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Active PK Reviews

Is this fat-burner an effective tool for weight loss? We investigate Active PK to find out if it's worth the cost.

Last Updated: Mar 30, 2022
Active PK Reviews

With over 40% of the adult population struggling with obesity, the topic of healthy weight loss is a pertinent one. The health and wellness supplementation market is flooded with products that claim they can burn fat, boost energy, and reduce cravings, but how effective are they? And are they safe?

Fat burners work in a variety of ways, depending on their ingredients. Some rely heavily on caffeine or herbal stimulants to boost energy, while others include natural compounds shown to decrease cravings and elevate metabolism.

We tried out Active-PK, an all-natural, stimulant-free supplement that claims to melt fat by accelerating the body’s production of the natural enzyme AMPK, which can boost weight loss. Read our full review below to learn about the pros, cons, and science behind Active-PK, so you can decide if this supplement may work for you.

Review Summary


  • Boosts metabolism and endurance
  • May help reduce abdominal fat
  • Caffeine-free, dairy-free, and vegetarian-friendly
  • No synthetic additives or fillers
  • Helps reduce cravings
  • Contains scientifically backed ingredients
  • Doctor-founded
  • 90-day money-back guarantee


  • Pricier than some alternatives
  • Not vegan-friendly
  • May cause minor side effects and medication interactions

Bottom line

We recommend Active-PK as a safe and effective supplement for people seeking to shed extra belly fat and boost their energy. Active-PK’s scientifically sound ingredients and approach to boosting metabolism without added stimulants make it a good choice for those who can’t tolerate caffeine and want to avoid synthetic products. However, as with all weight loss supplements, its effectiveness relies on consumers making necessary lifestyle changes like decreasing their caloric intake and increasing physical activity.

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Active-PK is designed to reduce cravings and promote fat loss by boosting metabolism and endurance. It’s a good value.

This doctor-founded supplement contains ingredients that are scientifically backed to stimulate your metabolism, all without caffeine. All purchases are covered by a 90-day money-back guarantee.

3 Bottles
Reviewed by Innerbody Research
1 Bottle
Reviewed by Innerbody Research
6 Bottles
Reviewed by Innerbody Research

Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

We extensively test each health service or product we review. We try our best to give you, our readers, an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality, the latest medical evidence and health standards, and a simple question: would we buy the product or service ourselves if it weren’t part of our job, and would we recommend it to family and friends?

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

What is Active PK?

Active-PK is an all-natural dietary supplement aimed at those seeking to lose weight or maintain a healthy weight. It is caffeine-free, dairy-free, and contains just three potent and scientifically backed ingredients to bring about:

  • Naturally boosted energy
  • Reduced cravings
  • Decreased body fat
  • Healthy weight loss

Active-PK comes in bottles of 60 capsules for a one-month supply. Taking the two-capsule dose is easy and convenient, as you can take it at any time of day with food or on an empty stomach.

About LCR Health

The Los Angeles-based nutraceutical company LCR Health manufactures Active-PK and other wellness supplements geared toward weight loss, longevity, and overall health. Dr. Rand McClain, the co-founder of LCR Health, heads the Regenerative & Sports Medicine clinic in Santa Barbara, California, where he works with celebrities and athletes to help them achieve optimal health.

Dr. McClain began his medical studies with clinical training in Eastern Medicine. This influence led to his eventual development of natural, holistic supplements after completing his medical residency at the University of Southern California.

In addition to Active-PK, LCR Health manufactures the following 11 supplements:

  • TeloGenesis promotes longevity and optimum health while combating cellular aging.
  • Master Cell supports the body’s natural detoxification system, assisting with brain fog and fatigue.
  • Prime ATP boosts endurance and energy by promoting the healthy production of ATP.
  • Pro Krill 1000 supports mental cognition, heart health, strength, and energy with Omega-3s derived from fish from the Antarctic Ocean.
  • Advanced Joint Support provides anti-inflammatories like turmeric and white willow extract for pain relief and supports mobility, endurance, and dexterity.
  • QL-5 is a caffeine-free energy-boosting supplement providing vitamin D3 and containing naturally derived compounds like ashwagandha and lion’s mane.
  • Midogen is a dietary supplement supporting cellular function and healthy mitochondrial production to promote energy and focus.
  • Sirtogen supports longevity, mental focus, enhanced strength and mobility, and healthy skin.
  • Active Stem is a powder supplement providing vitamin D and a proprietary blend of ingredients shown to boost adult stem proliferation and energy and support healthy joints and muscles.
  • UltimateH2 is a molecular hydrogen supplement that stimulates metabolism, boosts energy, and protects cells against rapid aging.
  • Keto Detox is a ketogenic support supplement that aids in eliminating toxins from the body and burning fat as fuel.

Does Active PK work?

Active-PK is effective in naturally reducing cravings and boosting energy. While we did not experience any significant loss in body fat during our trial, we also did not change our lifestyles, maintaining the same diet and workout regimen as before.

A low-calorie diet and regular exercise are vital if weight loss is your ultimate goal. Active-PK can provide reduced cravings and the needed boost to get you into the gym, but like all weight loss supplements, it doesn’t work alone.

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How Active PK works

Active-PK promotes fat burning by activating the enzyme AMPK in the body. AMPK (AMP-activated protein kinase) works as a natural cellular energy sensor and metabolism regulator. AMPK-boosters appear in several weight loss products based on their ability to diminish appetite and hike up the body’s metabolism, leading to the efficient conversion of fat into energy.

In addition to its potential for treating obesity, researchers have also studied AMPK-boosters as therapeutics for diseases, including cancer and metabolic syndrome. Below, we’ll look at the three primary ingredients in Active-PK and how they work together to ramp up AMPK production and boost metabolism.

Gynostemma pentaphyllum leaf extract (450 mg)

Gynostemma pentaphyllum is the primary component in Active-PK. This extract, derived from the leaves of an herbaceous vine native to South and East Asia, has traditional Chinese medicinal use as a therapy for:

  • Inflammation
  • Diabetes
  • Cardiovascular disease
  • Longevity

Today, scientists study Gynostemma pentaphyllum as an obesity treatment based on its ability to reduce total abdominal fat and BMI in subjects without significant adverse effects. While clinical research is limited, human and animal studies have demonstrated Gynostemma pentaphyllum’s ability to promote AMPK and favorably alter metabolism.

Quercetin dihydrate (100 mg)

Quercetin is an abundant bioflavonoid found in many plants and studied for its anti-obesity, anti-inflammatory, and anti-hypertensive activities. This antioxidant provides many health benefits, including:

  • Reducing inflammation
  • Preventing cardiovascular disease
  • Protecting against oxidative stress
  • Improving cognitive function
  • Treating and preventing cancer
  • Boosting immunity
  • Reducing blood pressure

Scientists have published fewer studies investigating quercetin’s role in treating obesity. Still, some findings indicate that quercetin effectively activates AMPK signal pathways and exerts anti-adipogenesis activities, leading to fat loss.

Berberine HCl (100 mg)

Berberine HCl is a derivative of the Berberis aristata root, a medicinal herb traditionally used in Ayurvedic medicine to treat cancers, diarrhea, bacterial infections, and more. Researchers have conducted multiple studies on the use of berberine as a treatment for:

  • Obesity
  • Metabolic syndrome
  • Insulin sensitivity
  • Insulin secretion
  • Cardiovascular disease

In one randomized, double-blind, placebo-controlled clinical trial, berberine demonstrated remission of metabolic syndrome in subjects and reduced waist circumference, blood pressure, and insulin secretion.

In a 2020 study, berberine proved to modulate gut microbe diversity and benefit gene regulation for cholesterol absorption. Researchers concluded that berberine shows potential for obesity treatment and prevention based on these findings.

Is Active PK safe?

LCR Health promotes Active-PK as safe for healthy adults but recommends consumers consult with their physicians before taking any new supplement. This is particularly important if you are pregnant, nursing, have a medical condition, or take any medications, as the ingredients in Active-PK may interact with them.

There are no reported adverse effects from Gynostemma pentaphyllum, but quercetin and berberine may evoke side effects such as gastrointestinal discomfort or headaches. Those with kidney damage or cancer should avoid this supplement, as it can lead to more severe side effects, including the promotion of tumor growth.


You can purchase Active-PK through third-party online retailers like Amazon, but we recommend buying directly from the company website to ensure you’re eligible for its 90-day money-back guarantee.

LCR Health does not offer any subscription service for its products, but you can earn significant savings by purchasing Active-PK in bulk. As seen in the chart below, purchasing the six-bottle bundle drops the price per serving from $1.33 to just $1.13. LCR Health provides free shipping on all orders in the US.

  Cost Price per serving
1 Bottle $39.95 $1.33
3 Bottles $107.85 $1.20
6 Bottles $203.70 $1.13

Is Active PK a good value?

Active-PK is a good value in our opinion. It is comparatively priced with other weight loss supplements, although it stands apart for its all-natural ingredients and lack of stimulants.

For example, Trimtone also claims to boost energy and metabolism while suppressing the appetite for weight loss. However, this product relies heavily on caffeine and other stimulants, which some individuals seek to avoid.

Below, we’ve compared the cost of Active-PK to other popular weight loss supplements. The crucial difference among these products is their ingredients, with most lacking the AMPK boosters found in Active-PK.

Note that all prices below reflect single purchases and do not take into account subscription or bulk discounts.

  30-day supply Price per serving
Active-PK $39.95 $1.33
Trimtone $49.99 $1.67
HUM Nutrition Skinny Bird $40 $1.33
Leanbean $59.99 $2
Legion Phoenix Stim-Free Fat Burner $29.99 $1
Transparent Labs Lean Pre-Workout $19.99 $0.67

HSA, FSA, and insurance

LCR Health does not accept HSA, FSA, or health insurance payments, so you’ll need to pay for Active-PK out of pocket.

Privacy considerations

Like most consumer sites today, LCR Health employs cookies and other tracking technologies to collect information about the users of its website. The company may use this information for targeted advertising purposes and more straightforward customer navigation of the site. LCR Health uses the latest SSL encryption technology to ensure privacy and security for all payment transactions.

How we evaluate health products and services

At Innerbody Research, we customize our evaluation criteria depending on the type and nature of the health-related service or product. But in general, for health products and services, we have five broad areas that we explore in our evaluations, including:

Quality: How well does the company deliver its core service(s) to the customer? How is advanced technology used for accuracy and safety? What evidence of efficacy does the company provide? Are manufacturing standards high-quality?

User-friendly: How intuitive and convenient is the service or product? To what degree is the company interface helpful and understandable?

Value: Are you getting your money’s worth? Are there any hidden costs or charges? Does the company offer discounts?

Privacy: If health data is stored, will your data be stored securely? Are payments secure? Does a company market your information?

Customer support: With personalized products and services, how well does the company address your individual needs? If a product or service turns out not to work for you, are there satisfaction guarantees or return policies that protect you?

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