ProSolution Plus Reviews: A supplement to treat PE?

Premature ejaculation (PE) is a common problem that nearly half of all men face at some point in their lives. As one recent clinical study points out, about 20-30% of men describe it as affecting their relationships and daily lives.1 ProSolution Plus is a nutritional supplement created to help men delay climax, with collateral benefits for sexual performance. Many men understandably find this potential solution appealing because it doesn’t require a prescription. Below, you’ll learn more about PE, how ProSolution Plus tries to help, and whether or not it’s the right choice for you.

ProSolution Plus is a relatively safe way to get help with premature ejaculation and one of the few supplements of its kind on the market. Its ingredients have been the subject of several relevant studies, albeit ones performed primarily on animals. A sponsored triple-blind study of the product in humans shows real promise but needs peer review. Long-term safety is still unknown, so you should proceed with caution and follow your doctor’s advice.

At Innerbody Research, we extensively research each health product we review, speak with customers, test products ourselves whenever possible, and rely on the expertise of professionals to ensure each review is helpful to you.

Our team has pored over more than 150 scientific studies focused on men’s sexual wellness, premature ejaculation, and the various ingredients included in ProSolution Plus. We considered dosages, reports of efficacy, and incidences of adverse effects, then compared those results with the findings we’ve gathered about ProSolution Plus’ peers and competitors.

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy. We will continue to monitor the premature ejaculation landscape and ProSolution Plus to keep this article up to date.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

Typically, when we set out to evaluate a men’s sexual wellness product, we have several dozen similar competitors to reference. We can compare ingredients, doses, and other aspects of their supplements and customer service strategies to help us determine which is best and where a given product falls within the landscape. ProSolution Plus is a little different in that it’s the only complex supplement formulated with premature ejaculation in mind. A few other products out there advertise similar PE benefits, but they often contain one or two ingredients that you could purchase elsewhere for less.

Why more companies haven’t released supplements to extend ejaculation time is unclear. It may have to do with the success of prescription treatments and topical delay products. Whatever the case, when we look into the efficacy and safety of ProSolution Plus, our understanding of its potential is mostly confined to research into its specific ingredients. This is something we take great care to examine, as efficacy and safety are our two most important criteria.

However, many of these ingredients appear in other male enhancement products, which allows us to get a greater sense of their efficacy and the value ProSolution Plus offers as its price points compare to those other products. We believe we can fairly make the same comparison when evaluating convenience, as other male enhancement products are offered with similar customer experiences.

Let’s take a closer look at these criteria to see how we came to regard ProSolution Plus:

Effectiveness

Judging the effectiveness of a product like ProSolution Plus requires more than anecdotal indicators; we compare its ingredients and doses to those used in studies and see if there’s enough variety or quantity of the components present to influence ejaculate latency. We examine studies looking at these ingredients’ neural impact, specifically on serotonin and dopamine — critical aspects of premature ejaculation treatment.2 In other cases, the studies looking into ProSolution Plus’ ingredients focus on sexual performance in general or erectile performance in particular. A few of them — all animal studies — make mention of ejaculate latency.

None of the ingredients in ProSolution Plus meet or exceed the doses used in studies, but that doesn’t necessarily mean they aren’t sufficient. Studies on individual ingredients that used the exact quantities present in ProSolution Plus were unavailable, but there’s no reason to believe that doses smaller than those used in many studies wouldn’t produce similar effects; not all ingredients create strictly dose-dependent outcomes.

The idea behind ProSolution Plus’ formula, and that of so many male enhancement products, is that the mixture will have an effect greater than the sum of its parts. For the most part, it’s rare to find studies mixing these specific herbal ingredients. But ProSolution Plus commissioned a third party to conduct a study on its exact formula, and the results of that study were promising.7 There are some shortcomings to the study that we’ll discuss later, including a dosage mystery and a conflicting source of funds. Still, the research is promising, and it allows us to give a relatively favorable rating to ProSolution Plus’ potential efficacy.

Safety

When investigating a product’s potential safety, we use an approach similar to how we assess effectiveness. We compare its contents to studies that include specific accounting of adverse effects. And we had the advantage of ProSolution Plus’ small-scale clinical trial to reference.

Adverse effects in the ProSolution Plus clinical trial occurred at a higher rate among the placebo group than among those taking the actual formula. All told, less than 2% of participants reported adverse effects.7 These are good numbers — generally superior to PDE-5 inhibitors like Viagra or Cialis and SSRIs like sertraline or paroxetine — and they’re likely attributable to the relatively low doses of each ingredient in ProSolution Plus.

Individual studies of these ingredients paint a slightly different picture. Some studies link ashwagandha to increased thyroid hormone levels, which can lead to hyperthyroidism or even thyrotoxicosis among populations already at risk.3 Ashwagandha can also:

• Increase sleepiness in people on sedatives
• Cause hypotension in people on anti-hypertensive drugs
• Cause hypoglycemia in people on anti-diabetics

And most of mucuna pruriens’ constituent compounds are toxic to humans in sufficient quantities, including its phenols, tannins, and hallucinogenic tryptamines.

Like most male enhancement products, ProSolution Plus seeks to improve erectile performance with several of its ingredients. A common way of achieving this with a supplement is to increase blood flow and nitric oxide production, which can lower blood pressure and make the supplement hazardous to men with low blood pressure or those on medication to control it.

Still, adverse reactions to the individual ingredients in ProSolution Plus are associated with far higher doses than those in the supplement, leading us to believe that it should be safe for most healthy men. Just make sure you talk to your doctor before taking it.

Cost

When we look at the cost of any supplement, we take the price into account first, and then we consider things like bulk or subscription savings opportunities, shipping costs, and return policies. And while ProSolution Plus inhabits a niche all its own, it’s still possible to compare its cost to similar male enhancement products (Test Boost Max shares some of ProSolution Plus' main ingredients) and to prescription SSRIs or topical delay products.

Up against any of those alternatives, ProSolution Plus is expensive. Let’s take a look at a one-month supply of ProSolution Plus compared to these alternatives for the same time period. For the sake of the chart, and to give ProSolution Plus a fighting chance, we’ll double the national average frequency of intercourse from 54 times per year to 108 (or eight times per month).

As you can see, ProSolution Plus is the most expensive option on this list. If the product works for you and you have enough money to spend up-front, you can buy up to a 12-month supply and bring that monthly cost down to around $35, which is still pricier than SSRIs or topical products and is also more expensive than Test Boost Max when you buy that product in bulk.

If you suffer from PE but still want to or already have intercourse several times per week, it’s possible that the cost of sprays or wipes could start to catch up to ProSolution Plus. But this is likely uncommon for most men with clinical PE.

Convenience

For a supplement like ProSolution Plus, we measure convenience by several factors, including quality of website design, shipping logistics, ease of contacting customer service, and dosage. And for the first of these factors, ProSolution Plus is among the worst in its class. We expect a relatively low ceiling of quality for the web design that goes into selling male enhancement products. But even the other offerings from ProSolution Plus’ parent company have better websites. Multiple modules on the ProSolution Plus website are simply broken, including links to the company’s clinical study and drop-down explanations of its ingredients. Of course, every button that could lead you to the purchasing page works like a charm.

From there, things get a lot better. Leading Edge Health has a phone number you can call for various issues and answers, and the ProSolution Plus website has a functioning contact form you can use to establish communication via email. Shipping is pretty straightforward, taking about a week unless you pay for a shorter time frame.

Dosage is also a bright spot for ProSolution Plus. Many men’s sexual wellness supplements force you to take 4-8 pills per dose, which can be frustrating for anyone and nearly impossible if you have trouble taking pills. ProSolution Plus is one of the few to offer its dose in two capsules, without them being meaningfully larger than others.

There are no subscription services like those offered on topical delay products from Promescent, Hims, or Roman, however. That means you have to keep track of your supply and be sure to reorder before you run out.

The clinical definition of PE is somewhat unclear, changing throughout the past century and including different criteria for men with lifelong PE and those with acquired PE.4 Older concepts of PE as a purely psychological issue grounded in Freudian theories about attitudes toward women that develop from the mother outward have largely been put aside. There are still undeniable psychological factors to consider, but as we’ve come to more deeply understand the internal processes involved in normal ejaculation timing, a physiological picture of PE’s underlying cause has been clarified.5

In 2007, the International Society for Sexual Medicine formed an Ad Hoc Committee for the Definition of Premature Ejaculation. The committee defined PE as follows:

• Ejaculation that always or nearly always occurs prior to or within about one minute of vaginal penetration from the first sexual experience (lifelong), or a clinically significant reduction in latency time, often to about 3 min or less (acquired).
• The inability to delay ejaculation on all or nearly all vaginal penetrations.
• Negative personal consequences, such as distress, bother, frustration, or the avoidance of sexual intimacy.

Lifetime PE sufferers have experienced this consistently since their first sexual intercourse. Acquired PE patients would have experienced normal ejaculation latencies up to a certain turning point, which doctors will attempt to trace as part of their diagnosis. Whether acquired or a lifelong condition, if early climax is negatively affecting your relationships, it’s worth investigating some remedies — both for the problem itself and for any underlying causes.

Seeing a doctor to figure out the severity and possible causes of your situation is a necessary first step. Depression, low serotonin or dopamine levels, performance anxiety, penis sensitivity, and relationship stress are all possible causes of PE, especially acquired PE. This condition demands a careful diagnosis to treat. To diagnose you, a doctor will ask questions like:

• Does this happen every time or only sometimes?
• How long have you had these symptoms?
• Are you suffering from anxiety or depression?
• Do you have trouble getting or maintaining an erection too?
• Are you experiencing relationship problems as a result?

Each of your responses will provide clues as to what treatment might work best and what you can do to mitigate the situation quickly. After reading our comprehensive review, we highly recommend speaking to a doctor to help decide if a supplement like ProSolution Plus is the right move for you.

ProSolution Plus is a nutritional supplement designed to ease PE over time. It aims to treat several clinical PE factors like low libido, performance anxiety, erection quality, and ejaculation control. There’s mixed evidence that its ingredients can do this, with some promising studies looking into a few of its ingredients and a lot of small-scale animal research that shows promise but needs to be repeated and eventually shown to be effective in humans.

ProSolution Plus’ parent company, Leading Edge Health, produces a handful of sexual wellness products, mostly targeted at males. The company has multiple male enhancement products, typically containing somewhat similar formulas, but ProSolution Plus is its only supplement marketed as a PE treatment.

Who should consider ProSolution Plus?

Sufferers of PE that affects their daily life and relationships could consider ProSolution Plus, especially if their experience is mild (either occasional PE or events that occur closer to the 60-second mark than the moment of penetration). If you’ve tried other PE remedies like SSRIs or ED meds to no avail or felt severe side effects, ProSolution Plus may be a viable alternative. It likely doesn’t have the same degree of efficacy as prescription treatments would, but there are some men for whom it may prove superior.

Who won't find ProSolution Plus useful?

The first group of men for whom we want to stress ProSolution Plus is not designed is men who have healthy ejaculation latency but still want to last longer in bed. As we’ve discussed, most clinical definitions of PE speak of intercourse lasting less than one minute. So, if you’re already lasting eight minutes but wish you could last 10-15 minutes, ProSolution Plus likely isn’t your best bet. Men in that camp would do better to consider topical delay products like wipes or sprays.

Men with PE related to serious psychological issues might not find ProSolution Plus helpful. One ashwagandha study suggests that it can diminish symptoms of anxiety and depression.6 Still, if your psychological problems are intense enough to cause premature climax, you likely need something more robust.

ProSolution Plus also may not be the answer for men whose PE stems from specific physiological problems like prostate issues. We can’t stress enough that PE is a complex condition with many possible causes. Talking to a doctor before buying ProSolution Plus (or any supplement designed for PE) is essential.

ProSolution Plus employs many of the same ingredients you’ll see in other men’s sexual wellness supplements, mostly ones geared toward erectile performance and libido, not necessarily PE. There are some links between ED and PE, which makes sense of these included ingredients, but ProSolution Plus includes a few components you don’t typically see in male enhancement products.

Of the seven active ingredients in ProSolution Plus, five have been shown to support healthy dopamine and serotonin activity, both of which are linked to pleasure and control over ejaculation. Selective serotonin reuptake inhibitors (SSRIs) are the go-to prescription treatment for premature ejaculation. Doses used in studies are usually much larger than what you’ll find in ProSolution Plus, and most of that research has been done in animals, but the act of combining them may have a synergistic effect. Without dedicated research into ProSolution Plus’ formula, that would be hard to say for sure, which is likely why the company commissioned a clinical study for its product.

ProSolution Plus clinical study

The American Journal of Therapeutics published a triple-blind, placebo-controlled clinical trial including two doses of the ProSolution Plus formula alongside a similar formula that had piper longum and Anacyclus pyrethrum added to it.7 Participants measured improvements according to standardized rubrics for erectile function, sexual satisfaction, and premature ejaculation. According to the ProSolution Plus website, the results showed a 64% reduction in premature ejaculation and a 67% increase in erection maintenance.

Unfortunately, there are some shortcomings with the published study that call these numbers into question. For starters, while the ingredients listed in the formula researchers investigated match those in ProSolution Plus, the study never specifies the doses used. The only reference the study gives to dosage is that one set of participants received a low dose, and the other received a high dose. What that means is a mystery. The lower dose actually performed better across all parameters than the high dose or the formula with added ingredients, but that still doesn’t tell us how much of it participants took.

Another significant issue with the study is that the data reporting lacks nuance, and the numbers provided don’t necessarily mesh with the claims on the website. Premature ejaculation was evaluated using the Index of Premature Ejaculation (IPE), which consists of 10 questions — four covering ejaculation control, four for sexual satisfaction, and two for distress. Each question has a range of five answers, with five being the best outcome for each. A perfect score would be 50 points, but scores are often adjusted to a scale of 0-100.

The only score provided in the study is the total score for the IPE at baseline and after 60 days for four groups (low dose, high dose, augmented formula, and placebo). None of the scores listed support ProSolution Plus’ claim of a 64% reduction in premature ejaculation, but it’s possible that number came from the IPE scores dealing exclusively with control and not satisfaction or distress. The study does not get into such specifics.

Our last gripe with this study is that Leading Edge Health (ProSolution Plus’ parent company) was the sole source of funding. The study describes various means by which researchers attempted to avoid bias, but it’s difficult to rule out that concern completely when the funding source represents such a direct conflict of interest.

ProSolution Plus ingredients

The results of the company’s commissioned study are promising, but given the important missing pieces of information about that study, we’d like to turn to the science behind each of ProSolution Plus’ ingredients to help verify or contradict what that study claims. Very few of these ingredients have been studied specifically for their effect on premature ejaculation. But, armed as we are with the knowledge of PE’s psychological and physiological factors, we can confidently infer from existing research how each is meant to help men last longer in bed.

Let’s take a closer look at each ingredient:

In the ProSolution Plus study, only 2% of participants experienced headache or heartburn, with no cases of flushing or dizziness reported. Compared to the 8-18% occurrence of all those symptoms in Viagra and Cialis trials, that would be a significant step toward safety. But ProSolution Plus is not analogous to those treatments. It may be fairer to compare it with SSRIs — a common prescription treatment for men with PE — or delay sprays (a topic, over-the-counter option to combat PE by gently numbing the penis).

Delay sprays are safe and pose basically no risk of side effects as long as:

• You use them as directed, meaning that you spray sparingly and wait the appropriate length of time before engaging in sexual activity.
• You and your sex partner have no allergies to benzocaine or lidocaine (as the case may be).

Allergies to topical benzocaine or lidocaine collectively happen in about 2.4% of the population (though being allergic to one of them doesn’t mean a person is allergic to the other).31 Putting that in perspective as an alternative to ProSolution Plus, this rate of allergic reaction to delay sprays will therefore be roughly the same as the rate at which people experienced side effects in ProSolution Plus’ study. But this isn’t meant to suggest that the side effects or allergic responses are comparable or similar in any way beyond how frequently they happen.

Meanwhile, this SSRI study reported that 38% of participants experienced some side effects. Changes in sexual functioning, sleepiness, and weight were the most common three. While that makes ProSolution a comparatively safe alternative, there are two things you should be aware of before you try it.26

ProSolution Plus may lower blood pressure and cause light-headedness if you’re already on blood pressure medication. People with diabetes may want to be careful since ProSolution Plus can shift your blood sugar levels, as well.

Shilajit is one potentially worrying ingredient. A clinical study discovered that 20% of shilajit supplements produced in the US and India contained heavy metals, including lead, mercury, and arsenic.27 This often results from low-quality extraction processes and a lack of oversight in testing. Some early signs of heavy metal contamination to be mindful of are rashes, increased heart rate, and dizziness.

An FDA letter from 2017 discovered unmarked additions of sildenafil in a counterfeit version of ProSolution. It’s unclear who the distributors in question are and how these counterfeit products made it to store shelves. But we strongly recommend buying directly from ProSolution Plus to ensure you’re getting the real deal.

ProSolution Plus offers progressive savings with bulk purchases that top off at nearly 50% with a 12-month order. There are more levels available here than from any of the other men’s sexual wellness supplements we cover. Most companies offer four or five levels compared to the seven options you get with ProSolution Plus. The company might not have the cheapest supplement in its class, but it does offer the most flexibility.

Here’s how the pricing breaks down:

The vast majority of ProSolution Plus’ competitors used to have similar shipping fees, which would often disappear at higher bulk levels. But those companies — including other brands sold by Leading Edge Health, ProSolution Plus’ parent company — have largely done away with this structure and have begun offering free shipping on all purchases regardless of quantity. ProSolution Plus is far behind the times on this account.

67-day money-back guarantee

ProSolution Plus offers a 67-day money-back guarantee on your purchase. The idea is that you can try the product for two months to see if it works for you and still have a week to set up a refund if you’d like. This is a standard return window for products made by Leading Edge Health, but it’s both shorter than most competitors in the male enhancement space and too short for many nutritional supplements to begin working. Two months is often the minimum to see effects, with 8-12 weeks being a more common timeline we’ve seen in the research.

Test Boost Max, a testosterone booster that shares some ingredients with ProSolution Plus, offers a lifetime guarantee on its product while costing less and boasting higher doses of ashwagandha and Tribulus terrestris than ProSolution Plus. However, it doesn’t have some of ProSolution Plus’ other dopamine- and serotonin-supporting ingredients like Mucuna pruriens.

ProSolution Plus could be a good value for some men looking for alternatives to traditional PE treatments. It’s on the pricey side, and there are clear issues with its shipping fees, website design, and ingredient doses. But the small-scale study of its efficacy and safety at least points toward a possibility that it can help.

If you aren’t sure ProSolution Plus is suitable for you, you’d be wise to consider other options first. There are several pathways to travel here, from other nutritional supplements to prescription drugs and topical numbing agents. Each has its benefits and drawbacks, so let’s take a closer look at them,

Similar men’s health supplements

While ProSolution Plus bills itself first and foremost as a way to combat premature ejaculation, it also offers benefits more commonly seen among male enhancement pills. These include improved erectile performance and increased libido. If you compare ProSolution Plus’ formula to that of many male enhancement pills, you’ll see a significant crossover of ingredients like Tribulus terrestris, shilajit, and ashwagandha.

That doesn’t necessarily mean that these other supplements will work for premature ejaculation. If anything, they can work against the symptoms of erectile dysfunction that are sometimes linked to PE. If you’re looking for a male enhancement pill that has the potential to treat PE, you’ll want to find one that also contains the kinds of dopamine-enhancing ingredients found in ProSolution Plus.

Here’s a quick look at a pair of male enhancement products that we’ve found to contain a few of the same ingredients in ProSolution Plus that might influence PE:

SSRIs

Selective serotonin reuptake inhibitors (SSRIs) allow extra serotonin to flow through your body. SSRIs are among the earliest prescription treatments for PE, and their efficacy is well-documented.30

However, SSRIs can cause side effects and react poorly with certain medications. One of the most common side effects, reported by as much as 25% of users, is sexual dysfunction. So, while SSRIs may help you with premature ejaculation, there’s a roughly one-in-four chance they’ll also prevent you from getting an erection, which would certainly work against your goals.

There’s also the issue of approaching your doctor about PE, which can be embarrassing. Fortunately, several online services can provide you with doctor consultations, prescriptions, and even delivery to treat your PE with the utmost privacy.

Popular SSRIs for treating PE include:

• Sertraline (generic for Zoloft)
• Paroxetine (generic for Paxil)
• Fluoxetine (generic for Prozac)
• Clomipramine (generic for Anafranil)
• Citalopram (generic for Celexa)
• Dapoxetine (generic for Priligy)

If you’re curious about using an SSRI to treat your PE, we recommend visiting Hims, where you can get sertraline or paroxetine if you qualify. You can also visit Roman, but Roman offers only sertraline. For PE treatments like this, HIms and Roman are ideal for men who:

• Don’t have insurance
• Have insurance, but it doesn’t cover SSRIs for PE.

Men with sufficient insurance coverage will likely pay less going through their insurance than they would using a telehealth provider like Hims or Roman.

As one example, both sertraline and paroxetine through Hims or sertraline from Roman start at $24/month. One United Healthcare plan we looked into covered a 90-day supply for just $23 — roughly a third of the cost of going the Roman or Hims routes.

Delay sprays and wipes

Provided you aren’t allergic to benzocaine or lidocaine, delay sprays and wipes are likely the safest way to combat premature ejaculation.31 These are topical products you apply to your penis before sex to provide you with a mild numbing sensation. You’ll still be able to feel everything, but the sensation won’t be quite as intense.

Most delay sprays are made with lidocaine, while most wipes are made with benzocaine, but this isn’t true across the board.

Here’s a quick look at our favorite delay products and their key details. We based the cost per use for sprays on the average number of sprays it took us to reach effective numbing in testing. Our effectiveness rating is not a reflection of numbing power, per se, but rather our estimation of the balance between effective numbing and the preservation of sensation.

One of the biggest advantages of topical delay products over supplements or prescriptions is that you don’t have to take something every day, and there is very little risk of side effects. Some users report some skin discomfort, and we advise anyone to talk to their doctor before using topical delay products to double-check for any allergies to numbing agents.

A significant downside to delay wipes is their application, which can be messy and time-consuming. It typically takes 10-15 minutes for the numbing to set in. Also, you need to be sure that your penis is dry before intercourse begins, or you might spread some of that numbing agent to your partner.

You can learn more about these products by checking out our guides to the best PE wipes and best delay sprays.