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Best Inositol Supplement

Inositol may support metabolic health, PCOS, and fertility — but which supplements actually reflect the research? We compare the top options to find out.

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Last updated: Feb 20th, 2026
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Lineup of the best inositol supplements, including Life Extension, Fairhaven Health, Wholesome Story and BulkSupplements

Photo by Innerbody Research

Inositol is best known for its role in polycystic ovary syndrome (PCOS), and for good reason. It’s one of the few supplements supported by human research suggesting it may help support insulin sensitivity, ovulatory function, and hormonal balance in people with the condition. As a result, many people first encounter inositol while searching for options to manage PCOS symptoms.

But PCOS isn’t the only context where inositol has been studied, nor is it the only reason people take it. Because insulin signaling affects both metabolic and reproductive function, researchers have also explored inositol’s use in areas like metabolic health, fertility, and pregnancy care.

As interest has grown, so has the number of inositol supplements on the market. Some closely match the doses and forms used in clinical research, while others fall short. In this guide, we break down what the research actually supports, where inositol appears most useful, and which supplements best reflect the evidence.

If you’re short on time, you can start with our summary of recommendations below — or keep reading to see how we evaluated each option.

Summary of recommendations

Our Top Pick

Life Extension provides convenient dosing flexibility of the right form of inositol at a price that is tops among capsules.

Myo-inositol is the form of inositol to seek, and that’s what Life Extension provides in its third-party-tested product, and it’s easy to titrate your dose upward. You can find the product on Life Extension’s website or in online marketplaces like Amazon and iHerb. Buying direct from Life Extension saves you the most money, while Amazon is more affordable than iHerb at this time.

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Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make informed decisions about their health and wellness.

Our team thoroughly evaluates every product and service we review — including the inositol supplements featured in this guide. We analyzed dozens of peer-reviewed studies, clinical trials, and expert reviews on inositol, examining how different forms and doses affect insulin signaling, metabolic health, PCOS-related outcomes, fertility, and pregnancy support.

Alongside this research, we evaluated the leading inositol supplements on the market, comparing their formulations, dosing strategies, ingredient quality, and transparency against what’s been used in human studies. We also purchased and tried the most promising products ourselves to better assess real-world factors like dosing practicality, tolerability, and overall user experience.

As with all health-related content on our site, this guide has been reviewed by members of our Medical Review Board for accuracy and balance, and it will be updated as new research and products emerge.

How we evaluated the best inositol supplements

When we set out to identify the best inositol supplements, we focused on the same factors most people consider before adding a product to their routine:

  • Effectiveness
  • Safety
  • Cost
  • Convenience

These four considerations guided our evaluation.

In the sections that follow, we explain how each of our top inositol picks performed in these areas and where certain products stood out. All of the supplements we selected met a high standard overall; when we highlight an “advantage,” it reflects a specific strength rather than a shortcoming in the others.

Effectiveness

Advantage: Life Extension Inositol Caps

When we looked at effectiveness, we started with a simple question: does this supplement provide the form and amount of inositol that’s actually been studied in people?

Inositol isn’t a single compound. Several forms exist, but myo-inositol (MI) is the most common form in the human body and the one used in most clinical research. It plays an important role in insulin signaling and cellular communication, which is why it has been studied for metabolic health, PCOS, fertility, and pregnancy-related outcomes.

Across human studies, myo-inositol is most often used in daily doses between 2,000mg and 4,000mg, typically split into two servings. Reviews and meta-analyses report improvements in insulin sensitivity, glucose regulation, and reproductive markers at these levels in specific populations.

We gave Life Extension Inositol Caps the effectiveness advantage because it makes working within these research-backed ranges straightforward:

  • Each capsule provides 1,000mg of pure MI
  • It’s easy to adjust intake over time, based on individual needs
  • There are no extra ingredients to complicate dosing

That flexibility matters. Some people do well starting lower, while others may benefit from gradually increasing their intake — and a simple, single-ingredient formula makes that much easier.

Some inositol supplements take a more targeted approach. For example, Wholesome Story’s Myo-Inositol & D-Chiro Inositol + Folate combines MI with D-chiro-inositol (DCI) in a 40:1 ratio, a balance that has been studied specifically in people with PCOS. It also includes folate, which is commonly paired with inositol in PCOS research.

But for broad, evidence-aligned effectiveness — especially for general metabolic support or insulin sensitivity — a straightforward MI supplement at a clinically relevant dose remains the most versatile option, which is why Life Extension earns the edge here.

Safety

Advantage: Life Extension Inositol Caps

Inositol has a strong safety profile and has been studied at doses well above what you’ll find in most supplements. Across clinical trials — including studies using up to 4,000mg per day — adverse effects are generally mild and uncommon, with gastrointestinal discomfort reported most often.

Because inositol is a naturally occurring compound found throughout the body, safety concerns tend to be less about the ingredient itself and more about formulation quality and unnecessary additions. For that reason, we paid close attention to both testing practices and ingredient simplicity.

Life Extension earns the safety edge here because its products are third-party tested for purity and potency, and its inositol formula is intentionally simple. It contains only MI, without added herbs, stimulants, or secondary active ingredients that could increase the risk of interactions or side effects. That simplicity also makes it easier to adjust dosing gradually, which can help minimize digestive discomfort for sensitive users.

Cost

Advantage: BulkSupplements Inositol Powder

BulkSupplements earns the cost advantage because its inositol powder combines a low base price with extremely high serving counts — an important factor for a supplement like inositol that’s typically taken in gram-level doses. In clinical studies, those doses are commonly delivered either as powders or as capsules, and neither format has consistently shown better results than the other.

A 1-kilogram bag of BulkSupplements MI costs $31.97 as a one-time purchase. Even after adding the $9.95 shipping fee, that works out to roughly $0.08 per day at a 2g dose, or about $0.17 per day at 4g. Buying larger sizes lowers the per-day cost further, and orders over $59 ship free, which makes BulkSupplements especially appealing for long-term use.

Among capsule options, Life Extension Inositol Caps is the most economical. Each capsule provides 1,000mg of MI, and a bottle of 360 capsules costs $38.48 (plus $5.50 shipping). That puts a 2g daily dose at about $0.24 per day, with 4g closer to $0.49 per day — still significantly more than powder, but reasonable for those who prefer capsules.

Complex formulas with additional active ingredients change the picture. Wholesome Story’s Myo-Inositol & D-Chiro-Inositol + Folate costs about $1.00 per day, while Fairhaven Health’s OvaBoost comes in closer to $1.33 per day. At that point, you’re not just paying for inositol — you’re paying for the added ingredients and the specific formulation.

The takeaway is straightforward: BulkSupplements powder delivers the most inositol for the lowest cost. That price advantage becomes more pronounced at the gram-level doses commonly used in research. Capsule products cost more in exchange for convenience, and combination formulas cost more still because they include additional active ingredients beyond inositol.

Insider Tip: BulkSupplements also lists its inositol on Amazon, where Prime shipping can eliminate the $9.95 delivery fee and lower the per-serving cost.

Convenience

Advantage: Life Extension Inositol Caps

While inositol is generally easy to take, convenience can vary by form and formulation. Powders require measuring and mixing, while multi-ingredient blends can make titration more complicated, since increasing or lowering your dose affects several ingredients at once.

Life Extension Inositol Caps stands out for three practical reasons:

  • Simple, flexible dosing: Each capsule provides 1,000mg of MI, making it easy to take 1g, 2g, or higher amounts without measuring powders or introducing additional ingredients. This flexibility is especially helpful for people easing into inositol or adjusting intake based on tolerance or goals.
  • Subscription savings and easy reordering: Life Extension’s subscription option reduces the bottle price from $38.48 to about $35.55, saving roughly $3 per bottle, while allowing users to set delivery intervals that match their dosing schedule. This helps avoid both running out and over-ordering. Additionally, subscribing earns you free shipping on your purchase.
  • Generous return policy: A one-year money-back guarantee provides ample time to assess whether inositol is helping you reach your goals.

For people who prefer not to take capsules, BulkSupplements Inositol Powder may be more convenient, but its return policy is more restrictive. Opened products may be eligible for only a partial refund, typically capped at the price of the smallest package size, which makes larger purchases riskier.

Taken together, Life Extension earns the edge on convenience for most users.

How our top inositol supplement picks compare

The chart below shows how our top recommended inositol brands compare in terms of cost, servings, composition, and other factors that may influence your purchase decision.

Life Extension Inositol CapsWholesome Story MI + DCI + FolateFairhaven Health OvaBoostBulkSupplements Inositol Powder
2g inositol servings per container1803030500
Container price (one-time)$38.48$29.95$34.95$31.97
Price per 2g$0.24$1.00$1.33$0.08
Shipping fee$5.50 (free with subscription or over $50 purchase)$5.50 (free over $40 purchase)$4.95 (free over $35 purchase)$9.95 (free over $59 purchase)
Additional active ingredientsNo
No
Third-party tested?
Not every batch
Vegan
Money-back guarantee?Yes, one yearYes, 90 daysNo, refunds only on unopened productsNo, limited partial refunds

What is inositol?

Inositol is a naturally occurring, sugar-like compound (often called a “sugar alcohol”) that your body uses to help build cell membranes and transmit signals inside cells. It’s present in virtually all living tissue, and you get it from both internal production and food sources (especially beans/legumes, whole grains, nuts, and some fruits). While you’ll sometimes see it labeled “vitamin B8,” inositol isn’t considered a true vitamin because the human body can synthesize it.

The term inositol refers to a group of nine stereoisomers (same atoms, arranged differently). In supplements and clinical research, two forms show up most often:

  • Myo-inositol (MI): the most abundant form in the body and diet, and the most commonly studied form in supplements.
  • D-chiro-inositol (DCI): a less abundant form that the body can produce from MI via an enzyme-driven conversion process; it’s also used in supplements, often combined with MI.

This "multiple forms" point matters because MI and DCI don't appear to behave identically in all tissues, and many trials (especially in reproductive and metabolic contexts) specify the exact isomer used.

What does inositol do in the body?

Inositol is best understood as a structural building block and a signaling helper:

It helps form cell membranes

Myo-inositol is a key component of phospholipids (notably phosphatidylinositol), which are foundational parts of cell membranes. From there, these membrane components can be modified into signaling molecules that help cells respond to hormones and other cues.

It helps cells communicate internally

Cells use inositol-containing compounds (including inositol phosphates — signaling molecules derived from cell membranes) as part of major signaling networks that influence many processes across the body. This is one reason inositol shows up in research across metabolic health, reproduction, and even neurochemistry.

How do inositol supplements work?

After you take an inositol supplement — most commonly MI, sometimes combined with DCI — the compound is absorbed in the small intestine and enters the bloodstream. From there, it’s taken up by tissues throughout the body, where it can be incorporated into cell membranes or converted into inositol-derived signaling molecules.

Unlike many nutrients that act primarily as cofactors or antioxidants, inositol’s effects are largely tied to cell signaling. Inositol-containing molecules form part of the phosphatidylinositol signaling system — a network that helps cells respond to hormones, including insulin, and regulate downstream metabolic and reproductive processes.

Because these signaling pathways influence insulin sensitivity, glucose handling, ovarian function, and even neurotransmitter activity, researchers have explored inositol supplementation across several clinical contexts. Importantly, while mechanistic data are strong, human outcomes vary by population, dose, and form, and many findings remain modest or preliminary.

The mechanisms most often discussed in the literature fall into a few overlapping categories.

Insulin signaling and glucose metabolism

The most widely studied role of inositol supplements relates to insulin signaling. Inositol-derived molecules (sometimes referred to as inositol phosphoglycans) appear to act as secondary messengers in insulin pathways, helping cells respond more effectively to insulin’s signal.

In human trials, MI supplementation has been associated with improvements in insulin sensitivity, fasting glucose, and postprandial glucose handling in certain populations — including people with insulin resistance and pregnant individuals at risk of gestational diabetes. Meta-analyses suggest a reduction in gestational diabetes incidence when inositol is used preventively, though authors consistently note the need for larger, higher-quality randomized trials before firm clinical recommendations can be made.

Ovarian function and hormone signaling

In ovarian tissue, MI plays a role in follicle-stimulating hormone (FSH) signaling and oocyte maturation. DCI, meanwhile, appears more involved in insulin-mediated androgen production. Because these roles differ, some researchers propose that the balance between MI and DCI may matter, particularly in polycystic ovary syndrome (PCOS).

Clinical trials in people with PCOS have reported improvements in ovulation frequency, menstrual regularity, and some metabolic markers with inositol supplementation. However, systematic reviews emphasize that many studies are small, heterogeneous, and of variable quality, and that more rigorous trials are needed before drawing strong conclusions.

Body weight and cardiometabolic markers

Beyond glucose control, inositol has been studied for broader metabolic effects. Some randomized trials and pooled analyses report modest reductions in body mass index (BMI), triglycerides, total cholesterol, LDL cholesterol, and blood pressure with inositol supplementation.

However, these outcomes are difficult to interpret in isolation. Many studies do not fully control for dietary intake, physical activity, or concurrent lifestyle changes — all of which independently affect weight and cardiometabolic risk. As a result, reviewers generally describe these findings as suggestive rather than definitive.

Neurotransmitter signaling and mental health (emerging evidence)

Inositol is also involved in signaling pathways in the brain, including those related to serotonin and other neurotransmitters. This has led to research interest in psychiatric conditions such as panic disorder, obsessive-compulsive disorder, and depression.

Small clinical trials have reported symptom improvements at relatively high doses (often 12–18g per day), but results have been inconsistent, and large, well-controlled studies are lacking. Most reviews conclude that while the mechanistic rationale is plausible, the current evidence is insufficient to support routine use of inositol for mental health conditions.

Inositol supplements appear to work by supporting intracellular signaling rather than acting as a direct hormone or drug-like agent. In practical terms, this means inositol doesn’t “force” a response; it helps cells respond more appropriately to signals that are already present.

This helps explain both their appeal — and their limitations. In situations where signaling pathways are impaired, such as insulin resistance or certain reproductive conditions, inositol may help restore more normal cellular responses and produce measurable benefits in some people. Where those pathways are already functioning well, the effects tend to be small or absent.

Inositol dosage

Clinical studies on inositol have tested a wide range of daily doses, with most human research clustering around 2,000–4,000mg per day of MI, often divided into two doses. This range appears most consistently across studies examining insulin sensitivity, metabolic outcomes, and reproductive health, including PCOS and gestational diabetes research.

Unlike vitamins or minerals with established recommended daily allowances (RDAs), there is no official RDA for inositol. Dosing guidance instead comes from clinical trial precedent. Across reviews and meta-analyses, benefits — when they appear — tend to emerge at gram-level intakes used in human studies, not at the tens or hundreds of milligrams sometimes seen in general supplements.

When DCI is included, it’s usually provided in much smaller amounts, often alongside MI. Many PCOS-focused trials use a 40:1 ratio of MI to DCI, which mirrors the physiological balance observed in healthy ovarian tissue.

At a practical level, inositol dosing can be grouped by how it’s been studied:

General metabolic and insulin support

Most trials examining insulin sensitivity, fasting glucose, or metabolic risk factors use 2,000–4,000mg per day of MI, split into two doses. Meta-analyses suggest this range may modestly improve insulin resistance and glycemic markers in certain populations, though effects are not universal.

PCOS and reproductive health

In PCOS research, the most common protocol is 2,000mg of MI taken twice daily (4,000mg total), sometimes paired with 50–100mg of DCI in a 40:1 ratio. Studies using this approach report improvements in ovulation frequency, menstrual regularity, and some metabolic markers, though reviewers consistently note variability in study quality and outcomes.

Gestational diabetes research

Preventive trials in pregnancy typically use 2,000–4,000mg of MI per day, often started in the first trimester. Several meta-analyses suggest a reduced incidence of gestational diabetes with this dosing strategy, but authors emphasize that evidence quality is moderate and that further large-scale randomized trials are needed before universal recommendations can be made.

Psychiatric research (high-dose, limited evidence)

Studies exploring inositol for panic disorder, obsessive-compulsive disorder, or depression have used much higher doses — often 12,000–18,000mg per day. While some small trials reported symptom improvement, results have been inconsistent, and these doses are far higher than those used for metabolic or reproductive purposes. Most reviews do not recommend high-dose inositol for mental health outside of clinical supervision.

Across contexts, higher doses do not consistently produce stronger effects. Reviews note that most observed benefits occur within commonly studied ranges, while gastrointestinal side effects — such as bloating or loose stools — become more common as intake increases.

For that reason, most evidence-based supplement protocols fall within the 2–4g per day range, which reflects the doses most often studied in humans and balances potential benefit with tolerability.

Are inositol supplements safe?

Inositol supplements are generally considered safe and well-tolerated for most healthy adults. Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.

A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects — specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea. The authors also noted that the severity of these effects did not increase with higher doses.

At the lower doses most often used in metabolic and reproductive research (typically 2–4g per day), inositol is described as well-tolerated across reviews, with gastrointestinal discomfort reported infrequently and primarily as intake increases toward the upper end of studied ranges.

When side effects do occur, they are typically:

  • Mild
  • Dose-related
  • Limited to the gastrointestinal tract

These effects appear more likely at higher intakes and are often manageable in practice by using lower doses or spreading intake across the day.

However, certain groups may want to exercise additional caution.

Pregnant or breastfeeding individuals

Inositol has been studied during pregnancy (especially for gestational diabetes prevention), and meta-analyses have not identified major safety concerns at typical study doses. Even so, pregnancy and breastfeeding are situations where supplementation should be individualized, so it’s best to consult a healthcare provider before starting inositol.

People prone to gastrointestinal upset

Because inositol is a sugar alcohol, higher intakes can contribute to gastrointestinal discomfort in some individuals. If you’re sensitive, starting lower and increasing gradually may improve tolerability.

Overall, inositol has a strong safety profile, especially when used within the 2–4g per day range most commonly studied in human trials.

Who are inositol supplements for?

Inositol supplements are best suited for adults interested in supporting insulin signaling and metabolic health, especially in situations where impaired glucose handling may affect hormone balance, ovulatory function, or fertility. Its potential benefits stem from its role in intracellular signaling pathways that influence insulin sensitivity and ovarian function — mechanisms that underlie many of the outcomes studied in clinical research.

Although inositol is often associated with PCOS, much of the research points to metabolic signaling as the common thread, with reproductive and fertility-related benefits often building on those effects. More specifically, the following groups are most likely to see benefit from consistent use:

People with insulin resistance or metabolic risk factors

Because inositol-derived molecules participate in insulin signaling, supplementation has been studied in people with insulin resistance, impaired glucose regulation, and related metabolic risk. Systematic reviews and meta-analyses report modest improvements in fasting glucose, insulin sensitivity, lipid markers, and blood pressure in some populations, particularly at doses between 2–4g per day.

Overall, the magnitude of these effects tends to be modest.

People with polycystic ovary syndrome (PCOS)

Many of inositol’s studied benefits in PCOS appear to stem from its effects on insulin signaling, which plays a central role in the condition’s metabolic and reproductive features. Meta-analyses and systematic reviews report that MI — alone or combined with DCI in a 40:1 ratio — may help support ovulation frequency, menstrual regularity, insulin sensitivity, and some hormone-related markers in people with PCOS.

That said, responses vary, and improvements tend to be gradual rather than dramatic.

People seeking fertility or egg-quality support

Inositol has been studied in fertility and assisted reproductive settings, where it appears to support oocyte maturation and ovarian responsiveness — particularly in people with PCOS or insulin-related reproductive dysfunction.

Some studies report improvements in egg quality and fertilization outcomes with consistent use, though evidence is strongest in PCOS populations and more limited in people without underlying metabolic or hormonal concerns.

Pregnant individuals at risk for gestational diabetes

Several clinical trials and meta-analyses suggest that myo-inositol supplementation during pregnancy may reduce the risk of gestational diabetes in people who are already considered higher risk.

Because pregnancy is a unique physiological state, decisions about inositol supplementation during pregnancy should be made with guidance from a healthcare professional familiar with your medical history.

Overall, inositol works best as a supportive tool, not a quick fix. Its effects tend to be most noticeable in people with underlying metabolic or signaling disruptions — such as insulin resistance or PCOS — and more subtle in those with normal metabolic and reproductive function.

Who are they not for?

Inositol is one of the more promising supplements in the hormone-and-metabolism space, but it isn’t a cure-all. The benefits seen in research are highly context-dependent, with the most consistent effects appearing in people with underlying insulin resistance or PCOS-related metabolic disruption. Even in these groups, reviews emphasize that results can vary.

If any of the points below sound familiar, it may help to reset expectations before supplementing.

People expecting a guaranteed PCOS “fix”

Inositol is commonly recommended for PCOS, and some trials show improvements in ovulation and metabolic markers. But a recent systematic review and meta-analysis conducted to inform international PCOS guideline updates concluded that the evidence supporting inositol for PCOS is limited and inconclusive.

That doesn’t mean it can’t help — it means outcomes aren’t predictable, and it shouldn’t be positioned as a reliable stand-alone solution.

People looking for rapid weight loss or dramatic metabolic change

Inositol can modestly improve insulin signaling and related markers in some people, but it’s not a stimulant and it doesn’t “flip” metabolism overnight. Across reviews, the changes tend to be small, and not everyone responds. If someone is hoping for clear weight loss or a large reduction in blood-sugar markers from a single supplement, inositol is unlikely to meet that expectation.

People who want to self-treat gestational diabetes

Inositol has been studied for gestational diabetes prevention, and some meta-analyses suggest it may reduce risk in higher-risk pregnancies. But the research is not definitive enough to treat it as a substitute for prenatal care or glucose monitoring, and pregnancy is not the setting for DIY experimentation. If inositol is used during pregnancy, it should be part of a plan coordinated with a clinician who’s following the pregnancy closely.

People using inositol primarily for mental health support

Inositol has been studied in psychiatric contexts (like OCD and panic disorder), but trials often use very high doses (e.g., 12–18g/day), and results are mixed. Reviews generally describe the evidence as limited and not strong enough for routine use — especially without clinician oversight. For most readers, this is not the best starting point for addressing anxiety or mood concerns.

Inositol tends to make the most sense when the goal is supporting insulin signaling and related reproductive function over time — not when someone is expecting a fast, guaranteed, or dramatic change.

Life Extension Inositol Caps

Best for general health

A shot of the Life Extension Inositol supplement bottle

Photo by Innerbody Research

Pros

  • Provides a clinically relevant dose of myo-inositol in a simple, single-ingredient formula
  • Well suited for metabolic support
  • Manufactured in NSF-registered, GMP-compliant facilities
  • Third-party tested for purity and potency
  • Flexible subscription intervals (1–12 months)
  • 365-day money-back satisfaction guarantee

Cons

  • Requires multiple capsules to reach higher clinical doses
  • Not formulated with D-chiro-inositol for PCOS-specific protocols

Founded in 1980 and headquartered in Fort Lauderdale, Florida, Life Extension is one of the most established supplement brands in the U.S. The company is known for transparent sourcing, clinically aligned formulations, and strong quality controls. All Life Extension products are manufactured in NSF-registered, GMP-compliant facilities and undergo independent third-party testing, with certificates of analysis available upon request.

Life Extension’s Inositol Caps use a single ingredient: myo-inositol (MI). This is the most abundant and biologically active form of inositol in the body, and the form most often used in human research. MI plays a central role in how cells communicate with one another — especially in pathways tied to insulin signaling and reproductive hormone function.

Because of that biology, MI has been studied most extensively for:

  • Metabolic support, particularly insulin sensitivity
  • Cell signaling, where it helps cells respond properly to hormonal signals
  • Reproductive function, including ovarian signaling pathways

From an effectiveness standpoint, the single-ingredient approach here is a strength. Across human trials looking at metabolic health and reproductive outcomes, MI is overwhelmingly the form of inositol used, typically at daily intakes between 1 and 4 grams. The 1g capsule format makes it easy to start at a lower dose and increase gradually, which many people find more comfortable for long-term use.

If your goal is general health support — rather than a targeted PCOS protocol — MI alone is often enough. Its safety profile is well established in long-term human studies, where it has been consistently well tolerated with few reported side effects. That makes Life Extension Inositol Caps a practical, evidence-aligned option for everyday use.

Pricing, subscriptions, and shipping

A bottle of Life Extension Inositol Caps costs $38.48 and contains 360 capsules. One-time purchases under $50 incur a $5.50 shipping fee. Subscribing reduces the bottle price by 8% and removes shipping costs entirely. Subscription deliveries can be scheduled at any interval from 1 to 12 months, offering the most flexible delivery options among brands featured in this guide.

Here’s how the pricing breaks down:

Total costTotal capsulesCost per capsule
One-time purchase$38.48360$0.11
Subscription (8% off)$35.55360$0.10

Refunds and guarantees

Life Extension stands out for its 365-day money-back guarantee, which applies even to opened bottles. Customers can request a full refund at any point within one year of purchase, making this one of the lowest-risk options in the inositol category.

No other company featured in this guide offers a guarantee of comparable length. Wholesome Story is the closest competitor, but its money-back window is limited to 90 days — roughly one quarter of Life Extension’s coverage.

Wholesome Story Myo-Inositol and D-Chiro Inositol Capsules (with Folate)

Best for PCOS

A shot of the Wholesome Story supplement bottle

Photo by Innerbody Research

Pros

  • Uses a 40:1 ratio of myo-inositol to D-chiro-inositol, considered ideal for PCOS
  • Adds folate, which is frequently paired with inositol in PCOS and fertility research
  • Includes vitamin D3, a nutrient commonly low in people with PCOS
  • Clean Label Project–certified
  • Third-party tested
  • 10% off with subscription
  • 90-day money-back guarantee

Cons

  • A full daily serving requires four capsules
  • The additional ingredients can make upward titration less flexible
  • No free shipping on orders under $40

Wholesome Story is a women’s health–focused supplement company founded in 2016, with a product lineup centered on PCOS, fertility, and hormone-related support. That focus is clear in this formula. Rather than offering MI alone, Wholesome Story builds a PCOS-specific blend around how inositol signaling appears to function differently in people with PCOS.

In PCOS, research suggests that the balance between MI and D-chiro-inositol (DCI) can become disrupted, particularly at the ovarian level. Higher relative amounts of DCI may impair oocyte quality, even while supporting insulin signaling elsewhere in the body. This insight led researchers to explore a 40:1 MI:DCI ratio, which more closely reflects physiological conditions and aims to support both metabolic and ovarian signaling without overloading DCI.

That rationale drives the structure of this formula. A full daily serving provides 2,000mg of MI paired with 50mg of DCI, preserving the 40:1 ratio most often used in PCOS studies. Clinical trials using this ratio have reported improvements in metabolic and endocrine markers, and it has been incorporated into research informing international PCOS guidelines — though outcomes vary.

In addition to inositol, the blend includes:

L-methylfolate (500mcg)

Folate frequently appears alongside inositol in PCOS and fertility research, particularly in studies focused on ovulatory function and assisted reproduction. Trials comparing MI plus folate with folate alone have reported improvements in oocyte and embryo parameters. Wholesome Story uses L-methylfolate (MTHF), the biologically active form of folate, which does not require conversion in the body and is often chosen in reproductive-health formulations.

Vitamin D3 (25mcg / 1,000IU)

Vitamin D insufficiency is common in PCOS and has been linked to insulin resistance and metabolic dysfunction. Supplementation has been studied for modest improvements in insulin sensitivity and related markers, particularly in individuals who begin with low vitamin D status. The 1,000IU dose included here is above the recommended dietary allowance but remains well below established upper intake levels for adults, making it appropriate for ongoing daily use with a low risk of oversupplementation.

One additional consideration is dosing flexibility. In PCOS research, MI is commonly studied at daily intakes between 2g and 4g, depending on the population and outcome measured. Wholesome Story’s standard serving delivers 2g, which aligns well with many clinical trials. The label also allows for two daily servings (4g total), placing intake at the higher end of the studied range.

Because this is a combination formula, increasing to two servings also doubles folate (to 1,000mcg) and vitamin D3 (to 2,000IU). Both amounts remain within established safety thresholds for most healthy adults. Still, it’s worth keeping in mind — especially for people who already supplement folate or vitamin D separately — that combination products offer less flexibility when adjusting servings.

Taken together, for someone seeking a streamlined, research-aligned PCOS option — rather than a general wellness inositol — Wholesome Story’s blend may be a strong fit.

Pricing, subscriptions, and shipping

Wholesome Story’s bottle costs $29.95 for 120 capsules (30 servings), since a full serving is four capsules. Subscribing reduces the price by 10% to $26.96. A larger bottle with 360 capsules costs $74.95, or $67.46 with a subscription.

Shipping is $5.50 unless your order exceeds $40, at which point shipping is free. Subscription deliveries can be scheduled every one, two, three, or four months.

One practical downside is that higher-dose use doesn’t align neatly with these intervals. If you take two servings per day, the 120-capsule bottle lasts just 15 days, and even the 360-capsule bottle lasts about 45 days, which can make timing subscriptions less convenient unless you plan ahead or reorder manually.

Total costTotal servingsCost per servingShipping
One-time (120 caps)$29.9530$1.00$5.50
Subscription (120 caps)$26.9630$0.90$5.50
One-time (360 caps)$74.9590$0.83Free
Subscription (360 caps)$67.4690$0.75Free

Refunds and guarantees

Wholesome Story offers a 90-day money-back guarantee on up to three bottles, full or empty, with customers responsible only for return shipping. That’s a strong policy for the supplement category and should give most people enough time to assess tolerance and potential symptom improvement related to PCOS.

The only company featured in this guide with a longer guarantee is Life Extension, which offers a 365-day satisfaction policy.

Fairhaven Health OvaBoost

Best for female fertility and egg quality

A shot of the Fairhaven Health OvaBoost supplement bottle

Photo by Innerbody Research

Pros

  • Fertility-focused formula built around IVF-related research
  • Made in the USA in a GMP-registered manufacturing facility
  • Third-party tested
  • 10% off with subscription
  • Vegan-friendly

Cons

  • Includes melatonin, which may make daytime dosing less practical for some users
  • Some ingredients, such as ALA, are included at doses lower than those most often used in clinical studies
  • Titration to higher inositol doses can be difficult due to the combination formula
  • A full daily serving requires four capsules
  • Return policy only covers unopened products

Fairhaven Health is a fertility-specialist brand with a long-standing focus on supplements for people trying to conceive — both women and men. That focus is clear in OvaBoost, a fertility stack designed around egg quality, oxidative stress support, and IVF-style outcomes.

A full daily serving of OvaBoost (four capsules) provides the following active ingredients:

  • Myo-inositol (MI): 2,000mg
  • Alpha-lipoic acid (ALA): 150mg
  • Vitamin E: 67mg
  • Grape seed extract: 60mg
  • Coenzyme Q10 (CoQ10): 30mg
  • Melatonin: 2mg
  • Folate (as L-methylfolate): 340mcg

At the center of the formula is MI (2,000mg per daily serving) — a dose that aligns with how inositol is commonly used in fertility research. Notably, Fairhaven pairs this core ingredient with melatonin and folate, a combination that has been studied in women undergoing IVF. Some trials suggest improvements in oocyte quality and select pregnancy-related outcomes in certain populations.

In addition, the formula includes:

CoQ10 (30mg)

Coenzyme Q10 (CoQ10) frequently appears in egg-quality discussions because of its role in mitochondrial energy production and oxidative stress defense. In women undergoing assisted reproductive technologies (ART), CoQ10 supplementation has been associated with improved ovarian response and embryo-quality measures in controlled studies, and meta-analyses suggest improvements in clinical pregnancy rates.

While many studies use higher doses (typically around 200–600mg per day), one meta-analysis suggested that 30mg taken for three months prior to fertility treatment may still be relevant, giving this dose some clinical context.

Alpha-lipoic acid (150mg), grape seed extract (60mg), and vitamin E (67mg)

This combination forms the formula’s antioxidant backbone. The rationale is straightforward: oxidative stress is a recurring theme in egg-quality research, and these ingredients are included to support antioxidant capacity.

For alpha-lipoic acid and grape seed extract, fertility-specific human data are earlier-stage and largely supportive or mechanistic rather than definitive. In human studies where these ingredients are evaluated for metabolic or antioxidant effects, the doses used are typically higher — often around 300–600mg per day for alpha-lipoic acid and 100–200mg per day for grape seed extract — which suggests their role here is complementary rather than central. The vitamin E dose (67mg) is a common supplemental amount, well above the adult recommended daily allowance (RDA) of 15mg and still far below the established upper limit of 1,000mg per day.

One practical consideration is dose flexibility. With a combination product like this, titration can get tricky. While many fertility- or PCOS-focused inositol protocols use 2g per day, some go up to 4g. OvaBoost’s label structure makes that less flexible, since increasing the inositol dose also increases melatonin, antioxidants, and folate simultaneously.

Melatonin is likely the limiting factor. While doubling the other ingredients would generally remain within reasonable ranges — and might even be beneficial for ALA or grape seed extract — increasing melatonin to 4mg per day may cause drowsiness in some users.

That said, from an overall effectiveness standpoint, Fairhaven’s design makes sense if you’re looking for a single, once-daily formula that mirrors how many fertility studies are structured.

Pricing, subscriptions, and shipping

OvaBoost is sold as a bottle of 120 capsules (30 servings). Fairhaven offers a 10% discount through subscription, with delivery options every one, two, three, or four months. Free shipping applies to orders over $35; otherwise, shipping costs $4.95 — and unfortunately, a single bottle falls just $0.05 below that threshold.

The cost breaks down as follows:

Total costTotal servingsCost per serving
One-time purchase$34.9530$1.17
Subscription purchase$31.4630$1.05

At one serving per day, the bottle lasts 30 days, which aligns well with monthly replenishment. If you’re attempting to push closer to 4g per day by doubling servings, the bottle lasts just 15 days, making subscription timing and inventory management less convenient.

Refunds and guarantees

Fairhaven does not offer a money-back guarantee. Returns are limited to unopened products within 30 days, and preauthorization is required. This is the most restrictive return policy in the guide; brands like Life Extension and Wholesome Story offer satisfaction guarantees, and BulkSupplements may refund some opened products under certain conditions.

BulkSupplements Inositol Powder

Best budget pick

A shot of the BulkSupplements bottle

Photo by Innerbody Research

Pros

  • Lowest cost per gram in this guide
  • Easy to titrate to clinically studied doses (2–4g per day)
  • Vegan and free from flavors, sweeteners, or fillers
  • Manufactured in an NSF-certified, FDA-registered, cGMP-compliant facility

Cons

  • Powder format requires measuring
  • No money-back guarantee
  • Limited refunds on opened products
  • Highest shipping cost in this guide for smaller orders

BulkSupplements specializes in producing single-ingredient supplements at very low cost, and its Inositol Powder fits that model exactly. This product contains just one ingredient — MI — in a format that makes it easy to reach research-aligned doses without paying for capsules, coatings, or additional ingredients.

From an evidence standpoint, MI is the same form of inositol used in most metabolic, PCOS, fertility, and gestational diabetes studies — including trials that administered it as a powder dissolved in liquid. The powder format also offers maximum dosing flexibility, making it straightforward to adjust intake based on tolerance or target dose.

Where BulkSupplements clearly stands out is value. Inositol is typically taken in gram-level doses, and capsule-based products can become expensive when used long term. By offering inositol as a bulk powder in multiple sizes, BulkSupplements dramatically lowers the cost per serving — especially at the larger bag sizes.

Taste and mixability

BulkSupplements Inositol Powder is nearly neutral in taste. Our testers noticed only a faint sweetness or mild aftertaste, and it dissolves easily in water without grit or residue. There should be no problem taking it on a regular basis.

It can also be blended into smoothies or mixed with juice or other beverages, where it’s typically undetectable. However, despite its mild sweetness, inositol isn’t used as a sugar substitute like erythritol or xylitol. Its taste is very subtle, and it isn’t intended to sweeten foods or drinks.

Pricing, subscriptions, and shipping

BulkSupplements offers inositol powder in several bag sizes, ranging from 100g to 1 kilogram. Subscription purchases receive a 10% discount, and larger sizes offer a significantly lower cost per 2g serving.

Size100g250g500g1kg
One-time price$14.94$17.97$25.97$31.97
Subscription price (10% off)$13.47$16.17$23.37$28.77
2g servings per container50125250500
Cost per 2g (one-time)$0.30$0.14$0.10$0.06
Cost per 2g (subscription)$0.27$0.13$0.09$0.06

Shipping is where BulkSupplements becomes less competitive. Orders under the free-shipping threshold incur a $9.95 shipping fee, which is the highest base shipping cost in this guide. Free shipping applies only once you cross the minimum order threshold of $59, which often requires combining items in a single order.

However, the product is also available through Amazon, where Prime shipping can help offset that cost.

Refunds and guarantees

BulkSupplements allows returns within 30 days, but its refund policy is more restrictive than most brands featured in this guide. Full refunds apply only to unopened products. Opened containers may be eligible for a partial refund, typically capped at the price of the smallest package size, which limits recourse on larger purchases. There is no formal satisfaction guarantee.

As a result, buyers take on more risk than they would with brands like Life Extension or Wholesome Story, which offer more consumer-friendly guarantees. That trade-off may be reasonable for value-focused shoppers or experienced users who already know they tolerate inositol well. For those prioritizing low cost per gram and dosing flexibility over a generous return policy, BulkSupplements remains a practical and economical choice.

Ritual Fertility Support

Honorable mention for fertility support

Pros

  • Fertility-focused blend built around commonly studied ingredients
  • Large 40% subscription discount
  • Free shipping on all orders
  • Third-party tested

Cons

  • Most expensive per serving without a subscription
  • Fixed-ratio formula limits upward titration
  • CoQ10 dose is lower than in many fertility studies

Ritual’s Fertility Support is not one of our top recommendations in this guide, but it earns an honorable mention for people who want an all-in-one fertility powder built around ingredients that appear repeatedly in metabolic and reproductive research.

A single daily scoop provides:

  • Myo-inositol (MI): 2,000mg
  • N-acetylcysteine (NAC): 600mg
  • Coenzyme Q10 (CoQ10): 100mg

From an evidence standpoint, MI is positioned to drive most of the expected effect in this formula. Its 2,000mg dose aligns with how inositol is typically used in human studies, while the remaining ingredients are included at supportive levels.

N-acetylcysteine (NAC)

NAC is a stable, supplemental form of the amino acid cysteine and a precursor to glutathione, one of the body’s primary antioxidant systems. In reproductive research, NAC has been studied for PCOS and fertility in randomized trials and meta-analyses, with evidence suggesting potential benefits for ovulation and pregnancy-related outcomes in some populations, most often at doses between 600mg and 1,800mg per day. Ritual’s 600mg dose aligns with the lower end of this studied range.

Coenzyme Q10 (CoQ10)

CoQ10 is frequently discussed in egg-quality and assisted reproduction research because of its role in mitochondrial energy production and oxidative stress defense. Evidence syntheses suggest CoQ10 supplementation may improve select fertility-related outcomes in some ART contexts. While many fertility studies use higher doses (typically 200–600mg per day), at least one study reported benefits at 30mg, placing Ritual’s 100mg dose above the lowest studied threshold reported in fertility research, though still below more aggressive protocols.

Some fertility and PCOS studies use 4,000mg per day of MI, often divided into two doses. Reaching that level with Ritual Fertility Support would require doubling the serving size, which also doubles NAC (to 1,200mg) and CoQ10 (to 200mg). While the higher CoQ10 intake moves closer to the range used in many fertility and egg-quality studies, increasing NAC at the same time may raise the likelihood of gastrointestinal discomfort, which is the most commonly reported side effect of NAC at higher doses. Because the ingredients can’t be adjusted independently, this limits dosing flexibility.

Pricing, subscriptions, and shipping

Ritual Fertility Support costs $99 for a 60-serving tub. Subscribing reduces the price by 40% to $59.40, and subscriptions can be canceled at any time. All purchases ship free from Ritual’s website.

Here’s how the pricing breaks down:

Bottle priceTotal servingsCost per serving
One-time purchase$99.0060$1.65
Subscription (40% off)$59.4060$0.99

Refunds and guarantees

Ritual offers a 30-day money-back guarantee, which provides a reasonable trial window to assess taste, routine fit, and tolerance. However, this guarantee is shorter than Wholesome Story’s 90-day return window and Life Extension’s 365-day satisfaction guarantee.

Alternatives to inositol supplements

If you’re exploring supplementation but have constraints (e.g., cost, tolerance, or formulation preferences) — or if you simply want to stack smartly with inositol — here are some well-researched alternatives:

Berberine

For metabolic health — particularly blood sugar regulation — berberine is one of the most consistently supported non-prescription options in the literature. Multiple reviews and meta-analyses show that berberine supplementation can modestly improve fasting glucose, HbA1c, and other cardiometabolic markers across diverse adult populations. While its effects are not dramatic, they’re repeatable and biologically plausible, which is why berberine is often discussed alongside diet and lifestyle strategies for metabolic risk.

For a deeper look at the research and how different formulas compare, see our full guide to the best berberine supplements.

N-acetylcysteine (NAC)

Among inositol alternatives for PCOS, NAC has one of the more established clinical records. A systematic review of randomized controlled trials found that NAC improved ovulation and pregnancy rates compared to placebo in women with PCOS, though the authors noted variability in study quality. More recent meta-analytic research continues to evaluate NAC across both reproductive and metabolic outcomes, suggesting it may offer measurable benefits for some individuals — particularly when ovulatory dysfunction and metabolic stress are present.

You can explore how NAC is used in PCOS research and see our top-rated options in our complete guide to NAC supplements.

Coenzyme Q10 (CoQ10)

For fertility support, CoQ10 is one of the most frequently studied supplements related to egg quality and assisted reproduction outcomes. A systematic review and meta-analysis of randomized trials found that CoQ10 supplementation may improve selected fertility-related endpoints in women undergoing assisted reproductive technologies. Additional clinical reviews describe CoQ10 as a mitochondrial-support nutrient that may support oocyte quality and ovarian function, particularly in women with diminished ovarian reserve.

If fertility or egg quality is your primary focus, our guide to the best CoQ10 supplements breaks down the evidence and highlights top product picks.

Diet

Inositol is widely present in foods, especially plant foods where it often appears in the form of phytic acid (IP6) — a major storage form in grains, legumes, nuts, and seeds. That means that if someone eats a diet rich in beans/lentils, whole grains, nuts, and seeds, they’re typically getting meaningful dietary exposure to inositol-related compounds. However, the forms and amounts obtained from food differ from the concentrated doses used in supplementation and clinical research.

Examples of inositol-rich foods include:

  • Whole grains (especially bran-containing options)
  • Beans and lentils
  • Nuts and seeds
  • Legumes and soy foods
  • Organ meats (like chicken liver and beef liver)

Inositol FAQ

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Innerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

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