Noocube Review

Is Noocube an effective nootropic supplement for memory and cognitive function? Here's our thorough analysis.

Last updated: Dec 29th, 2022
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In this Review

Our Findings
Why you should trust us
How we evaluated Noocube
What is Noocube?
Does Noocube work?
How Noocube works
Is Noocube safe?
Privacy considerations
Alternatives to Noocube
Nootropics FAQ
Noocube Review

Our Findings

Editor's Rating3.50

A caffeine-free formula, great chat support, and a 60-day money-back guarantee make Noocube a safe way for many people to try their first nootropic. It’s not the cheapest option available, but bulk purchases can bring its price well within the range of its competitors.


  • Caffeine-free and non-GMO
  • Contains all-natural, scientifically backed ingredients
  • Improves memory and focus
  • 60-day money-back guarantee
  • Reduces stress and anxiety
  • Relatively transparent labeling
  • Improves motivation and energy
  • Free shipping worldwide


  • Some claims lack scientific evidence
  • Alpha GPC contains soy
  • Not gluten-free
  • More expensive than many competitors
  • No subscription program

In today’s technological world, maintaining concentration is more challenging than ever. We’re constantly distracted by smartphones, televisions, computers, and other devices — not to mention the non-technical distractions we face daily.

As people feel increasingly overwhelmed and mentally exhausted, more and more are turning to nootropics — dietary supplements for brain health — a market projected to value over $5 billion by 2023. But can these supplements really boost memory and cognition? Can they help reverse the mental decline that accompanies aging?

We’ve recently tested Noocube, an all-natural nootropic that promises to improve memory, focus, and motivation while reducing mental fatigue. This review leads you through the product’s pros, cons, and details to see if Noocube can boost your brainpower.


Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

We extensively test each health service or product we review. Our content provides you, our readers, with an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality and the latest medical evidence and health standards. We ask ourselves two simple questions: Would we buy the product or service ourselves if it weren’t part of our job? Would we recommend it to family and friends?

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

How we evaluated Noocube


Rating: 7/10

We rate effectiveness based on available scientific research into products or their components. We also consider our personal experiences testing products and their competitors.

Almost all of Noocube’s ingredients boast some scientific backing, with several involved in multiple clinical studies directly linking them to cognitive health. Some can improve memory and cognition, while others help reduce stress and anxiety, which can lead to improved mental performance. A few of the company’s claims are a bit overblown, however. Certain ingredient doses are also well below the quantities that researchers used in the most prominent studies. This doesn’t mean that Noocube will be ineffective, but its effects may be less pronounced or take longer to set in than they do in trials.

Our personal testing experience was generally positive. None of our testers were admitted to MENSA overnight, but most experienced increased mental clarity. Some also found their moods improved and memories sharpened. None of our testers experienced any adverse reactions.


Rating: 6.5/10

Cost is a critical factor in evaluating any supplement, especially those that require consistent, long-term use to maximize efficacy. While there are certainly more expensive products among nootropics, Noocube is not cheap. The only reliable way to bring its costs closer to some competitors is to buy it in bulk.

Once you’ve tried it and determined that it works for you, a bulk purchase would make sense, as it effectively cuts your costs in half. But spending that much up-front on a product you haven’t tried might be a bit daunting. The lack of a subscription option that other companies provide removes another potential cost-saving avenue.


Rating: 7/10

As we mentioned above, none of our testers experienced any adverse reactions to Noocube. The majority of its ingredients exhibit stellar safety profiles in testing, and its lack of caffeine makes it suitable for anyone with caffeine sensitivity, as well as those who would refuse to give up their coffee habit if faced with the decision.

Where Noocube’s safety suffers is in its inclusion of soy-based and glutenous ingredients. There are viable alternatives the company could source, and given what they charge for a bottle, they really ought to improve those ingredients.

The most egregious part is that the company website claims that Noocube is soy- and grain-free. That could lead an unsuspecting consumer to purchase and take the product without realizing the potentially life-threatening danger involved. We only know about these ingredients because the label on the bottle indicates components containing soy and gluten. We’ve brought this discrepancy to the attention of Noocube’s web development team, and hopefully, they will remedy the issue soon.


Rating: 7.5/10

When we look at convenience, we consider things like the intuitive design of a website and the ease of purchasing and taking a product. In Noocube’s case, the website is easy to navigate, and the dosing schedule and pill size make actually taking the supplement a straightforward process. Free worldwide shipping and good chat support are nice, as well.

The big hit that Noocube takes in this category comes from their lack of a subscription option. Not only does this prevent an opportunity for added savings, but it also means that you have to manually order a new bottle any time you’re close to running out. And if you don’t time it just right, you might go a day or more without your daily regimen.

What is Noocube?

Noocube is a nootropic dietary supplement supporting brain health. Nootropics, also called “smart drugs,” are a class of substances shown to help cognitive function and memory. Some common nootropic ingredients you’ll find in memory-enhancing supplements include:

  • Omega-3 fatty acids
  • B vitamins
  • Vitamins A, C, E, and D
  • L-tyrosine
  • L-theanine
  • Alpha GPC

Many nootropic supplements also contain caffeine, which Noocube does not, making it more accessible for individuals with caffeine sensitivity. Among Noocube’s ingredients are vitamins, amino acids, and antioxidants that help to promote cell generation and communication, supporting the following benefits:

  • Less brain fog
  • More intense focus
  • Reduced anxiety and mental stress
  • Improved memory
  • Greater motivation

Does Noocube work?

As a nootropic intended for improved cognitive performance, Noocube works. It effectively promotes memory and focus with several scientifically backed nootropic ingredients. We tested the product ourselves and experienced noticeable changes within the first week. We had a generally better mood, experienced less mental fatigue, and found focusing less challenging.

After two weeks, we felt our productivity had significantly increased, and we felt physically healthier and more energized.

That said, some of Noocube’s claims about its potential benefits are supported by neither scientific evidence nor our testing experience. For example, the company claims that one of its ingredients — Lutemax — protects the eyes against “oxidative damage” from exposure to the blue light from computer and phone screens. There may ultimately be some truth to this, as carotenoids like lutein are integral to eye health. But the medical community’s understanding of blue light effects is nascent, at best. Claiming that it causes oxidative stress in the first place is a stretch, and going so far as to say that Lutemax can somehow protect against that specific stressor borders on dishonesty.

How Noocube works

Most people would appreciate improved cognition, mood, and memory, regardless of age. Noocube combines a potent blend of scientifically proven nootropics, antioxidants, and nutrients that support brain health and help prevent the mental decline of aging. Below, we’ll look at the science behind Noocube’s ingredients and how they work synergistically to restore mental clarity and focus.

Vitamin B1 (1.1mg)

Vitamin B1, also known as thiamine, is intrinsically linked to neurological health. As long ago as the 1930s, researchers identified correlations between thiamine deficiency and gross memory defects. Severe thiamine deficiency contributes to the development of Wernicke-Korsakoff syndrome, a degenerative brain disorder.

While thiamine supplementation has not demonstrated the ability to reverse the development of Alzheimer’s disease and other cognitive disorders, it has shown potential to improve working memory and executive functions in the early stages of Alzheimer’s disease.

Vitamin B7 (50mcg)

New studies have shown a connection between biotin (vitamin B7), mitochondria, and dementia. This 2021 review suggests that biotin supplementation may benefit those with dementia and various neurodegenerative diseases.

Vitamin B12 (2.5mcg)

B vitamins play a critical role in cellular energy production and oxygen transport. Inadequate supplies of B vitamins, including B6, B9, and B12, can lead to anemia and inhibit metabolic and functional pathways.

Research shows that these micronutrients are essential in establishing and maintaining brain structures and enabling intercellular connections during brain development and aging. Supplementation of vitamin B12 also improves energy and exercise tolerance and reduces fatigue.

Bacopa monnieri extract (250mg)

Bacopa monnieri, also known as Brahmi, is an herbal supplement with a long history in Ayurvedic medicine for its benefits on memory and cognition. Researchers have demonstrated Bacopa monnieri’s cognitive benefits in multiple studies.

In a 2016 six-week, randomized, placebo-controlled trial on Bacopa monnieri supplementation in medical students, scientists found that subjects taking 300mg daily of BM experienced improved acquisition, retention, and retrieval of learned facts.

In a 2021 randomized, double-blind, placebo-controlled trial on subjects over 55, researchers found that those supplemented with 320mg of BM daily over 12 weeks demonstrated significantly faster memory retrieval than those taking a placebo. However, there was some variance in the results.

L-Tyrosine (250mg)

Tyrosine is an amino acid and precursor of dopamine and norepinephrine. Studies have shown that tyrosine supplementation benefits healthy individuals under stress or cognitive demands by enhancing mental performance and mood.

Cat’s claw concentrate (175mg)

Cat’s claw is an antioxidant, anti-inflammatory vine native to the Amazon rainforest. In recent studies, scientists have determined that cat’s claw supplementation may inhibit plaque growth in the brain, effectively improving memory loss and declining cognitive function as we age.

In a 2021 review of clinical trials on cat’s claw supplementation, researchers confirmed its efficacy in reducing brain plaque in human and animal studies.

Oat straw extract (150mg)

Oat straw is another nootropic compound that enhances stress responses and memory and improves cognitive performance in humans at clinical doses of 800mg and 1,600mg daily. While Noocube contains a far lower dosage, researchers for this 2017 trial concluded that the optimal dose lies at or below 800mg.

L-theanine (100mg)

L-theanine is an amino acid derived from green tea. In a recent double-blind, randomized, placebo-controlled study, researchers concluded that L-theanine may benefit middle-aged and older adults by improving focus, enhancing working memory, and improving behavior under stress.

Alpha GPC (50mg)

In preclinical trials, alpha GPC has shown the potential to increase the levels of acetylcholine in the brain, improving cognition and memory in dementia patients.

In a 2003 double-blind, randomized, placebo-controlled trial involving subjects with mild to moderate dementia, those who received 400mg of Alpha GPC three times daily demonstrated cognitive improvements. In contrast, the placebo group remained unchanged or worsened after 90 days.

Lutemax 2020 (proprietary blend) (20mg)

Lutemax 2020 is a proprietary blend of the naturally occurring carotenoids lutein and zeaxanthin. Naturally derived from marigold flowers, Lutemax 2020’s ingredients have undergone multiple clinical trials that have shown effectiveness in promoting cognitive and vision health and improving mood and sleep.

Huperzia serrata (20mg)

Huperzia serrata has a long history in traditional Eastern medicine in treating cognitive disorders, including dementia, cognitive dysfunction, and schizophrenia.

In a 2021 study, researchers demonstrated Huperzia serrata’s neuroprotective effects, reducing oxygen-glucose deprivation and free radical-induced cytotoxicity. Adverse side effects may accompany high doses of H. serrata, including hypertension, dizziness, vomiting, and nausea.

Resveratrol (14.3mg)

Resveratrol is an antioxidant and anti-inflammatory compound found in grapes, berries, peanuts, and red wine. It’s found today in many dietary supplements for its benefits in:

  • Lowering cholesterol
  • Promoting heart health
  • Lowering blood sugar levels

Recent studies have also demonstrated that resveratrol can improve brain function and reduce the signs of aging and memory loss.

Pterostilbene (140mcg)

Pterostilbene is a phenol derived from blueberries and grapevines with similar properties to resveratrol. In a 2019 animal study, researchers showed that pterostilbene supplementation in rats demonstrated its potential as a therapeutic for age-related cognitive decline.

Is Noocube safe?

Noocube states that its ingredients have no known side effects, and our testers had no adverse reactions during their use. However, this product is inappropriate for children under 18 and pregnant or lactating adults. If you have a chronic medical condition or take any ongoing medications, we recommend consulting your doctor before taking Noocube or any dietary supplement.

Additionally, our research showed that some ingredients, such as Huperzia serrata, have shown adverse gastrointestinal effects in high dosages.

It’s also important to note that Noocube’s formula contains both gluten and soy, making it unsuitable for anyone with associated allergies and intolerances.


Noocube is only available from the company’s website, but this buying option is optimal for its 60-day money-back guarantee. If you’re dissatisfied with the product, contact customer service within 60 days of your order for a full refund. This satisfaction promise applies whether you purchase a single bottle or buy in bulk.

Noocube does not provide a subscription program, but purchasing in bulk earns significant savings. As seen in the chart below, purchasing the six-month bundle cuts the cost per daily serving in half.

Noocube provides free worldwide shipping on all orders.

Is Noocube a good value?

Noocube is in the upper range of nootropic supplements in terms of cost. However, purchasing Noocube in the six-month bulk package drops the cost by half, so if you benefit from the supplement, you can easily lower your daily cost to just $1.

The pricing below does not consider subscription plans or bulk purchases, which can deliver significant savings.

HSA, FSA, and health insurance

Noocube does not accept payments from HSAs, FSAs, or health insurance.

Privacy considerations

Noocube uses cookies and other tracking technologies to collect user information on its website. It may use this information for targeted marketing and ease of use. Noocube may share your personal information with its affiliates or partners to provide services or advertising. Noocube encrypts payment information with SSL technology for security and privacy and does not keep payment records on file.

Alternatives to Noocube

As the nootropics landscape continues to expand, it’s critical that we consider the wide range of available alternatives to companies like Noocube. Some offer similar benefits at comparable prices, while others make for great bargain options. And, perhaps not surprisingly, several companies out there charge even more than Noocube for a boost in brain power.

Here’s a quick look at how Noocube compares to some of the top companies in the nootropics space. We’ve used the lowest possible price per bottle, including any available subscription or bulk discounts.

Let’s take a look at some of Noocube’s most ardent competition.


Despite its high price tag, Thesis is one of our favorite nootropics companies. They provide outstanding customer service, especially if you like getting support over the phone. Comparatively, Noocube has a pretty good live chat system, but the personal touch Thesis provides over the phone goes a long way in our book.

Thesis includes generous doses of highly effective ingredients. You can organize a monthly supply to include up to four different formulas with a week's supply of each. You can also choose to include or exclude caffeine from any of their blends.

The Thesis model is subscription-only, which makes them a better choice than Noocube if you're liable to forget about reordering before you run out. A quick quiz about your age, health, and goals helps the company assemble your first shipment, which is a mixed sample pack. Because of the cost, many people will start elsewhere and find that some nootropics are effective for them. Then, they eventually make their way to Thesis to see the difference a high-end product with targeted formulas can make.

For a closer look at Thesis, check out our complete review.

Focus Factor

Thanks to its low price and extensive ingredient list, Focus Factor is one of the best places for anyone interested in nootropics to get started. Their original formula contains more than 40 ingredients, dramatically increasing the odds that you'll feel some positive effects. It's also undergone clinical testing that showed undeniable improvements in cognitive performance.

Of course, that many ingredients also means that you won't know which ones are making the most significant difference and which might not be doing much. That's one of the things that makes a big ingredient list frustrating. If you're someone who wants something relatively inexpensive that has a high likelihood of working, Focus Factor is a fine pick. But Noocube's more streamlined formula offers a lower risk profile and reduces the potential to ingest ingredients you don't need.

In addition to their original formula, Focus Factor offers extra strength options, kids' nootropics, energy shots, and more. This might make them an attractive choice for parents looking to optimize their kids' academic performance while bolstering their own cognition.

One last benefit Focus Factor offers that Noocube doesn't is a dedicated smartphone app. Focus Factor's app lets you track your progress, play fun cognitive games that can improve your mental performance, and even guide you in thoughtful meditations. It isn't free, and you can pay a monthly or yearly price or opt to pay one large sum that grants you a license for life. And there's a free trial for the app, so you can make sure it's something you'd enjoy.

To get a complete picture of Focus Factor's lineup, read our comprehensive review.

Mind Lab Pro

Mind Lab Pro is probably the closest nootropic to Noocube on the market. Both contain abbreviated B vitamin complexes, choline precursors, bacopa monnieri, tyrosine, and theanine. Both are also caffeine-free. There are a few important ingredient differences, though.

Let's take a look at them side-by-side for a clearer picture:

With its 500mg dose, Lion's mane plays a significant role in Mind Lab Pro's effectiveness. Studies link this mushroom with increased neurite growth, which can help improve learning and memory by encouraging neuroplasticity.

Noocube doesn't boast ingredients with as much scientific backing to increase neurite growth, but their formula has more neuroprotective ingredients like pterostilbene. That means Mind Lab Pro might be better for someone already experiencing age-related cognitive decline, and Noocube could act more as a prophylactic against it.

There are other subtle differences between them, most notably that Mind Lab Pro is soy- and gluten-free, making it the only viable option for anyone with allergies or intolerances.

You can learn more about Mind Lab Pro by reading our dedicated review.

Nootropics FAQ