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Bio X4 Reviews: Will it lead to weight loss or a healthier gut?

Or are its claims too good to be true? Find out all of the pros and cons.

Last Updated: Jan 3, 2023
Bio X4 Reviews

If you’re one of the 41% of Americans who characterize themselves as overweight, you’ve likely fallen into weight-loss industry rabbit holes once or twice. Currently, the global market for weight loss products and services is projected to reach $377.3 billion by 2026.

New products emerge every day with promises of weight loss, fat-burning, appetite suppression, boosted energy, and more. How do you know which companies are legitimate and which aren’t?

We recently tested Bio X4, one of the fastest-growing weight-loss and gut health supplements on the market today. In our full review below, we’ll examine the science, statistics, and our personal experiences with the product so that you can determine if it’s right for you.

Review Summary


  • Free from lactose, gluten, and allergens
  • Third-party tested
  • Boosts metabolism and immunity
  • Regulates and supports gut health
  • Doctor-developed
  • 90-day money-back guarantee


  • Can cause some side effects
  • Requires taking several capsules daily
  • Elusive refund process

Bottom line

We recommend trying Bio X4 if you’re seeking better gut health and boosted metabolism, but not as a “weight-loss miracle drug.” As noted by developer Dr. Amy Lee, customers will achieve optimal results by incorporating this supplement with other lifestyle modifications, such as eating healthy and consistently exercising. In our testing team’s trial using Bio X4 over a 60-day period, the team did not experience significant weight loss or gain, but they did benefit from fewer sugar cravings and better overall digestion. In those important ways, the product was beneficial.

Our Top Picks

Bio X4

Bio X4 is a doctor-developed supplement designed to boost metabolism, curb cravings, and support gut health.

Each capsule contains a probiotic blend, as well as ingredients shown to promote weight management and craving control. Bio X4 is third party tested, and Nucific protects all purchases with a 90-day money back guarantee.

1-Month Supply
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6-Month Supply
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Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

We extensively test each health service and product we review. We try our best to give you, our readers, an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality, the latest medical evidence and health standards, and a simple question: would we buy the product or service ourselves if it weren’t part of our job, and would we recommend it to family and friends?

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

What is Bio X4?

Bio X4 is a probiotic-based nutritional supplement supporting weight management, better digestion, and boosted metabolism. The supplement is designed for people who want to enhance their gut health and those seeking to maintain or lose weight.

Bio X4 boasts five probiotic strains to aid digestion alongside three essential digestive enzymes that help break down food efficiently, allowing you to absorb more nutrients from what you eat. It also contains green tea extract and Caralluma fimbriata for appetite suppression and boosted metabolism.

Nucific, the manufacturer of Bio X4, is a widely respected supplement manufacturer that produces several products addressing a range of interests, including digestion, weight management, mobility, heart health, and brain health.

Dr. Amy Lee, a board-certified doctor of internal medicine and specialist in nutrition and obesity treatment, partnered with Nucific in developing Bio X4. Dr. Lee serves as Chief Medical Officer for over 30 nutrition clinics in the Los Angeles area.

Does Bio X4 work?

Bio X4 effectively promotes gut health and better digestion and may aid weight loss. While the company boasts some pretty lofty claims regarding its ingredients, the scientific research is frankly more mixed across the board. However, some of these ingredients do show great promise in clinical trials for the treatment of obesity and various digestive disorders.

How Bio X4 works

Bio X4 recommends taking one capsule with each meal, three times a day. You can take up to two capsules with each meal, but do not exceed six capsules daily.

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Bio X4 addresses weight management, craving control, digestive health, and boosted metabolism by combining four proprietary blends:

  • Weight Management Blend (100mg)
  • Craving Control Blend (166 mg)
  • Digestive Enzyme Blend (43 mg)
  • Probiotic Blend (4 billion CPU/capsule)

These blends are added into each capsule, which are taken with every meal. In order to best assess if these blends work, we’ll take a look at the ingredients below.

Green tea extract (50% EGCG)

Green tea extract, the sole ingredient of the Weight Management Blend, contains EGCG, a natural antioxidant that boosts the body’s fat-burning capacity. A randomized, double-blind, placebo-controlled clinical trial in 2015 showed that, when given at a dosage of 856.8 mg daily, EGCG brought about significant weight loss, reduced waist circumference, and a consistent decrease in total cholesterol on obese subjects after 12 weeks. The dosage of EGCG in Bio X4 is just 50 mg, so it is difficult to determine if it would show similar results.

Slimaluma (Caralluma fimbriata extract)

The lone component of the Craving Control Blend is Caralluma fimbriata, an extract derived from an edible succulent plant native to India, Pakistan, and Afghanistan. Caralluma fimbriata has undergone several studies for its use in the treatment of obesity with mixed results. For instance, in a 2015 study, there was little to no difference found between subjects who were administered Caralluma fimbriata versus those given a placebo. However, a more recent study from 2021 showed promise for Caralluma fimbriata in maintaining body weight, reducing waist circumference, and reducing daily caloric intake in subjects over a 16-week period.


Part of the Digestive Enzyme Blend, amylase is a natural digestive enzyme that helps the body break down sugars. While researchers have studied enzyme supplementation therapy with mixed results, they may benefit those with deficiencies due to certain illnesses.


This is the second ingredient of the Digestive Enzyme Blend. Bromelain, a protein-digesting enzyme derived from pineapple, boasts a wide range of therapeutic benefits, including the treatment of osteoarthritis, diarrhea, cardiovascular disorders, certain cancers, and diabetes. Note that Bromelain may interact with some medicines, such as the antibiotic amoxicillin, so talk with your doctor before starting any supplements.


Also part of the Digestive Enzyme Blend, lipase is another natural enzyme that breaks fats down into glycerol and fatty acids. Researchers have conducted studies on lipase in relation to obesity with conflicting results.

Lactobacillus Blend

The Lactobacillus Blend includes three probiotic strains (L. acidophilus, L. rhamnosus, and L. plantarum). Lactobacillus probiotics are normally found in the human digestive and urinary tracts and are good for gut health. While most studies on its use to treat obesity have been inconclusive, it is often consumed by those seeking treatment for irritable bowel syndrome, colic in infants, and other digestive problems. Bio X4 includes it here as part of its Probiotic Blend.

Bifidobacterium Blend

Also part of the Probiotic Blend, Bifidobacterium Blend includes B. lactis and B. animalis. Bifidobacterium microbes, another healthy probiotic species, are among the first to colonize in the human gut. According to an outline on probiotics from the NIH, research in mice has indicated that the use of probiotics like Bifidobacterium may impact both energy expenditure and calorie burning. The results of clinical trials in humans with obesity have been inconsistent, but some have shown potential in reducing waist circumference while not affecting weight or body mass index (BMI).

Is Bio X4 safe?

Bio X4 is considered safe for adults, and an independent third party tests all of its products to ensure they are free of contaminants. Additionally, it is gluten-, lactose-, and allergen-free.

According to clinical trials, probiotic supplements are generally safe for healthy adults and have minimal side effects. However, bromelain may interact with some antibiotic medicines. We recommend consulting with your doctor if you take any medications prior to beginning a nutritional supplement, or if you are an expecting or lactating parent.

Bio X4 may cause some side effects, but the worst we encountered were occasional bloating and flatulence.


Bio X4 is sold directly from the company website. There are no subscription options, but you can save considerably by purchasing in bulk. Bio X4 offers free shipping and accepts all major credit cards and PayPal. However, as it is a supplement, this product is not eligible for HSA, FSA, or insurance as forms of payment.

  • One-month supply (90 capsules): $99
  • Three-month supply (270 capsules): $261.36 (11% savings)
  • Six-month supply (540 capsules): $487.08 (18% savings).

Is Bio X4 a good value?

Bio X4 is a bit pricier than competing brands with similar ingredients. For instance, Bio Complete 3 sells a one-month supply of its prebiotic, probiotic, and post-biotic formula for just $69.95, and there are several similar products available on Amazon for as low as $20 for a single months’ supply.

Additionally, some customers have complained about the elusiveness of Nucific’s 90-day money-back guarantee. While the company promises this guarantee on its website, there are no direct links or information about the process of returns and refunds.

Privacy considerations

Nucific collects personal and non-personal information about users on its website through the use of cookies and other technologies. The company will not share personal information with third parties without your specific consent, but may share non-personal information. Nucific follows Payment Card Industry Data Security Standards (PCI DSS) when handling credit card data.

How we evaluate health products and services

At Innerbody Research, we customize our evaluation criteria depending on the type and nature of the health-related service or product. But in general for health products and services, we have five broad areas that we explore in our evaluations, including:

Quality: How well does the company deliver its core service(s) to the customer? For testing services, does the company adhere to the latest and most advanced testing technologies and achieve a very high degree of accuracy? For non-testing telemedical or teletherapy services, is the quality of the service high enough that we would recommend it to loved ones without hesitation? If not, why not? For health products, does the product or device meet a high level of safety? Is it manufactured with high quality standards? Has it – or have its ingredients – been subjected to studies that confirm effectiveness?

User-friendly: How intuitive and convenient is the service or product? Does the device, program, app, or website achieve a good degree of user-friendliness for its customers?

Value: Are you getting your money’s worth? Are there any hidden costs or charges? Does the company offer discounts?

Privacy: If health data is stored, will your data be stored securely? Are payments secure? Does a company market your information?

Customer support: Particularly in situations where ‘one size fits all’ doesn’t make sense, how well does the company help to make the service or product ideal for you or address your individual needs?

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