Best Leaky Gut Supplements

Craving relief from mysterious gut symptoms? Our top seven leaky gut supplements of 2022 might help.

Last updated: Jul 7th, 2022
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In this Review

Summary of recommendations
Leaky gut supplements: top considerations
How our top recommendations compare
What is leaky gut?
What causes leaky gut?
How do leaky gut supplements work?
Are leaky gut supplements a good choice for you?
Terra Origin Healthy Gut
Gundry MD Bio Complete 3
NatureM.D. GutConnect 365
KaraMD Vital Restore
1MD Nutrition GutMD
Biotrust Gut Reg
Liver Medic Leaky Gut Repair
FAQ about leaky gut supplements
Alternatives to leaky gut supplements
Why you should trust us
Best Leaky Gut Supplements

Nearly two-thirds of Americans experience at least one gastrointestinal (GI) problem daily. About 8 million annual trips to the emergency room are related to GI concerns. Yet, these problems often never receive a diagnosis, and even the lucky few with diagnoses don’t often receive treatment that alleviates their symptoms. When IBS feels more like IDK, mounting frustrations with modern medicine might spill over, worsening your symptoms.

Some attribute chronic GI distress to leaky gut syndrome, a constellation of symptoms related to separations in cells in the intestinal walls. While most medical doctors do not recognize the condition, GI health supplements offer some hope for those suffering.

Among other tests and nutritional changes, adding a GI health supplement — particularly those labeled as leaky gut supplements — to your daily routine can mean the difference between feeling uncomfortable and an easy start to your day. We’ve rounded up the top seven best leaky gut supplements and analyzed them in this guide.

Don’t have enough time to read the entire article right now? Check out our top picks below.

Summary of recommendations

Our Top Picks
Terra Origin logo
Terra Origin Healthy Gut

Terra Origin Healthy Gut combines high-powered gut-healing ingredients into a delicious powder.

Terra Origin includes scientifically backed ingredients proven to boost gut health. Choose between 5 great tasting flavors, and enjoy free shipping on orders over $25. Purchases are covered by a 100% satisfaction guarantee.

Leaky gut supplements: top considerations


Winner: Terra Origin

When it comes to a supplement’s cost, we consider several factors. Is the supplement a relatively low price, and do you receive a decent amount of it for what you pay? Is it a high-quality product? Are there other deals, savings, and subscriptions you can opt into for an even lower price? Do you have multiple purchase options to find the best deal?

Terra Origin’s Healthy Gut checks all of those boxes. It is the second least expensive leaky gut supplement on our list and has two size options for bulk deals ($0.90 or $0.82 for 30 and 90 servings, respectively). You can also join a subscription program that can save you an additional 5% on every order. All orders over $25 can get free shipping if you’re in the contiguous United States (but with the lowest price for a single serving of Healthy Gut at $27, you’ll always meet the minimum). They also frequently offer bonus deals and sales. Plus, they have a generous 30-day 100% satisfaction guarantee and bold return policy, so you can feel confident knowing that you have flexibility in your financial choices.


Winner: KaraMD

Your GI system is one of the most important parts of your body. You have more frequent, direct interactions with — and control over — it than almost any other internal organ system. When you’re experiencing leaky gut symptoms, it makes sense that anything you’d put into it should be extremely high quality. When we evaluate a product for quality, we look at its ingredients and sourcing (including fillers and additives), safety and testing measures, manufacturing process, and how much information the company is willing to share with its customers.

KaraMD shies away from proprietary blends, stating every ingredient it includes (except for magnesium stearate) to the milligram. It’s also one of the best-tested: KaraMD’s Vital Restore has been third-party tested for purity and potency and was made in an FDA-registered lab in the United States. It is certified gluten-free, non-GMO, and vegan, offering a 90-day money-back guarantee if it doesn’t agree with you.


Winners: NatureM.D. and Terra Origin

Finding the right combination of ingredients that works for your leaky gut symptoms is hard. Since everyone’s body is different and symptoms might come from several different causes, the right blend and balance can vary wildly between people. So while the best supplement still won’t work for everyone, the leaky gut supplement that ranks highest in our efficacy category will still have research-proven ingredients in efficacious doses that you can see without fillers, proprietary blends, or overpromising results.

NatureM.D. and Terra Origin have highly similar ingredient lists. They both have 5g of L-glutamine — the most on our list — and both have substantial amounts of zinc (NatureM.D. has 3mg; Terra Origin has 2.15mg). And while Terra Origin has more NAG, slippery elm, and marshmallow root, NatureM.D. contains more quercetin and licorice root. The best part is that each difference in ingredient strength is only a matter of 50-100mg. However, Terra Origin’s vegan formula has a much shorter ingredient list, missing most beneficial ingredients that its non-vegan counterparts rely on.


Winner: Liver Medic

Gut health supplements often come in capsule and powder form. Powders are slightly easier for your body to absorb, but a supplement is only convenient when it’s easy for you to take and dose too. Taking multiple capsules or measuring an odd fraction of a teaspoon for proper dosing gets complicated and only worsens if there are strict rules about when and how you can take them.

None of our top picks are perfectly convenient, but Liver Medic’s Leaky Gut Repair comes close. It only requires two capsules a day to maintain good gut health (whereas most of our other top picks in capsule form need four or more), and you can take it either right before bed or on an empty stomach first thing in the morning. They offer a flexible dose, so you can safely take more if you feel like you aren’t getting good results from taking two a day.

How our top recommendations compare

To help you understand the similarities and differences among our top picks, we’ve created a chart that breaks down all the information you need.

What is leaky gut?

Leaky gut refers to a set of general GI symptoms related to issues with your intestines “leaking” toxins and bacteria into your bloodstream as it processes food. Specifically, leaky gut is tied to:

  • Chronic diarrhea or constipation
  • Gas and bloating
  • Nutritional deficiencies
  • Sugar or carbohydrate cravings
  • Fatigue
  • Headaches
  • Difficulty concentrating
  • Joint pain and other forms of inflammation

Some people believe that a leaky gut is the cause of their GI problems on its own, referring to it as “leaky gut syndrome.” Leaky gut syndrome isn’t something that a doctor will diagnose you with. While the theory that it’s a separate diagnosable disease is becoming more popular, it hasn’t yet hit contemporary Western medicine. A doctor cannot administer formal and reliable tests to check for a leaky gut. Since a leaky gut is a symptom of many GI diseases, it’s more likely that if you present with these symptoms, you’ll be tested for things like celiac disease and Crohn’s disease.

What causes leaky gut?

Leaky gut is more formally known as increased intestinal permeability or decreased intestinal mucosal barrier function (MBF). To understand what a leaky gut is, we need to investigate the mucosal barrier and what it does.

Every inch of your intestinal tract is covered in a mucosal barrier. This physical barrier helps keep the lumen — the inside of your intestines — separate from the rest of your body. A normal intestinal mucosal barrier is full of several different kinds of cells, which all work together to absorb nutrients and keep things moving through your intestines. Tight junctions connect your intestinal cells, regulating the movement of water and other substances through your GI tract.

When your mucosal barrier is compromised, those tight junctions between cells in the intestinal walls open up, leading to small gaps where bacteria and other toxins can move freely. Leaky gut is thought to occur when these tight junctions open up relatively widely, allowing for a greater influx of harm from the intestinal tract. This hyperpermeability can expose your bloodstream to bacteria and other toxins and is thought to affect the contents of your gut microbiome. The protein zonulin helps to mediate this permeability as well.

There are dozens of different reasons that your intestinal barrier could be weakened. These include (but aren’t limited to):

A leaky gut could also be indicative of more complex health concerns, such as:

Despite some claims, it doesn’t appear to be related to autism, depression, anxiety, or skin problems like eczema. That said, there is a strong link between gut health and mental health due to the number of neurotransmitter receptors across the digestive system, so poor gut health can affect how you feel.

How do leaky gut supplements work?

Leaky gut supplements are designed to help quell your symptoms and rebalance off-kilter gut properties. There are three main places and mechanisms that leaky gut supplements support:

  • Digestion
  • Intestinal MBF
  • Gut microbiome

Leaky gut supplements contain many ingredients to ease digestion, support your intestine, and bolster your gut microbiome. We’ve rounded up some of the most common ingredients so you can understand exactly what they do to help.


Glutamine is the most common amino acid in your body and one of the most critical nutrients to soothe leaky gut symptoms. It’s made in your muscles and used in all parts of your body to create proteins and other amino acids. In your GI system, it’s used as fuel for your intestinal cells and has anti-inflammatory effects, both of which are necessary for well-rounded MBF. It also helps to keep tight junctions together, preventing bacteria and toxins from slipping out, playing a core role in your intestinal permeability.


Your gut microbiome is made of billions of good bacteria that help fight off harmful bacteria, send food from your stomach to your intestines, and a host of other protective factors. Taking probiotics adds more good bacteria to your system, improving your digestive health and preventing the overgrowth of bad bacteria. Research has shown that good bacteria can, in some cases, reverse the symptoms of leaky gut through tight junction proteins, though researchers are still working to understand exactly how that works.


Like probiotics, prebiotics work to improve your gut microbiome’s health. Prebiotics are food for the healthy bacteria in your microbiome, stimulating their growth. Most prebiotics are made from carbohydrates found in plant fibers that your body can’t otherwise digest. By feeding the good bacteria in your gut, prebiotics help to promote growth and prevent the overgrowth of bad bacteria.

Digestive enzymes

While your body naturally makes digestive enzymes, which break down your food so you can access its nutrients, a leaky gut can deplete how many enzymes you can access. Adding digestive enzymes like amylase, lipase, and protease can start the breakdown process before food reaches your compromised intestines, ensuring that you’re still getting all the necessary nutrients out of your diet.


Having too little zinc can alter your intestinal permeability for the worse. For more than two decades, clinical researchers have known that adding zinc to your diet can reinforce tight junctions. Zinc helps with keeping a robust immune system, helping cell growth, building protein, and healing damaged tissue, all of which help improve the symptoms of leaky gut.


A recent discovery showing its protective role against leaky gut, tryptophan is an essential amino acid better known for making you sleepy after eating turkey on Thanksgiving. Not having enough tryptophan can shrink your gut microbiome and increase systemic inflammation. Increased intestinal permeability has been linked to lower levels of tryptophan for those very reasons, so keeping stable dietary tryptophan can help prevent inflammation that loosens tight junctions.

Vitamin D

About 80% of people have some level of vitamin D deficiency, yet the vitamin is critical for our daily functioning. Our skin can turn sunlight into vitamin D when it gets enough exposure. The vitamin helps to build and maintain bones, protect your nervous system, and keep your immune system working its best. In the GI system, vitamin D plays an integral role in diversifying your gut microbiome, ultimately protecting your intestines from damage.


Magnesium, like other minerals, has a cyclical relationship with leaky gut: not having enough can make inflammation happen faster, and more inflammation means you absorb less magnesium through your diet. It also plays a secondary role by improving fatigue, a common leaky gut symptom. Supplementing magnesium can help to quell that inflammation, but be warned that too much can have a laxative effect by increasing the amount of water moving through your intestines.


Omega-3 fatty acids are found in many foods but are most common in fish, crustaceans like krill, walnuts, and flaxseed. While there’s still research to be done on exactly how omega-3s support gut health, it appears to change the bacterial makeup of the gut microbiome to prioritize healthy bacteria and provide anti-inflammatory compounds. The interaction between the gut microbiome and omega-3’s anti-inflammatory properties appears to positively affect intestinal mucosal barriers.

N-acetyl glucosamine (NAG)

NAG is a chemical related to glucose that helps build joints and connective tissues. It’s primarily found in shellfish, so most supplements with NAG aren’t vegan-friendly. Most of the time, NAG is used to treat IBD, as it creates a biofilm that supports the intestine’s mucus layer. This also means that there’s a chance it can help with leaky gut symptoms, though research is still growing.


Demulcent plants — such as marshmallow root, slippery elm, licorice, and aloe vera — have anti-inflammatory properties that coat the mucus membranes in your intestines. This additional mucosal coating is thought to protect irritated, sensitive mucosal barriers from extra leakage while it heals. Clinical research on this is limited, however.


Quercetin is the most common plant flavonoid in dozens of plants and foods. As a flavonoid, it adds pigment to plants and has antioxidant and anti-inflammatory properties. It plays a role in capillary permeability, so increasing your quercetin intake can help keep toxins from a leaky gut out of your bloodstream.


Best known for its role in skincare, collagen still plays a role in maintaining your cell’s structural health. It is broken down into amino acids in your stomach, which then help build proteins that support things like tight junctions. However, research on collagen’s role in leaky gut is still limited.

By combining these ingredients, a good leaky gut supplement provides structural support for your intestinal lining while building up good bacteria in your microbiome, so your body can continue healing long after you take the supplement.

Are leaky gut supplements a good choice for you?

Most leaky gut supplements offer some benefit if you’re struggling with GI distress. They are generally designed with holistic gut health in mind, so finding the right one for you is a matter of identifying ingredients that can best offer the most relief for your specific symptoms.

Of course, like all supplements, leaky gut supplements are not regulated by the FDA in the same way as pharmaceutical medications or food. They cannot legally claim to cure, diagnose, treat, or prevent any disease.

Since ingredients can vary wildly between leaky gut supplements, read the Supplement Facts before purchasing to ensure that there are no potential adverse effects for you. Most include L-glutamine, which people with a history of liver or kidney disease shouldn’t take. If you have any history of psychiatric conditions, be cautious when starting a leaky gut supplement. Adding glutamine to your daily routine can worsen mental health symptoms such as psychosis. It can also interfere with anti-epileptic medications.

Probiotics are safe for most people. However, if you have pancreatitis or a severely compromised immune system (such as those undergoing chemotherapy), you should take a leaky gut supplement that doesn’t include them. This is because probiotics are still bacteria, even though they’re beneficial and necessary for our bodies.

Pregnant or lactating people should avoid leaky gut supplements, as should children. As with any supplement, reach out to your doctor before beginning a new regimen.

Don’t mix leaky gut supplements in powder form into hot liquids, as L-glutamine deteriorates under heat. Likewise, don’t cook or bake with any leaky gut supplements.

Terra Origin Healthy Gut

Best overall, best budget pick, and best powder


  • Long ingredient list combines just about every gut booster

  • Strong, scientifically-backed doses

  • Low cost with some bulk order options

  • Comes in five flavors and a vegan option

  • Subscribe & Save 5%

  • 100% satisfaction guarantee policy

  • Free shipping on orders over $25 to the contiguous U.S.


  • No international shipping

  • No subscription option

  • Only one size for some flavors

  • Stevia may cause stomach upset for some

Terra Origin’s Healthy Gut is a powdered formula specifically designed to taste good and help you feel better. This powder comes in six different flavors:

  • Mint
  • Berry
  • Peach banana
  • Matcha (green tea)
  • Honey lemon
  • Vegan (unflavored)

The vegan, honey lemon, and matcha formulas are currently only offered in 30-serving containers. These flavored Healthy Gut powders have a long, rich ingredient list full of gut-healthy ingredients, including:

  • L-glutamine (5g)
  • NAG (500mg)
  • Slippery elm (200mg)
  • Marshmallow root (200mg)
  • Licorice root (100mg)
  • Quercetin (50mg)
  • Aloe vera extract (10mg)
  • Zinc (2.15mg)
  • MSM (200mg)
  • Stevia (10mg)
  • Inulin

The flavored versions of Healthy Gut contain inulin in an unmarked dose. While it isn’t marketed as such, inulin is a prebiotic, adding an extra layer of support to your gut. However, because the dose isn’t specified, Healthy Gut likely doesn’t have enough to make a big difference in your digestive system.

Stevia is likely included to give the powder a little sweetness and boost its flavor. However, stevia can cause stomach upset in some people, including bloating and excess gas (which most people are trying to stop when looking for a leaky gut supplement). If you know you’re sensitive to stevia, try Healthy Gut’s vegan option. This vegan powder has a much shorter list of ingredients, including:

  • L-glutamine (5g)
  • Zinc (2.15mg)
  • Arabinogalactan, an immune-supporting plant starch (2g)
  • Vegan NAG (500mg)
  • MSM (200mg)
  • Licorice root (100mg)
  • Aloe vera extract (10mg)

While it doesn’t have the same variety and breadth of benefits, this vegan formula still hits every category of leaky gut protective ingredients.


You can order Terra Origin’s Healthy Gut Powder in either 30 or 90 serving containers, but that availability depends on the flavor. Either way, all prices are standardized.

Subscription options are only available for 30-day supplies and automatically ship at your pace. You can get free shipping on all orders over $25 (so your Healthy Gut Powder will automatically qualify) as long as you live in the contiguous United States. Orders to Alaska, Hawaii, and Puerto Rico, as well as orders under $25, are charged a small shipping fee.

Terra Origin also has frequent sales and extra deals, such as free shipping on all orders and “spend $50, get 20% off” offers. They have a 30-day return policy with a 100% satisfaction guarantee, so no matter how much you’ve tried, you can return your Healthy Gut Powder for a full refund as long as it’s within 30 days of purchase.

Gundry MD Bio Complete 3

Best probiotics and best capsule


  • Pre-, pro-, and postbiotics cover every angle of the gut microbiome

  • Consistently gets results within four weeks

  • May help you curb cravings as well as improve gut health

  • Physician-founded and developed

  • Independently tested by a third party for quality and purity

  • 90-day money-back guarantee

  • Free shipping on orders over $49


  • Very few non-branded ingredients

  • Contains maltodextrin

  • No CFUs specified on the label

  • Requires four capsules per day

Gundry MD is not just a brand name, but it’s also the name and title of the founding physician who developed every single medication formula he sells. Dr. Gundry uses his medical degree to help others access healthy alternatives, such as his gut health formula Bio Complete 3. This supplement is designed for complete, holistic gut health but is excellent for helping leaky gut.

One serving is four capsules, which Gundry MD suggests you split into two doses (two with breakfast and two with dinner). There are three major ingredients listed:

CoreBiome (1,000mg)

This 30% tributyrin formula is a postbiotic, which cleans up waste left behind by both pre- and probiotics. Tributyrin is a triglyceride alternative to butyrate that is easier to absorb and releases more slowly throughout your GI tract, ensuring that every inch of your insides is scrubbed to perfect health.

Sunfiber (200mg)

This branded prebiotic provides gentle, soluble fibers to your system. It’s low FODMAP, meaning it doesn’t have much sugar and is, therefore, easier on a leaky gut. This (alongside Sunfiber’s eight other certifications) helps it absorb quickly without bloating or excess gas.

Bacillus coagulans (ProDura) (16mg)

This good bacteria isn’t naturally found in the body, but it works similarly to Lactobacillus, which is found in the body. It creates lactic acid and helps to improve diarrhea and bloating. While we know there is 16mg of B. coagulans per serving, we don’t know the CFU, which is a more informative measurement of how many millions of bacteria you’re ingesting.

Bio Complete 3 hits all three major additions that can help you improve the health of your gut microbiome, but pre-, pro-, and postbiotics aren’t the only thing that helps a leaky gut. Bio Complete 3 contains unmarked portions of fatty acids and magnesium, which help to decrease inflammation on the way down. However, it also contains maltodextrin, a simple carbohydrate that converts to glucose, used for preservation and increasing supplements’ shelf lives.

While it isn’t a perfect supplement, Bio Complete 3 has several ingredients to help your leaky gut heal itself without supplementary intervention. After all, it’s much better to take a supplement for a little while as your body heals than to depend on it forever. And if you find that Bio Complete 3 doesn’t target your leaky gut symptoms, you’ll know to shift your focus away from your gut microbiome to other aspects like tight junctions or improving your daily diet.


There are several different ways you can order Bio Complete 3. You can get single or multiple bottles in bulk, and creating a free Gundry MD account unlocks extra savings. We’ve included a chart to help you understand the price differences among your options.

Gundry MD used to offer a subscription program that would save an additional 10% off every order. However, this program appears to have stopped in the last six months.

You can get free shipping on every order over $49 (so every purchase of Bio Complete 3 will ship free to your home). And if you try it and find it doesn’t agree with you, Gundry MD offers a 90-day money-back guarantee so you can get all of your money back (minus the cost of return shipping).

Interested in learning more? Check out our full review of Bio Complete 3.

NatureM.D. GutConnect 365

Most potent


  • Low-calorie formula also works as a meal replacement

  • Contains hefty amounts of many gut-healthy ingredients

  • Vegan, non-GMO, and soy-free formula

  • Two flavor options

  • Order in bulk for more savings

  • Free shipping on orders over $50

  • 60-day money-back guarantee

  • Subscribe & Save up to 32%


  • Contains stevia

  • Some ingredients not as scientifically sound

  • Makes big promises that don’t always hold up

  • Only sweet flavors available

One of two supplements on our list that provides 5mg of L-glutamine per serving, the heavy-hitting GutConnect 365 substantially boosts tight junction regulation and anti-inflammation signaling, even if 5g is less than clinical recommendations. Most studies use about 0.5g per kg of body weight.

Other ingredients you can find in GutConnect 365 include:

  • Zinc (3mg)
  • Quercetin (250mg)
  • Slippery elm bark (150mg)
  • Organic marshmallow root (150mg)
  • NAG (150mg)
  • Licorice root (150mg)
  • Aloe vera extract (50mg)
  • Maitake mushroom extract (30mg)
  • MCT oil powder
  • Stevia

While maitake mushrooms might not have the most scientific evidence pointing to gut support, they do add beneficial fiber to the powder.

GutConnect 365 comes in both chocolate and vanilla flavors. The powder is completely vegan, gluten-free, soy-free, and non-GMO. NatureM.D. advertises that it can work as a meal replacement, but with only ten calories per serving, it may not be enough to sustain you through a long workday.


NatureM.D. can be purchased directly from the company or from popular websites like Amazon. has both bulk options and a subscription plan that you can mix and match for maximum savings. The amount you save with the subscription plan varies depending on how many containers of GutConnect 365 you’ve ordered. We’ve put together a quick chart to break down your pricing options and the maximum percent you could save per jar.

All purchases over $50 are eligible for free shipping; the shipping price for a one-jar subscription (the only option under $50) is $5. If you or your gut aren’t happy with GutConnect 365, you can return it for a full refund within 60 days of purchase, even if you’ve opened and tried it.

KaraMD Vital Restore

Best for restricted diets


  • Includes berberine, a supplement usually sold separately

  • Gluten-free, non-GMO, and vegan

  • Independently third-party tested

  • Made in an FDA-registered lab

  • Free shipping on orders of two or more products

  • 90-day money-back guarantee

  • Bulk discounts up to 20%


  • May not be safe for people with diabetes

  • Very few low-dose, gut-specific ingredients

  • No subscription option

KaraMD’s Vital Restore is made with five simple ingredients, all of which are well-tolerated by most people. Specifically, it contains:

  • Zinc (50mg)
  • L-glutamine (1g)
  • Berberine (500mg)
  • Turmeric root powder for curcumin (250mg)
  • Slippery elm powder (250mg)

Berberine is a particularly interesting inclusion in this leaky gut supplement. The alkaloid is found in several plants (including goldenrod and Oregon grape) and activates AMPK, impacting type 2 diabetes, metabolic syndrome, hypertension, and high cholesterol. Specifically, it lowers blood sugar and HbA1C as effectively as some hardcore prescription medications like metformin without the gut-churning side effects.

Research about berberine’s effects on a leaky gut is minimal. It’s likely included because lower blood sugar means fewer cravings, and a streamlined metabolic process means less bloating, leading to improved GI symptoms. So, this supplement has less to do with fixing the symptoms of leaky gut than overall gut health. It may not be safe for those with diabetes, so consult your doctor before trying Vital Restore.

One serving of Vital Restore is three capsules, which you can take at any point in the day. The formula is gluten-free, vegan, and non-GMO. It’s made in an FDA-registered facility and independently tested by a third party for quality assurance.


Right now, there’s no subscription option for Vital Restore. You’ll need to remember to purchase a new bottle every month as long as you want to take it. However, KaraMD offers some excellent bulk deals on all of their products.

If you aren’t happy with your order, you have 90 days to return it for an unconditional full refund.

1MD Nutrition GutMD


  • Decent amount of L-glutamine and oligosaccharides

  • Realistic results timeline provided

  • Shellfish-, gluten- and GMO-free

  • Made in GMP-compliant factories

  • Bulk and subscription savings available

  • 90-day money-back guarantee

  • Free shipping available on almost all orders

  • Save 10% on your first order when you sign up for their newsletter


  • Not safe for the lactose intolerant

  • Must be taken on an empty stomach one hour before eating

  • Few ingredients can feel sparse

If you’re interested in trying a supplement for leaky gut that’s a little experimental, GutMD may be the best option for you. This leaky gut supplement has four main ingredients:

  • Licorice root extract (150mg)
  • CARE4U, a branded form of human milk oligosaccharide (250mg)
  • L-glutamine (1.5g)
  • Tahl gum, a newly granted dietary fiber also called acacia fibergum (280mg)

Three of these ingredients have a clear, well-established purpose and can be found in other leaky gut supplements. CARE4U, on the other hand, might be a little shocking. Artificial human milk oligosaccharides (HMOs) are sugars found in breast milk and contain up to fifteen different chemical structures, including lactose, that are easily absorbed by gut microbes. Research analyzing how HMOs influence adult gut health is still growing, but some recent studies show that it can improve immune function through the gut microbiome and intestinal barrier strength. If you’re not lactose intolerant, it’s an interesting approach on the cutting edge that may prove beneficial with more research.

There are some incredibly specific instructions you’ll need to follow when taking GutMD. Three capsules equal one serving, and 1MD Nutrition states that you should take it on an empty stomach with a full glass of water one hour before eating. It’s inconvenient, but gut health supplements are best absorbed on an empty stomach. So, the recommendation is based on real science.

GutMD is free of all major allergens, non-GMO, and made in a facility using up-to-date GMP standards. The webpage for GutMD features a realistic timeline, breaking down when you can expect to see different results over the first three months you regularly take GutMD.


1MD Nutrition has a complicated pricing structure for their supplements. They offer bundle discounts and a subscription program, which saves variable amounts depending on how many bottles you order. We’ve created a chart below that illustrates how much you’ll pay — and how much you’ll save — when purchasing GutMD. (Each price listed below is the price per bottle, not the total price.)

Every Subscribe & Save shipment — and both one-time bulk orders — are eligible for free shipping. You can set your subscription to ship at an interval that works best for you, and you’re free to pause, skip, or cancel at any time without punishment or fees.

If you aren’t happy with your order — whether or not you’ve joined the subscription program — you can return it for a full refund (minus the shipping cost) within 90 days of your purchase. However, you’ll need to send in a written notice for the refund to be accepted. This can be a note on the inside of the package or an email or letter sent ahead of time to 1MD Nutrition’s customer service.

Biotrust Gut Reg


  • 7-stage research and testing process

  • Independently third-party tested

  • Mix and match bundle deals and subscription savings

  • 60-day money-back guarantee

  • Free shipping on all subscription orders

  • 20% off one purchase and eBook access when you sign up for emails


  • Not vegan-friendly

  • Ingredients may not be available in large enough quantities

Biotrust takes a roundabout approach to their leaky gut supplement. Gut Reg is made of four ingredients:

  • PepZin GI, a combination of zinc and L-carnosine clinically used to treat gastric ulcers (75mg)
  • L-glutamine (500mg)
  • Ginger extract (250mg)
  • Vitamin D3 (25mcg)

PepZin GI is the strongest ingredient on their list by far. It contains 15mg of zinc — about the average recommended dose for an adult man — within its 75mg formula. PepZin GI may be a branded supplement, but it plays several roles in leaky gut support, including improving mucosal membranes and stopping inflammation caused by H. pylori infections. And while vitamin D3 and L-glutamine are relatively common ingredients in leaky gut supplements, ginger extract is also unique yet effective as part of gut support.

While one serving of Gut Reg is two capsules, you’ll need to split that dose up over the course of the day: Biotrust recommends taking one capsule after breakfast and one before bed. If you try this regimen and it doesn’t work, you can also double each serving for added effect. (However, this means one bottle will only last two weeks.)

Gut Reg may not have any major allergens, but it is made in a facility that also processes them, so if you have celiac disease or severe food allergies, you may want to try a different leaky gut supplement. Biotrust uses an independent third party to test each batch's purity, potency, and safety.


There are several combinations of Gut Reg you can order for different savings and benefits. We’ve put together a chart so you can see your purchasing options more clearly.

All subscription orders earn free shipping. One-time orders to the United States have a flat shipping fee of $6.95 no matter where you are, including Hawaii, Alaska, Puerto Rico, Guam, and the U.S. Virgin Islands. (Shipping varies if you live outside of the United States.)

If you aren’t happy with Gut Reg, Biotrust will provide a full refund (minus the shipping cost) if you send back the bottle within 60 days of purchase. It doesn’t matter how much you have or haven’t tried — Biotrust will even accept an empty bottle in the mail. Just reach out to customer service to get the ball rolling.

Liver Medic Leaky Gut Repair


  • Variable capsule regimen allows flexibility depending on symptoms

  • Highly scientific breakdown clearly explained on website

  • NSF-certified

  • Produced in a GMP-certified facility

  • 100% satisfaction guarantee

  • Free shipping on orders over $50


  • Uses a low-dose proprietary blend

  • Contains shellfish

  • No discount with subscription service

Liver Medic’s chief scientist and product formulator’s wife experienced an intense case of thrush after giving birth but was cured by taking several gut-healthy ingredients curated by her husband. He went on to formulate Leaky Gut Repair based on his wife’s health success. This capsule-based formula contains slightly less than 1g of a gut repair proprietary blend, which includes:

  • L-glutamine
  • Organic slippery elm
  • Organic marshmallow root
  • NAG
  • Licorice root extract
  • Aloe vera leaf powder
  • MSM
  • Quercetin
  • Bromelain, the digestive enzyme found in pineapple
  • Copper

It also includes a whopping 25mg of zinc, which is more than 225% of your recommended daily value. Obviously, less than 1g of the proprietary blend isn’t great. But all the ingredients play off each others’ strengths, allowing you to experience the most benefit in the fewest ingredients. Copper, for example, is included because increased zinc flushes copper out of the body, so its inclusion offsets the supplement’s large quantity of zinc.

Leaky Gut Repair has a flexible dosing strategy that lets you customize your health plan. They recommend taking two capsules daily for gut health maintenance and four capsules (two in the morning and two at night) if you’re actively experiencing severe symptoms. Their Supplement Facts dose information is based on a two-capsule serving. Take them with water, and it’s best to take them on an empty stomach if possible.

The website’s graphic design isn’t always intuitive, but it provides a wealth of clear and easy-to-understand information. Sometimes, the depth of information is enough to raise an eyebrow — one award specifies that they don’t use any “suspicious fillers.” For the most part, however, Liver Medic goes out of their way to help you understand exactly what may be happening in your GI system and how they can help quiet it.


There is only one price point for Leaky Gut Repair: $23.99. This doesn’t change no matter how many bottles you order, and while Liver Medic offers a monthly subscription service, there is no discount associated with that repeat order. However, they occasionally offer “buy one, get one free” coupons, and you can get 10% off your first order when you subscribe to their mailing list. Orders over $50 ship for free.

Don’t love Leaky Gut Repair? You can return it for a full refund. There aren’t any hard time limits set, and you can still return it after you’ve tried it. Just reach out to customer service to start the process.

FAQ about leaky gut supplements

Alternatives to leaky gut supplements

Not sure if a leaky gut supplement is the right move for you? Because of leaky gut syndrome’s ubiquitous symptoms, there are several other options you can try to solve your GI problems. We’ve laid out a few of them below for you.

GI tests

Investigating suspicious symptoms is always a good choice. You can complete some tests at home, like a gut microbiome survey or food sensitivity testing, or you can go to your doctor’s office for an endoscopy to check for more severe problems like celiac or Crohn’s. Since leaky gut symptoms overlap heavily with other GI diseases — and sometimes leaky gut is a symptom of a larger GI disease — ruling out other problems should generally be your first step.

Dietary changes

We are what we eat. And when there isn’t a clear answer to your symptoms, changing your diet to be more gut-healthy can make a difference. This means eating less refined sugar, saturated fats, alcohol, and caffeine and eating more whole grains and high-fiber foods.


Post-Thanksgiving dinner walks aren’t just to get away from your family for a few minutes. Research shows that taking a 15-20 minute walk after eating can help stimulate your stomach and intestines, helping your body digest food more efficiently.


Taking probiotics on their own can massively improve your gut health with leaky gut. The beneficial bacteria can help to heal the mucosal wall by promoting mucus secretion and tightening junctions through increased zonulin. They also help to break down food more efficiently, meaning you’ll take in more nutrients from what you’re eating.

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