Innerbody Labs NAD+ Support Review

Aging takes a toll in ways seen and unseen.1 Among the unseen changes your body endures through the years, few things have as profound an effect on your longevity as your cellular health. Raising your nicotinamide adenine dinucleotide (NAD+) levels may be central to improving cellular health and safeguarding your healthspan.2

But taking NAD+ directly doesn’t seem to do the trick, mainly due to poor oral bioavailability.3 That’s where precursors to NAD+, like nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), can make a big difference. Which one to take remains a lingering question, but some companies have begun combining the two precursors into a single supplement to maximize their potential.

One of those supplements is NAD+ Support from Innerbody Labs, a combination of NR and NMN alongside several ingredients that aid in NAD+ production efficiency. In this review, we’ll break down the science behind this formula to help you decide if NAD+ Support is right for you.

NAD+ Support is built around a combination of NMN and NR, sustainably increasing NAD+ levels while improving the likelihood you’ll experience the known secondary benefits of both precursors. Its high TMG and spermidine doses provide additional longevity benefits while also keeping the salvage pathway — your body’s main NAD+ production system — from running out of fuel for its conversion processes or having its byproducts misappropriated to form unhelpful compounds. Ultimately, there’s no other product on the market that provides this thoughtful combination of ingredients and doses for NAD+ maintenance and longevity.

At Innerbody Research, we carefully scrutinize every product and service we review, including the wide variety of NAD+ boosters on the market. Innerbody Labs is the product arm of Innerbody Research, and it was our years spent investigating the NAD+ research landscape that led us to a couple of realizations:

• Too many NAD+ products provided insufficient doses to align with research into NAD+ precursors’ varied potential benefits.
• Too many products lacked ingredients that can safeguard NAD+ production efficiency.

As a result, Innerbody Labs developed NAD+ Support. We’re confident that it’s the best NAD+ product available, but we also aim to be honest about its role in the marketplace. It’s not going to be the right choice for everyone, and we’ll point out when that’s the case and discuss available alternatives that we’ve tried for ourselves and can recommend.

Additionally, like all health-related content on this website, this guide was thoroughly vetted by members of our Medical Review Board for accuracy and will continue to be monitored for updates by our editorial team.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

To honestly evaluate Innerbody Labs NAD+ Support, we had to compare it to the wide variety of competitors on the market and rate it for the same criteria we apply when reviewing those competitors. These typically include effectiveness, safety, cost, and convenience, as they prove to be the most common concerns for the average consumer seeking a NAD+ booster.

Let’s take a close look at each criterion to see how NAD+ Support measures up.

Effectiveness

NAD+ Support contains two NAD+ precursors that both effectively raise NAD+ levels. Research has shown that NR doses as low as 100mg and NMN doses as low as 300mg can increase blood NAD+ after a single administration.4 5 In both cases, increases appear to be dose-dependent, with higher doses leading to greater NAD+ concentration up to around 1,200mg of either precursor. NAD+ Support provides 400mg of NR and 700mg of NMN — higher than the average dose of either — for a combined dose of 1,100mg.

However, there’s evidence that this increase in NAD+ production tapers off after 2-3 months of supplementation. In one NMN study, NAD+ levels peaked at week eight but tapered off by week 12.6 And an NR study in 140 participants saw NAD+ levels peak at 14 days and drop slightly by day 56 in all three dose groups (100mg, 300mg, and 1,000mg). 4

The likeliest culprit of NAD+ precursors’ time-limited efficacy lies in the metabolic process they affect most directly: the salvage pathway. We’ll go way deeper into the mechanics of the salvage pathway later in this guide, but the fundamental issue with NAD+ precursors is that, by increasing NAD+ levels, they also increase the byproducts of NAD+ utilization, which recycle back into the salvage pathway and demand more fuel to turn into NAD+ once again.7

Without adding the appropriate fuel alongside a given NAD+ precursor, the works eventually gum themselves up. Innerbody Labs puts this fuel back into the process by providing a 500mg dose of trimethylglycine (TMG) in every serving. Also known as betaine, TMG acts as a critical methyl donor to NAD+ production, ensuring the salvage pathway continues to operate at an increased pace.8 The added 15mg of spermidine plays a similar role, staving off an enzyme that could hijack NAD+ byproducts out of the salvage pathway and convert them into unhealthy metabolites.9

Rounding out the formula, 10mg of BioPerine is twice the dose that was shown in one impressive study to increase NMN absorption and conversion to NAD+ by around 15%.10 That increases the efficacy of the 700mg NMN dose to that of an 805mg dose. It may increase NR efficacy by a similar margin, though direct data for that have not been established.

Safety

Innerbody Labs NAD+ Support gets high marks for safety for a number of reasons. For one, as we discussed above, the inclusion of spermidine in the formula helps prevent NAD+ byproducts from being misappropriated. Specifically, we’re referring to spermidine’s ability to suppress nicotinamide N-methyltransferase (NNMT), which can turn nicotinamide (NAM, a byproduct of NAD+ use) into 1-methylnicotinamide, a substance associated with fat accumulation and insulin resistance.11

NAD+ Support also introduces a little extra safety by splitting its precursor dose between NMN and NR and by keeping that combined dose within safe limits. Research has shown that NR doses up to 2,000mg/day and NMN doses up to 1,200mg/day are safe and yield only occasional GI side effects.12 13 NAD+ Support’s 400mg of NR and 700mg of NMN together equal 1,100mg total — more than most competitors’ precursor totals without reaching into unsafe territory.

Finally, Innerbody Labs subjects all of its supplements to rigorous third-party testing and publishes the results on each product page. Other companies take similar steps, including Neurogan and Nootropics Depot, but Innerbody Labs is the only one among them to include a clinically relevant amount of spermidine alongside such a well-calibrated precursor dose.

Cost

We measure cost as distinct from value. If we’re just talking about value, then we would take the other three criteria here into account, and that would muddy the discussion of pure cost. Looking purely at cost, NAD+ Support fares well, especially on the basis of cost-per-gram of NR or NMN. However, there are several NAD+ boosters with a lower barrier to entry if you don’t have the capital to purchase multiple bottles at once.

Here’s a handy chart that breaks it down:

As you can see, Innerbody Labs has a better cost per gram of precursor than about half of the field. The brands with lower precursor costs-per-gram either have higher total dose costs or lack other useful ingredients to sustain increased NAD+ production.

Convenience

While convenience is a somewhat subjective measure, certain things are objectively assessable, like customer support, money-back guarantees, capsule size, regimen, and dose flexibility.

Where Innerbody Labs’ convenience really comes through is in its regimen and the dosing flexibility it creates.

Each serving is three capsules, which you can divide to titrate up from a single capsule that, per most research, should be at least a little effective in its own right. The two-capsule dose is even more effective, aligning with a wealth of research for NAD+ boosting and benefits from spermidine, BioPerine, and TMG. Here’s what that breakdown looks like.

Competitors typically provide doses closer to the middle column, so there isn’t a lot of room for effective titration.

In addition, Innerbody Labs offers very responsive customer service through phone and email, though it lacks the convenient chat support that Renue by Science and some others offer. It also has a relatively standard 30-day money-back guarantee, which may lag behind Renue by Science (60 days) and ProHealth Longevity (100 days) but beats the nonexistent guarantees of Nootropics Depot and Tru Niagen.

Innerbody Labs NAD+ Support is a complex supplement formulated to increase NAD+ levels, boosting cellular health and promoting longevity through the various primary and secondary effects of its ingredients. It contains five ingredients in all, two of which are direct NAD+ precursors, another two of which promote healthy and sustained NAD+ synthesis in the body, and the last of which improves nutrient absorption overall.

Here’s a quick look at the ingredient bill:

• NMN: 700mg
• NR: 400mg
• TMG: 500mg
• Spermidine: 15mg
• BioPerine: 10mg

Before we get into the science behind these ingredients and their roles in NAD+ production, it would help to examine why someone might want to raise their NAD+ levels in the first place.

NAD+ is a coenzyme that helps fuel and manage metabolic activity in the mitochondria — the portion of a cell that turns the food you eat into energy. That energy powers everything from muscle contractions to neural signaling, and healthy mitochondria tend to keep healthy cells. As you age, NAD+ levels decline, creating an imbalance between NAD+ and NADH.14 An overabundance of NADH is seen both in aging patients and in people after a night of heavy drinking, so it's related to both acute inflammation and illness and chronic, long-term physical decline.15 16

It stands to reason that restoring balance between NAD+ and NADH, or even having a greater abundance of NAD+, could reap anti-aging benefits. To date, the benefits seen in studies looking at increased NAD+ levels include:17

• Bolstered cellular health
• Anti-aging support
• Increased energy
• Strengthened heart health
• Improved cognition
• Better sleep
• Faster healing

So, how do the ingredients in Innerbody Labs NAD+ Support increase NAD+ levels?

NAD+ Support relies on the two most well-regarded and widely studied NAD+ precursors available: NMN and NR. It also includes a pair of ingredients with impressive track records in longevity research: TMG and spermidine.

Here’s how those four ingredients — and a fifth, BioPerine — have performed in NAD+ and longevity research:

Taken together, these five ingredients have the potential to increase NAD+ production, provide secondary benefits associated with both NMN and NR, deliver longevity enhancements from spermidine and TMG, and prevent a drop-off in NAD+ production often seen in long-term precursor supplementation.

Some competitors include similar ingredients in their formulas, like AEON from Perpetua.Life. AEON also combines NR with NMN and includes TMG, spermidine, and black pepper fruit extract. However, in all but the last of those ingredients, AEON’s doses are less than half of what Innerbody Labs offers.

A crash course in NAD+ production

Understanding how the ingredients in NAD+ Support come together to increase NAD+ levels sustainably requires some understanding of NAD+ metabolism.

NAD+ precursors almost all rely on one metabolic system for NAD+ production: the salvage pathway. The other two pathways for producing NAD+ are the Preiss-Handler and de novo synthesis pathways, which rely on dietary vitamin B3 and tryptophan, respectively, and only account for about 15% of all NAD+ production.2 That means that 85% of all NAD+ production occurs via the salvage pathway.7

Here’s what the salvage pathway looks like in action, with inputs illustrated for supplemental NR, NMN, TMG, and spermidine:

In the salvage pathway, NAM combines with 5-phosphoribosyl-1-pyrophosphate before becoming NMN, then turning into NAD+. When you take NMN, it jumps ahead of NAM and turns into NAD+ directly. When you take NR, it turns into NMN before becoming NAD+.2

You’ll notice TMG and spermidine in the diagram above, as well. TMG’s role is in fueling NAM’s conversion to NMN. Without enough methyl donors like TMG in the picture, increases in NAD+ production can fade after around 12 weeks.8

Meanwhile, spermidine fends off NNMT, which is trying to divert a bit of NAM from the salvage pathway and repurpose it for what ultimately might do more harm than good.9 11

With these four ingredients in supplement form (NMN, NR, TMG, and spermidine), NAD+ production can increase and sustain itself.

Why combine NMN and NR?

As we alluded to above, NMN and NR enter the salvage pathway at different points. They also rely on different processes and transporters to get into cells before becoming NAD+.3 By supplementing with both, NAD+ production efficiency should be greater than if you were to supplement with just one or the other.

The only problem with this hypothesis is that it hasn’t been tested directly. There aren’t any studies pitting combined precursor administration against a monotherapy of one or the other.

Despite the data that’s missing from the research landscape, there are compelling reasons to combine precursors, and they come from the studies of each individual ingredient: NMN research has revealed certain secondary effects that NR studies haven’t produced, and vice versa.

For example, NMN’s abilities to improve sleep and telomere length haven’t been reproduced in NR studies.19 20 And NR’s ability to improve biomarkers of neurodegenerative disease hasn’t been reproduced in NMN research.21 It’s entirely possible that these effects are linked more to increased NAD+ levels than to either precursor, but if you look at where the science is today, taking both should offer a greater range of potential benefits than taking just one.

Innerbody Labs NAD+ Support is ideal for anyone concerned with aging and age-related NAD+ decline. At this point, exact rates of decline are still being studied, making it hard to determine when you really need to worry about your NAD+ levels. Several papers have connected NAD+ decline with middle age, with 45 being the point when significant declines become evident.14

That point in time tracks with a more recent paper illustrating two distinct periods in life when aging takes a jump in most people: at around 44 and around 60 years of age.28 So, NAD+ Support is probably best suited to anyone 40 and above, though it may also provide protective benefits to younger people concerned with their eventual decline.

Who might want to look elsewhere?

As we just discussed, NAD+ levels are likely rather high in most young adults, making an NAD+ booster less of an ideal supplement for them. There are also some areas where NAD+ boosters have shown promise but lack a wealth of research behind them.

For example, while NR has shown potential to improve certain biomarkers of neurodegenerative disease, it isn’t a prime candidate for treating dementia. Similarly, although NMN has the potential to improve sleep, it isn’t a better choice than a good OTC sleep aid.

At best, NAD+ boosters could serve as supportive aspects of a multipronged approach to tackling these issues in consultation with your doctor. For now, boosting NAD+ levels remains the primary target of NMN, NR, and Innerbody Labs NAD+ Support.

Innerbody Labs clearly considered the available research when formulating NAD+ Support, as its combined precursor dose comes in at just under the 1,200mg level that’s been shown safe for NMN consumption.13 The same can be said when comparing it to NR doses reaching above 2,000mg with safe results.12 Even with the 15% boost in NMN efficacy provided by BioPerine, and assuming that a similar boost applies to NR, you only get to an equivalent precursor dose of 1,265mg.10

The other ingredients all have good safety profiles, including:

• TMG, which boasts research showing safety at five times the amount included in NAD+ Support24
• Spermidine, toxicity studies of which show no adverse effects at doses as high as 6.5g/day for 90 days, more than 400 times the dose seen here29
• BioPerine, research into which has illustrated safety at numerous doses, including the 10mg in NAD+ Support27

All that said, there are some unanswered questions surrounding any NAD+ precursor’s long-term safety, especially as it relates to cancer risk, with research seeming to point in opposite directions. Some research has pointed toward NAD+ restrictions as a potential therapy to starve tumor growth, implying that excess NAD+ could do the opposite, fueling tumor growth in already present cancer.30 However, other research has shown that increased NAD+ levels inhibit tumorigenesis in the first place.31

It’s possible that both are true: that NAD+ can inhibit initial tumor growth and also increase tumor intensity if levels rise after a tumor has formed. Much more research is needed in this field, and it makes it all the more important for you to talk with your doctor before adding any NAD+ precursor to your regimen.

Innerbody Labs employs both subscription and bulk discounts on its NAD+ Support, allowing you to save a little money by subscribing, then more if you opt for larger, more infrequent shipments. Here’s how it works out:

All orders from Innerbody Labs ship for free, whereas most competitors (Neurogan, Renue by Science, Nootropics Depot) add shipping charges unless you subscribe or meet certain thresholds. However, Innerbody Labs only ships domestically within the United States. International customers would do better looking into Renue by Science or Perpetua.Life for complex NAD+ booster formulas.

You also get a 30-day money-back guarantee from Innerbody Labs. Competitors Nootropics Depot and Tru Niagen don’t offer any kind of guarantee, while Neurogan and Perpetua.Life offer the same 30-day promise. That said, Renue by Science offers a 60-day guarantee, and ProHealth Longevity protects your purchase for up to 100 days.

Whether you’re not sure that NAD+ Support is the right product for your cellular health or you want to approach your anti-aging and general wellness efforts from a different angle, there are undoubtedly plenty of choices out there. Here, we’ll discuss a few direct competitors and look at alternative solutions for your health goals.

Other NAD+ boosters

We’re confident that the combination of ingredients in NAD+ Support is the best route to sustained NAD+ increases and the health benefits that accompany them, but there are good reasons that someone might want an alternative for their NAD+ needs. It could be a question of affordability, as there are certainly some less expensive NAD+ boosters out there. It could also be a desire to start with a single-ingredient approach — if only to see how the isolated ingredient affects you — even if the research indicates that your NAD+ levels might plateau or even drop off after around 12 weeks of use.

Here’s a brief look at some of the top competing NAD+ boosters that make viable alternatives to NAD+ Support:

Other NAD+ boosting and longevity strategies

Outside of traditional NAD+ precursors, there may be effective ways to elevate NAD+ levels. And beyond that, there are additional things you can do to improve your healthspan and longevity — strategies you can combine with NAD+ boosting to maximize your results.