Best Saffron Supplement

Wondering about saffron’s health benefits? Find out how taking supplements of the world’s most expensive spice can help boost mood, curb cravings, and more.

Last updated: Jun 12th, 2022
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In this Review

Summary of recommendations
Saffron supplement: top considerations
How our top recommendations compare
What is saffron?
How saffron supplements work
Are saffron supplements a good choice for you?
Are saffron supplements safe?
Nuzena Saffron Super Spice +
Life Extension Optimized Saffron
BrainMD Happy Saffron Plus
Nutricost Saffron Extract Capsules
Mother Nutrient Saffron Extract
Additional saffron supplements
Saffron supplement FAQ
Why you should trust us
Best Saffron Supplement

If you’ve ever shopped for spices, you definitely noticed that saffron costs way more than any other seasoning. It’s actually considered “the world’s most expensive spice” because it is so difficult to grow, harvest, and cultivate.

But did you know that saffron also has a wealth of health benefits? Not only can it help make your dinner taste better, but it also has been shown to improve eyesight, aid in weight loss, boost mood, and improve memory. In fact, some cultures have been using it as a medicine for thousands of years.

These days, there are numerous saffron supplements on the market. Read our guide to find out how they measure up regarding price, effectiveness, ingredients, and other important criteria.

If you don’t have time to read the whole guide, take a look at our Top 5 recommendations below.

Summary of recommendations

Our Top Picks
Nuzena Saffron Super Spice + logo
Nuzena Saffron Super Spice +

Nuzena's Saffron Supplement contains clean, safe, and simple ingredients. It's truly effective in improving mental health.

Nuzena boosts memory and mood, while decreaseing anxiety and stress. Each capsule is vegan, and contains zero sugar and GMOs. Enjoy free shipping on orders over $50.

Saffron supplement: top considerations

When evaluating our top choices, we considered several criteria: cost, ingredients, effectiveness, safety, and convenience. Below, we detail those criteria so you can gain a better understanding of each product and its benefits.


Winner: Nutricost

When considering the cost of a saffron supplement, it’s important to keep in mind the unit price and what you’re getting for your money. Just because a supplement is expensive doesn’t mean you’re getting a top-tier product. And inexpensive products don’t signal low quality.

Our winner in this category is Nutricost because this company provides — hands down — the most inexpensive saffron supplement on the market that is still of high quality. In one bottle, you get an 8-month supply of capsules for only $27. This equates to a little under $4/month. Most other saffron supplements cost between $30-$50 for a one-month supply. Nutricost contains pure saffron extract with 88.5mg of saffron per pill, meeting industry standards.


Winner: Nuzena

When taking a saffron supplement, you want to ensure that the ingredients are pure, natural, and safe. To get the most out of the supplement, it should include saffron extract as the main ingredient, and any other ingredients should serve to bolster the effects of the saffron. You don’t want a supplement with a lot of fillers or unnecessary components.

Our winner in this category is Nuzena because this powerful supplement keeps it simple. It contains sustainably sourced, all-natural ingredients, including 88.5mg of pure saffron extract per serving. The supplement does not include sugar, gluten, or GMOs and is vegan-friendly.


Winners: Life Extension and BrainMD

It can be difficult to measure the effectiveness of a saffron supplement. But by looking at scientific studies and clinical research, we can gauge which supplements are likely to be the most effective. Check out the supplement ingredients and any info provided by the company or your own research about their effectiveness.

Our winners in this category are Life Extension and BrainMD. Life Extension includes patented Satiereal saffron extract, which has been shown in an 8-week clinical trial to help participants curb cravings and lose weight. BrainMD uses three main ingredients: saffron, curcumin, and zinc. Curcumin is known for improving anxiety and depression, and zinc is an essential nutrient that can help improve mood and immunity.


Winner: Nuzena

Because the FDA does not yet regulate dietary supplements, it is important to be vigilant about how companies ensure product safety. Some may use certifications or third-party testing. A common safety measure includes manufacturing the supplements in a GMP-certified facility.

Nuzena is our winner for safety because they go the extra mile. Not only are their supplements manufactured in a GMP-certified facility, but they also include a quality certification tracker to view the testing of each product in real-time. Nuzena also publishes third-party test results to ensure their products do not contain allergens, heavy metals, or other contaminants.


Winner: Mother Nutrient

Dietary supplements come in many forms — from capsules and gummies to tinctures. There are also guidelines about when and how to take the supplements. Some you should take in the morning or at night, with or without food, etc. One way to ensure that you’ll stay consistent with a new supplement is by choosing one that’s convenient to take.

Our winner in this category is Mother Nutrient. You only have to take one capsule per day to reap the health benefits of saffron. Some of the other supplements in this guide require 2-3 capsules per day at different times, before or after meals, or with other considerations. Mother Nutrient keeps it simple: one capsule per day at any time.

How our top recommendations compare

What is saffron?

Saffron is an extremely valuable and high-priced spice used in cooking. If you’ve ever tried to buy saffron at the grocery store, you know that it costs way more than other spices — a pound costs between $500-$5,000, depending on quality. Even though it’s a common spice, its high price is due to the intricacies of its harvest and production.

Saffron comes from the saffron crocus or Crocus sativus flower. The flower’s threads — called stigma — are dried to produce the saffron powder. Saffron flowers are harvested during a 3-4 week window every year and must be gathered before or right after sunrise because direct heat from the sun can damage the stigma. Each flower grows three stigmas which must be gathered and dried for 12 hours.

Because the flowers are so delicate, mechanical collection is not an option. They must be harvested by hand. It takes 70,000-200,000 flowers and about 400 hours of work to produce only one kilogram of saffron powder. This explains the high price.

Saffron has been used for many years in countries like Iran and India as a medicine that helps treat physical and mental issues, including:

  • Low sex drive
  • Memory issues
  • Mood disorders

Some studies have shown that saffron can lower cholesterol and blood sugar and may also improve eyesight and memory. In addition to these qualities, saffron has been shown in clinical research to:

  • Have antioxidant qualities
  • Show benefits to depression and low mood
  • Fight free radicals (including cancer cells)
  • Reduce stress and anxiety
  • Combat PMS symptoms, including irritability and cravings
  • Improve erectile dysfunction
  • Increase libido in men and women
  • Suppress appetite (helping with weight loss)

In addition to cooked food and supplements, saffron tea is a popular way to consume the spice. Saffron tea has been shown to have benefits for the cardiovascular system, memory, and brain function.

How saffron supplements work

If you don’t want to consume saffron in cooked dishes or tea, you can opt for a saffron supplement. These dietary supplements come in capsule, gummy, and tincture forms and include saffron in addition to other healthy ingredients. In general, saffron supplements are used to help with:

Each saffron supplement product specifies what benefits it provides since saffron is known for its vast array of advantages.

Generally, supplements provide a dose of 20-100mg per day. You don’t need much of the spice — in a supplement or cooking — to reap the benefits. Supplements also include other ingredients that enhance the effects of saffron or improve taste. Saffron is also sometimes prescribed by doctors for certain conditions and may even help with illnesses like Alzheimer’s disease.

Keep in mind: even though saffron is one of the most expensive spices, saffron supplements don’t cost much more than your average dietary supplement. For the supplements in this guide, the average cost per saffron capsule is only $.61. The supplements contain a small amount of saffron, making the price manageable while still benefiting from saffron’s many restorative qualities.

Are saffron supplements a good choice for you?

If you live with any of the conditions that saffron has been shown to treat, supplementation may be a good choice for you. Talk to your doctor to find out the correct dosing, as too much saffron can cause adverse side effects.

In general, saffron is safe for most people if taken as directed. Many who use saffron supplements report boosted mood, better focus, and enhanced memory.

Who should avoid them

Saffron can interact with some medications, particularly those used to treat high blood pressure and diabetes. You also shouldn’t take the supplement if you live with a chronic illness, are pregnant or breastfeeding, or have had recent surgery. Saffron can also impact the effects of sedatives, making them potentially unsafe. Consult with your doctor before taking a saffron supplement or introducing any new supplement into your routine.

Are saffron supplements safe?

Saffron is generally safe to take for healthy adults. If taken as directed, it produces very few side effects. Up to 100mg of saffron should be safe to take per day, but you need far less than that to experience health impacts: only about 30mg per day. Taking more than 5g per day can have health hazards, especially if you are pregnant or breastfeeding. Some people are also allergic to saffron.

Common side effects from saffron supplementation are mild and include:

  • Drowsiness
  • Stomach issues
  • Nausea
  • Vomiting

A few health conditions and lifestyle choices may make saffron supplementation dangerous for you.

  • Because saffron may lower blood pressure, you shouldn’t take it if you are on antihypertensive medication.
  • Saffron may also lower blood sugar, making it potentially dangerous to take with antidiabetes drugs.
  • If you take sedatives, avoid saffron because it can cause sleepiness and slower breathing.
  • Studies have also shown that saffron may affect mood, which can cause adverse effects for those with bipolar disorder.
  • Don’t take saffron if you’ve recently had surgery, as it slows the central nervous system.

Nuzena Saffron Super Spice +

Best for most people


  • Helps with memory, mood, anxiety, and stress

  • All natural ingredients

  • No sugar, gluten, or GMOs

  • Vegan-friendly

  • Extensive third-party safety testing

  • Free shipping on orders over $50


  • No subscribe and save option

  • Take it for 90 days to see full benefits

Nuzena Saffron Super Spice + is our top pick because of its simple ingredients, safety, and effectiveness in improving mental health. It is a sustainably sourced, natural formula made with a pure saffron extract that goes through extensive third-party testing to guarantee safety. The supplement is free of sugar, gluten, and GMOs and is vegan-friendly. Nuzena created the supplement to help improve:

  • Mood
  • Memory
  • Stress
  • Anxiety

Saffron Super Spice + is manufactured in a facility that follows the FDA’s GMP guidelines. The Nuzena website also includes a quality certification tracker that allows you to view product testing results as they happen to ensure the products are high-quality. Nuzena uses third-party testing to check their products for allergens, heavy metals, and other contaminants. You can view these third-party tests on their website as well.

Each bottle of Nuzena includes 60 capsules, which is a 1-month supply. Take two capsules each day. Nuzena recommends taking the capsules 20-30 minutes before a meal, one at mid-day and one in the evening. Some users will notice effects right away, but Nuzena encourages customers to take the supplement for at least 90 days for full benefits.

You should take the supplements as directed and not exceed the suggested dose. If you are under 18, pregnant, nursing, or living with a medical condition, consult your doctor before using the supplement.


One 60-count bottle of Nuzena costs $35, which is a 1-month supply. Nuzena also offers free shipping on orders over $50. They offer a 30-day return policy on unused and unopened products.

You can also benefit from bulk savings discounts as outlined below:

  • 2 bottles: $65 (save $5)
  • 4 bottles: $105 (save $35)
  • 6 bottles: $140 (save $70)

Life Extension Optimized Saffron

Best for weight loss


  • Helps control cravings to aid weight loss

  • Does not contain caffeine, gluten, or GMOs

  • Vegetarian-friendly

  • Certificate of Analysis certifies product safety

  • AutoShip & Save option

  • Free shipping over $50


  • Best results after eight weeks

  • One-time purchase incurs shipping charges

Life Extension Optimized Saffron is best for weight loss because its formulation is designed to limit the urge to snack between meals. Satiereal saffron extract — the main ingredient in the supplement — was shown in a controlled trial to aid weight loss in women over an 8-week testing period. Take the supplement in combination with a healthy diet, adequate hydration, and regular exercise to see the best results.

The supplement does not contain caffeine, gluten, or GMOs and is vegetarian-friendly. In addition to Satiereal, the capsule also contains small amounts of microcrystalline cellulose, vegetable cellulose, silica, and acacia gum. Life Extension provides a Certificate of Analysis on every supplement to certify safety.

Take one capsule every morning and evening with food. The supplement is not intended for children or those who are pregnant, nursing, or living with a medical condition. Consult your physician before starting any new supplement.


A one-time purchase of 60 capsules is $27, a 1-month supply. You can also choose the AutoShip & Save option to take advantage of free shipping. You can choose to have the supplement shipped every 1-12 months for $24 per bottle, an 11% savings. Life Extension offers free shipping on orders over $50; orders under that amount incur standard shipping rates.

BrainMD Happy Saffron Plus

Best mood booster


  • Includes three active ingredients to help boost mood

  • Clinical trials show the efficacy of ingredients

  • Vegan-friendly

  • Does not contain gluten, wheat, dairy, or artificial additives

  • Subscribe & Save for deep discounts

  • Try a 7-day free trial


  • Contains trace amounts of soy

  • High-end price tag

BrainMD Happy Saffron Plus is our pick for the best mood booster because of its combination of ingredients. It includes saffron — already known for its mood-boosting qualities — plus curcumin, a chemical commonly found in turmeric that has been shown to improve anxiety and depression. The supplement also contains zinc, an essential mineral that has been shown to treat mood disorders. The blending of these ingredients produces a supplement that can help improve:

  • Mood
  • Anxiety
  • Focus

Happy Saffron Plus is a vegan product that does not contain milk, dairy, gluten, wheat, yeast, eggs, corn, or artificial colors and flavorings. The supplement does contain trace amounts of non-GMO soy.

One bottle contains 90 capsules, which is a 30-day supply. Take three capsules daily between meals. BrainMD states that children ages 4-18 years can also take the supplement. They should take one capsule per 40 pounds of body weight with a maximum of three daily capsules. Check with your doctor before beginning any new supplement, especially if you are pregnant, nursing, or living with a chronic condition.


In addition to saffron, Happy Saffron Plus contains two other potent ingredients intended to boost your mood. Read about all of its components below.

Affron (30mg)

Affron is a saffron extract that has been shown in clinical studies to help with anxiety, depression, and overall mood.

Longvida Optimized Curcumin (400mg)

Longvida is a curcumin concentrate shown in a controlled trial to enhance mood and working memory.

Zinc (20mg)

Zinc is an essential nutrient that helps with immunity and fighting infection. It has also been linked to improvements in depression.

In addition to these active ingredients, the supplement also contains small amounts of vegetable cellulose, microcrystalline cellulose, soy lecithin, magnesium stearate, stearic acid, ascorbyl palmitate, silicon dioxide, maltodextrin, and soy.


A one-time purchase of a 30-day supply of Happy Saffron Plus costs $49.95. You can also select the Subscribe & Save option:

  • Monthly supply: $42.46 (save $7.49)
  • Three-month supply: $39.96/bottle (save $29.97)
  • Six-month supply: $37.46/bottle (save $74.93)

Subscribe & Save orders provide free shipping and anytime cancellation. You also receive free shipping on any one-time orders over $75. BrainMD offers a 60-day money-back guarantee on unopened products. Used products can be returned for store credit.

If you want to try out any of BrainMD’s best-selling supplements (including Happy Saffron Plus), you can do so with a 7-day free trial. Pay $2.95 for a 1-week supply of the supplement to be shipped to you for free. After two weeks, you’ll be auto-enrolled in a monthly subscription to the supplement, which you can cancel anytime.

Nutricost Saffron Extract Capsules

Best budget pick


  • 8-month supply of capsules for only $27

  • Vegetarian

  • Made with pure saffron extract

  • Does not contain gluten, soy, GMOs

  • Free Shipping on orders over $59


  • No subscribe and save option

  • Only basic information about the supplement available online

If budget is a top concern, we recommend Nutricost Saffron Extract Capsules because one bottle contains 240 capsules, which is an 8-month supply, for only $26.95. This is — by far — the least expensive supplement on our list. But the low price does not mean an inferior product. The vegetarian capsules are made with pure saffron extract, small amounts of rice flour, and cellulose. They do not contain gluten, soy, or GMOs.

The product is manufactured in a GMP-compliant facility that is FDA-registered. You should take one capsule per day for maximum benefits. As with all dietary supplements, consult your doctor if you are pregnant, nursing, or living with an illness.


Nutricost offers free shipping on orders over $59. They ship only to the contiguous U.S. Each bottle of capsules costs $26.95, and there is no subscription option. Nutricost does provide a 90-day money-back guarantee (minus shipping costs) on all products. Purchase directly from the company or from popular websites like Amazon.

Mother Nutrient Saffron Extract

Easiest to take


  • Receive a 6-month supply for only $23

  • Subscribe & Save for further discounts

  • Helps to improve mood, energy, weight loss, and eye health

  • Contains pure saffron extract

  • Made in a GMP-certified facility


  • No international shipping

  • Provides a 6-month supply but autoships each month

Mother Nutrient Saffron Extract is our easiest supplement to take because you only have to consume one capsule per day to reap the health benefits of saffron. Each capsule contains 88.5mg of 100% pure saffron extract that may help to:

  • Improve mood
  • Boost energy
  • Help with weight loss
  • Enhance eye health

The supplement does not contain milk, gluten, wheat, soy, eggs, tree nuts, peanuts, GMOs, or artificial colors, flavors, or preservatives. The capsules are vegetarian, and they are manufactured in a GMP-certified facility.

Mother Nutrient’s supplements are created specifically for parents (mainly mothers) to help them better navigate the difficulties of child-rearing. The Saffron Extract supplement is designed to help new mothers manage their weight and deal with the mental and emotional challenges of motherhood.

Take one capsule daily. If you are pregnant, nursing, under 18, living with a chronic condition, or starting a new supplement, consult with your doctor.


A one-time purchase of a 180-count bottle is $22.99, which is a 6-month supply. You can also choose the Subscribe & Save option to save 5%. The supplement will be delivered every 30 days for $21.84. Mother Nutrient offers a 30-day return policy on unopened products. If the product is open, you can return it for store credit.

Mother Nutrient provides free shipping on orders of $50. They currently ship only within the contiguous U.S. Orders under $50 incur standard shipping fees.

Additional saffron supplements

Many high-quality saffron supplements on the market did not make our top 5 list. Each of these products offers specific health benefits. Read the descriptions below to find out if one of these products is right for your health journey.

Saffron supplement FAQ

Why you should trust us

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Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.