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Noocube Review

Is Noocube an effective supplement for memory and cognitive function? Here's our thorough analysis.

Last Updated: Jun 7, 2022
Noocube Review

In today’s technological world, maintaining concentration is more challenging than ever. We’re constantly distracted by smartphones, televisions, computers, and other devices — not to mention the non-technical distractions we face each day.

As people feel increasingly overwhelmed and mentally exhausted, more and more are turning to dietary supplements for brain health, a market projected to value over $5 billion by 2023. But can these supplements really boost memory and cognition? Can they help reverse the mental decline that accompanies aging?

We’ve recently tested Noocube, an all-natural nootropic supplement that promises boosted memory, focus, and motivation while reducing mental fatigue. This review will lead you through the product’s pros, cons, and details to see if Noocube can boost your brainpower.

Review Summary


  • Caffeine-free and non-GMO
  • Contains all-natural, scientifically backed ingredients
  • Improves memory and focus
  • 60-day money-back guarantee
  • Reduces stress and anxiety
  • Relatively transparent labeling
  • Improves motivation and energy
  • Free shipping worldwide


  • Contains a proprietary blend
  • More expensive than many competitors
  • Only available from the company website

Bottom line

We recommend Noocube for anyone looking to boost their mental cognition, focus, and memory — from overwhelmed students and busy professionals to aging individuals. Noocube contains scientifically backed ingredients that promote cell generation and communication, naturally reducing anxiety and mental fatigue. Additionally, it’s caffeine-free, so you won’t get the jitters accompanying many cognitive supplements. Noocube provides a 100% 60-day money-back guarantee on all products if you’re not completely satisfied.

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Noocube offers quality, brain-boosting supplements that improve focus and memory across all ages.

This nootropic contains all-natural, scientifically backed ingredients that improve mental cognition and reduce stress and anxiety. All orders ship for free, and purchases are covered by a 60-day money-back guarantee.

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Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

We extensively test each health service or product we review. We try our best to give you, our readers, an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality, the latest medical evidence and health standards, and a simple question: would we buy the product or service ourselves if it weren’t part of our job, and would we recommend it to family and friends?

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

What is Noocube?

Noocube is a nootropic dietary supplement supporting brain health. Nootropics, also called “smart drugs,” are a class of substances shown to help cognitive function and memory. Some common nootropic ingredients you’ll find in memory-enhancing supplements include:

  • Omega-3 fatty acids
  • B vitamins
  • Vitamins A, C, E, and D
  • L-tyrosine
  • L-theanine

Many nootropic supplements also contain caffeine, which Noocube does not, making it more accessible for individuals with caffeine sensitivity. Among Noocube’s ingredients are vitamins, amino acids, and antioxidants that help to promote cell generation and communication, supporting the following benefits:

  • Less brain fog
  • More intense focus
  • Reduced anxiety and mental stress
  • Improved memory
  • Greater motivation

Does Noocube work?

Noocube effectively promotes memory and focus with several scientifically backed nootropic ingredients. We tested the product ourselves and experienced noticeable changes within the first week. We had a generally better mood, experienced less mental fatigue, and found focusing less challenging.

After two weeks, we felt our productivity had significantly increased, and we felt physically healthier and more energized.

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How Noocube works

Most people would appreciate improved cognition, mood, and memory, regardless of age. Noocube combines a potent blend of scientifically proven nootropics, antioxidants, and nutrients that support brain health and help prevent the mental decline of aging. Below, we’ll look at the science behind Noocube’s ingredients and how they work synergetically to restore mental clarity and focus.

Vitamin B1 (1.1mg)

Vitamin B1, also known as thiamine, is intrinsically linked to neurological health. As long ago as the 1930s, researchers identified correlations between thiamine deficiency and gross memory defects. Severe thiamine deficiency contributes to the development of Wernicke-Korsakoff syndrome, a degenerative brain disorder.

While thiamine supplementation has not demonstrated the ability to reverse the development of Alzheimer’s disease and other cognitive disorders, it has shown potential to improve working memory and executive functions in the early stages of Alzheimer’s disease.

Vitamin B7 (50mcg)

New studies have shown a connection between biotin (vitamin B7), mitochondria, and dementia. This 2021 review suggests that biotin supplementation may benefit those with dementia and various neurodegenerative diseases.

Vitamin B12 (2.5mcg)

B vitamins play a critical role in cellular energy production and oxygen transport. Inadequate supplies of B vitamins, including B6, B9, and B12, can lead to anemias and inhibit metabolic and functional pathways.

Research shows that these micronutrients are essential in establishing and maintaining brain structures and enabling intercellular connections during brain development and aging. Supplementation of vitamin B12 improves energy and exercise tolerance and reduces fatigue.

Bacopa monnieri extract (250mg)

Bacopa monnieri, also known as Brahmi, is an herbal supplement with a long history in Ayurvedic medicine for its benefits on memory and cognition. Researchers have demonstrated Bacopa monnieri’s cognitive benefits in multiple studies.

In a 2016 six-week, randomized, placebo-controlled trial on Bacopa monnieri supplementation in medical students, scientists found that subjects taking 300mg daily of BM experienced improved acquisition, retention, and retrieval of learned facts.

In a 2021 randomized, double-blind, placebo-controlled trial on subjects over 55, researchers found that those supplemented with 320mg of BM daily over 12 weeks demonstrated significantly faster memory retrieval than those taking a placebo. However, there was some variance in the results.

L-tyrosine (250mg)

Tyrosine is an amino acid and precursor of dopamine and norepinephrine. Studies have shown that tyrosine supplementation benefits healthy individuals under stress or cognitive demands by enhancing mental performance and mood.

Cat’s claw concentrate (175mg)

Cat’s claw is an antioxidant, anti-inflammatory vine native to the Amazon rain forest. In recent studies, scientists have determined that cat’s claw supplementation may inhibit plaque growth in the brain, effectively improving memory loss and declining cognitive function as we age.

In a 2021 review of clinical trials on cat’s claw supplementation, researchers confirmed its efficacy in reducing brain plaque in human and animal studies.

Oat straw extract (150mg)

Oat straw is another nootropic compound that enhances stress responses and memory and improves cognitive performance in humans at clinical doses of 800 and 1,600mg daily. While Noocube contains a far lower dosage, researchers for this 2017 trial concluded that the optimal dose lies at or below 800mg.

L-theanine (100mg)

L-theanine is an amino acid derived from green tea. In a recent double-blind, randomized, placebo-controlled study, researchers concluded that L-theanine may benefit middle-aged and older adults by improving focus, enhancing working memory, and improving behavior under stress.

Alpha GPC (50mg)

Alpha GPC has shown in preclinical trials the potential to increase the levels of acetylcholine in the brain, improving cognition and memory in dementia patients.

In a 2003 double-blind, randomized, placebo-controlled trial involving subjects with mild to moderate dementia, those who received 400mg of Alpha GPC three times daily demonstrated cognitive improvements. In contrast, the placebo group remained unchanged or worsened after 90 days of treatment.

Lutemax 2020 (proprietary blend) (20mg)

Lutemax 2020 is a proprietary blend of the naturally occurring carotenoids lutein and zeaxanthin. Naturally derived from marigold flowers, Lutemax 2020’s ingredients have undergone multiple clinical trials that have shown effectiveness in promoting cognitive and vision health and improving mood and sleep.

Marigold extract (20mg)

As mentioned above, marigold is the source of the carotenoids lutein and zeaxanthin, which benefit cognitive function and vision health. By including both Lutemax 2020 and marigold extract, Noocube essentially doubles these beneficial effects.

Huperzia serrata (20mg)

Huperzia serrata has a long history in traditional Eastern medicine in treating cognitive disorders, including:

  • Dementia
  • Cognitive dysfunction
  • Schizophrenia

In a 2021 study, researchers demonstrated Huperzia serrata’s neuroprotective effects, reducing oxygen-glucose deprivation and free radical-induced cytotoxicity. Adverse side effects may accompany high dosages of H. serrata, including hypertension, dizziness, vomiting, and nausea.

Resveratrol (14.3mg)

Resveratrol is an antioxidant and anti-inflammatory compound found in grapes, berries, peanuts, and red wine. It’s found today in many dietary supplements for its benefits in:

  • Lowering cholesterol
  • Promoting heart health
  • Lowering blood sugar levels

Recent studies have also demonstrated that resveratrol can improve brain function and reduce the signs of aging and memory loss.

Pterostilbene (140mcg)

Pterostilbene is a phenol derived from blueberries and grapevines with similar properties to resveratrol. In a 2019 animal study, researchers showed that Pterostilbene supplementation in rats demonstrated its potential as a therapeutic for age-related cognitive decline.

Is Noocube safe?

Noocube states that its ingredients have no known side effects, and our testers did not have any adverse reactions during their use. However, this product is inappropriate for children under 18 and pregnant or lactating adults. If you have a chronic medical condition or take any ongoing medications, we recommend consulting with your doctor before taking Noocube or any dietary supplement.

Additionally, our research showed that some ingredients, such as Huperzia serrata, have shown adverse gastrointestinal effects in high dosages.


Noocube is only available from the company’s website, but this buying option is optimal for its 60-day money-back guarantee. If you’re dissatisfied with the product, contact customer service within 60 days of your order for a full refund. This satisfaction promise applies whether you purchase a single bottle or buy in bulk.

Noocube does not provide a subscription program, but purchasing in bulk earns significant savings. As seen in the chart below, purchasing the six-month bundle cuts the cost per daily serving in half.

  Price Cost per day
One-month supply $59.99 $2
Three-month supply $119.99 $1.33
Six-month supply $179.99 $1

Noocube provides free worldwide shipping on all orders.

Is Noocube a good value?

Noocube is in the upper range of nootropic supplements in terms of cost. However, we believe this product provides a superior ingredient list compared to the competition — and it is caffeine-free, making it more appropriate for those with sensitivities.

Unlike many competitors, Noocube provides research studies backing up its nootropic ingredients. Purchasing Noocube in the six-month bulk package drops the cost by half, so if you benefit from the supplement, you can easily lower your daily cost to just $1.

Pricing below does not consider subscription plans or bulk purchases, which can earn significant savings.

  Cost (1 bottle) Cost per daily serving
Noocube $59.99 $2
Thesis Motivation $79 $2.63
Stonehenge Health Dynamic Brain $43.95 $1.47
Advanced Bionutritionals Advanced Memory Formula $39.95 $1.33
Neuriva Nootropic Brain Support Supplement $38.18 $1.27

HSA, FSA, and health insurance

Noocube does not accept payments from HSAs, FSAs, or health insurance.

Privacy considerations

Noocube uses cookies and other tracking technologies to collect user information on its website. It may use this information for targeted marketing and ease of use. Noocube may share your personal information with its affiliates or partners to provide services or advertising. Noocube encrypts payment information with SSL technology for security and privacy and does not keep payment records on file.

How we evaluate health products and services

At Innerbody Research, we customize our evaluation criteria depending on the type and nature of the health-related service or product. But in general, for health products and services, we have five broad areas that we explore in our evaluations, including:

Quality: How well does the company deliver its core service(s) to the customer? For testing services, does the company adhere to the latest and most advanced testing technologies and achieve a very high degree of accuracy? For non-testing telemedical or teletherapy services, is the quality of the service high enough that we would recommend it to loved ones without hesitation? If not, why not? For health products, does the product or device meet a high level of safety? Is it manufactured with high-quality standards? Has it – or have its ingredients – been subjected to studies that confirm effectiveness?

User-friendliness: How intuitive and convenient is the service or product? Does the device, program, app, or website achieve a good degree of user-friendliness for its customers?

Value: Are you getting your money’s worth? Are there any hidden costs or charges? Does the company offer discounts?

Privacy: If health data is stored, will your data be stored securely? Are payments secure? Does a company market your information?

Customer support: Particularly in situations where ‘one size fits all’ doesn’t make sense, how well does the company help make the service or product ideal for you or address your individual needs?

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