Best NMN Supplement

Aging is inevitable, but some interventions might be able to improve the process, allowing you to live a longer, healthier life. A growing body of evidence suggests that NAD+ — nicotinamide adenine dinucleotide — could hold the key to better aging.1 NAD+ levels decline as we age, but certain supplements could restore your NAD+ levels to those of a much younger person.

Unfortunately, taking NAD+ directly isn’t very effective.5 The good news is that NAD+ precursors have become widely available in recent years. Among the possibilities, nicotinamide mononucleotide (NMN) has emerged as a potential frontrunner.

Here, we’ll break down the potential benefits and risks of taking an NMN supplement and describe the best options on the market. We’ll help you determine which one is right for you.

At Innerbody Research, we extensively test each health service we review, including these NMN supplements. All told, our team has spent over 1,200 hours testing and researching these supplements and the customer service their manufacturers provide. We’ve tried numerous lipo options, intranasal sprays, enteric-coated capsules, sublinguals and powders, and, of course, traditional veggie capsules.

In addition to that real-world experience with NMN, our team has pored over dozens of scientific journal articles devoted to NAD+ production and NMN metabolism. We've also consulted with medical professionals whose insights have been illuminating. All of this preparation allows us to confidently suggest which available supplements stand the best chance of increasing your NAD+ levels. It also revealed to us the need to create a NAD+ boosting supplement of our own — Innerbody Labs NAD+ Support, which contains a high therapeutic dose of NMN among other ingredients integral to NAD+ metabolism. We’re confident that it’s the best option for most people interested in elevating NAD+ levels, but we’re also aware that it’s not the best choice for everyone. This guide is critical of all options, and we’ll be quick to point out situations in which an alternative might be better for you. The purpose of this guide is to help you find the best ways to improve your health.

Additionally, like all health-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for accuracy. We’ll continue to monitor the landscape of NMN supplements and other NAD+ boosters to ensure our content stays up-to-date.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

In evaluating NMN supplements, we closely considered four criteria we felt would matter most to the average consumer:

• Effectiveness
• Safety
• Cost
• Convenience

Below, we’ll break down which companies rose to the top of each ranking category. In some cases, we’re pitting complex formulas against single-ingredient supplements, which can complicate considerations, but we’ll provide context and alternative paths at each turn, so you can make an informed choice.

Effectiveness

Advantage: NAD+ Support by Innerbody Labs

NMN studies tend to point toward a dose-dependent increase in effectiveness — the higher the dose, the more effective it is — at least for raising NAD+ levels.2 More effect-specific studies are scarce enough that only a handful of doses may have been tested for any given effect, and these run a range from 250mg at the low end to 2,000mg at the high end.

NMN also isn’t the only NAD+ precursor in town, with nicotinamide riboside (NR) offering a similar profile for NAD+ boosting and some secondary effects.28 Fascinatingly, despite being two similar NAD+ precursors with similar NAD+ boosting abilities, each ingredient has shown effects in clinical studies that the other hasn’t replicated. That means, if you wanted to get the full potential of NAD+ booster-related benefits, you might want to take them both.

This is one big reason why we found NAD+ Support to be the best option for efficacy. It boasts a relatively high 700mg NMN dose alongside a 400mg NR dose. That brings the total NAD+ precursor dose to 1,100mg — more than nearly any competitor — all while providing the wider range of benefits from NR and NMN combined.

Beyond the dosage of precursors, another reason behind our recommendations involves a significant risk to efficacy in the metabolic system that converts NMN and NR into NAD+ (the salvage pathway) — a risk that many brands overlook: it’s not uncommon in both NMN and NR studies to see NAD+ levels increase at the outset but then actually decrease after about 12 weeks of supplementing. This risk likely arises from a depletion of methyl donors in the salvage pathway. The most effective NAD+ boosters are those that safeguard against this risk, and Innerbody Labs provides a dose of the methyl donor trimethylglycine (TMG), in addition to spermidine, that makes it most effective over the long haul.

A quick note about bioavailability enhancers: All NAD+ precursors suffer from bioavailability issues, even if you’re delivering them intravenously.3 In the digestive tract, they begin to break down into more basic forms of vitamin B, typically niacinamide and niacin. Companies try to get around this bioavailability issue by using novel delivery mechanisms like enteric-coated capsules, sublingual powders or lozenges, oral gels, or nasal sprays. These may all make a difference, but there’s almost no human research on how any of those methods could impact NAD+ metabolism specifically, making it difficult to recommend them over traditional capsules at this time.

Safety

Advantage: Neurogan NMN 500

While most of these products have similar ingredient profiles, a lot can happen during the manufacturing process that can potentially contaminate a supplement. There are also secondary and tertiary ingredients that can make one brand a better choice than another, whether they’re included for their own merits or to increase the bioavailability or NAD+ production efficiency of each NMN dose. Innerbody Labs, Renue by Science, and Neurogan all have some of the strongest third-party testing in the business, with a publicly available certificate of analysis on each product page.

Neurogan has the advantage here, however, mainly due to its third-party testing, use of traditional capsules, and the dosage flexibility its NMN 500 offers. Each capsule of NMN 500 actually contains just 250mg, with two capsules in a serving. That allows users to start small if they please and titrate up in measured increments that allow them to push upward to the point where they encounter adverse effects and pull back a bit from there. You can titrate upward with our top recommendation as well, though you begin at a higher 367mg dose if you do. With Neurogan’s 900mg capsules, meanwhile, you’re stuck starting at a high dose, and increasing by just one capsule sends the dose beyond the 1,200mg level that’s been shown to be safe in at least one study.6

Among complex formulas, Innerbody Labs is a clear winner for safety, thanks to that third-party testing, its use of traditional capsules that align with safety research, and its use of only a few effective NAD+ production supporters. Another safety advantage of Innerbody Labs is its inclusion of spermidine and TMG, which prevent excessive NAM from being converted into 1-methylnicotinamide (MNAM) and thereby posing a risk of fat accumulation and increased insulin resistance.

We should also point out that there’s a big safety caveat that affects all NMN supplements and anything else that’s designed to increase NAD+ levels: a known but poorly understood link between NAD+ levels and cancer growth.4 At this point, researchers have confirmed that starving tumors of NAD+ can cause them severe damage, making a reduction in NAD+ levels a potential treatment.25 But as NAD+ is essential for proper mitochondrial activity, that can have unintended consequences, including the development of age-related diseases.26 There’s also some evidence of NAD+ boosting tools being used to fight cancer.

The picture is muddy, and we’ll dive a little deeper into the risks and the relevant research in our safety section later, but those with active cancer, cancer in remission, or a history of cancer in their family might want to consider alternatives to achieving wellness goals. As with many supplements and medications, the lowest dose that gives you benefit is ideal, so supplements that provide lower doses — or give you control over the dose — may be preferable from a safety standpoint. And, as always, you should talk to your doctor before beginning any new supplement.

Cost

Advantage: Neurogan NMN 900

Understanding the value of a given NMN supplement relies on comparing both the costs per gram of NMN and other NAD+ precursors and the costs per dose. The latter is important because several NMN supplements employ additional ingredients that could artificially inflate the cost per gram of precursor.

Here’s a quick look at those costs for some of the top NMN supplements on the market:

As you can see, Neurogan has two of the best deals on NMN available, with its 900mg capsules providing the lowest cost per gram of NMN you’ll find in capsule form. There are less expensive powdered NMN supplements out there, but given the ingredient’s susceptibility to stomach acid and the lack of research on powder-based forms, sticking with a capsule remains the best way to go.

The downside? Research studies often show that NMN and NR supplementation leads to NAD+ levels dropping over the span of months, after rising initially, likely because of methyl donor depletion. So while your up-front cost here is low, you may find the need to add a TMG supplement to your regimen, potentially erasing the savings. This is a big reason why Neurogan isn’t our top recommendation for most people.

Among the three complex formulas in that chart, AEON has the lowest cost per dose, but it delivers less than half as much precursor as Innerbody Labs, making Innerbody the superior deal and the best complex formula for anyone looking to get the most bang for their buck.

Convenience

Advantage: Renue by Science

Renue by Science has the edge here thanks to the various ways you can take its supplements. You can choose from the following:

• Powders
• Capsules
• Sublingual tablets
• Nasal sprays
• Oral gels

One big caveat here is that these delivery methods don’t have much research to support any particular dose. There are studies comparing sublingual or intranasal administration of completely different drugs, but these results don’t translate directly to NMN. For many people, these are more convenient options, but they might not provide the same benefits as traditional capsules, which boast the lion’s share of available clinical research.

Beyond dosing, Renue’s website is well designed, and its live chat feature connects you with helpful people who can answer various questions about NAD+, its precursors, and the company’s policies.

The NMN supplement landscape can get complicated, so we’ve put together a simple chart to summarize the features of the best options on the market:

NMN stands for “nicotinamide mononucleotide.” It’s a precursor to a coenzyme in the body called nicotinamide adenine dinucleotide (NAD+). Your body converts NMN into NAD+, which, in turn, can enhance the efficiency with which your body’s cells function.5 Some studies show that it also enhances athletic performance by increasing your VO2 max after a short period of use.6 Others connect it with improved insulin resistance, resulting in lower diabetes risk and, potentially, a trimmer waistline.7

How NMN becomes NAD+

NMN’s conversion to NAD+ takes place in the salvage pathway, one of three metabolic systems that generate NAD+ in the body. The other two systems, the Preiss-Handler and de novo synthesis pathways, rely on dietary sources of vitamin B3 and tryptophan, respectively. But the salvage pathway can use external sources like vitamin B or the NAD+ precursors NR and NMN while also being able to recycle NAM back into the salvage pathway when it's released as a byproduct of NAD+ usage.29

That's why the salvage pathway is sometimes referred to as an NAD+ recycling system: NAM converts to NMN and then to NAD+, and when your body uses NAD+, it releases NAM that the salvage pathway can use again.

Here’s a look at the salvage pathway in action:

Balance is critical in the salvage pathway, especially concerning methyl donors, which allow NAM to convert into NMN on its way to becoming NAD+.29 Since NAD+ utilization leaves behind NAM as a byproduct, if you ramp up NAD+ production, you end up with an overabundance of NAM without enough methyl donors to sustain the newly increased conversion rate.29 30 That can give other actors, like NNMT, license to convert unclaimed NAM to MNAM, introducing a potential source of cellular harm — the opposite of what you want.36

Some NMN products contain additional methyl donors to support increased NAD+ production. Trimethylglycine (TMG) is among the most effective and widely used in NAD+ supplements, and Innerbody Labs is tied with a few other companies for having the highest dose (500mg) in its class.

When the salvage pathway is well-managed, NMN supplementation can result in some noteworthy health benefits. Let’s take a slightly deeper look at how NMN supplementation has been shown to improve health.

Boosting NAD+ levels is at the core of NMN’s potential to improve health and wellness, but some NMN-specific research has revealed certain secondary effects not seen from other NAD+ precursors. Whether these are ultimately attributable to NAD+ levels or NMN itself is still under investigation, but the results are important to investigate.

Here are a few of the ways NMN has improved health parameters for participants — beyond increasing NAD+ levels — in prominent research:

Nicotinamide riboside (NR) is another NAD+ precursor that boasts a fair amount of convincing scientific evidence supporting its effectiveness.28 While most research looks at one precursor or another, and most companies provide one or the other in their supplements, the choice between the two might not be entirely necessary.

If we were pressed to make a recommendation between the two, we’d likely say that NMN’s larger body of human research and closer metabolic proximity to NAD+ make it the superior choice, but both will effectively raise NAD+ levels.

To make the choice yourself, you might want to ask yourself if there are specific goals you have in mind beyond longevity and increased NAD+ levels. For example, if you were determined that your NAD+ precursor should also improve brain health and protect against neurodegenerative disease, you’d want NR. There’s research to back up NR’s role in brain health that doesn’t yet exist for NMN.28 The reverse is true for increasing telomere length and improving sleep, where NMN boasts positive research that NR doesn’t.34 31

Here’s a handy reference for the current state of the research:

Ultimately, you may tolerate one better than the other, and it’s up to you to decide which one to try first. Our guide to the best NAD+ supplements includes some NR options you won’t find on this list.

Compared to NAD+, NMN is a smaller molecule and can more easily pass through cell membranes. That makes it far superior to direct supplementation with NAD+, which the body has difficulty absorbing.

When you take NMN, a transporter on the cell’s surface invites it in, where it can convert to NAD+ in the liver within 15 minutes. Studies using intramuscular injection of NMN showed its ability to create NAD+ in various organs and systems.5

NAD+ production is dose-dependent, which means that the more NMN you consume, the more NAD+ you’ll produce — up to a certain limit. As we mentioned above, there could be long-term safety concerns with high NMN doses. There are cancer risks that haven’t been fully explored, as well as the potential for the salvage pathway to stall if you don’t supply it with methyl donors to support an increased NAM-to-NAD+ conversion rate, resulting in MNAM accumulation and increased risk of fat accumulation and insulin resistance.9 36 It’s up to you to balance your risk-to-reward ratio with a given dose.

How NMN supplements absorb

The supplements you’ll see in this guide come in various forms, which can significantly impact their effectiveness. One form of medicine will absorb more or less quickly than another, and it depends mainly on how the company compounds its drugs and the mechanism by which they’re delivered.

Currently, most NMN research has used capsules as the delivery mechanism, so there’s too little data on other delivery methods as they pertain to NMN. However, NMN is similar to a vitamin in many respects, and other mechanisms for vitamin delivery have been studied extensively. These include studies of liposomal nanocarriers as well as intranasal, sublingual, and transdermal delivery methods.

While sublingual delivery may be faster-acting, it doesn’t seem to increase long-term bioavailability, at least according to one vitamin B study.13 And lipid nanocarriers can theoretically protect NMN until it gets to the small intestine, where a dedicated NMN transporter is waiting to help you absorb it, but there’s more than one type of liposomal delivery system, and each will act differently in delivering specific elements or compounds.14 To date, the only liposomal NMN study that’s been published was extremely small (just 15 participants) and resulted in a modest 25% increase in NMN efficiency.46

So, for those of you more interested in using cutting-edge delivery mechanisms with the highest potential for fast and thorough absorption, novel methods like sublingual or intranasal delivery or liposomal encapsulation might be enticing. But if you want to go with what’s been shown to be both safe and effective, standard encapsulation should be your choice at this time.15

NMN has a fair amount of research supporting its potential to improve various biomarkers on its own, but numerous supplement makers have seen fit to combine it with other ingredients. In some cases, these ingredients serve to support healthy NAD+ production, while, in others, their presence is more related to specific goals like anti-aging.

Let’s take a closer look at some of these extra ingredients you’re likely to find within our top picks:

NMN supplements haven’t consistently shown any adverse effects in the research, including in trials that used up to 1,200mg/day.8 6 When adverse effects do crop up in NAD+ precursor studies, they typically come from NR, not NMN, and the effects include:35

• Headache
• Dry mouth
• GI upset
• Muscle cramps or spasms

It’s possible that NMN could create some of the same effects, given its similar role in NAD+ metabolism, but they haven’t been seen in studies at any rates higher than a placebo.

Currently, one problem in NAD+ data in general seems to be a lack of research into long-term usage related to cancer. There’s no evidence to suggest that NMN or elevated NAD+ levels can cause cancer. Still, there’s some evidence that NAD+’s ability to increase cellular efficiency also applies to cancer cells. Researchers successfully inhibited tumor growth by reducing those cells’ access to NAD+.9 This implies that an abundance of NAD+ might fuel preexisting or developing cancer in the body. But at the same time, there’s contradictory research that shows NAD+’s protective potential against certain other types of cancer.10

So, both of these things may be true:

• NAD+ has anti-aging effects that may involve protecting against the development of cancer.
• NAD+ could make already-developing cancers worse.

We need more data to conclude whether elevated NAD+ levels pose a cancer risk. At the moment, we know too little about NAD+’s entire metabolic lifespan and its effects in the body’s various systems to narrow down which of those two things is more characteristic of NAD+. Scientists may eventually identify an ideal dose of NMN or NR — or find a quick, accurate, and inexpensive way to measure and maintain a Goldilocks NAD+ level in the body — but for now, it’s essential to be aware of the unknowns. Talking to your doctor or nutritionist is always a smart move when considering a new supplement.

Best overall and best complex formula for NAD+ boosting

Innerbody Labs, the product side of Innerbody Research, formulated NAD+ Support to include both NMN and NR because the current body of clinical research has demonstrated differing benefits of each precursor. It's unclear whether these differences are real and due to their entrance into the salvage pathway at different points or if further study will reveal their effects to be closer to identical.

Based on the available research, the most reliable and efficient NAD+ boosting supplement would combine the two at effective, but not excessive, doses. NAD+ Support takes this approach — a combined 1,100mg dose (700mg NMN and 400mg NR) — which could conceivably outperform 1,100mg of one precursor or the other across a broader array of benefits documented in human research.

Here’s a closer look at the formula:

• NMN: 700mg
• NR: 400mg
• TMG: 500mg
• Spermidine: 15mg
• BioPerine: 10mg

As straightforward as it is, this complex of five ingredients serves to maximize the potential you get from each precursor while keeping the combined dose within safe limits.6 The addition of targeted ingredients like TMG and spermidine adds distinctive longevity benefits while promoting more resilient NAD+ production over time.

With the addition of BioPerine, you can bank on about a 15% increase in the NMN’s efficacy, bringing the effective dose up to 1,205mg.40 That’s a stronger dose than just about anything in its class without increasing side effect risks — more than double the dose from Perpetua.Life in its AEON complex.

The formula is delivered in a three-capsule dose, allowing for reasonable titration from as little as one capsule. Here’s how that titration breaks down:

As you can see, even with just one capsule, you get a precursor dose that can reliably increase NAD+ levels, along with more TMG than full doses from competitors like Codeage, Thorne, Perpetua.Life, and Renue by Science. The spermidine dose in a single capsule might be a little low for its enhanced longevity benefits, but it may be sufficient to help streamline NAD+ production.

The two-capsule dose gets even more powerful, with a combined 734mg precursor dose and therapeutic doses of TMG, spermidine, and BioPerine. And with the boost provided by that black pepper fruit extract, you’re getting more like 844mg of NAD+ precursor.

Innerbody Labs also has its supplements tested for purity, potency, and contaminants, including a full pesticide panel, with batch-specific certificates of analysis available on every product page.

Innerbody Labs NAD+ Support pricing

Innerbody Labs typically combines subscription discounts with bulk purchasing savings to give you various ways to lower its prices. Here’s how the breakdown goes for NAD+ Support:

As you can see, the best price per bottle comes with a six-month subscription, though any subscription keeps your cost per dose under $2. And since Innerbody Labs ships all orders for free, there are no additional costs to expect. Most of the other supplements in this guide ship for free — some on all orders, but others because their free-shipping thresholds are lower than the cost of their NMN. However, Neurogan only ships for free on subscriptions or orders over $70, with costs calculated by weight and distance for lesser orders.

You get a 30-day money-back guarantee from Innerbody Labs, which is a nice insurance policy, though it’s less than the 60 days from Renue by Science or the 100 days from ProHealth Longevity.

Best budget pick and best NMN-only option

For anyone seeking a simple NMN-only supplement, the most important considerations include dose flexibility, cost, safety measures, and subscription convenience. Neurogan earns high marks in every category. On the cost side, it offers two of the lowest per-dose costs and one of the lowest per-gram costs of NMN on the market. It does so with outstanding safety measures, including rigorous third-party testing, U.S.-based manufacturing in GMP-certified facilities, and adherence to the bulk of the available science in its simple encapsulation.

Neurogan offers its NMN in several other forms, as well, likely because the company is aware of the demand for alternatives to capsules (to either increase convenience or improve bioavailability). But unlike a company like Renue by Science, which focuses solely on those alternative or enhanced methods, Neurogan makes sure to provide NMN in the same capsule delivery mechanism used in the majority of human scientific research.

The two products we recommend come as a 90-count bottle of 900mg capsules (a one-capsule dose) or as a 120-count bottle of 250mg capsules (a two-capsule dose). NMN 900 is ideal for anyone seeking a high dose in a single capsule for a great price. Its cost per gram of NMN is a big draw, but you can’t titrate lower than 900mg, and if you want to go higher, you have to jump to 1,800mg. At a dose that high, you might begin to encounter some side effects.

By comparison, NMN 500’s 250mg capsules allow you to start low and titrate up gradually, potentially hitting 1,000mg or 1,250mg to align with some higher-dose studies that appear to be safe.6 The only issue there is that the great value NMN 500 offers at the 500mg level starts to fade once you’re taking 4-5 capsules per day.

Neurogan NMN pricing

Neurogan offers a 25% discount to subscribers, with renewals every one, two, or three months. Here’s how those discounts play out:

Unlike most other companies in this guide, which either offer free shipping outright or whose free-shipping thresholds are lower than the cost of their NMN products, you’re likely going to have to pay for shipping from Neurogan if you make a one-time purchase. Fortunately, subscriptions ship for free, so you can save a little extra by going that route. Neurogan also offers a 30-day money-back guarantee similar to the one from Innerbody Labs.

Best for customers outside the U.S.

Given how closely linked NMN supplementation is with an overall anti-aging effort, it makes sense to include a good anti-aging complex that provides a fair amount of NMN in this guide. Perpetua.Life is one of the few companies out there (along with Innerbody Labs) offering a combination of NMN and NR in a capsule. Its dose of each is lower than what you get with Innerbody Labs, but there are a few extra ingredients in here that might be of interest to some people.

Here’s a look at the formula:

• Vitamin B2: 1mg
• Vitamin B6: 5mg
• Vitamin B12: 2mcg
• Nicotinamide DUO: 500mg (400mg NMN, 100mg NR)
• Quercetin: 250mg
• Trans-resveratrol: 150mg
• Fisetin: 100mg
• Astragalus: 100mg
• L-Theanine: 100mg
• EGCG: 100mg
• TMG: 85mg
• Piperine: 10mg
• Spermidine: 10mg

As you can see, AEON has all five of the ingredients in Innerbody Labs NAD+ Support, but it provides four of those five in smaller doses, with the same amount of black pepper fruit extract. That said, if you were already considering a smaller dose of NAD+ Support and you also wanted to incorporate some of the ingredients seen in AEON, this might be a better path. It also helps that Perpetua.Life ships internationally outside the U.S. Customers outside the U.S. can’t currently acquire products from Innerbody Labs.

We’ve discussed most of AEON’s extra ingredients earlier in this guide, but we should touch on two others here that we haven’t mentioned: L-theanine and epigallocatechin (EGCG).

Both L-theanine and EGCG are derivatives of tea, and both boast a good amount of human research supporting their respective roles in wellness. With L-theanine, the focus is on lowering stress and cortisol levels and improving sleep, albeit more typically with a 200mg dose than the 100mg seen in AEON.42

EGCG has been studied for even more benefits, including:43

• Diabetes
• Oxidative stress
• Parkinson’s disease
• Alzheimer’s disease
• Stroke
• Obesity

However, many of these studies relied on higher doses than the 100mg in AEON, with roughly three times that amount being seen as a reliable daily dose.44

Despite these shortcomings, AEON still represents a good value for the variety of ingredients it includes and for its liposomal delivery. There isn’t enough data on liposomal delivery specific to these ingredients, but a study on liposomal NMN showed about a 25% increase in efficacy. It was a small-scale study that will need to be repeated in much larger groups before we can say anything definitive, but if you’re looking for an edge in bioavailability and don’t mind the technology obscuring your dose a bit, that could be an added benefit to AEON or our next pick, Renue by Science.

Perpetua.Life AEON pricing

Perpetua.Life employs a decidedly simple price structure, with one-time purchases or monthly subscriptions as your only options. Here’s how it works out:

You can save about $0.40 per dose by opting for a subscription, and both purchase levels qualify for free shipping, on par with the likes of Innerbody Labs. AEON also comes with a 30-day guarantee similar to those from Innerbody Labs and Neurogan.

Best powder and best for novel delivery methods

Renue by Science offers a range of products focused on NAD+, including a handful of smartly designed NMN supplements. The company tackles one of any NAD+ supplement’s most significant problems head-on: absorption. NAD+ precursor bioavailability isn’t great, so things like liposomal technology, enteric-coated capsules, or sublingual and intranasal delivery could get around this.

The problem is that those methods lack useful research guiding dosing for safety or efficacy. There’s plenty of evidence about liposomal delivery, but its effect changes depending on the ingredient it protects.45 Similarly, there are plenty of studies looking at various drugs delivered sublingually or intranasally, but none looking into NMN delivered this way. One liposomal NMN study exists, but it included just 15 participants — far too few for statistical significance — and it showed a modest 25% increase in efficacy over non-liposomal formulations.46 Also, liposomal formulations tend to be more expensive, when a larger dose of a less expensive NMN might prove just as useful.

Renue by Science NMN pricing

Renu by Science has a larger catalog of available NMN supplements than most others, with numerous delivery mechanisms and doses to consider. We break them down below, with their one-time prices shown. Subscriptions knock an additional 10% off each price.

Renue by Science also offers NMN pet chews designed for dogs or cats, but the science behind these is far from conclusive.17

Renue by Science provides free shipping on its orders without your purchase needing to reach any price threshold. And its return policy has significantly improved; whereas the company used to accept returns only on unopened products, now you're protected by a 60-day money-back guarantee, no matter what. That's a nice improvement for customers, though it's worth pointing out that some competing companies, like ProHealth Longevity, offer longer return windows.

ProHealth Longevity offers numerous anti-aging and energizing supplements. Its collection of NMN products provides you with several doses and administration methods to consider. There are powders, capsules, tablets, and lozenges, most with a few dosages available. It’s one of the more expensive brands out there, but it’s one of the few companies to offer a branded NMN.

Uthever, a product of biotech company Effepharm, is one of the only branded NMN supplements on the market, and it’s the only NMN that ProHealth Longevity uses. But the self-funded research into this specific form of NMN (available to review on the company site) reveals performance on par with unbranded NMN used throughout the scientific literature. In other words, there doesn’t appear to be anything special about it beyond a standard of quality that good third-party testing on unbranded forms can easily confirm.

Here’s a breakdown of ProHealth Longevity’s NMN offerings.

ProHealth Longevity offers multiple-bottle discounts on its capsules and lozenges, as well. If you spend more than $30 on your order, you’ll be eligible to receive free shipping. This is a very low threshold and amounts to free shipping on any NMN product.

Perhaps most important, ProHealth Longevity has the longest money-back guarantee in our guide at 100 days. That’s 40 more days than Renue by Science and 70 more days than the rest of the field. Many NAD+ boosting effects can take a few months to kick in beyond the early increase in NAD+ levels, so having a longer guarantee is nice.

The word “longevity” gets bandied about quite a bit by companies selling NMN and similar products. There’s some evidence that increasing NAD+ levels can offset some of the common markers associated with aging, but enduring the passage of time is an incredibly complex ordeal that pills can’t solve. (At least, not yet.)

Longevity wellness is an industry unto itself, with NMN just one of many avenues for exploration. Let’s take a quick look at some other supplements and approaches you can take to enhance your lifespan, either by lengthening it or improving the time you have. Some of these can be utilized in conjunction with NMN or each other, but there may also be some instances in which taking too many anti-aging products can have the opposite effect. Be sure to discuss your longevity goals with a doctor and develop a comprehensive and safe approach fit for your needs.