Best Anti-Aging Supplements

If you zoom out far enough, you’ll quickly see that we’re living much longer now than ever before. But that doesn’t always mean we’re living better as we age. Aging is such a complex, multifaceted process that living longer has revealed a multitude of new issues our great, great ancestors never faced.1

In 1900, the average life expectancy in the U.S. was just over 47 years — hardly enough time for most people to develop Alzheimer’s disease or various age-related disorders.2 By 2010, that average was more than 78 years, and most of the problems that come with growing old had become well-documented in the scientific literature.

There are innumerable approaches to living both longer and healthier in the face of age-related disease and cognitive decline, as well as new and innovative ways to measure how much your body has aged physically, not just temporally. Anti-aging supplements are one part of a multi-prong approach, and the best of these contain a slew of potentially beneficial ingredients for the brain, skin, and other organs and systems. With the right cocktail, you might look and feel younger for years to come, but the options are nearly endless.

We took a deep dive into the anti-aging space to find out what supplements on the market contain ingredients and doses that actually align with cutting-edge science involving the aging process. We’ll go into greater detail below, but here’s a quick summary of our findings:

At Innerbody, we thoroughly test and research every product and service we review, including the various anti-aging supplements in this guide. We’ve spent years reviewing the scientific literature related to aging and cellular health, visited supplement manufacturers and genetic testing centers, and tried dozens of products for ourselves.

For this guide specifically, we read through more than 150 scholarly articles, including many clinical trials of the ingredients we’ll discuss below. We’ve also ordered and tested each product you’ll see here, giving us deep insights into the customer experience, from phone support to the way a product tastes.

Additionally, like all health-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for accuracy and will continue to be monitored for updates by our editorial team.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

To evaluate anti-aging supplements, we applied several criteria relevant to much of our supplement content, including their effectiveness, safety, cost, and convenience. But anti-aging supplements often contain large enough doses of certain ingredients that they’re better delivered as powdered drink mixes; making pills out of such doses would force consumers to take up to a dozen capsules per day. That opens up taste as a final criterion for us to consider, where applicable.

Let’s dig a little deeper into each category to see what brands lead the pack.

Effectiveness

Winner: Viome Precision Supplements

We’ll discuss how to begin interpreting the term “anti-aging” in greater depth below, but suffice it to say that a well-rounded and complex anti-aging supplement should help you stave off physical, emotional, and cognitive aspects of decline, including age-related changes to your appearance. In short, it should help you feel better, live longer, and even look younger.

That said, aging is an incredibly complex and multifaceted process that everyone experiences differently, and a one-size-fits-all approach may not be the best course of action.1 That’s why Viome gets our nod for the most effective anti-aging supplements. The company is better known for its microbiome testing and custom probiotics, but it also offers epigenetic testing and a custom-tailored supplement blend that is more likely to help you and your specific aging needs than anything off the shelf.

There are more than 200 ingredients at Viome’s disposal for preparing its custom products, including nearly every ingredient you’ll find in competitors’ products.

If you don’t want to go through a blood test or wait for a custom formula to be prepared, a close runner-up in this category would be NOVOS Core. The power of its ingredient bill starts with a pair of basic minerals, of which too many people are deficient: calcium and magnesium.3 In the doses provided here, they can help with bone health, muscle maintenance, and sleep hygiene — all critical to healthy aging. Beyond those, ingredients like Rhodiola rosea and L-theanine can help combat stress,4 5 while hyaluronic acid supports healthy skin.6

Other ingredients in NOVOS Core play similar roles, which we’ll get into more deeply in the product’s dedicated section below.

Safety

Winner: Viome Precision Supplements

For the same reason that Viome rose to the top of our consideration on efficacy grounds, it also wins out for safety. When you reach for an anti-aging supplement off the shelf, there is a risk that one or more of the ingredients just won’t agree with you, that they could be contraindicated against another medication you take or condition that you have, or that they just aren’t what you need most to fight your aging process.

That’s why having your supplements custom-tailored based on the results of a thorough biomarker test is ideal. And throughout the process, if there are certain ingredients you’re interested in including in your Viome blend, ones you know won’t agree with you, or ones you’d like excluded for safety reasons, you can have that conversation with Viome and adjust your blend accordingly (for no additional charge).

For people more interested in taking the off-the-shelf approach, you’d likely do better seeking out a single ingredient for sleep (or a sleep support with a limited but effective set of ingredients). Sleep is integral enough to health that maximizing both the duration and the quality of your sleep could go a long way toward combating aging.7 And numerous sleep-boosting ingredients — like L-theanine, saffron, and lemon balm — are among the safest on the market.

Fortunately, we have an entire guide to the best OTC sleep aids for you to check out that includes these three ingredients and more.

Cost

Winner: Perpetua.Life AEON

This category was a close race between Perpretua.Life AEON, Blueprint’s Longevity Blend, and Renue By Science’s sublingual NMN powder. We often keep our cost analyses pretty strict, attempting to feature a product that offers the lowest barrier to entry for anyone interested in a given supplement or service category, always with an eye on long-term monthly costs. We try to avoid casting overall value judgments here, as those are reserved for big-picture honors like our summary of recommendations above.

That said, anti-aging supplements are likely to be more effective when they contain high doses of multiple anti-aging ingredients, so we couldn't ignore the superior deals that Blueprint and Perpetua.Life offer on their complex, well-dosed products compared to Renue By Science's single-ingredient NMN powder.

Here’s a quick breakdown of costs for the top picks in this guide:

The key differentiator between Blueprint and Perpetua.Life here is shipping. Their prices are nearly identical, but Blueprint charges $5 for shipping (not reflected above). With Perpetua.Life, orders over $40 ship for free. That’s a difference of $4.35 per month, or just over $50 yearly.

Convenience

Winner: Perpetua.Life AEON

While certain aspects of a given supplement’s convenience are subjective, things like customer service and money-back guarantees are not. Perpetua.Life doesn’t have the longest guarantee around, but it has the fewest caveats that could spoil your experience. Rather simply, you have 30 days to try it, and you can return it for a refund in that time if you don't like it.

Also, with anti-aging supplements, some ingredients require large enough doses that formulating a drink mix makes more sense than asking a consumer to take half a dozen or more pills per dose.

Perpetua.Life AEON gets around this by creating a supplement that employs targeted doses of specific ingredients, many of which don’t require the larger quantities associated with things like creatine, for example. That creates a dose that fits into only two pills per day — far fewer than Viome’s daily regimen of eight capsules.

Of course, if you have difficulty swallowing pills, AEON might pose a problem for you, as its pills are somewhat large. If that’s the case, you might do better with a drink mix like NOVOS Core. We prefer NOVOS to Blueprint among drink mixes for its flavor, which we’ll discuss below.

Taste

Winner: NOVOS Core

We were able to evaluate three of the products in this guide on the basis of taste: NOVOS Core, Blueprint Longevity Mix, and Renue by Science NMN Powder. Of the three, most of our testers preferred NOVOS over the others, and Blueprint was generally considered to be the worst-tasting of the trio.

NOVOS Core only comes in one flavor — orange — but it’s tangy enough to be enjoyable when mixed with the right amount of water. If you water it down too much, the tang dissipates and lets some bitterness through, so we recommend mixing a single packet into no more than 10 ounces of water.

Renue by Science NMN Powder is actually designed to be taken sublingually — held under the tongue and allowed to dissolve. It's extremely sour at first, but becomes very bitter soon after that, and it can clump a little under your tongue. Still, you shouldn't mix it with water. If you do, then too much will likely break down through your digestion; the purpose of sublingual delivery is to get it into your bloodstream through oral membranes, instead.

Blueprint simply doesn't do enough to mask the unpleasant flavor of its active ingredients. They may have reached the limit of what they could do without adding artificial flavors or sweeteners that would be counterproductive to a health supplement, but competitors with similarly robust ingredient bills seem to do better.

Here’s a simple breakdown of the core aspects of each product highlighted in our guide:

Anti-aging supplements are any OTC ingredients or complex formulas designed to counter one or more aspects of aging. If you stop and think about all the ways the body and mind age, you can see how quickly this category could get out of control. Fortunately, the scientific support for many of these ingredients is still in its infancy, allowing us to focus on what few products out there boast clinical research to back up their claims.

These aren't just botanical ingredients, either. Chinese and Ayurvedic medicine certainly provide many plant ingredients that scientists are starting to recognize for their anti-aging potential. But others are ingredients we've long associated with better health outcomes if not longevity per se.

You'll commonly find ingredients like magnesium and calcium or amino acids like L-theanine or L-lysine in anti-aging supplements. These aren't newfangled ingredients or foreign imports, but researchers are starting to link them more overtly with the fight against aging.

Science continues to improve its understanding of how we age: cellular function and turnover deteriorate, production of various critical hormones slows down, and DNA fragments (breaks down).1

But why can’t we just turn off aging?

If we zoom out far enough, we can see that the expression of any species as individual organisms consuming energy is an aberration from a state of pure balance. You can think of all the available energy in the universe as a heart monitor. The flat line is a state of balance, while the peaks of a given heartbeat are the momentary expressions we might recognize as life. And any system in which energy fluctuates like that has to return to a state of balance, or entropy, per the second law of thermodynamics.8

Zoom back into the individual scale, and we can see that we’re born, we soak up energy from the sun through food, and we ultimately give that energy back, one failing cellular function at a time.

Now that we’ve gotten the marriage of science and philosophy out of the way, we can zoom in one more time to look at those cells in action. In youth, they perform beautifully, replicating DNA relatively seamlessly. Over time, cells’ ability to utilize energy wanes, and those replication efforts lose some of their accuracy. Cells stop replicating, cellular turnover suffers, and leftover cellular material builds up. This buildup of cells that are no longer dividing is called senescence, and it’s a main driver of metabolic and age-related disease.8

Worsening cellular function leads to other problems that we don't necessarily classify as diseases but that accompany aging and contribute to our eventual demise. A young, healthy person will have higher levels of NAD+, growth hormones, and other substances that give youth its very vitality. Those levels decline over time, often as a result of reduced cellular efficiency and intracellular communication.9

If supplements can help, they’ll need to have a relatively simple answer to an incredibly complex problem.

Plenty of individual ingredients have scientific support to fight specific aspects of aging. If you're struggling with a single issue, like rapidly aging skin, you might be able to address it with just one ingredient. But some ingredients only address a particularity of aging through one mechanism of action, while others could target the same issue from a different angle. Aging is such a tremendously complicated process that more complex supplements are usually better suited to addressing the various aspects of aging.1

To fully comprehend how different ingredients can make a difference in your aging process, it helps to look more closely at each of these processes, understand how they work, and explore the science that supports certain ingredients to treat them.

Cellular aging and longevity

Cellular aging is a redundant phrase; all aging occurs at a cellular level. But to discuss the aging process and our attempts to slow it, the term serves a useful function by delineating aspects of aging that we can potentially treat by targeting general cellular health and efficiency.

For example, as turnover among skin cells becomes less efficient, visible signs of aging can appear.10 Some products are specifically designed to address skin aging, while others are intended to address general cellular wellness, which should, in turn, address skin aging. Ultimately, the term “cellular aging” helps us understand a given product’s potential.

Many anti-aging supplements seek to improve cellular health by either providing cells with more fuel for their various tasks or clearing out senescent cells to prevent the buildup of potentially toxic material.

Let’s take a quick look at some popular supplemental ingredients that might achieve these goals:

Brain aging and mood

Heart disease remains the number one killer in the U.S., with Alzheimer’s disease occupying a spot on the list just a few items down.79 The former correlates directly with stress, while the latter has a known relationship with stress that’s still under investigation.18 19 As increasing longevity remains a key component of any anti-aging regimen, mitigating stress and attending to your mood seems central to the effort.

This is why nootropics (supplements for cognition and brain health) often include various ingredients associated with reducing stress and cortisol levels, like ashwagandha and Rhodiola rosea.20 But nootropics can also include ingredients with the potential to prevent certain hallmarks of brain aging and possibly stave off the development or progression of neurodegenerative disorders like Alzheimer's.21 Again, ashwagandha makes an appearance, this time in a rat model of Alzheimer's in which it “significantly reversed both…cognitive deficit and the reduction in cholinergic markers.”22

Other anti-aging ingredients with good research supporting their potential to improve brain health include:

Musculoskeletal aging

One of the more palpable effects of aging is the increase in general physical discomfort, manifesting as pain and weakness. Loss of muscle mass and bone density dramatically increase the odds of injury as we age, and significant injuries beyond a certain age can increase mortality rates. For example, one study of women 75 and older found that an increased number of falls directly correlated with a decrease in lifespan.31

Fortunately, there are several things you can do to improve your odds of avoiding falls in the first place. Regular strength training from an early age is critical. You don’t need to transform yourself into a bodybuilder; you just need to build a healthy amount of lean muscle and keep it as best as you can.32

Regular balance work, like yoga or pilates, can also improve your odds of avoiding falls, as can aquatic exercise.33

Beyond these practical interventions, some supplements can help safeguard the muscle and bone you already have, preventing weakness and making it less likely that anything will break if you take a spill. Here’s a look at some of the best ingredients to combat musculoskeletal aging:

Skin aging and appearance

Understandably, most people would want an anti-aging supplement to help them feel younger and look younger. The good news here is twofold. First, many of the anti-aging ingredients that help with cellular health will have a positive effect on skin quality. For example, in vitro studies have shown that NAD+ boosters can improve skin and protect it against photoaging (aging caused by UV exposure).38 And an animal study from 2021 showed that spermidine can enhance wound healing.39 Second, there are other ingredients common to anti-aging complexes that are included for their primary roles as skin enhancers.

These ingredients can often play other roles in the anti-aging battle, as well, but their main purpose is to make your skin look healthier. Let’s consider a few of them:

The anti-aging landscape comprises hundreds of promising ingredients, making the dozen or so we’ve touched on here just the most effective tip of the iceberg. We’ll touch on additional ingredients later in this guide when they play pivotal roles in the products we mention.

Given the breadth of anti-aging supplement options out there, there’s probably a good fit for just about anyone. That said, their core demographic is definitely anyone 30 and above or those who have begun to notice specific signs of aging. This can include a wide array of symptoms, but you might want to consider an anti-aging supplement if you’re experiencing any of the following:

• Decreased energy
• Deteriorating skin quality
• Lapses in memory and cognitive function
• Chronic pain
• Irritability and stress
• Reduced sex drive

There are also two specific ages at which recent research suggests the aging process tends to accelerate. These occur around 44 and 60 years of age, so anyone approaching either of those milestones would do well to consider adding an anti-aging supplement to their regimen.44

Who might want to look elsewhere?

The most obvious group of people who might want to look elsewhere for their longevity concerns includes the very young. While some of the ingredients in these products can be good for most adults’ mood and well-being, younger people likely wouldn’t see much benefit from the components that can improve skin health and musculoskeletal strength.

Certain anti-aging ingredients have potentially dangerous contraindications, as well. For example, NAD+ boosters may exacerbate certain active cancers, making them a poor choice for anyone battling cancer, cancer survivors, and possibly even those with a family history of cancer.45

Most of these ingredients also lack evidence to support their safety in pregnant or nursing people, but we’ll take a deeper look at safety concerns next.

There are too many different ingredients in the anti-aging space for us to declare that anti-aging supplements are completely safe. Some are far safer than others, however, so let’s take a quick look at some of the most common anti-aging ingredients we see on the market and evaluate each in terms of safety:

Of course, there are groups for whom some of these ingredients would be a poor choice, and there are also less common ingredients in many anti-aging complexes that deserve some safety attention, as well. Ultimately, the most important thing you can do before taking any anti-aging treatment is to speak with your doctor.

Best overall and best supplement/testing combination

Given the complexities with which we age, the most sensible approach to fighting the aging process would be to have everything personalized for you, from your diet and exercise regimen to your supplements. While things like full-body scans and personal chefs are unrealistically expensive for most people, at-home tests for various biomarkers, microbiome status, and epigenetic age have become much more affordable in recent years.

With these tests at your disposal, you can get a firm sense of how well or poorly your body is aging. And from there, it’s a relatively straight line to developing a supplement that can provide you with the specific support you need.

To do this, Viome collects blood, saliva, and a stool sample, and you’ll have to wait at least a month for your results to come in. After that, the company can formulate custom supplements, probiotics, and prebiotics for your needs. These supplements can include any of the more than 200 ingredients Viome has available for its custom complexes, and doses are typically based on your weight and test results.

These ingredient bills can include many of the components you’ll find in the top pre-formulated anti-aging supplements, like:

It’s not a complete list, however. Some notable items missing from Viome’s ingredient catalog are:

• Nicotinamide mononucleotide
• Lithium
• Spermidine
• Trigonelline
• Lion’s Mane

Viome Precision Supplements pricing

While the monthly cost of Viome’s custom supplements is somewhat eye-popping, similar price tags from other companies sometimes offer a lot less. Mitopure, for example, is an anti-aging supplement that costs $125 for a one-time purchase, and it only contains a single ingredient with no testing or lifestyle recommendations included. By comparison, Viome’s price tag includes complementary annual retesting with the company’s Full Body Intelligence Test. On its own, that test costs $400. You can also save 15% for the first six months with promo code INNERBODY15.

Here’s how that all works out for your first year:

• First six months with promo code: $126.65/month
• Monthly cost after that: $149/month

Shipping on these orders is free, but the cancellation policy gets a little complicated. The simplest way to understand it is that Viome demands a 4-month commitment when you sign up. If you want to cancel before that time is up, you have to pay for whatever months are left in your commitment. After four months, you can cancel free of charge. This is a very strict policy — especially compared to some of the money-back guarantees offered by competitors — but it protects the company from people trying to sign up for the subscription to get a test on the cheap and then cancel, so we understand it.

Best anti-aging drink mix

NOVOS offers a small handful of supplements alongside a comprehensive aging test that relies on cutting-edge formulas to determine not just your biological age but the pace at which you’re aging. This measure has been shown to better evaluate the success or failure of interventions; you can more clearly see whether a supplement or change in behavior slows your pace of aging than you can see if it alters your biological age.63

But NOVOS doesn’t formulate your supplements from scratch in response to these test results, the way that Viome does. Its supplements are all pre-formulated. That said, it offers some of the best pre-formulated anti-aging supplements on the market, certainly among those in beverage mix form.

Here’s a quick look at the formula for NOVOS Core:

• Vitamin C: 100mg
• Calcium: 231mg (from 1,100mg calcium alpha-ketoglutarate)
• Magnesium: 304mg (from 2g magnesium malate)
• Glycine: 2g
• Glucosamine sulfate: 1,000mg
• Rhodiola rosea: 300mg
• L-Theanine: 150mg
• Hyaluronic acid: 100mg
• Fisetin: 100mg
• Ginger root extract: 100mg
• Pterostilbene: 50mg
• Microdosed lithium: 20mg

We covered most of these ingredients in our sections on efficacy and safety above, but some others deserve a little attention here, as well.

Two great ingredients in this blend to help manage anxiety are L-theanine and Rhodiola rosea. L-Theanine is an amino acid derivative of tea and some mushrooms that can offset the jitteriness associated with caffeine,64 and studies have shown it can help with both sleep and stress.65 5 Meanwhile, Rhodiola rosea is a botanical ingredient that offers many similar benefits for stress, and both ingredients are present at effective doses.66

You’ll also see lithium at the bottom of this ingredient list, and it’s worth noting that this is a mere fraction of the lithium doses used in treating major depression and bipolar disorder. Those patients take doses up to 1,200mg/day, more than 50 times what’s in NOVOS Core.67 That said, there is some evidence that small amounts of daily lithium may be tied to increased lifespan.68 Whatever the case, if you’re considering a longevity supplement containing lithium and you have bipolar disorder or another mental health concern, you’ll definitely want to talk to your doctor before starting to take it.

NOVOS Core pricing

You can get NOVOS Core on its own or as part of a bundle that includes Core, Vital (an organ support chew), Boost (NOVOS’ NMN supplement), and Age (the test). Bulk and subscription savings are available for Core, but you can only save on the bundle by subscribing. The bundle also only ships yearly, so you have to have the whole amount of money ready up-front.

Here’s how the two approaches compare:

NOVOS products ship for free, but the company doesn't really have a money-back guarantee. If you've purchased several months' worth of a product and decide you don't want to take it anymore within 30 days of your order, you can return anything you didn't open. So, the policy only applies to bulk purchases of one kind or another. And those returns incur $60 in shipping costs and “restocking fees,” which can significantly affect your refund.

Best anti-aging capsules and best budget pick

Perpetua.Life takes some of the best anti-aging ingredients around and combines them into a convenient two-capsule dose. Unfortunately, the only way to do that is to leave out some well-known anti-aging powerhouse ingredients that would require larger doses and make for a much higher capsule count.

That means you won’t find collagen, magnesium, creatine, or calcium here. But you will find the following:

• Vitamin B2: 1mg
• Vitamin B6: 5mg
• Vitamin B12: 2mcg
• Nicotinamide DUO: 500mg (400mg NMN, 100mg NR)
• Quercetin: 250mg
• Trans-resveratrol: 150mg
• Fisetin: 100mg
• Astragalus: 100mg
• L-Theanine: 100mg
• EGCG: 100mg
• TMG: 85mg
• Piperine: 10mg
• Spermidine: 10mg

Most of those doses are within clinically relevant ranges for certain aging concerns, and the list includes a few ingredients we haven’t touched on yet that are worth discussing:

So, AEON is not a perfect anti-aging supplement, but it’s among the best you’ll find in a capsule. Its convenient two-capsule dose is also a lot easier to take than Viome’s typical 8-capsule daily regimen for its custom Precision Supplements.

AEON pricing

AEON’s pricing is pretty simple, with a single subscription option as your lone avenue for savings. Here’s how it breaks down:

Shipping is free on orders over $40, which includes either purchasing path for AEON. The company also offers a true 30-day money-back guarantee, which is more generous than either Viome or NOVOS.

Best senolytic supplement

Qualia Senolytic takes a somewhat unconventional approach to anti-aging supplementation, though it’s not an approach without scientific merit. Specifically, Qualia employs what researchers call the hit-and-run approach, in which a drug or supplement is delivered at a higher dose but over a much shorter period.72

For example, each dose of Senolytic contains 1,400mg of fisetin. A normal fisetin dose in other supplements is around 100mg, but you have to take those supplements daily. That’s around 3,000mg of fisetin per month. The regimen for Senolytic is two doses on successive days, once per month. That delivers 2,800mg of fisetin per month — nearly an identical dose.

So, what’s the advantage of taking a senolytic ingredient less frequently but in larger doses — the so-called hit-and-run approach? Well, research indicated that cells take some time to give up the ghost and become senescent. The process can take around six weeks, at least in cell cultures.73

The theory goes that a large dose can knock out senescent cells more effectively, but it doesn’t make sense to take that larger dose daily, as new senescent cells haven’t formed yet. You’d essentially be throwing away good supplemental ingredients and risking adverse effects without any positive potential.

The hit-and-run approach allows for some senescent cell buildup, but only enough for a good senolytic to do its job before those senescent cells become problematic. Using a smaller dose on a daily basis might be more akin to Sisyphus pushing that boulder up the hill; you never quite make it to the top without it rolling back over on you. Senolytic is meant to act like a crane that picks up the boulder and drops it on the healthy side of the hill.

Of course, this extends beyond just fisetin. Here’s a look at Qualia Senolytic’s full ingredient list:

• Fisetin: 1,400mg
• Quercetin: 750mg
• Curcumin extract: 400mg
• Olive leaf extract: 250mg
• Soybean seed extract: 200mg
• Luteolin: 150mg
• Milk thistle extract: 125mg
• Piper longum root extract: 50mg
• Senactiv: 50mg

It’s tempting to simply divide each dose on this list by 15 (remember, there are two servings per package) and compare that to how much of a given ingredient you could get from something like Perpetua.Life’s AEON on a daily regimen. That product gives you 3,000mg of fisetin to Qualia’s 2,800mg, and 7,500mg quercetin to Qualia’s 1,500mg.

At face value, this discrepancy makes Qualia seem like an inferior choice, but the hit-and-run approach has its merits, and the formula Qualia has developed specifically excludes ingredients that wouldn't fit the regimen.74 In other words, you can’t take 30 AEON capsules one day, and another 30 the next, and not have a significantly higher risk of side effects than you would with Senolytic.

That said, from a pure cost standpoint, Qualia has you paying for the formulation more than the ingredients. Clearly, competitors provide higher quantities of similar ingredients for less. But if the pure senolytic hit-and-run approach seems like the right fit for you, this is the best way to get it.

Qualia Senolytic pricing

Qualia has a very simple pricing system. You can make one-time purchases or subscribe, and subscribers get a lower monthly cost and a significant discount on their first month. Here’s how that works out:

Qualia charges $9 for shipping, which is more than other companies in this guide. There isn’t any threshold above which you can get free shipping. Its money-back guarantee is more generous than most competitors, however. It provides you with 100 days to return a product if you don’t like it. The only catch is that the guarantee covers one unit of product.

So, if you sign up for a subscription to Senolytic, get three deliveries in the first 90 days, then decide you want your money back, you’ll only get back the cost of one unit. In all likelihood, that would be the first unit, which Qualia sold at a deep discount of just $39.50. The company will keep the remaining $138 you spent on the other two shipments (plus shipping!).

Best NAD+ booster

If all you’re looking to do in your anti-aging journey is support mitochondrial efficiency and cellular health, boosting NAD+ levels is one reliable way to do it. And we regard Renue by Science’s NMN Pure Powder to be among the best NAD+ boosters out there.

Despite consistent research using standard capsules for NMN delivery, there is reasonable concern and some noteworthy evidence that NMN doesn’t make it through first-pass metabolism intact, and that its breakdown into other forms of vitamin B renders it less likely to boost NAD+.80 Companies take pains to get around this risk by employing enteric-coated capsules, liposomal technologies, and sublingual or intranasal delivery mechanisms. The problem with these approaches is that they make dosing difficult to recommend. We can look at the vast majority of NMN research and see that a daily dose of around 1,000mg is ideal, and that doses up to 1,200mg are safe.75 But those studies all use standard capsules. As soon as you introduce a technology that might deliver more NMN to cells, those doses go out the window, as do reliable gauges for safety and efficacy.

Fortunately, a sublingual powder has an advantage over enteric-coated capsules or liposomal delivery. It allows you to adjust your dose as you see fit. If you want to start smaller and titrate up, you can. If you want to start larger and see how you feel, titrating down only if adverse effects occur, you can. And because you get most of each dose into your bloodstream through oral membranes, your digestion won’t alter the NMN and give you something you didn’t ask for.

Renue by Science Pure NMN pricing

One bottle of Pure NMN Powder costs $64.95, and you can save 10% by subscribing. But that bottle contains 100 grams of powder, or 100 doses of 1,000mg each. If you home in on a 500mg or 1,200mg dose, your cost will be a little different. Here’s how some scenarios might play out:

Renue is the only company in our guide with a money-back guarantee that's capable of covering your whole purchase. Other companies here either have guarantees that are too short to be meaningfully effective or that only cover enough product for you to try it for a month or so without risking additional investment.

Renue covers you for 60 days, and its Pure NMN Powder should last 100 days at a 1,000mg daily dose. That means you can try the product for a full two months and still get a complete refund (minus shipping charges).

We’d be remiss not to include Blueprint in a guide about anti-aging supplements, as Bryan Johnson, the company’s founder, has become an icon of the anti-aging movement. Blueprint sells a wide range of supplements, food products, and branded merchandise, and most of its consumable products are intended to be part of a larger anti-aging approach.

Among the products Blueprint sells, we looked for one that had the most promising combination of ingredients to serve as an anti-aging blend without forcing you to purchase anything else. Its Longevity Mix is the closest thing the company has, though it also sells massive capsule stacks akin to what Johnson himself takes on a daily basis.

Here’s a look at the ingredients in Longevity Mix:

• Vitamin C: 250mg
• Calcium (from CaAKG): 400mg
• Magnesium (from magnesium citrate): 150mg
• Creatine monohydrate: 2,500mg
• Taurine: 1,500mg
• Glycine: 1,200mg
• L-Lysine: 1,000mg
• Glucosamine sulfate: 750mg
• L-Glutathione reduced: 250mg
• L-Theanine: 200mg
• Sodium hyaluronate: 120mg

If you look at the label, you’ll see that Calcium Alpha-Keto Glutarate is also listed at 2,000mg, but this is actually just the source of calcium used to deliver the 400mg already listed higher on the label. We see this sometimes in the supplement space, especially among specialized versions of certain vitamins or minerals. Companies have to state them plainly as calcium or magnesium on the top part of their labels, but many also want to be able to advertise the specific forms of ingredients that are popular or that boast specific scientific support. There are better ways to do this; even on this label, the initial calcium is billed as “from CaAKG.” That should be enough, but doing it their way makes the product seem stronger than it actually is.

Despite that little bit of subterfuge, most of the other ingredients appear here at sufficient doses to tackle different aspects of aging. We’ve gone over most already, but we should point out that sodium hyaluronate is a form of hyaluronic acid, and its dose here aligns well with studies into skin health.

The big downside of Longevity Mix revealed itself in testing, as its flavor was the worst among the anti-aging drinks we tried. It starts out tasting like it's about to get tangy, but then it falls short, and some bitterness sneaks in. The bitterness doesn't last long, though, which would be a good thing if it didn't give way to a strong alkaline flavor bordering on something spoiled in the fridge. To be clear, this was the Pineapple Yuzu flavor. Blood Orange is likely better (it would have to be).

Blueprint Longevity Mix pricing

One bag of Blueprint Longevity Mix costs $49 for a one-time purchase or $46.55 for a subscription purchase. That’s a mere 5% savings for subscribers; competitors typically offer at least 10% off on their products. Shipping also costs a flat $5, with no threshold to achieve free shipping.

Blueprint offers a 30-day money-back guarantee, but its specifics are vague. There is some language in the policy about “a partial or full refund [being] approved depending on the circumstances.” However, the company explicitly states that it doesn’t ask you to ship anything back, so even if you only get a partial refund, you still don’t have to pay for any return shipping.

Perhaps you’re concerned about nascent research not ferreting out all the potential dangers or contraindications of certain anti-aging ingredients. Or, you already take a multivitamin or supplement you like, and you would have to give it up if you added an anti-aging supplement to your regimen to prevent over-supplementation of one or more ingredients. Whatever the reason, there could be a perfectly good justification for you to avoid anti-aging supplements altogether.

Fortunately, you can still do some things instead of (or alongside) taking anti-aging supplements to fight the ever-forward march of time.