing this result to others of your age and sex, it’s possible to estimate how well you appear to be aging compared to others of your demographic, according to the company database.

Best for Cellular Aging
TeloYears: Telomere Health

TeloYears: Telomere Health

The only direct-to-consumer test on the market that measures and analyzes telomere lengths.

TeloYears has developed state of the art technology to give you a unique perspective on your health and well-being. It also offers an above-average ancestry-focused test if that interests you.

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How we choose our recommendations

We customize our evaluation criteria depending on the type and nature of the health-related test. For DNA test kits, we have five areas that we use to evaluate and ultimately form our recommended tests. They are:

Testing Technology: Does the testing company use the latest and most accurate testing technologies available? How frequently does the company update its gene chips to reflect the latest scientific advances and new links between DNA and disease, genes, and base pairs?

Results Presentation: How clearly are the test results presented? Are the results be easy to understand? For those who want it, how much scientific detail do the results offer?

Value: Are you getting your money’s worth? Will you have (free) access to new results as the testing company updates its gene chips in response to new scientific advances? Are there any hidden costs or charges (shipping, etc.)?

Privacy: Will your data be stored securely? Could your data ever be shared without your permission? How clear is the testing company’s privacy policy?

Customer Support: If you have any issues with your test, how well does the testing company respond? How well does it answer questions you may have regarding the test results?

How DNA tests work

23andMe's DNA Testing Lab

DNA is the genetic code that governs the functioning of our cells and essentially determines every biological aspect of who we are. You can think of it as a kind of blueprint that controls the way your body works, which is passed down through the generations in the form of sequences of code called genes. All humans share over 99.5% of our DNA with one another, but it is the genes making up the 0.5% difference that account for all the diversity we see among individuals. These gene differences are called “variants,” and while most gene variants are neutral, or account for the normal variation among us all, some can cause serious diseases.

DNA testing involves providing a sample of your DNA (usually in the form of a saliva sample) which is sent to a lab for analysis. Using the extensive databases and associated research, testing companies can predict your risk of developing certain diseases based on what gene variants are present in your code. You’ll receive comprehensive reports outlining your risk factors for each disease, along with your carrier status and additional information explaining how to interpret the results.

For a more detailed explanation of how DNA testing works, we created an entire guide on this topic: Comprehensive Guide to How DNA Tests Work.

Interpreting your results

There is a lot to consider both before and after undertaking a health DNA test. If you’re planning on taking health DNA tests, 23andMe advises you to get in touch with a genetic counselor beforehand to discuss your expectations regarding the test, whether you may be distressed by the resulting information, and whether the benefits of learning such information outweigh the drawbacks. Genetic counselors are healthcare professionals with special training in the interpretation of these kinds of reports. Consultation in advance is of course optional, and many customers don’t feel the need to do it.

However, it’s extremely important to discuss any worrying or alarming DNA health test results with a genetic counselor or healthcare provider, rather than trying to interpret the risk information yourself. Even if the test does not recognize any variants for a particular illness in your genome, this doesn’t necessarily mean you are not at risk of, or a carrier of, that disease variant. Not all variants for these illnesses have been identified yet (in the case of 23andMe, further information on this would be available in the report itself). If you do test positive for a particular disease risk variant or carrier variant for some specific illnesses, there are a variety of options you might consider to effectively minimize your risk and that of your children, and so you should share your results with your doctor.

Privacy Considerations

Your genetic data is the most personal information you possess, and privacy is an important consideration when deciding which DNA testing provider to use. All DNA testing companies will have comprehensive privacy statements, and these are the best places to start when evaluating different providers. In the case of 23andMe, you have a number of decisions to make before receiving your results, including:

  • Whether you want your saliva sample discarded or stored once it has been analyzed
  • Which health reports you would like to opt into or out of
  • Whom you would like your information shared with
  • Whether or not you consent to the use of your DNA results for scientific research purposes

Most companies go to great lengths to ensure confidentiality, but if you’re concerned about privacy, some research on the company website is advisable before committing to a particular test provider. You may also want to take a look at our popular guide: DNA Testing Privacy: 5 Recommendations for New Test Takers.