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What's the Best ED Treatment in 2023?

Our ED guide examines cost, effectiveness, convenience, and other facts about erectile dysfunction treatments along with free trial information.

Last Updated: Apr 12, 2023
best ED treatments

Erectile dysfunction (ED) is a common condition. One recent study estimated that roughly a third of men struggle with ED.¹ Though the condition does affect more older men than younger men — half of the erectile dysfunction patients in the U.S. are over the age of 60 — men who suffer from ED span age groups. Another study found over 25% of men under age 40 suffered from ED to some extent.² If any of this describes you, then you’re certainly not alone at all.

Thankfully, ED is also a condition that is very treatable. Several treatments work for most men with ED, but the question still stands: what is the best treatment for you? It can get complicated. Aside from underlying health considerations, everything from price to how you take the medication can affect your decision.

To help you out, we’ve reviewed the major online providers and treatments and analyzed a large swath of relevant scientific research. In this guide, we’ll break down all of your best options.

First, for those in a hurry, here’s a quick snapshot of our advice.

Our top choice in 2023: BlueChew

BlueChew has a simple interface that quickly leads you through the consultation process to get your prescription sent to you expediently. They offer two tadalafil doses intended for as-needed use in several quantities depending on your activity level. Both doses are in typical clinical ranges for effectiveness with minimal risk for side effects.

Bluechew Tadalafil

And BlueChew is our Editors’ Choice for best ED treatment in 2023 for several additional reasons:

  • BlueChew’s medications (tadalafil, sildenafil, and vardenafil) are chewable, which eliminates the need for water to take them.
  • BlueChew’s monthly subscriptions keep the cost per pill at a minimum.
  • You can try it for free for a month using the INNERBODY coupon code.
  • Taking tadalafil once per day, as if it were a multivitamin, is less potentially disruptive than taking other ED treatments an hour before you intend to have sex. Tadalafil stays active in your body for 18-36 hours, unlike sildenafil, vardenafil, or Stendra.
  • Tadalafil effectively poses the same low risk of mild side effects as sildenafil and vardenafil.

In our opinion, tadalafil edges out sildenafil and vardenafil, which makes it the best choice for most men. But more compellingly, scientific research seems to lead to the same conclusion. In a meta-analysis of numerous studies, couples preferred tadalafil to sildenafil — and it wasn’t very close.³ In one study, nearly 80% of women preferred their sexual partners to use tadalafil, compared to sildenafil (15% preference).⁴ Therefore, the chances are pretty good that tadalafil will be ideal for you, too.

Our Top Choice

BlueChew Tadalafil

BlueChew offers tadalafil at an incredible price and in a chewable form that can take effect in as little as 20 minutes.

In studies, tadalafil is a top choice among couples -- we believe it will be best for most people. Plus, BlueChew offers our readers an exclusive opportunity to try BlueChew ED treatment for a free month! Just use the links on this page in order to access your free trial.

Current Deals: Try it for a FREE MONTH

Sildenafil is a solid treatment option, as well. It works reliably, and many doctors recommend it and prescribe it with great efficacy. Vardenafil is nearly identical to sildenafil and makes a good choice for the few men who don’t have success with the latter.

Ultimately, what works best for you — and what dosage you take — depends on what the consulting physician determines is suitable. They’ll base this determination on your medical background and how you tolerate the medication when you begin using it. You’ll also have some say in the dosage you use to start.

Close runner-up: Hims

Hims is a great telemedicine company where, after a free consultation with a doctor, you can access a few different ED treatments proven to be effective: sildenafil (and brand-name Viagra), tadalafil (and brand-name Cialis), and Stendra. Hims also very recently introduced its own chewable ED treatment options. As a company, Hims impresses us very much, and there are circumstances in which we recommend Hims above all others for ED treatment.

Hims Sildenafil

Why you should trust us

At Innerbody Research, we extensively test each health service we review, including ED medication services, whenever possible. All told, our team has collectively spent over 1100 hours researching erectile dysfunction, its potential treatments, and the companies offering them.

Our team has considered over 100 clinical studies related to erectile dysfunction and its treatments. We’ve heard from men who rely on them and women whose partners require them. To get as clear a picture of the market landscape as possible, we’ve completed the consultation and ordering process for all of the top online ED medication providers. We’ve spoken with primary care physicians and urologists. And, like all health-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for accuracy. We’ll continue to monitor developments among these providers and in the broader landscape of ED treatment.

Over the past two decades, Innerbody Research has helped tens of millions of people make more informed decisions about staying healthy and living healthier lifestyles.

How we evaluated ED treatments

Each of the treatments we cover in this guide will work for most men with ED. Some men may need higher doses than others, and it might take some time to arrive at the dose that maximizes efficacy while maintaining a low risk of side effects.

We focus here on what most men would need to consider before investing in medication for erectile dysfunction. When you look at what these pills offer and how you need to take them, dose timing becomes an important factor. It’s less a matter of better or worse and more a matter of preference, but there is one type that’s likely to please more users than others, and research supports this position. Combined with cost, safety, and medication format, we have a set of fundamental factors that form our overall value assessment of each medication type.

While sildenafil is often the least expensive option, our evaluation led us to prefer tadalafil over other medication types. Its available doses are similarly flexible to sildenafil’s, but the dose timing — taking it as needed and having it work for up to 36 hours — is preferable for many men who’d rather not try to predict precisely when sex will happen. There are some caveats, and one medicine might work better for you than another. Both are highly effective, but tadalafil is likely a solid place for most men to start.

Dose timing

Winner: Tadalafil

Some ED treatments are effective within a specific time window after you swallow a pill and require a short wait before they become effective. Others give you more leeway to forget about timing altogether. Are you somebody who will be irritated by a certain amount of planning for sex? For some people, this can be a mood-killer, while other men don’t mind, especially those who don’t like the idea of taking a daily pill for occasional sex.

Ultimately, we prefer tadalafil for dose timing because you can take a daily dose to ensure you’re ready at any time or take one pill within 24-36 hours of any anticipated intercourse. So, if you don’t want to take a daily pill but have a date at night, you can take tadalafil sometime that day and see reliable effects well into the next day. And since tadalafil is active in the system well within an hour, you can still use it in cases of spontaneous sex and not have to wait too long for it to kick in.

Here’s a quick visual comparison of ED medication dose timing:

  Dose Time to work Lasts for
Cialis (tadalafil) 10mg <30 minutes Up to 36 hours
Viagra (sildenafil) 50mg <30 minutes 2-4 hours
Vardenafil 10mg <30 minutes Up to 8 hours
Stendra 100mg 15-30 minutes Up to 6 hours
Apomorphine (sublingual) 4mg <20 minutes Up to 8 hours

And if this sounds like the right path to try first, BlueChew is the best way to try it out. As long as you’re a suitable candidate to try PDE-5 inhibitors like tadalafil and sildenafil, you can get several doses for free from BlueChew to see how well they work for you; you only pay the few dollars for shipping.


Winner: Sildenafil

Most insurance, including government insurance like Medicare, won’t cover the costs of ED medication, so it’s essential to consider your available budget. Prescription ED medications vary in price, and in most cases, sildenafil is available at the lowest cost per pill. To provide the best price for the most effective treatment, many companies have various billing cycles, shipping quantities, and dosages you can mix and match.

Let’s visualize how much you might pay for the lowest available doses on telemedicine platforms with the best prices:

  Doses start at Prices per dose start at Who has the best price per dose
Tadalafil 2.5mg $2.97 Hims
Sildenafil 20mg $2.65 BlueChew
Vardenafil 8mg $4 BlueChew
Stendra 100mg $52.50 Hims

This is why BlueChew sildenafil is our top choice for men for whom budget is a huge factor. BlueChew offers the lowest price for the most affordable prescription ED medication available today. For budget-conscious, try BlueChew first. Then, if you find that you can’t achieve proper dosage via BlueChew’s plans, head to Hims to take advantage of the next-lowest prices and greater dosage flexibility.


Five-way tie

Any medication designed to affect male sexual anatomy is going to be met with extreme caution, and rightly so. Beyond the psychological importance most men place on their genitalia, there is the practical use for reproduction and waste elimination to consider. We take all of these issues seriously when considering ED treatments.

Most studies show that PDE-5 inhibitors (the class of medications that includes sildenafil, tadalafil, and others) are safe for most healthy men. The men who are most at risk for severe adverse effects are those on medications that affect blood pressure.⁵ PDE-5 inhibitors act as vasodilators, effectively lowering blood pressure by increasing nitric oxide production. If your blood pressure is already lowered due to an ailment or medication, adding a PDE-5 inhibitor can prove fatal.

Insider Tip: Doctors require a recent blood pressure reading to prescribe any PDE-5-inhibiting ED medication. This can pose a hurdle for some, potentially negating the cost- and time-saving benefits telemedicine offers. But you can get a blood pressure reading elsewhere if needed. Devices for at-home use cost as little as $20, and pharmacy chains like CVS often have free heart health programs or open-access machines that can measure it for you.

Most studies comparing oral medications for erectile dysfunction come to the conclusion that there are no meaningful differences in their respective safety profiles. Some men develop visual color processing issues when they take PDE-5 inhibitors that also act to inhibit PDE-6 — a common but usually benign collateral effect. For these men, vardenafil (which acts on PDE-5 without affecting PDE-6) would be preferable to sildenafil. Tadalafil is also less associated with visual disturbances than sildenafil.

Common but typically mild side effects associated with popular ED medications include:

  • Headache
  • Flushing
  • Backache
  • Dyspepsia
  • Nasal congestion

Access to these ED medications requires a prescription, which means you’ll have the opportunity to talk with a physician along the way. Take that time to ask your doctor about any of these issues during your consultation.


Winner: BlueChew (by a hair)

You deserve a high degree of discretion when acquiring medication for erectile dysfunction, especially considering the stigmas around ED and the shame you may feel about the issue. All of the companies we’ve included here provide significant protections and stringent practices for the safeguarding of medical data. They all abide by HIPAA regulations, or else they would lose their right to offer prescription medications.

So, when it comes to comparing these companies to one another on the basis of privacy, the only two parameters left are their online tracking practices and medication delivery systems. All of these companies use cookies and web beacons to track your browsing habits on their site. The data shouldn’t link to you directly, but it will connect with your IP address and possibly information about your device. We want to see these companies make it as easy as possible to opt out of their tracking systems.

There are options for restricting the sale of your information on each of the top sites we cover here, but BlueChew has the easiest interface. You don’t have to send an email or make a phone call. When you’re logged into your account, you can click “Do Not Sell My Information” at the bottom of almost any page and quickly submit an automated request to opt out.

For the actual delivery, none of these companies ship their products in boxes that show what’s inside. Some Hims and Roman deliveries will have Hims or Roman in the return address, but those companies’ product lineups are large enough that no one could deduce the box’s contents.

BlueChew gets the edge here because of the way their pills are packaged. Since they’re individually wrapped tablets, their packaging is rather flat; it doesn’t look like it would contain medicine, and there’s no audible rattling of pills in a bottle.

Medication format

Winner: Chewable tadalafil

Another way to think of medication format is, essentially, “convenience.”

When Viagra hit the market in 1998, it quickly became known as the “little blue pill,” a coy way for men to gain some distance from any potential stigma associated with ED at the time. It wasn’t hard in those days to imagine the “little” or the “blue” aspects of Viagra evolving as generic sildenafil and competitive medications came out. But recently, it seems the industry is paying closer attention to the “pill” aspect of erectile dysfunction treatment.

Sildenafil, tadalafil, Stendra, and vardenafil are typically delivered in pill form, but pills aren’t always the most convenient format. Many people have trouble swallowing pills, and — particularly in the case of pills you take just before intercourse — finding a drink to wash those pills down can be an annoyance. BlueChew and Rugiet work around this issue by providing chewable tablets and dissolving lozenges, respectively.

There is some evidence that chewable and dissolvable delivery methods can accelerate the time to action since the medication can absorb through oral membranes and into the bloodstream without having to pass through the digestive tract. However, it may only be the difference of a few minutes. These methods are ultimately more about maximizing convenience than anything else.

BlueChew’s chewable tadalafil gets our endorsement here because the company’s tablets are a bit more convenient than Rugiet’s lozenges, which need to be kept at or below room temperature to stay solid.

It’s worth noting that the “chewables” arena just got a little more crowded, as Hims recently developed its own chewable tablets for tadalafil, vardenafil, and a combination of sildenafil and tadalafil. Hims does offer a prescription for daily-use chewable tadalafil, but it’s only available at a 6mg dose at this time; many men interested in daily tadalafil should start at a 2.5mg dose. So, if you take the 6mg Hims tadalafil chewables daily and experience side effects, there’s no way to titrate down from there. Also, the pricing of its chewable tadalafil is higher at this time than BlueChew’s. Right now, comparing Hims daily chewable tadalafil to BlueChew’s same-dosage plan with 28 pills per month, your cost per dose is 12% higher with Hims than with BlueChew.

Right now, BlueChew remains the only source of chewable sildenafil on its own.

What is erectile dysfunction?

ED is the term used to describe the condition of being unable to get or keep an erection long enough to engage in satisfying sexual activity. It encompasses a few circumstances:

  • You can get an erection but can’t maintain it for a long enough period of time.
  • You can get semi-erect but not fully firm.
  • An erection just won’t happen at all.
  • Erections sometimes happen, but sometimes they won’t.

ED prevalence is much greater than you might think. Various studies indicate that anywhere from one-third to one-half of all men deal with ED at some point.⁶ And incidences of ED increase steadily with age.

What causes ED?

There are numerous potential causes of ED. Though it occurs more frequently as men age, this isn’t a condition that’s a natural part of the aging process; erectile dysfunction isn’t something that men or their partners should just accept. And it’s not at all something that should be a source of shame or embarrassment. ED is a common condition, and many roads may lead to it, including:

  • Hypertension (high blood pressure)
  • Obesity
  • Diabetes
  • Stress
  • Use of alcohol, tobacco, or drugs (recreational or prescription)
  • Exhaustion and sleep disorders
  • Depression and anxiety

It would be wise to speak with your doctor to rule out any of these potential causes before taking a prescription for ED, as each of those listed ailments can have far-reaching consequences beyond sexual health. Dealing with the greater issue should alleviate most (if not all) ED symptoms, but if it doesn’t, you can still reach for an ED prescription.

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What to discuss with a healthcare provider

It’s always a good idea to talk with a healthcare provider before you embark on an ED treatment journey. If you hope to use any prescription ED treatments, you’ll have to get the prescription from a doctor who will review your medical history and current health to determine if one of these medicines is suitable for you.

But even if a prescription treatment isn’t the best course of action, it’s still wise to consult with a healthcare provider. Because there are many possible causes of ED, your erection difficulties might signal an underlying condition that requires medical attention.

Thankfully, our top recommendations for the best ED treatment include complimentary consultations with a physician who can help you. This is an incredible value for anyone without insurance, for whom a simple doctor’s visit might be prohibitively expensive. Here are some topics that you might discuss during a consultation.


ED is a common health condition with many possible underlying causes. One of these potential causes happens to be low testosterone. A testosterone test can help you determine if this is what’s behind your ED. Thankfully, these days you have the option of testing your testosterone at home without a lab order or waiting in a medical office. We recommend you check out the high-quality at-home Testosterone Test from LetsGetChecked, as well as our guide to the best testosterone tests.

History of diabetes

Diabetes mellitus can cause ED.⁷ Thankfully those with diabetes-induced ED (DMED) tend to respond very well to ED treatments. If you have prediabetes or your family has a history of diabetes, this is something you should bring up in your consultation.

Nitrate drugs

Unfortunately, people who take nitrates for cardiovascular conditions may not be suitable candidates for PDE-5 inhibitor ED treatments. In this case, you will likely have to pursue alternative ED treatments.

History of heart disease or cardiovascular problems, including high or low blood pressure

A consultation with a doctor will help you determine whether you can safely take ED medications, which can affect blood pressure and interact dangerously with certain heart medications.⁸ If you already have low blood pressure or are being treated for high blood pressure, there is a possibility that ED treatments could lead to hypotension, which is a serious risk. The doctor will be able to advise you on safe treatment options. You will need recent blood pressure results to acquire a prescription for PDE-5-inhibiting ED medications.

Lifestyle choices

Certain behaviors can make it harder to maintain an erection for men who don’t have ED. These include sleep patterns, alcohol and drug use, stress management, and even lack of exercise.¹ Try to keep track of your sleep, exercise, and other habits for at least a week leading up to your consultation.

Psychological factors

Psychological factors can contribute to erectile dysfunction and make it difficult for a consulting physician to pinpoint the cause of your ED. You should still respond well to ED medications, but if you’ve exhausted possible physical causes, you may want to speak with a counselor to rule out psychological conditions like depression or anxiety.⁹

Prescription ED treatment options

When it comes to readily available ED medications, you have several options to consider. Believe it or not, all of these medications work by achieving the same effect: they are all PDE-5 inhibitors, supporting or enhancing the effects of nitric oxide in our bodies. However, they each have specific onset times and durations that may make one a better option for your lifestyle than another.

Here’s a comparison of our top choices:

  BlueChew sildenafil 30 mg BlueChew tadalafil 6 mg Roman sildenafil 40 mg Hims Stendra 100 mg Roman Viagra 50 mg Rugiet Ready Maximum Strength
Lowest price per dose $2.65 $3.21 $4 $52.50 $90 $19.44
Free trial?
How fast does it work? 30 minutes 30 minutes 30 minutes 15-30 minutes 30 minutes 15 minutes
How long can it work? Up to 6 hours 18-36 hours Up to 6 hours Up to 6 hours Up to 6 hours Up to 36 hours
Medication form Chewable Chewable Pill Pill Pill Lozenge

How PDE-5 inhibitors work

Nitric oxide (NO) mediates vasodilation (widening of blood vessels) in the penis, increasing blood flow. PDE-5 inhibitors promote the release of nitric oxide, causing improved blood flow and helping the muscles in the penis to relax, causing the penis to enlarge and grow rigid, forming an erection.¹⁰

Meanwhile, PDE-5 (phosphodiesterase-5) is a chemical that the body releases to signal that it’s time for the erection to end. PDE-5 inhibitors slow the activity of PDE-5, allowing the NO activity to continue, bringing forth a sustained erection.

Taking one of these medications should not result in an instant erection — stimulation is still required. But when stimulation occurs, the medicine gives a helping hand to boost nitric oxide and its effects.

Branded vs. generic ED medications

When we break down your top choices for ED medication, we find it useful to refer only to the names of the active ingredients (i.e., sildenafil, tadalafil, etc.) as opposed to their brand names. Unless you’re going through your insurance company, there’s almost never a good reason to buy branded ED medication — generic options are therapeutically identical.

We always recommend that people start with generics, so let’s look at which medications are available in generic form:

  Brand name(s) Generics available?
Sildenafil Viagra
Tadalafil Cialis, Adcirca
Avanafil Stendra  
Vardenafil Levitra, Staxyn
Apomorphine N/A  


Generics — with no additional word to modify the meaning — are produced by companies other than the original manufacturer. They bear only the name of the active ingredient (i.e., sildenafil), and telemedicine companies typically advertise them as such. Effects on the body are identical to the original; the only differences may be in the appearance of the pills and the inactive ingredients used.

Authorized generics

Authorized generics are either made by the original manufacturer or by a company they’ve permitted to do the manufacturing. These pills are completely identical to the original branded option, right down to the inactive ingredients and appearance, but they usually don’t include the original brand name on the label.

To make matters more confusing, telemedicine providers will sometimes use original brand names when selling generics that are not “authorized generics” because it makes it easier for their customers to understand what they’re choosing. Others sell branded pills, authorized generics, and regular generics without doing enough work to explain the differences to their customers.

Sildenafil and Viagra present the most complex situation in this regard, and we’ll break that down a little later. If you’re confused by all of this, make sure to ask your doctor which one would be right for you.

Are ED medications safe for me?

Every ED drug has contraindications (i.e., reasons why a person should not use it). Men with certain liver, kidney, or cardiovascular conditions may not be able to take ED medications safely. Men taking nitrates and alpha-blockers to treat hypertension may need to find other ways to treat their ED. Other health conditions could make PDE-5 medications unsafe for men as well.

These potential complications are why you need a prescription for ED medication. Your consulting physician will determine what will be safe and effective based on your medical history and any current medications that you use. Thankfully, PDE-5 medications for ED are prescribed very widely, and the healthcare community considers them safe for most men, with side effects rarely reported.

Side effects of PDE-5 inhibitors

When side effects happen, they tend to be mild and commonly include some of the following:

  • Headache
  • A sensation of flushing in the face
  • Nasal congestion
  • Nausea or indigestion
  • Muscle pain
  • Dizziness

Though they rely on the same primary mechanism to treat ED, research confirms that these different PDE-5 inhibitors tend to produce side effects to varying degrees. For instance, a slightly higher percentage of people who take sildenafil (and Viagra) report flushing and headaches,¹¹ while a slightly higher percentage of tadalafil (and Cialis) users report muscle pain.¹² All in all, most men barely notice any side effects, if at all.

Any of the PDE-5 inhibitors can also cause your blood pressure to drop (though Stendra is less likely to cause this to happen). You might think that’s a good thing, but blood pressure that gets too low is also dangerous. If you get dizzy from taking any of these medications, you should share this observation with a healthcare provider; it could indicate a potentially unsafe drop in blood pressure.

One rare but noteworthy side effect of many PDE-5 inhibitors is a change in visual color processing. This occurs when a PDE-5 inhibitor collaterally inhibits PDE-6. If you’re one of the very few men to experience this phenomenon, you should ask your doctor about vardenafil, which does not have any collateral effect on PDE-6.

Tadalafil and Cialis


  • Among the most effective ED treatments
  • Less planning needed with its extended duration of action
  • Can be taken daily or as needed
  • Can be taken with or without food
  • Tends to be preferred by men and their partners, compared to sildenafil
  • More affordable than medications like Stendra


  • Costs a little more than sildenafil
  • Risk of mild side effects is slightly higher than Stendra

Often known by the common brand name Cialis, tadalafil is a PDE-5 inhibitor that you can take once per day to provide 18-36 hours of effectiveness. This significantly reduces the planning typically involved in using other treatments like sildenafil. That said, some users only take tadalafil as needed, and those dosages can sometimes be different. You and your doctor will decide what dosage and schedule are right for you.

Side effects with tadalafil are about as common as with sildenafil and are similarly mild. Dose for dose, tadalafil is also a little bit more expensive than sildenafil. However, we believe tadalafil is the better value, mainly because:

  • In studies, men and their partners prefer tadalafil to sildenafil.
  • Tadalafil has superior psychological outcomes to sildenafil, providing more sexual confidence.¹³
  • The larger window for sexual activity (18-36 hours, compared to 4-6 hours with sildenafil) for many people justifies the slightly higher expense.

Common tadalafil dosing

Branded Cialis and generic tadalafil are available in the same dose increments across most platforms, with 2.5mg, 5mg, 10mg, and 20mg being the most common. Daily doses typically start at 2.5mg, while as-needed doses typically start at 5mg.

BlueChew and Rugiet differ from the norm, with BlueChew offering 6mg and 9mg doses and Rugiet offering 14mg and 22mg doses (possibly blended with sildenafil and apomorphine). We’ll get a little more into Rugiet’s offering in the “Apomorphine” section below. Ultimately, you’ll decide with the prescribing doctor which dose and schedule are best for your lifestyle.

Here’s a quick visual reference to let you know what kinds of branded and generic tadalafil our top choices carry:

  Branded Generic Authorized generic

Tadalafil from our top choice provider, BlueChew, is considerably more affordable than branded Cialis, which relies on tadalafil as its active ingredient. BlueChew also has prices that are on par with or better than their competitors selling generic tadalafil. Additionally, the chewable format of BlueChew’s tablets allows you to take them without water, so you have one less obstacle to deal with. Hims recently developed chewable tadalafil, as well, but it’s much more expensive than the offering from BlueChew. And right now, BlueChew is offering our readers a free month of tadalafil as a way to test their service; all you pay is a small shipping fee. As far as we know, no other platform offers such a low-cost way to try the medication.

Bluechew Tadalafil Package

Insider Tip: If you’re willing to take on some hassle and you know your goal is to take as-needed tadalafil at a dosage no stronger than 5mg, then tadalafil from Hims could conceivably be your most economical option. That’s because you could request daily tadalafil on a quarterly billing cycle, which brings the cost per dose below $3 (slightly less money than the $3.21/dose cost of BlueChew’s 6mg chewable doses). You could then temporarily cancel your Hims subscription until you make your way through that stock of 90 doses and reinstate it whenever you need more. Canceling and restarting through Hims carries no financial penalty, but there’s also the value of your own time to consider; resubscribing would be a nuisance. And lastly, doses lower than 5mg would be considered on the low side for as-needed tadalafil. But if they work for you, then all the better.

Sildenafil and Viagra for ED


  • The most economical major treatment
  • Has been studied the most thoroughly
  • Efficacy rate is greater than 90%
  • Allows for more flexibility in dosage


  • The window of effectiveness requires a bit of planning
  • Loses efficacy when you take it with meals
  • Mild side effects like headache are more common than with other treatments like Stendra

Most people can’t predict with complete certainty whether or not they’ll have sex on any given day. Even if you’re accustomed to daily intercourse, your partner could get sick, you could strike out at the club, or your in-laws could pay you a surprise visit. For that reason, some men prefer not to take a daily tablet of Cialis or tadalafil when the prospect of sex is not guaranteed. This is even truer for men who’ve experienced some mild side effects from frequent or daily tadalafil use.

On the flip side, sildenafil and Viagra (as well as a specific regimen of Cialis and tadalafil) offer you the choice to take them as needed. So, if you want to spend all day in bed playing video games, you don’t have to worry about missing a daily pill. And if you know that sex is on the horizon, you can take these meds accordingly.

You’ll need to take this medication 30-60 minutes before sex. Some men report that BlueChew’s chewable sildenafil and Rugiet’s lozenges kick in faster, but this is not guaranteed.

Viagra vs. sildenafil

Viagra’s active ingredient is sildenafil, but you might not know it from looking around at your ED options. Why would Viagra be so much more expensive than sildenafil (the active ingredient in Viagra)? Why does anyone opt for the more expensive Viagra if both have the same ingredient?

Some men familiar with Viagra, having used it before successfully, want to stick with what works. They trust it, and the brain is the largest and most important sex organ after all; psychology can be a potent tool in combating ED.

But a complete understanding of your options requires a little knowledge about the differences between Viagra, generic Viagra, and generic sildenafil.

Branded Viagra

This is the original “little blue pill,” and it’s the most expensive option. Made by Pfizer, Viagra is available in 25mg, 50mg, and 100mg tablets from most providers. Many men start with 50mg. We consider Roman the best choice for branded Viagra thanks to their low per-dose pricing compared to Hims ($90 vs. $138).

Generic Viagra

This is a generic form of Viagra either made by Pfizer or by an authorized company with which Pfizer has shared their exact formula. It’s identical to branded Viagra in every way except that it won’t say “Viagra” on the prescription label. This is one of the least expensive options, though it’s often pricier than generic sildenafil.

Generic sildenafil

This is a formula therapeutically identical to branded Viagra but with discrepancies in inactive ingredients, color, shape, and delivery mechanism. Doses are theoretically supposed to be the same, but there are caveats. This is often the least expensive option.

Sildenafil is also the active ingredient in Revatio, a drug designed to treat pulmonary arterial hypertension. The drugs are identical in almost every way — they’re even both made by Pfizer. But Revatio is made only in 20mg tablets.

Many providers that stock generic sildenafil for erectile dysfunction prefer these 20mg tablets because they allow for more dose flexibility from a single stockpile of pills. A doctor can prescribe 20mg, 40mg, 60mg, or 100mg, and the patient simply takes the corresponding number of 20mg pills. Both branded and generic Viagra come in 25mg tablets, 50mg tablets, and 100mg tablets. If the most common dose is 50mg, then those 100mg doses are going to sit on the shelf, gradually approaching their expiration date and causing providers to lose money.

Like tadalafil, sildenafil doses can vary to greater degrees, especially as delivery mechanisms change. BlueChew’s chewable tablets come in 30mg and 45mg doses, and Hims chewable sildenafil is only available in combination with tadalafil. In these combinations, the sildenafil dose is always 10mg, while the tadalafil dose ranges from 8mg-18mg. Rugiet’s combination pills include sildenafil doses of 40mg, 60mg, 80mg, or 110mg.

Here’s a quick visual reference detailing which versions of sildenafil our top choices offer:

  Branded Generic Authorized generic

Our recommendation here, for most men, is generic sildenafil. Sildenafil is far more economical and allows for better dosage tailoring.

Specifically, we recommend BlueChew’s chewable sildenafil; BlueChew’s dosages allow for good flexibility. However, there are also a few situations in which you might want to opt for Hims instead.

  • Hims sildenafil is available in a wider number of doses, making it our top choice for men who find they need to fine-tune their dosage of sildenafil for the best effect.
  • Hims telemedical support is fantastic for men who are dealing with ED alongside efforts to treat premature ejaculation.
  • If you’re one of the many men who already use Hims for hair loss treatment, then it could be convenient to use them for ED treatment as well.
  • Hims offers classic, brand-name Viagra or an authorized generic for men who want it. BlueChew doesn’t offer classic Viagra or the authorized generic.

Hims is the only company we recommend that sells an authorized generic Viagra. Interestingly, Roman lists their options as “Branded Viagra” and “Generic Viagra.” That second option is actually generic sildenafil — it is not an authorized generic made by Pfizer. Roman lists their sildenafil this way because they believe it makes it easier for potential patients to understand that the two drugs are practically identical. Visit our Roman reviews to learn more.



  • Nearly identical in efficacy to sildenafil
  • Starts working in as little as 30 minutes
  • Lasts for up to eight hours
  • Doesn’t cause a particular — but rare — side effect of sildenafil
  • Available in chewable form from BlueChew and Hims


  • More expensive than sildenafil
  • Less thoroughly researched than other options
  • Not offered by many online providers

While it isn’t the most widely available option from telemedicine providers, vardenafil is an important option for the few men who might not have success taking sildenafil but still want an effective medicine they can take on demand 30-60 minutes before sex. Studies show that vardenafil behaves the same way in the body as sildenafil, with one known exception.

A very rare side effect of sildenafil is an alteration in color perception due to the drug’s inhibition of PDE-6 in addition to PDE-5.¹⁴ Vardenafil is somewhat more selective in this regard, having no known effect on PDE-6 and, thus, no known effect on color perception. And while vardenafil is less thoroughly researched than sildenafil, there are still numerous studies looking at thousands of users over nearly two decades, so its safety and efficacy are without question.¹⁵

For a while, BlueChew was the only provider among our top picks to offer vardenafil, but Hims included it in its recent development of chewable mint tablets. From BlueChew, you can get vardenafil in 8mg doses with monthly deliveries of four, eight, 15, or 30 tablets. Hims vardenafil has a little more dose flexibility, offering 12mg and 18mg doses, but you’d be out of luck if those doses are too high for your needs. And BlueChew’s prices are still better than Hims for vardenafil. A limited-time BlueChew free trial is also available for Innerbody readers that gets you four free tablets of vardenafil, so you can see how it works for you.

You can find out more about BlueChew’s vardenafil and other treatments by reading our complete BlueChew reviews.

Stendra (avanafil)


  • Starts working in just 15 minutes
  • Lasts for around six hours
  • Per-dose cost via Hims is cheaper than Viagra
  • Less risk of side effects
  • Can take it with or without meals
  • Alcohol won’t reduce efficacy


  • Not as affordable as sildenafil or tadalafil
  • Studied less than sildenafil or tadalafil

Many men prefer to take an ED medication only when they need it rather than at the start of a day when they may or may not have sex. Understandably, these men also want that drug to take effect as quickly as possible and with the lowest chance of side effects.

Avanafil (brand-name Stendra) is a newer medication in the landscape of ED treatments. While other ED medications like sildenafil affect enzymes like PDE-1 and PDE-6 alongside PDE-5, Stendra is more micro-targeted to inhibit the specific PDE-5 enzyme related to a man’s ability to get and keep an erection. This increases Stendra’s efficacy while reducing its side effect profile. Here are some other benefits of Stendra:

  • According to FDA data, close to 3 in 10 men using the maximum dosage of Viagra report headaches. By contrast, about 1 in 10 men using the 200mg Stendra (highest dosage) report headaches.
  • Only about 4% of men using 200mg Stendra experience flushing of the face, compared to 18% of men using the maximum dosage of sildenafil.
  • Heartburn, muscle and back pain, congestion, and vision changes are all less likely with Stendra.

Stendra also acts quicker in the body than others — some studies showed efficacy in as little as 15 minutes.¹⁶

This speed makes Stendra a great treatment choice for men who don’t always know when they’ll want to have sex and are happy to take something shortly beforehand. If this describes you, then we recommend Hims Stendra.

Stendra is also our top choice for couples who enjoy morning sex. Tadalafil taken in the morning can sometimes require about an hour before it is fully effective. This experience with tadalafil varies — some men find tadalafil to be effective for a full 36 hours (which would make the prior morning’s dose still effective), while others find its effects wear off in closer to 18 hours. If you are in the latter camp, Stendra will be better for your morning rituals because you can take a dose as you wake up and then be ready for fun in as little as 15 minutes.

However, Stendra will cost you significantly more than sildenafil or tadalafil. Hims — our top choice for convenient access to Stendra — offers a monthly subscription for four 100mg Stendra tablets at $116 per month, billed quarterly. If you can afford the cost, this may be the best choice for you. If not, then we’d suggest you explore daily tadalafil.

There are three standard dosage options for Stendra:

  • 50mg
  • 100mg
  • 200mg

Both the 100mg and 200mg dosages take effect in about 15 minutes, which is even faster than BlueChew’s chewable sildenafil. It lasts about six hours, which is basically on par with sildenafil (and Viagra).

Apomorphine for ED


  • Works in under 20 minutes
  • Relatively few side effects reported
  • Sublingual dose requires no water to take
  • FDA-approved for use in Parkinson’s patients


  • Does not mix well with alcohol
  • May cause fainting in a small fraction of users
  • Nausea is a common initial side effect
  • Lozenges melt above room temperature
  • Hard to find outside Rugiet’s blended ED treatment

Apomorphine has been used since the 19th century as everything from a sedative to an aid in kicking heroin addiction, and it’s currently FDA-approved for treating Parkinson’s disease. However, multiple studies indicate its potential as a treatment for ED.¹⁷ The name can be a source of confusion since most people outside the medical professions would likely hear the “morphine” in apomorphine and assume opioid properties. But apomorphine doesn’t bind to opioid receptors and is non-addicting.

For Parkinson’s patients, apomorphine is delivered via subcutaneous injection at doses often higher than those used in erectile dysfunction treatment. Studies into its use for Parkinson’s often revealed intense nausea as a side effect, to the point that doctors would often have to prescribe an antiemetic to deal with nausea and vomiting. ED patients taking apomorphine as a sublingual film — or in the case of Rugiet, a lozenge — may also experience some nausea, but this appears to decline with regular use.¹⁸

Apomorphine appeared on target to become a viable alternative to Viagra in 2000, but the manufacturers behind its two branded forms intended for ED patients pulled it from FDA consideration despite what appeared to be a sure path to approval. They cited the need for further study, particularly into the drug’s interaction with nitrates and its potential to cause fainting in less than 0.2% of trial participants. Today, apomorphine remains FDA-approved for Parkinson’s disease but is only prescribed for ED treatment as an off-label use.

The only major provider we recommend that offers apomorphine in any form is Rugiet, but they don’t stock apomorphine on its own. Instead, they combine it with tadalafil and sildenafil in a lozenge that dissolves under the tongue and may decrease the time it takes to start working. As you can imagine, combining these three medications theoretically increases the chances that they will work for you quickly and remain active in your system for a good 24-36 hours. The specific combinations available to you depend on the results of your doctor’s consultation, but here’s a look at their standard mixes:

  Cost Dose count Sildenafil Tadalafil Apomorphine
Low strength $80 6 40mg 14mg 2mg
Medium strength $100 6 65mg 22mg 2mg
Most popular $120 6 80mg 22mg 3mg
Maximum strength $140 6 110mg 22mg 3mg

As you can see, the obvious downside to Rugiet is its cost. If you sign up for recurring shipments of 18 doses every three months, the company will knock $70 off the cost, resulting in a monthly cost ranging from $57-$150 and a per-dose cost ranging from $9-$25.

A less apparent downside to Rugiet’s lozenges is their tendency to melt in the package at any temperature above 72 degrees Fahrenheit. That makes it ill-advised to carry them in a pants pocket for a night out and expect to be able to take one easily just before intercourse. Rugiet recommends that you keep them in the refrigerator.

To learn more about Rugiet’s offering, check out our comprehensive review of their services.

New ED treatments in 2023

Despite the tremendous success of currently available PDE-5 inhibitors like sildenafil and tadalafil, research continues into additional treatments that could have greater efficacy, fewer side effects, or both. Some of these are additional oral medications, while others involve new medical devices applied to the penis directly.

Sildenafil and tadalafil, the active ingredients in Viagra and Cialis, remain the most reliable treatments for erectile dysfunction. Sanofi — the pharmaceutical giant that makes Cialis — is currently designing a study that would put them on track to alter Cialis’ designation from a prescription drug to an over-the-counter medication.

The most compelling new treatments being researched are acoustic wave and low-intensity shockwave therapies (LI-SWT).¹⁹ These treatments both use soundwaves, but the much faster-moving shockwaves appear to be more effective at stimulating blood flow and improving vascular performance in penile tissue.

There are currently several clinics around the country that perform LI-SWT, but no at-home device has been approved yet.

Ultimately, the safest, most effective treatments imaginable are already available. Nothing coming down the pike seems poised to challenge their supremacy in the near future. We’ll continue to stay on top of the latest research so you can rely on us as a resource for future ED treatment developments.

Other alternatives to prescription ED medication

Prescription ED medications are safe and effective ways for most men to treat ED. However, not all men want to take prescription medication, and some men cannot take PDE-5 medicine safely.

Based on our research, we believe you may find an effective treatment for very mild cases of ED using a nutritional supplement. As with any medication or supplement, it’s imperative to discuss this with your primary care provider to make sure there’s nothing in your medical history that might make these alternative treatments unsafe for you.

Nutritional supplements don’t work anywhere near as well as prescription ED medications, based on clinical research. Research is also still less thorough for supplemental ingredients, which makes it harder to assess safety. They also typically come in only one dose, so the efficacy can be wildly different in men with disparate BMIs and metabolisms. And from a cost standpoint, supplements are often much more expensive than prescriptions, especially considering generic options.

Still, if your ED isn’t too severe, and you’re determined to avoid getting a prescription for it, these alternatives may be sufficient.

L-arginine and pycnogenol

L-arginine is an amino acid we naturally have within our bodies. Under normal circumstances, it plays a role in nitric oxide production, which in turn plays a crucial role in allowing blood to rush into the penis to cause an erection.

In one study, a third of men reported that they experienced significant improvement in sexual function while using L-arginine.²⁰

A separate study of men ages 25-45 examined the effect of taking both L-arginine and pycnogenol (chemicals taken from French pine trees) together for ED treatment.²¹ Participants were given L-arginine for one month; nothing happened.

Then the men were given both L-arginine and pycnogenol for a month. After this second month, 80% of the men reported that their sexual function was mostly restored. Using this same combination for a third month, over 92% of the men had what they considered normal erections.

While promising, this study also illustrates the elusory nature of just the right combination of supplements to do what we already know prescription medications can do. It’s also worth noting that L-arginine doses in supplements like Male Extra or Semenax are significantly lower than those used in these studies. Comparatively, studies into prescription options almost always use clinically relevant and commonly prescribed doses.

Also, L-arginine supplementation may be unsafe for men with blood pressure problems or men who have had a heart attack, allergies, or asthma.

Red ginseng

Panax ginseng (red ginseng) is sometimes called “herbal Viagra.” There have been more than a handful of studies providing evidence that Panax ginseng can help with ED. However, the studies leave a fair bit to be desired in their methodologies and size.²² The evidence thus far points to the need for more research and the alluring potential of red ginseng as an effective treatment.

Panax ginseng likely will not work for everyone. There’s no contest when compared with something like sildenafil’s more than 90% success rate, so if you want a “sure-shot” treatment, this isn’t it. But if you’ve got some patience to give it a try and either want to avoid prescription medication or cannot take those medications, you might find that you’re one of the lucky men for whom this does the trick.

DHEA, a potential choice for diabetics

DHEA (dehydroepiandrosterone) is a hormone that our body’s adrenal glands typically produce. Production of DHEA naturally drops as we age, but DHEA is a precursor to the sex hormones testosterone and estrogen.

ED can often occur as a result of diabetes. Several studies on diabetics have uncovered an inverse relationship between serum DHEA levels and the incidence of ED.²³ The results of this study suggest that possibly a third of men with diabetes-related ED could treat their ED using DHEA.

The World Anti-Doping Agency and many collegiate and international competitive organizations have banned DHEA as a performance-enhancing drug. The quantities you’ll encounter in male enhancement supplements aren’t likely to help you break any home run records, but they could still show up on mandatory drug tests. You might also find that DHEA raises your cholesterol levels, so if you have high cholesterol levels already, DHEA might not be the right choice.

Ultimately, these complicating factors make DHEA an inferior choice for diabetics compared to a combination of prescription ED medication for the short term and dietary or lifestyle changes — and perhaps medication to address high blood sugar — in the long term.

ED-specific supplements

Some companies tailor their supplements to target ED and increase sex drive and performance. Unfortunately, you have to shop very carefully because these can be highly sketchy products from disreputable companies. The safest first step may be to try supplements of single ingredients like the ones detailed above, but that also requires patience and a higher budget for trial and error. When it comes to broader, multi-ingredient supplementation for ED, we can recommend these few options:

Male Extra

Male Extra is built on a 600mg foundation of L-arginine, with support from a generous 45mg dose of zinc. Most of its individual ingredients appear in insufficient doses, but they might make a difference when combined.

Max Performer

Max Performer is very similar to Male Extra, but it contains many more ingredients (learn more about them in our full review of the product). This can increase the chances of Max Performer working for you, but it will decrease your ability to know which ingredients are effective. More ingredients mean more potential for side effects, as well.


Semenax belongs to a subset of male enhancement products called volume pills. These contain ingredients that can bolster erectile performance in some men and increase the quantity and quality of ejaculate.

Side effects with all of the supplements mentioned here tend to be mild if any occur. Most men don’t experience any, but it’s always wise to share your supplement plans with your healthcare provider before adding anything new to your regimen. Notably, men who take medications for cardiovascular problems may not be suitable candidates for ED supplements.

Most of the supplements you can use to combat ED are more expensive than generic drugs. You also have to take them every day for them to be effective, unlike certain ED meds that you can take as needed. Ultimately, the choice between a prescription ED treatment and a supplement comes down to budget and lifestyle, and the choice is yours to make.

Erectile dysfunction FAQ

How do I know if I have ED?

Erectile dysfunction is the recurrent inability to generate an erection strong enough to achieve penetration. If you consistently find that you can’t get hard enough for sex, you might have ED. But if you’ve only recently had this happen once or twice — especially if you can identify contributing factors in the moment, like fatigue or inebriation — you shouldn’t worry.

What causes ED?

ED can have numerous causes, and many men have multiple contributing factors to their ED. These can include cardiovascular or mental health issues, diabetes or obesity, and a reaction to certain medications. If you’re experiencing ED, a thorough conversation with a doctor can help you identify potential causes.

Can depression or anxiety cause ED?

Yes, depression or anxiety can definitely cause ED. The experience may be consistent or episodic, but there is a well-established connection between mental health and erectile performance.

Is there a cure for ED?

Technically, there is no cure for ED. If you have ED and you’re treating it with prescription medication, your ED will still be there if you stop taking those meds — except perhaps in cases where it’s the result of self-doubt, and the performance of those meds helped you restore that confidence. Because ED can often be traced back to specific causes, treating those underlying conditions can potentially eliminate it. And you can use prescription medication as a bridge while working on those issues.

Will Viagra or other ED meds give me an erection automatically?

Contrary to popular belief, Viagra — or any similar ED medication — won’t automatically give you an erection. These medications create an environment in the body where appropriate stimulation — physical or psychological — will cause an erection the same way it would in individuals without ED.


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[2] Capogrosso, P., Colicchia, M., Ventimiglia, E., Castagna, G., Clementi, M.C., Suardi, N., Castiglione, F., Briganti, A., Cantiello, F., Damiano, R., Montorsi, F., Salonia, A. (2013, July 1). One Patient Out of Four with Newly Diagnosed Erectile Dysfunction Is a Young Man—Worrisome Picture from the Everyday Clinical Practice. The Journal of Sexual Medicine. 10(7), 1833-1841.

[3] Gong, B., Ma, M., Xie, W., Yang, X., Huang, Y., Sun, T., Luo, Y., & Huang, J. (2016). Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. International Urology and Nephrology, 49(10), 1731-1740.

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[7] Li, X., Zhao, Q., Wang, J., Wang, J., Dai, H., Li, H., & Wang, B. (2018). Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction: Protocol for a systematic review. Medicine, 97(40).

[8] Jackson, G. (2013). Erectile dysfunction and cardiovascular disease. Arab Journal of Urology, 11(3), 212-216.

[9] Korfage, I. J., Pluijm, S., Roobol, M., Dohle, G. R., Schröder, F. H., & Essink-Bot, M. L. (2009). Erectile dysfunction and mental health in a general population of older men. The Journal of Sexual Medicine, 6(2), 505–512.

[10] Kass, D.A., Takimoto, E., Nagayama, T., Champion, H.C. (2007 July). Phosphodiesterase regulation of nitric oxide signaling. Cardiovascular Research, 75(2) 303–314.

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[13] Gong, B., Ma, M., Xie, W., Yang, X., Huang, Y., Sun, T., Luo, Y., & Huang, J. (2016). Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. International Urology and Nephrology, 49(10), 1731-1740.

[14] Doggrell S. A. (2005). Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction. Expert Opinion on Pharmacotherapy, 6(1), 75–84.

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[18] Heaton J. P. (2000). Apomorphine: an update of clinical trial results. International Journal of Impotence Research, 12 Suppl 4, S67–S73.

[19] Geyik S. (2022). A single-centre result of two courses of low-intensity shockwave therapy (Li-SWT) in erectile dysfunction. Andrologia, 54(2), e14324.

[20] Chen, J., Wollman, Y., Chernichovsky, T., Iaina, A., Sofer, M., & Matzkin, H. (1999). Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU International, 83(3), 269–273.

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[23] El-Sakka, A. I. (2018). Dehydroepiandrosterone and Erectile Function: A Review. The World Journal of Men’s Health, 36(3), 183-191.

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