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GenF20 Plus Reviews

We’ll tell you how this HGH booster works, whether it’s a good value, and if it’s likely to work for you.

Last Updated: Jan 4, 2023
GenF20 Plus Review

Human growth hormone (HGH) is naturally produced in the body by the pituitary gland. This hormone contributes to growth in childhood and helps sustain organs and tissues as you grow. When you reach middle age, the body slows down HGH production, leading some to believe that supplementing HGH in the body will reverse aging and increase vitality.

The trouble is that there isn’t conclusive evidence that taking real or synthetic HGH has anti-aging effects or increases muscle mass. In fact, HGH injections are costly and could lead to side effects like joint and muscle pain, edema, and diabetes.

GenF20 Plus does not contain HGH. Instead, it is a natural dietary supplement that stimulates your pituitary gland to produce more HGH. A Clinical trials show that GenF20 Plus is generally safe with no severe side effects and that long-term use could yield improvements in weight, muscle tone, energy level, libido, and aging.

Is GenF20 Plus right for you? How long does it take to work? If it doesn’t contain HGH, then what’s in it? Read on to find out the answers to these questions and more.

Editor's Summary

Overall Rating 8.2 / 10

GenF20 Plus is an all-natural, HGH-boosting supplement that is safe to take long-term. A clinical trial showed that it effectively increases HGH levels, though it didn’t show much improvement regarding weight loss or other factors.

Pros & cons


  • A clinical trial showed that it increases HGH levels in adults
  • Does not contain real or synthetic HGH, but stimulates HGH production in your body
  • No significant side effects during clinical trial
  • Extensive FAQ page – answers questions and debunks myths about HGH
  • 67-day money-back guarantee
  • Ships quickly and discreetly
  • Free shipping on order of 6-month supply


  • Weight loss and other factors were inconclusive after a 12-week clinical trial
  • Some ingredients have questionable effectiveness, according to research
  • Contains milk and soybean (potential allergens)
Our Top Picks

GenF20 Plus

GenF20 Plus is an all natural supplement designed to increase lean muscle mass, sex drive, and energy levels.

GenF20 Plus helps your body naturally produce more HGH, with no severe side effects. Pick a custom supply amount and rest easy with a 67-day money-back guarantee.

2-Month Supply
Reviewed by Innerbody Research
3-Month Supply
Reviewed by Innerbody Research
1-Month Supply
Reviewed by Innerbody Research

Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

We extensively test each health service or product we review. Our content provides you, our readers, with an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality and the latest medical evidence and health standards. We ask ourselves two simple questions: Would we buy the product or service ourselves if it weren’t part of our job? Would we recommend it to family and friends?

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

How we evaluated GenF20 Plus

Our evaluation criteria help us provide a comprehensive view of the company. When evaluating GenF20 Plus, we considered quality, cost, ingredients, safety, and convenience.



An HGH booster like GenF20 Plus does not contain HGH but, instead, contains natural ingredients that help your body produce more HGH. Typically, if someone needs more HGH, a doctor prescribes HGH injections, which are clinically proven to increase levels of HGH. There has not been much testing to show that HGH supplements actually work, which makes it challenging to rate their effectiveness.

GenF20 Plus, however, has been through its own clinical trial. The trial showed that the drug was well-tolerated during the testing period and that researchers noticed an increased level of the hormone IGF-1 in patients over age 40 within 12 weeks. Your liver releases IGF-1 when HGH increases. This indicates that GenF20 Plus could be most effective at raising HGH levels when used consistently over at least three months.



GenF20 Plus has a high-end price tag compared to other popular HGH-boosting supplements. A one-month supply (120 tablets) costs $69.95. The company does offer bulk savings discounts and free shipping on orders over $200. You can also take advantage of Leading Edge Health’s 67-day money-back guarantee.

Here is how GenF20 Plus compares to other comparable HGH boosters:

  1-month supply Subscribe & save options? Bulk savings discount? Money-back guarantee length
GenF20 Plus $69.95 No
67 days
HyperGH 14X $69.95 No
67 days
Provacyl $59.95 No
67 days
HGH-X2 $64.99 No
60 days
GenFX $49.95 No
67 days



GenF20 Plus includes a long list of all-natural ingredients, and clinical trials have also shown the effectiveness of many of them. For example, anterior pituitary powder stimulates the pituitary gland, which helps the body produce and release more HGH. All in all, GenF20 Plus is a potent formulation that has the potential to provide many anti-aging benefits. However, more research is needed to verify the effectiveness of some ingredients, specifically deer antler velvet and L-tyrosine.

Even though the ingredients are all-natural, the supplement is not vegan-friendly, and some active ingredients contain potential allergens. For example, colostrum contains milk, and phosphatidyl choline contains soybean.



Leading Edge Health lab tests its supplements to ensure safety and quality. GenF20 Plus is manufactured in a facility that follows Current Good Manufacturing Practice (cGMP), a set of regulations created by the FDA to ensure quality, safety, and effectiveness standards. While dietary supplements are not regulated by the FDA (like food and prescription drugs are), meeting cGMP standards is a way for supplement companies to show their dedication to customer safety.

In addition, the researchers who conducted the GenF20 clinical trial indicated that the supplement was well-tolerated by all subjects, even over three months. HGH supplements, in general, don’t cause serious side effects. However, there has been some concern about one of the supplement’s ingredients — L-tyrosine — because the safety of its long-term use has not yet been thoroughly tested.



GenF20 Plus is easy to order and ships quickly. Leading Edge Health sends a confirmation email after each purchase and a follow-up email with tracking info once the product ships. Our testers received the product within four days with standard shipping. It arrives in discreet packaging that does not indicate where the product originated. Also included in the package is a brochure that lists other supplements produced by the company and info on their 67-day money-back guarantee. Our testers also reached out to Leading Edge Health customer care via chat and received a response within five minutes.

The supplement is somewhat easy to take, but you must have a good memory or set a reminder to take it at specific times of the day. The package instructions indicate that you should take two tablets one hour before lunch and two tablets one hour before dinner. This may not be easy for those with an irregular meal schedule.

How GenF20 Plus works

GenF20 Plus is an all-natural daily dietary supplement that stimulates HGH production in the body and is designed to combat aging. Unlike HGH injections that require a prescription, GenF20 Plus does not contain real or synthetic HGH and can be purchased online.

We spoke with Reda Elmardi, a registered dietician and certified nutritionist who owns the website The Gym Goat, about the differences between an HGH supplement and HGH injections. He says, “HGH boosters are not as effective as HGH injections, but they can still help you achieve your goals if you use them correctly. There are many different types of HGH supplements that claim to work just like human growth hormone injections, but they don’t have the same effect.”

Elmardi advises those that want to use an HGH supplement to pay attention to clinical testing and natural ingredients to find the best product. Making sure a supplement delivers what it claims to can help you feel confident in your purchase. Elmardi recommends HGH supplements with natural ingredients like “L-arginine, L-glutamine, zinc, and vitamin B6. All of these ingredients work together to create a synergistic effect that helps to stimulate the production of HGH naturally.”

GenF20 Plus meets these two qualifications. It was tested in a clinical trial and shown to be effective. The trial tested GenF20 Plus on patients over 40 for 12 weeks. The patients showed increased levels of IGF-1, which is a hormone released in your body when HGH increases. GenF20 Plus is also an all-natural supplement, including many ingredients like L-arginine and L-glutamine.

Order the GenF20 Plus as an oral tablet and have the option to pair it with the GenF20 Plus Alpha GPC Oral Spray, which also stimulates HGH. The spray and tablet taken together complete the GenF20 Plus Anti-Aging System.

Elmardi tells us that HGH supplementation can have many benefits for the body, including:

  • Improved and bone density
  • Reversed effects of aging
  • Weight and fat loss
  • Better recovery and healing
  • Increased sex drive and sexual performance
  • Improved mental health
  • Improved energy and stamina
  • Better memory
  • Increased lean muscle mass

Much the same way that hair loss treatments like minoxidil work best when coupled with a healthful diet, you’ll see many of the best results when combining GenF20 Plus with a healthy diet and regular exercise.

The ingredients in GenF20 Plus – including amino acids, nutrients, and peptides – stimulate your pituitary gland. When more HGH is released, your liver and other tissues release IGF-1, a hormone that promotes the healthy growth of bones and tissues.

The supplement is developed by Leading Edge Health, a popular and well-established brand in the natural health space. It is manufactured in an FDA-approved lab.

What ingredients are in GenF20 Plus?

GenF20 Plus includes quite a few ingredients, and the supplement is all-natural. Each ingredient stimulates HGH production in the body and promotes anti-aging, weight loss, and muscle-building properties.

GenF20 Plus includes:

  • Astragalus root extract
  • Colostrum
  • Deer antler velvet
  • GTF chromium
  • L-arginine
  • L-glutamine
  • L-glycine
  • L-isoleucine
  • L-lysine
  • L-ornithine
  • L-tyrosine
  • L-valine
  • Anterior pituitary powder
  • Gamma-aminobutyric acid
  • Phosphatidyl choline

Below, find out how each component helps to facilitate HGH production, among other benefits.

Anterior pituitary powder

Anterior pituitary powder helps the body produce and release more HGH by stimulating the pituitary gland. The anterior pituitary gland produces hormones that impact growth, and this production can slow as we age.

Astragalus root extract

Astragalus root extract can help to boost your metabolism, immune system, and digestion. It has been used in traditional Chinese medicine for hundreds of years and may also help with kidney and lung function.


GenF20 Plus includes bovine colostrum, a milky substance produced close to or a few days after giving birth. This ingredient is said to improve bone density, accelerate healing, and help with aging. Colostrum contains IGF-1, a hormone produced by the body when HGH is released.

Deer antler velvet

Deer antler velvet contains chondroitin, glucosamine, and collagen. It is said to promote joint, skin, and nail health. It also includes IGF-1, a hormone that helps with growth. Some of the claims about the health benefits of this extract are up for debate.

Gamma-aminobutyric acid

Gamma-aminobutyric acid (GABA) stimulates HGH production, improves immune function, and can calm the nervous system. Studies show that it may help with stress and sleep.

GTF chromium

Chromium helps maintain glucose levels, which can impacting energy, metabolism, and fat burning. Studies have shown that dietary chromium supplements can improve growth.


L-arginine is an amino acid that helps increase energy levels and improve exercise performance. Most studies show that arginine can dramatically increase your HGH levels, especially when combined with physical activity.


L-glutamine is an amino acid that helps lower cholesterol and blood pressure and increases energy and metabolism. Studies show that it can help relieve fatigue, especially during intense workouts.


L-glycine is an amino acid that occurs naturally in the body. In studies, L-glycine has been shown to stimulate HGH production in the pituitary gland.


L-isoleucine is an amino acid that can help control blood sugar, boost energy levels, and improve healing. Studies also show that L-isoleucine helps boost the body’s immunity.


L-lysine is an amino acid that does not naturally occur in the body. When combined with L-arginine, L-lysine has been shown in studies to stimulate the release of HGH.


Like L-lysine, L-ornithine works in combination with L-arginine to boost the release of HGH in the body.


L-tyrosine is an amino acid that reduces fatigue and depression and improves metabolism. Studies have shown that it positively impacts cognitive issues that can result from stress. There is some question about its safety when taken long-term.


L-valine is an amino acid that does not occur naturally in the body. But, with supplementation, it can positively affect muscle mass and repair.

Phosphatidyl choline

Phosphatidyl choline is an extract that facilitates nutrient absorption, allowing the supplement to enter the bloodstream quickly.

Is GenF20 Plus safe?

Because of its all-natural ingredients, GenF20 Plus is generally safe to take and has no known side effects. In a clinical study performed with the supplement, researchers found that GenF20 Plus was “well-tolerated by all the subjects” with no severe side effects.

According to Elmardi, HGH supplements like GenF20 Plus are a great alternative to HGH injections because of cost and safety. He says, “There are two main reasons why people choose to take HGH supplements over injections. First, they are much less expensive than HGH shots. Second, they are easy to use and require no medical training. You simply need to follow the instructions provided by the manufacturer, and you will soon start seeing results.”

GenF20 Plus is also cGMP-certified, an FDA regulation that monitors quality and purity in the manufacture of drugs. This ensures that the supplement is made with high-quality ingredients and in regulated facilities.

As always, check with your doctor before starting any new supplement. Even though GenF20 Plus is generally safe to take, make sure it’s the best course of action for you before beginning.

Some doctors do not recommend taking an HGH booster before age 20 because it may affect natural development. If pregnant or breastfeeding, consult your doctor before starting any new supplement.

Side effects

HGH supplements don’t cause side effects when taken as directed. They are generally safe for healthy adults to take. If you experience any adverse reactions to GenF20 Plus, discontinue use and consult your doctor.

Injections of HGH have been shown to cause certain side effects, including:

  • Insulin resistance
  • Edema
  • Joint and muscle pain

These treatments can also cause or worsen the symptoms of certain conditions like:

  • Type 2 diabetes
  • Certain cancers
  • Carpal tunnel syndrome
  • Gynecomastia (swelling of breast tissue in men)

Is GenF20 Plus FDA-approved?

The GenF20 Plus site states that the supplement is FDA-approved but gives no further details about what this means. Our testers reached out to the company and discovered that the supplement is manufactured in an FDA-approved lab. This means that the lab meets cGMP processing standards for quality and safety. It does not mean that GenF20 Plus has been tested or approved by the FDA. The FDA does not certify dietary supplements in the same way they do food or prescription drugs — at least, not yet.

How much does GenF20 Plus cost?

Leading Edge Health offers a 67-day money-back guarantee for GenF20 Plus. Try the supplement for 60 days before initiating a return. Even if they’ve been used, you can send back the products for a full refund.

  Cost Free shipping?
1-month supply $69.95  
2-month supply $134.95  
3-month supply $199.95
4-month supply $249.95
5-month supply $299.95
6-month supply $349.95

When you purchase a monthly supply of GenF20 Plus, you’ll be prompted to add the comparable month’s supply of GenF20 Plus Alpha GPC Oral Spray. The supplement and spray constitute the GenF20 Plus Anti-Aging System. Like the tablet, the spray is taken daily. Alpha GPC is a supplement that has been shown to increase the secretion of growth hormones.

You can opt out of purchasing the spray, but here is the cost breakdown per month:

  • 1 month: $39.95
  • 2 months: $69.96
  • 3 months: $99.96
  • 4 months: $119.96
  • 5 months: $139.95
  • 6 months: $159.96

Placing an order

To purchase GenF20 Plus, follow a few easy steps:

  1. Visit Leading Edge Health and find the GenF20 Plus page. Or, go directly to the GenF20 Plus site.

  2. Choose how many months of product you’d like to order, between 1-6 months.

  3. Enter your personal info and pay using a credit card, debit card, or Paypal.

  4. Orders ship within one business day.

Insider Tip: Buying larger quantities makes sense because of the 67-day money-back guarantee. If you buy a larger amount, you’ll end up with more of it per dollar as long as you’re happy with the results.

HSA, FSA, and health insurance

You can’t use HSA or FSA funds to purchase GenF20. It’s also not covered under most health insurance plans.

How long does it take to work?

Like any supplement, repeated use of GenF20 Plus provides the best results. Many GenF20 Plus customers report that they began to see changes in energy levels within the first 2-3 weeks.

How long it takes to work depends on many factors. If you already eat a healthy diet and exercise regularly, you may start to see effects on your muscles and weight within a couple of weeks. How much HGH you already have in your system naturally can also impact efficacy. If your HGH is already low, it may take several weeks for you to begin to see the supplement’s effects.

Continue to take the supplement for at least three months to see maximum results.

The clinical trial of GenF20 Plus showed that patients over age 40 started seeing increased levels of IGF-1 within 12 weeks. IGF-1 is a hormone released by your liver when HGH increases.

Customer reviews of GenF20 Plus

According to Trust Pilot, customers give GenF20 Plus a 4.1 out of 5 stars, with 57% of reviews labeling the product as excellent. Most positive reviews commend the company for stellar customer service and prompt shipping. Many customers report anti-aging benefits with consistent use over several weeks to several months. One review stated that the product reduced the appearance of fine lines and wrinkles while helping to boost energy for longer workouts.

Negative reviews express issues with not seeing any improvements after using the product. A rep from the company responded to each of these reviews with a reminder that best results occur after three months of consistent use. The rep also provided info about the company’s generous 67-day money-back guarantee.

How GenF20 compares to other HGH boosters

GenF20 Plus is designed specifically for its anti-aging benefits, while other HGH boosters are formulated with other benefits in mind. This doesn’t mean that GenF20 Plus won’t help with these other factors, but if you’re looking for an HGH booster for a specific purpose, it might be worthwhile to consider how GenF20 Plus stacks up to the competition.

For example, HyperGH 14X is an HGH booster created to help build muscle. It uses a high-dose system to help your body boost HGH before, during, and after a workout. You take one dose in the morning and one before bed, which helps improve sleep quality and muscle recovery.

Another popular HGH booster is Provacyl, designed to boost testosterone levels and improve the male sex drive. Its ingredients help men balance hormones and combat fatigue, memory loss, and other negative impacts of low testosterone.

There are also HGH supplements that are specifically designed to improve:

  • Bone health
  • Workout recovery
  • Stamina
  • Lean muscle building
  • Overall health

Privacy considerations

Leading Edge Health does not trade or sell your personal information with third parties. Online payments are SSL Secured, and the company follows a strict anti-spam policy. Your order will show on your statement as a charge from or Your package ships discreetly in plain packaging that does not reveal the shipper.