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Cove Migraine Review: Your Answer for Migraine Relief?

The pros, cons and everything you need to know about Cove migraine treatments and subscription service

Last Updated: Feb 1, 2021

Cove review

Migraine is a common and debilitating condition. Some people are surprised to learn that migraine is the 3rd most common health condition in the world; globally over one billion people suffer from migraines, while in the United States alone 39 million people struggle to cope with it. No migraine sufferer would be surprised that it ranks 6th most debilitating among all known illnesses. When a migraine strikes, nine in ten people find that it totally disrupts their work and normal routines.

In spite of the pain, nausea, and vision changes, many people put off going to the doctor, leave the migraine untreated, or opt for treatments that are not effective enough. But thankfully, medicine and technology are improving fast, with many companies now trying to tackle this problem.

Cove, the only telemedicine company dedicated to migraine, has rapidly grown to offer more than 20 clinically proven migraine treatments. The company’s selection includes acute and preventative medications, supplements, and even an FDA-approved device. A licensed doctor makes sure you’re getting the right treatment for your needs, and the treatment is delivered to your door every month.


  • Wide selection of expert-recommended, FDA-approved treatments
  • Offers effective prescription treatments for both acute pain relief and prevention
  • Personalized treatment plans based on your specific needs and migraine history
  • Ongoing access to a licensed doctor with experience treating migraine
  • 24/7 doctor access
  • Reliable delivery that ensures you never run out of medication
  • You can use your favorite local pharmacy if you prefer
  • Phone helpline is very useful when migraine sufferers need to reduce visual stimuli
  • Right now Cove is offering our readers an exclusive 60% off your first order.


  • Can’t be used to treat other types of headaches, like cluster headaches
  • Not useful if your migraines aren’t frequent enough to require monthly medication deliveries
  • Insurance isn’t accepted unless you’re prescribed Nurtec ODT (though pricing is lower than what you typically pay at a pharmacy)
  • Not for patients under age 18

Bottom line

If you are a migraine sufferer, we strongly suggest you try Cove. Cove offers a variety of research-backed migraine treatments at affordable prices. The company assigns you a licensed doctor who works with you to find the right treatment plan for you and then follows up to make sure the treatment is working. Also, convenient monthly deliveries make running out of medication a thing of the past.

Our Top Picks


Cove provides an immensely valuable service for migraine sufferers, without trips to the doctor or pharmacy. EXCLUSIVE: Get 60% off your first order!

With unparalleled access to doctors who have extensive experience treating migraine, a Cove subscription is a true bargain. Cove provides over 20 treatments that are proven effective. Cove can deliver the best migraine treatment plan for you.

Acute Relief Treatments
Reviewed by Innerbody Research
Preventative Treatments
Reviewed by Innerbody Research
Dietary Supplements
Reviewed by Innerbody Research

There are many reasons why doctors recommend Cove. This company has created a thoughtful, effective and very valuable service for the many people suffering from migraine. Whether you have found effective treatment already or need help finding treatments that work, we like their approach and recommend that you give it a try.

Why you should trust us

Innerbody Research recently celebrated its 20-year anniversary online. Over the past two decades, we have helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

We extensively test each health service we review, including Cove. We try our best to give you, our readers, an unbiased exploration of at-home health services, free of marketing jargon or gimmicks. We evaluate the service based on our adherence to quality, the latest medical evidence and health standards, and a simple question: would we buy the product or service ourselves if it weren’t part of our job, and would we recommend it to family and friends?

Additionally this review of Cove, like all health-related content on this website, was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

What is Cove?

unboxing a Cove migraine medication

Cove is a telemedicine company with a single focus: helping people with migraine. They’re migraine specialists, offering over 20 different treatments – including prescription medications, dietary supplements, and an FDA-approved device – in order to comprehensively address acute pain relief, migraine prevention, and nausea associated with migraine.

Working with Cove means that you will get a treatment plan tailored specifically for you. Cove achieves this level of service by pairing you with a doctor who will virtually help you in a dedicated role. For just $4 a month, you will enjoy limitless messaging with your Cove migraine doctor.

Cove’s thorough online consultation, which you fill out before placing your first order, includes the same kinds of questions that a neurologist would ask during an in-person visit – but without the travel time and appointment fees. Unlike a typical doctor, your Cove doctor can be contacted at any time for no additional charge. And the company’s subscription model means never having to pick up your medication at the pharmacy. (If you prefer to pick up from your local pharmacy, however, Cove lets you do it.)

Cove’s doctors are all board-certified and specialize in treating migraines.

How Cove works

Getting started with Cove migraine treatment is very straightforward – here are the steps:

Step 1: Choose a plan

Some of us already know what kind of treatment has worked very well in the past and are hoping for convenient access to the treatment, without having to go to a doctor’s office or pharmacy. Cove can facilitate that! Just go to Cove and select the plan you feel works best.

But for those of us who aren’t sure what treatment plan is right for us, we can indicate that we’re not sure and would like to speak with a doctor who can advise which path we should take.

Step 2: An online consultation

Set aside about 20 minutes in total for this consultation. This is more time than what some initial telemedicine consultations require and is absolutely time well spent. We were impressed and feel that when it comes to online medical consultation, you often get out what you put in. Your consultation involves answering questions about your migraine and medical history and also includes a portion for video uploads. Be thorough and forthright in this phase, so that you provide the doctor with as much valuable information as possible.

One of Cove’s licensed doctors – all of whom have vast experience treating migraines – will review the information you provided. Based on this assessment, the doctor will determine the best treatment plan specifically for you.

Step 3: Begin treatment and adjust as needed

Once you approve the plan, you will be able to begin immediately. Assuming you opted for the most economical and convenient option of treatment delivered straight to you, Cove will ship your treatment (3-5 days) and you can begin.

As your treatment proceeds, you may find the need to make a change in your treatment plan. No problem – your affordable Cove subscription provides 24/7 access to medical advice from migraine specialists, with unlimited messaging. Cove will help you tailor your treatment plan so that it works best for you.

This is why Cove’s subscription model is so valuable.

Cove subscription

What do you get for $4 per month? For starters, you get Cove migraine treatments delivered straight to your door each month – no trips to the doctor or pharmacy necessary. But you also get a level of access to medical attention for migraine that many would find totally staggering.

For every 80,000 migraine sufferers, there’s only one doctor specializing in migraine treatment. And migraine is notoriously tricky to treat, requiring calibration and fine-tuning.

Were it not for the subscription service that Cove provides, how likely is it that all of us could find a migraine specialist AND get the level of medical attention necessary to arrive at the best possible treatment plan? How long would that process take, scheduling follow-ups that fit not only into our busy schedules but also occur at times of availability for the migraine specialists who are so scarce?

Cove’s subscription service solves this problem with unlimited messaging each month and 20+ treatment options, many available only via prescription. With Cove, you will be able to treat acute pain effectively. And for those suffering frequent and severe migraine, prescriptions are available to prevent migraine before it happens or lessen the severity when it does.

Cove’s 4 product lines

Cove’s product lines for migraine treatment fall into four categories:

  • Acute medications for pain and nausea relief
  • Preventive medications that, as the label suggests, are taken in ongoing fashion to prevent migraine from happening or at least lessening the severity of migraine when it does happen
  • Dietary supplements that evidence suggests are important in combating migraine
  • Neuromodulation device (Nerivio), which is a totally unique and fascinating approach capable of both acute relief and prevention

Acute medications

Acute medications relieve migraine symptoms as soon as an attack begins. Cove’s prescription acute medications include triptans, NSAIDs, anti-nausea medications, an anti-CGRP treatment, and an over-the-counter pain reliever.


NSAIDs (non-steroidal anti-inflammatory drugs) are common pain relievers that include drugs like aspirin, ibuprofen and naproxen. You might know them by brand names like Advil, Aleve, Motrin and others. While some NSAIDs are available over the counter, many require prescriptions.


Triptans are tryptamine-based medications used to treat both migraine and cluster headaches. By stimulating the serotonin in your brain, this type of medication decreases the inflammation and constricts your blood vessels to produce effective relief within 30-90 minutes.

Anti-nausea medications

Migraine sufferers often experience aura, which is a disturbing and sometimes completely debilitating visual phenomenon that can be accompanied by nausea and even speech difficulties. Cove’s anti-nausea medications, often taken alongside acute pain relievers, help people overcome this double-whammy effect by bringing relief from the nausea.

Anti-CGRP treatment

CGRP (calcitonin gene-related peptide) is a substance that the body releases around the brain. The headache pain of many migraine sufferers is actually caused by this CGRP release, which inflames the brain’s meninges (the outer membrane covering the brain). Anti-CGRP medications interfere with CGRP’s release and effects, and thus reduce or stop the inflammation and pain.

Preventive medications

These are medications you take every day to make migraine attacks happen less often. Cove offers beta blockers, anticonvulsants, and antidepressants that are clinically proven to reduce the frequency of migraine headaches.

Beta blockers

Beta blockers are medications – often prescribed for cardiovascular issues like hypertension – that block adrenaline from binding to beta receptors, thereby keeping your heart rate and blood pressure lower. Examples include propranolol and metoprolol.


Anticonvulsants, typically prescribed to prevent conditions like seizures, have shown to be effective for those with migraine as well. They soothe the excited nerve cells in your brain, which otherwise could be triggered and set off the series of events that cause a migraine.


A drop in the levels of serotonin has been proven to play a role in migraine. Antidepressants like amitriptyline regulate serotonin levels and, for some people, keep serotonin at a healthy enough level to prevent migraine.

Over-the-counter supplements

Certain dietary supplements have been shown to reduce migraine frequency in clinical trials, including magnesium, CoQ10, and riboflavin. You can order all three through Cove without having to complete the consultation.


Supplementing with magnesium is beneficial for some migraine sufferers, helping to prevent migraine or reduce the severity. Magnesium plays a role in disrupting the wave of nerve signals that set off a migraine. But it’s also a vital nutrient for cardiovascular health, and a surprising number of us don’t absorb sufficient amounts of magnesium from our diet.


CoQ10 (or coenzyme Q10) reduces the level of a protein called CGRP, which is elevated during a migraine. By reducing the CGRP levels in the body, it seems CoQ10 supplementation can be an effective preventative measure for some with migraine – studies also suggest this to be true.


Riboflavin (also called vitamin B2) has been shown to help prevent or reduce the severity of migraine at very high doses (which are nonetheless apparently safe, since excess B-vitamins are simply removed from the body through the kidneys and urination). The mechanism by which B2 helps prevent migraine is not currently known.

Neuromodulation device

Nerivio device

Nerivio is an FDA-approved wearable migraine treatment device. It uses electrical signals to relieve migraine symptoms during an attack, and can even stop one altogether. It is a medication-free treatment.

Worn on your upper arm and controlled by your smartphone, Nerivio works by sending electrical signals that disrupt the pain messages being sent through your brain. A 2019 study proved the device to be effective for stopping headache pain in over one-third of participants.

Nerivio is a non-invasive treatment, not an implant. Ordering through Cove is the easiest way to get your hands on this innovative migraine treatment.

What causes migraines?

Causes of migraine likely include genetic and environmental factors, but it’s a complex picture that truly varies from person to person. This is why treating migraine can be so challenging for people – and why a service like Cove is so valuable, with easily accessible migraine experts available to help develop a tailored treatment approach that suits you.

Common causes of migraine include an assortment of factors:

  • Environmental and behavioral factors, often called migraine “triggers”
  • Brainstem and trigeminal nerve changes
  • Imbalances in neurotransmitters like serotonin and CGRP (calcitonin gene-related peptide)
  • Hormonal changes sometimes related to a woman’s menstrual cycle
  • Dietary insufficiencies

A migraine attack is brought about by a triggering or activating event, which can be a multitude of possible factors. But once triggered, nerve cells in the brain send signals to the massive trigeminal nerve and also to blood vessels which dilate across the brain’s surface. This signaling event is often called a cortical spreading depression.

Migraine triggers

Migraine triggers are an incredibly diverse group of substances, activities, or environmental conditions that migraine sufferers identify as inciting elements, triggering a migraine like clockwork. Here are just a few examples of things that can commonly trigger migraine:

  • Certain drinks (like wine or coffee)
  • Foods like aged cheese and high-sodium (or high-MSG) meals
  • Changes in daily behavioral patterns (for instance, skipping a meal or getting less sleep)
  • Stress
  • Stimuli like certain bright lights or loud noises
  • Even sexual activity or changes in the weather

What triggers one person’s migraine may have no effect at all on someone else.

Does Cove have any side effects or other downsides?

There are possible side effects from treatments offered by Cove. Cove only provides treatments with evidence of success in treating migraine, but every individual is different and prescription medications require a prescription for good reason.

Consultation with a doctor is very important when taking prescription medication for any condition, because of the possibility of side effects and because not every person is a suitable candidate for a prescribed medication.

During your initial consultation, Cove migraine doctors will identify safe treatments that are not contraindicated for you given your symptoms, medical history, health conditions, and current medications. If the doctor recommends treatment, you’ll also be able to review information about how the treatment works and if there are potential side effects.

As you begin and continue treatment, you will be able to watch for those side effects or any other questionable experiences. The beauty of Cove’s subscription service is that it enables you to share questions or concerns with a truly experienced migraine specialist throughout treatment, at any time.

How we evaluate health service companies

At Innerbody Research, we customize our evaluation criteria depending on the type and nature of the health-related service. For Cove and other health services and products, we have five areas that we use for our evaluations, including:

Quality: How well does the company deliver its core service(s) to the customer? For testing services, does the company adhere to the latest and most advanced testing technologies and achieve a very high degree of accuracy? For non-testing telehealth services, is the quality of the service high enough that we would recommend it to loved ones without hesitation? If not, why not?

User-friendly: How intuitive and user-friendly is the service? Does the device/program/app/website achieve a good degree of user-friendliness for its customers?

Value: Are you getting your money’s worth? Are there any hidden costs or charges? Does the company offer discounts?

Privacy: If health data is stored, will your data be stored securely? Are payments secure?

Customer support: Particularly in situations where ‘one size fits all’ doesn’t make sense, how well does the company help to make the service ideal for you?

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