Best NAD+ Supplement

Not too many people are eager to grow old, and if you’re worried about losing energy or mental acuity as the years go by, you don’t need to feel hopeless about it.27 There’s emerging evidence in clinical research that boosting NAD+ levels might correlate with improved aging, potentially leading to things like heightened energy levels and focus.1 2 Some evidence even points toward improvements in appearance, such as more youthful-looking skin.25

You don't need to look any further than the biohacking community to realize there's genuine interest in the potential for NAD+ as a cornerstone in physical maintenance.3 But with that much buzz around it, it can be hard to separate fact from fantasy or determine which supplements — and what doses — could be safe and effective for you.

In this guide, our team compares several of the best-formulated NAD+ boosters with one another and with the available research, so you can make an informed decision. For a quick sense of the landscape, here's a summary of our top picks.

At Innerbody Research, we have been studying NAD+ for years. Each year, we gain fresh consumer experience ordering and trying dozens of NAD+ supplements ourselves, including the supplements in this guide. All told, we've spent over 1,340 hours researching NAD+ products and the science surrounding NAD+.

Trying supplements ourselves allows us to share helpful details about flavor, order fulfillment, and other aspects of customer experience, but it certainly wouldn't be enough to describe all the potential effects of these supplements on us because that's not exactly a scientific analysis. That's why we've examined more than 200 scholarly journal articles about aging in general and NAD+ metabolism in particular. We've pored over the clinical studies and systematic reviews of the main NAD+ precursors flooding the marketplace (NMN and NR). And we've consulted with medical professionals as well as supplement manufacturers to gain their valuable insights.

Part of the picture of trust, in this case, is also an acknowledgment that our sister company, Innerbody Labs, has recently developed a supplement of its own, geared toward increasing NAD+ levels in the body. We include it in this guide because our assessments indicate that it's one of the best on the market. At Innerbody Research, we operate independently and apply the same assessment criteria to all products we analyze, no matter who makes them. This is no different for Innerbody Labs products.

As you read this guide, it should be clear that no product is ideal for everyone or in all circumstances. We frequently point out pros, cons, and tradeoffs associated with all of the products we recommend and endeavor to describe the circumstances in which they're most recommendable — and when they're not. Our goal is to help you make the best decision for your health, whether that's an NAD+ supplement or a different supplement or lifestyle adjustment altogether.

Additionally, like all health-related content on this website, our guide to NAD+ supplements was thoroughly vetted by members of our Medical Review Board for accuracy.

Taken orally, NAD+ — a critical coenzyme for whole-body cellular health — is itself too poorly bioavailable.60 Therefore, elevating NAD+ is best done through precursors that transform to NAD+ once in the body.61 These precursor supplements, typically called NAD+ boosters, often include one of just two ingredients known to boost NAD+, but there’s still a surprising amount of variety among them.

To compare NAD+ boosters, we relied on a simple set of criteria that could apply to any of the market’s top products. There are instances where varying formulas cause comparisons for things like cost to get a little muddy, but the information here should still add clarity to your understanding of the field and help calcify specific things you want to see in your NAD+ booster.

Specifically, we looked into the following areas:

• Safety
• Effectiveness
• Cost
• Convenience

Let’s take a look at each criterion in a little more detail.

Safety

Advantage: Toniiq NMN 300

In humans, NMN doses as high as 1,200mg/day and daily NR doses up to 2,000mg have been illustrated as safe for use over a six-week period.4 31 So, a daily dose of either NMN or NR — or a combination of the two — up to 1,200mg should be safe for most otherwise healthy people. As with many supplement ingredients, there is a lack of data about the effects of daily supplementation over the span of years. We’ll discuss some of the potential concerns around long-term dosing later in this guide, but as they apply evenly across the NAD+ booster landscape, they don’t impact our product selection in a meaningful way.

That said, a single 1,200mg capsule wouldn’t necessarily win out for safety. There would be no way to ease yourself into the regimen or decrease your intake if you experience any of the adverse effects sometimes seen in high-dose NAD+ booster studies, like headache, GI upset, and muscle cramps.32 It would be better to start with a lower dose that would let you titrate up toward the 1,200mg mark, assuming you and your doctor agreed on that as a target.

Toniiq’s NMN 300 is a good pick for just that. A bottle of it provides 60 capsules, each containing 150mg. That allows you to start at either a safe lower dose and titrate upward, or a more dialed-in dose (e.g., 600mg or 900mg). Dose-response research into NMN’s effects often uses 300mg increments, as well, so this approach puts you in line with several clinical studies.4 51 However, as we’ll explain in our cost section below, those interested in a 900mg dose would get the best deal by reaching for Neurogan’s NMN 900.

For added peace of mind, Toniiq subjects its supplements to rigorous third-party testing for dose, purity, microbial contamination, and heavy metals. The company also posts the results of those tests right on its product page, aligning with best practices in the sector also employed by Innerbody Labs and Neurogan.

If you’d prefer a complex formula, however, NAD+ Support from Innerbody Labs would likely be a solid choice for safety. Its combined NAD+ booster dose is 1,100mg (700mg NMN and 400mg NR), keeping it within a range of precursor dosage found safe in clinical studies to date, though at the high end of that range. And its three-capsule serving means you could opt for a lower dose if you wish. Inclusions of trimethylglycine (TMG) and spermidine may also help prevent the NAD+ production chain from producing any unwanted side effects due to an overaccumulation of byproducts — a phenomenon we’ll discuss a little later.41

Effectiveness

Advantage: NAD+ Support by Innerbody Labs

One of the big questions about the effectiveness of NAD+ boosting is the precursor you use to affect it: NMN or NR. Many NAD+ boosters contain just one of those two ingredients to get the job done, making it relatively easy to compare potential efficacy by looking at each product’s dose and comparing it to how a given precursor performed in clinical research. But NAD+ metabolism is a complex process, and while research indicates that you could ramp up NAD+ production with a single precursor, fueling other aspects of the production process may make your NAD+ increases more efficient and sustainable.2

In some studies, NAD+ levels rise for around eight weeks, then begin to decline again.62 One potential explanation for this is that a necessary fuel for the conversion of NMN or NR to NAD+ is missing.34 That’s why a hefty dose of TMG or another methyl donor may also be important to a complex NAD+ boosting formula; it can create the conditions to sustain increased NAD+ levels.38

NMN and NR both effectively raise NAD+ levels in research, but each one has exhibited some other effects in human studies that haven't been replicated in the other. For example, NMN has been shown to increase telomere length and improve sleep, but NR hasn’t.28 29 On the flip side, NR has been shown in research to improve neurodegenerative biomarkers, making it a potentially superior choice to NMN for brain health.30 These apparent differences between NMN and NR could be real. However, they could just as easily be a consequence of the studies’ designs and the limited set of studies as of the nature of the precursors themselves. Innerbody Labs NAD+ Support combines both NMN and NR, eliminating the need to choose and aligning the individual doses and their cumulative precursor amount with clinical research. Until there is more clarity through scientific research about the effects of each precursor, this strikes us as the most reliable approach for achieving positive effects.

For most users interested in a single-ingredient NAD+ booster, we would recommend NMN, thanks to its superior quantity and quality of supportive research, as well as the fact that NMN is metabolically one step closer to cellular NAD+ than NR is.33 To that end, you could consider Neurogan’s NMN capsules a budget option for efficacy.

A quick note about delivery mechanisms. There’s a lot of interest in things like sublingual drops or tablets, enteric coatings, powders, and nasal sprays to get around NAD+ boosters’ middling bioavailability. Numerous companies offer these formats, but there’s one big problem: there’s no clear science to guide dosing. Nearly every NR and NMN study in humans has used simple, uncoated capsules containing either ingredient.61 Without knowing how these other technologies impact performance, it’s impossible to create clear guidance for a dose that could be safe or effective. And because we hew closely to the latest and best science when making our recommendations, we chose to focus our guide on traditional capsules for NAD+ booster delivery.

Cost

Advantage: Neurogan NMN 900

NMN and NR supplements have similar effective doses for raising NAD+ levels in studies, so it can be helpful to look at the cost per gram of either precursor to compare prices across companies. However, some companies choose to include other ingredients involved NAD+ metabolism, so it also becomes important to consider the cost per dose.

Here’s how different companies’ costs compare at the lowest available prices, accounting for bulk or subscription discounts:

Renue by Science may have the lowest cost per dose and cost per gram, but that’s in a loose powder you mix into water, a form factor significantly less well-researched than capsule-based delivery.61 That makes it hard to justify your potential savings if bioavailability is less reliable. Neurogan’s NMN 500 and NMN 900 capsules both have a very low cost per dose, and the cost per gram of precursor is remarkably low with NMN 900, making it our top pick for the budget-conscious.

Convenience

Advantage: Renue By Science

While the company has far less scientific guidance for its dosing, safety, and efficacy, there’s no denying that the variety of delivery mechanisms in Renue by Science’s product lineup makes for a convenient user experience. With Renue, you can get a NAD+ booster as a capsule, sublingual powder or tablet, oral gel, or nasal spray. Although not every formula is available in every configuration — in fact, most formulas are available in only one form or another — it offers much more variety than any other brand in this guide.

In our testing experience, the most convenient of these products was the company’s fast-dissolve NMN tablets, which dissolve under the tongue in a little under a minute and leave behind only a light citrus taste. One downside to them is the dose, as they contain just 125mg per tablet, but the bigger issue is that there are few to no sublingual tablet NMN studies to rely on for dosing clarity. (This problem repeats itself any time Renue offers a novel delivery mechanism.) That leaves some significant question marks around safety and efficacy, but if ease of use is a priority for you, Renue will have the most options for you to choose from.

Given the variety and complexity of the NAD+ booster landscape, we thought it’d be useful to summarize some key components of the top brands in a handy chart:

NAD stands for “nicotinamide adenine dinucleotide.” Without the plus sign, NAD serves as an umbrella term for a group of chemicals, including NAD+. But you might wonder, what does any of it do in the body?

NAD+ is a coenzyme integral to the function of our mitochondria — often referred to as the powerhouse of the cell. Most human cells contain mitochondria, where fundamental components of your diet that are broken down through the digestive process are metabolized to form your body’s primary energy currency, adenosine triphosphate (ATP).69 You could think of them essentially like electrical generation stations, taking in raw materials and converting them to the energy that travels throughout the entire grid.

Efficient mitochondrial function also relates to better cell performance and waste removal.5 Researchers are investigating whether these improvements could have pronounced downstream effects for aging and disease.

NAD+ is available as a primary ingredient in some supplements, but the current understanding of NAD+ metabolism is that its bioavailability is severely limited compared to a pair of its precursors: NMN and NR.6 60

By using NAD+ precursors instead of NAD+ itself, you can end up with more NAD+ available for your body to utilize. But there's plenty of disagreement about which precursor is the safest and most effective. Understanding how NAD+ forms in the first place can give us a glimpse into the potential of either ingredient.

The body makes most of its NAD+ along three pathways:33

It makes sense for both researchers and supplement companies to focus on NMN and NR, as the salvage pathway is responsible for so much NAD+ production.34 But most studies and companies focus on one or the other, which has created some friction in the NAD+ boosting community between advocates of NMN and advocates of NR. Is one safer or more effective than the other?

Common NAD+ precursors: NR, NMN, and beyond

There’s a small handful of ingredients available as over-the-counter nutritional supplements that research shows have the potential to increase NAD+ concentrations in your body. Most are derivatives of vitamin B3. Some have more research to support them than others, with two ingredients in particular — NR and NMN — among the best-researched in the bunch. As a result, they occupy a stronghold in the marketplace among NAD+ precursors.

Here’s a quick look at the most promising NAD+ boosters:

NMN vs. NR: Which should you take?

If NMN becomes NAD+ more directly than NR, why bother with NR at all? Until recently, research showed that exogenous NMN had to become NR to enter human cells before it could go back to NMN and eventually become NAD+. That would be relatively inefficient, so NR seemed like the superior choice. More recent studies have revealed a specific amino acid and polyamine transporter that's extremely selective for NMN and allows it to enter a cell without first becoming NR.7

Concentrations of this transporter in the guts of mice appear to increase with age, suggesting that the body tries to get extra NMN from its food supply to compensate for deteriorating levels of NAD+ that coincide with aging. It’s still a theory, but it suggests that NMN's NAD+ production may be more closely tied to the activity and health of the microbiome than was previously thought. But proving this requires a tremendous amount of additional research that has only just begun.36

The bottom line is that both NR and NMN are capable of increasing levels of NAD+ in the human body, according to clinical research.8 Which one you ultimately choose may have to do with your tolerance for either. If the body becomes better able to absorb NMN directly as it ages, older individuals might want to consider NMN over NR, given its closer metabolic proximity to NAD+.

This all might be a false choice, though. Some supplement companies have chosen to combine NMN and NR, based on their relative safety and the apparent differences in some of their secondary effects research. NMN has exhibited some effects secondary to NAD+ boosting that NR research hasn’t replicated, and vice versa.

For example, NMN has human research to support its ability to improve skin health and enhance aerobic capacity, which NR doesn’t.37 4 Meanwhile, NR has human research that shows it can improve biomarkers associated with neurodegenerative disease, which can’t be said of NMN.30 If you wanted to boost NAD+ levels, improve aerobic capacity, and protect your brain with a single supplement, a synthesis of all that research suggests that a combination of NMN and NR may be superior to either in isolation.

However, it’s crucial to note that this synthesis is undertaken by the supplement companies themselves, and that research into combined dosing of NMN and NR has yet to be published in any peer-reviewed journal.

Questions around NMN’s FDA status

If you’ve been looking into NMN for any length of time, you might be aware of its controversial standing with the FDA. To be clear, this is an unintended consequence of a recently adopted law that results in the revocation of an ingredient’s supplement status if that ingredient is being investigated for a new drug application, regardless of that supplement's standing in the marketplace.

In other words, if a pharmaceutical company thinks it can make a prescription drug out of a popular supplement ingredient, it can file a new drug application for a patented form of that ingredient, and the FDA will put out a letter stating that further sales of that ingredient in supplement form are prohibited.

Products like CBD and N-acetyl cysteine (NAC) have endured similar status questions, with a few pharmaceutical companies investigating refined versions of these ingredients for possible new drug applications. But NMN, CBD, and NAC are all still on the market. That’s because the FDA understands that its enforcement discretion is the only thing keeping drug makers from investigating patented versions of everything from vitamin C to St. John's Wort. If they could, pharma companies would likely try to corner the market of all supplements.

In fact, the FDA was so aware of how integrated NMN had become in the supplement market that it reversed course from its initial 2022 ruling and clarified its position in late 2025, officially reinstating NMN as a dietary supplement.

How NAD+ supplements absorb

NAD+ precursors certainly absorb better than NAD+ itself, but NR and NMN are both going to break down a bit in your GI tract.6 60 For supplement companies, this presents a challenge and a marketing opportunity. If one company can figure out how to bypass the GI tract in its precursor delivery, it could hold an edge over the others.

The biggest problem with this approach is the lack of support for anything but traditionally encapsulated NMN and NR powders in clinical research. We know that there’s a specific transporter in the small intestine dedicated to metabolizing NMN, so bypassing the stomach here would hypothetically yield superior results.9 But there isn’t enough scientific data to back up these methods yet. To date, nearly every human study looking at NAD+ production from NR or NMN supplementation uses traditional capsules with no special coatings or other technologies included to protect against stomach acid.61

Still, you’ll see sublingual drops, nasal sprays, and enteric-coated capsules on the market that claim superior absorption. They might be right, but these companies have no scientific data to provide safe and effective dosing guidance.

Once they get into the body, NMN and NR make their way into your cells through various complex pathways that will result in different levels of efficacy for just about everyone who takes them.10 Short of taking each on its own for at least a few weeks with a washout period in between, it will be difficult to determine which option is best for you. But given the fact that NMN and NR have exhibited individual effects in studies that the other hasn’t been able to produce, taking both of them might be the most reliable way to achieve positive effects seen in research.

Can liposomal delivery make a difference?

Among the most popular novel delivery mechanisms is liposomal delivery, a method of encapsulating a precursor’s molecules in microscopic fat cells that can survive the acidity of the stomach. Liposomes have been used for numerous drug applications, and there’s a lot of research behind them, but their specific effect on absorption varies from study to study and from drug to drug.

Only one study has been published looking at the liposomal delivery of an NAD+ precursor in humans. It was a small-scale study (just 15 participants) whose researchers received their liposomal NMN from a company that sells it (a potential introductory point for bias). The results indicated a roughly 25% increase in efficacy for the liposomal group.45

That would mean a liposomal 400mg NMN dose would be about as effective as a 500mg non-liposomal dose of the same NMN. But companies often use liposomal preparations in much smaller doses that wouldn’t rise to a therapeutic level from a 25% increase in efficacy. And those delivery mechanisms often also result in a higher price tag.

At this point, considering the lack of direct scientific support and the tendency for companies to underdose their liposomal NAD+ precursors, we recommend most people begin with a traditional capsule delivery mechanism. It’s the most reliable way to achieve the positive results seen in human studies.

While many companies sell NAD+ boosters on their own, others see fit to pair NMN or NR with additional components. In some cases, the added ingredients are there to help the NAD+ booster work or absorb more effectively. In other cases, the companies claim complementary benefits to those NAD+ boosters, such as anti-aging and anti-inflammatory activity.

Here’s a quick look at the most common supporting ingredients you’ll find in NAD+ boosters:

In the short term, NAD+ supplements appear to be safe and well-tolerated in healthy individuals. Studies looking at NR doses up to 2,000mg per day and NMN doses up to 1,200mg per day found no differences in adverse effects between intervention and placebo groups.31 4 In studies of higher doses that produced adverse effects, typical reactions included:32

• Headache
• Dry mouth
• GI upset
• Muscle cramps or spasms

As with many forms of vitamin B, NR has the potential to cause some flushing, and both NR and NMN can cause digestive upset. But these side effects are rare and usually mild.

There are no long-term studies examining the safety of NR or NMN. Right now, our understanding of NAD+ is significantly incomplete. The supplement industry talks about it as though it's the fountain of youth, but cancer researchers have successfully starved tumors of the fuel they need to grow by limiting the presence of NAD+, indicating the inverse possibility: that higher NAD+ levels could spur tumor growth.16

It's entirely possible that NAD+ can stave off the onset of various age-related disorders while also contributing to the growth of cancers in the body. For now, we recommend using NAD+ supplements with care. Seek advice from your doctor before starting an NAD+ supplement, especially if you have a personal or family history of cancer.

Best overall

Innerbody Labs is the supplement arm of Innerbody Research, which leverages our research and editorial processes to develop products that we then review with the same degree of honest scrutiny we apply to every other product we investigate. Innerbody Labs added a NAD+ supplement to its lineup in part because the market was missing a high-dose option combining therapeutic doses of NMN and NR that might attain the broader spectrum of NAD+ boosting benefits. There were also too few options for a high-dose NAD+ supplement that included enough TMG to offset the methyl donor shortage often seen in precursor supplementation.38

The result is a complex NAD+ booster formula that’s still pretty straightforward:

• NMN: 700mg
• NR: 400mg
• TMG: 500mg
• Spermidine: 15mg
• BioPerine: 10mg

We discussed the merits of each ingredient earlier, but in this specific combination, you should see the NMN and NR content increase NAD+ levels, while the TMG content acts as a methyl donor for the increase in NAM (niacinamide) that comes with enhanced NAD+ production and utilization. The spermidine also works on NAM’s behalf, staving off NNMT and preventing it from rerouting that NAM to become something less useful, or even dangerous.40 41 And BioPerine improves your absorption of each of the other ingredients, including a clinically demonstrated 15% boost in NMN absorption and efficacy.44

Innerbody Labs offers its NAD+ Support as a one-time purchase or on a subscription basis in one-, three-, or six-month intervals. Here’s how the pricing works out:

NAD+ Support’s full dose is contained in three capsules, allowing you the option to take two capsules and still align with a majority of NAD+ precursor studies with plenty of TMG, spermidine, and BioPerine to deliver consistent efficacy for a slightly lower cost.

Innerbody Labs offers free shipping on all of its U.S. orders over $50, which covers any NAD+ Support purchase, but the company only ships within the U.S., U.K., Ireland, Australia, New Zealand, and Canada at this time. International customers will pay shipping and any duties, and these fees can add up significantly. If you’re ordering anywhere outside of the U.S. right now, you might be better off purchasing ProHealth Longevity products through iHerb, which ship internationally for reduced fees.

You get a 30-day money-back guarantee, as well. That’s long enough to know whether it’s working if you also get your NAD+ levels tested, but most of the positive effects of NMN and NR supplementation take longer to feel.

Best budget pick

Neurogan started as a CBD company, but it expanded its supplement lineup in recent years under the brand name Neurogan Health. This new brand offers more than 60 supplements, many with a focus on longevity, but most are single-ingredient only. There are very few complexes in the company’s catalog.

Among those single-ingredient supplements are two excellent NMN offerings:

• NMN 500: a 500mg dose packed into a single capsule
• NMN 900: a 900mg dose packed into a single capsule

Choosing between the two is a matter of cost and titration needs. The 900mg dose is a far better deal per gram of NMN, but if you wanted to take more, you’d have to jump up to 1,800mg, which is 600mg above what high-dose safety studies have scrutinized.4

By comparison, the 500mg dose is less affordable per gram of NMN, but it’s easier to take 1,000mg or 1,500mg (much more in line with safety data).51

Neurogan Health also sells an NMN supplement that includes resveratrol, as well as an NMN liposomal capsule. At this time, there isn’t enough research into liposomal delivery mechanisms to advocate for their use.

Here’s how the pricing looks for Neurogan Health’s NMN-only products:

Shipping is free on orders over $70 or with a subscription (certainly less generous than the lower $45 free-shipping threshold from Renue by Science). Otherwise, you’ll pay based on your location and the weight of the product. For our testers on the East Coast, this typically amounted to around $5 per shipment (costlier than the free shipping you get from Innerbody Labs on every NAD+ Support order).

Neurogan Health offers a 30-day money-back guarantee on its products, which is on par with the likes of Innerbody Labs and far better than Nootropics Depot’s strict policy against returns of opened merchandise. But it’s not quite as long as Renue by Science’s 60-day guarantee or ProHealth Longevity’s 100 days.

Best NAD+ booster with resveratrol

You might be familiar with resveratrol, a polyphenol present in red wine, dark chocolate, and many other foods. It was once the star compound in the longevity health space, but its star has fallen somewhat, owing to some data fabrications, poor oral bioavailability, and (relative to its hype) limited outcomes in human clinical trials.46 47 48

But a murky research history aside, resveratrol is still a prominent player in longevity science. More recent research, such as a 2018 review in Biosciences, supports its long-purported anticancer, antioxidant, and cardioprotective potential.49 There’s also now some evidence that it can modulate several aging-related cellular pathways, including sirtuins, a family of enzymes closely linked to NAD+.50

So Primal Harvest’s combination of NMN and resveratrol makes some sense from a research standpoint. So does its dosing, as 425mg is within the ranges used in successful research on both ingredients.52 However, we could not confirm whether Primal Harvest’s resveratrol is micronized, or decreased in particle size, a technology that has clinically yielded increased plasma resveratrol levels.53 That could hamper the ingredient’s ability to work effectively, and it may be enough to convince some people to purchase their resveratrol separately.

Primal Harvest offers one-time and subscription purchases of Primal NAD+:

Compared to the other NAD+ boosters we recommend, Primal Harvest lands in the middle of the price pack. And of the lower-cost options, none has a second longevity-supporting ingredient like resveratrol.

As for guarantees, Primal Harvest has one of the longest ones in our guide, with a 90-day money-back guarantee, behind only Life Extension and ProHealth Longevity.

Best NMN only

A pair of prominent dose-response studies has compared NMN doses for specific markers at 300mg, 600mg, and 900mg, with safety studies illustrating the absence of adverse effects up to 1,200mg.4 51 For individuals interested in titrating up from a lower dose to make sure they can tolerate NMN to a point of reliable efficacy, choosing a supplement that employs 300mg or 150mg capsules could be ideal, as it would put them squarely in line with that research.

Toniiq’s NMN 300 offers 60 150mg capsules per container, giving you the opportunity to start as low as 150mg and work your way up through doses that have clear relationships to effects in that research.

And Toniiq subjects its NMN 300 to rigorous third-party testing, evaluating it for dose, purity, microbial contamination, and heavy metals, with the results of those tests available right on the product page. Neurogan and Innerbody Labs do the same, but Innerbody Labs’ formula is more complex, and Neurogan’s NMN 500 recently changed from offering 250mg per capsule to consolidating its 500mg dose into a single capsule. That’s why Toniiq has taken over as our top pick for those interested in an NMN-only supplement.

Pricing

Per dose, Toniiq NMN 300 is fairly priced, though that value wanes compared to some other picks on the market as you get into higher doses. Here’s how it works out:

Compared to Neurogan 500, these prices are relatively high, especially the cost per gram of NMN. Neurogan’s cost per gram is only $1.20 and $0.69 for the 500 and 900, respectively. So, if you’re titrating up from 150mg or 300mg using Toniiq, and you end up at a higher dose than 450mg, you might eventually want to switch to one of these two Neurogan products to save more money over time.

On the bright side, Toniiq has one of the longer money-back guarantees in our guide, offering 60 days for you to try the product. That makes it easier to start at that low 150mg dose if you’re determined to take things slowly, without worrying that you’ll get into your second month of supplementation and not be able to initiate a return.

Best NR-only supplement

It makes sense that Nootropics Depot would have a good NR supplement in its catalog. The company is all about boosting brain performance, and NR has shown promise in the treatment of neurodegenerative disorders, whereas NMN has not.30 There’s certainly an NMN in its catalog as well, but the pricing is poor, especially for an NMN-only product.

Each NR capsule from Nootropics Depot contains a 300mg dose of NR chloride, the specific type of NR used in the vast majority of NR research. Other forms exist on the market, including NR hydrogen malate, but these boast too little research in humans to verify their safety and efficacy.

That 300mg dose puts users in a good spot to titrate. And with NR safety research reporting few to no adverse effects up to 2,000mg per day, there’s a lot of room to experiment (under a doctor’s supervision, of course).31

You can get NR from Nootropics Depot in 30-, 90-, and 365-day supplies. That last option offers dramatic savings and is far better designed than comparable offers elsewhere. With other one-year supplies we’ve seen, they amount to a shipment of 12 bottles containing 30 capsules each. That adds up to just 360 capsules, meaning you’ll have to make a note to reorder some 350 days after you receive your shipment — an undue burden compared to the convenience of Nootropics Depot’s full-year shipment.

Here’s how the pricing works out for Nootropics Depot NR:

As you can see, if you have the cash up front to purchase the one-year supply, you could save a lot per dose and per gram of NMN. Just be cognizant that these ingredients can degrade at warm temperatures or in humid climates, so you might want to keep a long-term supply in the fridge, which can prove inconvenient if you lack the storage space.

Nootropics Depot has a $50 free-shipping threshold, below which you have to pay $10.50 for domestic shipping in the U.S. The company also has the worst guarantee in our guide. It doesn’t accept returns on opened merchandise, so there's essentially no money-back guarantee. Compared to things like the free shipping on all U.S. orders for Innerbody Labs NAD+ Support or the 60-day satisfaction guarantee from Renue by Science, these are poor policies.

Best powder and best for novel delivery methods (liposomal, intranasal, sublingual, etc.)

Renue By Science sells NR and NMN supplements in capsules, tablets, powders, and sublingual drops, as well as combination supplements in capsules and nasal sprays. Many of these products contain NR or NMN processed in a liposomal format that protects them against stomach acid and theoretically allows them to get the most out of the specific NMN transporter found in the small intestine.

Unfortunately, the company uses its liposomal technology to justify occasionally reducing the doses of these products, and the only available liposomal research in humans indicates that the technology isn’t powerful enough to make up for this difference in dosing.45 Renue specifically references this study on its product pages but relays the information from the study somewhat inaccurately.

The product pages point out that the liposomal formula outperformed the non-liposomal formula, which is true. But the pages also say that the liposomal formula increased blood NAD+ levels by 84% while leaving out the fact that the non-liposomal formula increased levels by 67%. A visitor could easily get the impression that the lipo formula was 84% more powerful than the non-lipo formula, even though the math reveals only a 25.3% increase in efficacy.45

Here’s how that plays out practically: Research shows that a 1,000mg daily dose of NMN could improve blood pressure.56 Renue’s Lipo NMN delivers 500mg per serving divided into two capsules. That 25% increase in effectiveness from liposomal encapsulation would give each of those 250mg capsules the equivalent power of a 312.5mg capsule. That means you’d still need four capsules to reach 1,000mg or higher — the same number of capsules you’d need from a non-liposomal formula.

Renue’s products are generally promising and typically dosed well, even despite a lack of clinical dosing guidance to rely on. It’s generally a better resource for people who want to maximize their NAD+ precursor intake without quite as much regard for potential side effects that could crop up at higher doses.

Here's a breakdown of the available NAD+ boosters from Renue By Science:

Renue By Science has a subscription program you can join with any purchase. The program automatically bills you and delivers new products every 30, 45, 60, or 90 days. You’ll save 10% on subscription orders, which is nice, but it pales in comparison to other companies’ subscription discounts, like the combination of bulk and subscription discounts from Innerbody Labs or Elysium that can save you up to 33%. Still, many of Renue By Science’s products are priced low enough to compete with those deeper discounts.

Renue by Science has improved its return policy over the past few years. In the past, you could only return unopened products, but now, you’re protected by a 60-day money-back guarantee. At the same time, Renue By Science reduced the policy period from 90 days to 60 days. The duration of the return period is not as generous as that of some competitors, like ProHealth Longevity, which offers a 100-day guarantee, but we're happy to see that the policy is generally more protective of you.

Best for customers outside the U.S.

ProHealth Longevity offers several supplements designed with the goal of fighting the aging process and providing you with extra energy. Its NMN supplements come in various forms, so you can choose which one you find easiest to take, though dosing accuracy gets muddied outside of traditional capsules.

One of ProHealth Longevity’s most compelling products is its NMN Pro Complete, which combines a 1,000mg dose of NMN with 1,000mg of trans-resveratrol and 500mg of TMG. Those are the two largest doses of those supporting ingredients you’ll find in this guide, with only Innerbody Labs providing as much TMG.

Here's a closer look at some of ProHealth Longevity's NMN offerings:

ProHealth also has a selection of NR supplements in its catalog, though these are all capsules. There’s a 300mg and 500mg option, but no 1,000mg option for NR.

That said, NR is central to the company’s NAD Triple Boost, a combination of 500mg NR, tryptophan, apigenin, PQQ, quercetin, and a handful of other ingredients intended to support NAD+ synthesis and fight aging. Ultimately, the tryptophan dose is too low, the apigenin and quercetin lack support from human studies, and the price is a little too high at $100 for a one-time purchase or $70 for a subscription.

You can take 10% off of any of these prices by signing up for ProHealth Longevity’s subscription program, which allows you to set your deliveries for every 30, 60, or 90 days.

Free shipping kicks in once you’ve spent $30 or more, which is a low enough threshold to apply to any of the company’s NAD+ products. You can also get some ProHealth Longevity products through iHerb, which is especially useful for international customers outside the U.S. Most companies that can deliver internationally still see their customers absorb sometimes outlandish international customs fees. iHerb’s international shipping program absorbs many of these fees for its customers, making purchases through that platform — including ProHealth products — ultimately much more affordable for an international audience.

ProHealth Longevity offers the second-best money-back guarantee of the supplements on this list. Its 100-day policy is long enough to let you try its products for over two months to see if they make you feel any better. It’s not as long as Life Extension’s one-year policy, however.

At AEON’s core, you’ll find the same central ingredients used in Innerbody Labs NAD+ Support, but in smaller doses. AEON has less than half as much NMN and NR, less than one-fifth the TMG, and only two-thirds of the spermidine. The formula attempts to make up for those shortcomings by rounding out an approach to anti-aging that includes certain popular ingredients like quercetin and fisetin, but we still think that the smaller list of all clinically dosed ingredients from Innerbody Labs will yield better results for most people.

Here’s a quick look at the whole formula:

• Vitamin B2: 1mg
• Vitamin B6: 5mg
• Vitamin B12: 2mcg
• Nicotinamide DUO: 500mg (400mg NMN, 100mg NR)
• Quercetin: 250mg
• Trans-resveratrol: 150mg
• Fisetin: 100mg
• Astragalus: 100mg
• L-Theanine: 100mg
• EGCG: 100mg
• TMG: 85mg
• Piperine: 10mg
• Spermidine: 10mg

Of all those extra ingredients, the only ones that might make a significant difference per human research are L-theanine and EGCG, though doses of both are on the lower side of effective. For example, a 2019 L-theanine study revealing positive effects on stress biomarkers used a daily 200mg dose, twice what you see in AEON.63 Similarly, a review of studies looking at EGCG’s potential to improve metabolic biomarkers found positive impact from doses ranging from 379-870mg daily, many times more than what you see in AEON.64

Perpetua.Life uses a liposomal delivery system, so you can tick its precursor doses up by about 25%, according to the one relevant study in humans.45 That still only gives you 625mg of precursors compared to the 1,100mg you get from Innerbody Labs.

Fortunately for Perpetua.Life, its prices are on the low side, even for one-time purchases:

Shipping is also free from Perpetua.Life on all orders over $40, making it effectively free for any purchase of AEON. And the company offers a 30-day money-back guarantee, similar to many others, but still inferior to ProHealth Longevity’s 100-day guarantee.

Life Extension sells a lot of different supplements. Its range is so broad that the company offers a convenient quiz to help you figure out which ones you might need. For anyone interested in NAD+ supplements, Life Extension offers two products that contain Niagen, the form of NR you'll find in Tru Niagen — a competing product. Chromadex, the company that owns the Niagen patent, also owns Tru Niagen, but it appears to have given rights to Life Extension to sell its NR under another banner.

Life Extension’s 30-count bottle of just Niagen is a little less expensive than Tru Niagen, but Tru Niagen’s bulk purchasing options result in superior savings.

Life Extension's NAD+ Cell Regenerator and Resveratrol combination offers a handful of ingredients in addition to Niagen and Resveratrol. These include:

• Bio-Quercetin 14mg, a flavonoid that research suggests may be good for immunity and cardiovascular health20
• Fisetin, a flavonoid with the potential to be good for bone health and anti-inflammation21
• Fenugreek, a botanical ingredient with some research demonstrating anti-inflammatory and antioxidant benefits22

Life Extension obscures some of these ingredients’ doses within proprietary blends, but the overall doses of each blend reveal that each ingredient dose is excruciatingly small.

Here's what Life Extension NAD+ price structure looks like:

Orders over $50 receive free shipping, as do any subscription orders. If you wish to make a one-time purchase that falls short of the $50 threshold, you’ll pay the following rates:

• Basic: $5.50
• UPS 2nd Day Air: $18
• UPS Overnight: $29.50

Life Extension offers the longest guarantee of the companies in our guide, allowing you to try them for up to a year before initiating a return. The next closest guarantee is the 100-day policy from ProHealth Longevity.

Tru Niagen is likely the foremost name in NR supplements. Its specific nicotinamide riboside chloride — branded Niagen — has been the subject of several studies. Study participants who have taken it saw definite increases in NAD+ levels.61 We should note that many of those studies looked at doses above what Tru Niagen provides in a serving of its standard formula, sometimes reaching more than three times that quantity.

Original Tru Niagen is available in 150mg and 300mg capsules, as well as a powder you can dissolve in water to make a drink. The powder stick packs are the most expensive form of Tru Niagen, likely due to the added packaging and processing to make the substance dissolve nicely. The company also makes Tru Niagen Pro, which provides a 1,000mg NR dose in two capsules.

Tru Niagen also offers an immunity support supplement called Tru Niagen Immune that combines a 150mg dose of NR with vitamins D and C, zinc, and a curcumin derivative that may be more bioavailable than typical curcumin supplements. Here’s a quick look at the doses:

• Niagen: 150mg
• Theracurmin: 30mg
• Vitamin C: 180mg
• Vitamin D3: 50mcg
• Zinc: 20mg

The company sells a bundle of its original and immune products together, which would take your effective NR dose up to 450mg/day.

The most recent addition to Tru Niagen’s lineup is Tru Niagen Beauty, which combines only 100mg of Niagen with a handful of supportive ingredients, some of which have good research behind them for improving skin, hair, and nail health. Here’s a look at the formula:

• Niagen: 100mg
• Vitamin E: 30mg
• Biotin: 5mg
• Hyaluronic acid: 120mg
• Grape seed extract: 100mg
• Astaxanthin: 4mg

Of these ingredients, vitamin E, hyaluronic acid, and astaxanthin have the most potential. For example, a large review of vitamin E’s role in dermatology found that oral consumption could improve atopic dermatitis symptoms and skin-based immunity.57 However, doses used were much higher than those seen in this product. The hyaluronic acid dose is more aligned with good skin research, like this clinical trial that used 120mg for 12 weeks and saw improvements in wrinkles and dry skin.58

Here's how Tru Niagen's top products price out:

To read more about Tru Niagen and its offerings, you can check out our comprehensive review.

Tru Niagen offers free shipping on all standard orders, which is a nice perk, but it also lacks any kind of money-back guarantee, something most of the companies in this guide have.