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GenF20 Plus Reviews

We’ll tell you how this HGH booster works, whether it’s a good value, and whether it’s likely to work for you.

Last Updated: Mar 6, 2022
GenF20 Plus Review

Human growth hormone (HGH) is naturally produced in the body by the pituitary gland. This hormone contributes to growth in childhood and helps sustain organs and tissues as you grow. When you reach middle age, the body slows down HGH production, leading some to believe that supplementing HGH in the body will reverse aging and increase vitality.

The trouble is that there isn’t conclusive evidence that taking real or synthetic HGH has anti-aging effects or increases muscle mass. In fact, HGH injections are costly and could lead to side effects like joint and muscle pain, edema, and diabetes.

GenF20 Plus does not contain HGH. Instead, it is a natural dietary supplement that stimulates your pituitary gland to produce more HGH. Clinical trials show that GenF20 Plus is generally safe with no severe side effects and that long-term use could yield improvements in weight, muscle tone, energy level, libido, and aging.

Is GenF20 Plus right for you? How long does it take to work? If it doesn’t contain HGH, then what’s in it? Read on to find out the answers to these questions and more.

Review Summary


  • Improves muscle tone, weight loss, sex drive, and energy levels
  • A clinical trial showed that it increases HGH levels in adults
  • Does not contain real or synthetic HGH, but stimulates HGH production in your body
  • No significant side effects during clinical trial
  • Extensive FAQ page – answers questions and debunks myths about HGH
  • 67-day money-back guarantee
  • Free shipping on order of 6-month supply


  • Weight loss and other quality of life factors were inconclusive after a 12-week clinical trial
  • Some ingredients have questionable effectiveness, according to research

Bottom line

GenF20 Plus is an all-natural and relatively safe supplement that does help stimulate human growth hormone (HGH) production in the body. A clinical trial demonstrated that GenF20 Plus effectively increases HGH levels, though the timeline of effectiveness will depend on your levels of HGH at the time you begin using the supplement. It does not contain real or synthetic HGH; instead, its ingredients work to boost HGH levels in your body naturally. Although a clinical trial didn’t show much improvement with regard to weight loss or other factors, it established that the supplement has no severe side effects and could be effective when taken long-term.

Our Top Picks

GenF20 Plus

GenF20 Plus is an all natural supplement designed to increase lean muscle mass, sex drive, and energy levels.

GenF20 Plus helps your body naturally produce more HGH, with no severe side effects. Pick a custom supply amount and rest easy with a 67-day money-back guarantee.

2-Month Supply
Reviewed by Innerbody Research
3-Month Supply
Reviewed by Innerbody Research
1-Month Supply
Reviewed by Innerbody Research

Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

We extensively test each health service or product we review. We try our best to give you, our readers, an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality, the latest medical evidence and health standards, and a simple question: would we buy the product or service ourselves if it weren’t part of our job, and would we recommend it to family and friends?

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

How GenF20 Plus works

GenF20 Plus is an all-natural daily dietary supplement that stimulates HGH production in the body. Unlike HGH injections that require a prescription, GenF20 Plus does not contain real or synthetic HGH and can be purchased online.

Order the supplement as an oral tablet and have the option to pair it with the GenF20 Plus Alpha GPC Oral Spray, which also stimulates HGH. The spray and tablet taken together complete GenF20 Plus’s Anti-Aging System.

Stimulating HGH in the body can lead to:

  • Improved muscle tone and bone density
  • Weight and fat loss
  • Increased sex drive and sexual performance
  • Improved energy and stamina
  • Better memory
  • More youthful appearance without wrinkles and fine lines

Much the same way that hair loss treatments like minoxidil work best when coupled with a healthful diet, you’ll see many of the best results when combining GenF20 Plus with a healthy diet and regular exercise.

The ingredients in GenF20 Plus – including amino acids, nutrients, and peptides – stimulate your pituitary gland. When more HGH is released, your liver and other tissues release IGF-1, a hormone that promotes the healthy growth of bones and tissues.

The supplement is developed by Leading Edge Health, a popular and well-established brand in the natural health space. It is FDA-approved and tested in a clinical trial.

What ingredients are in GenF20 Plus?

GenF20 Plus includes quite a few ingredients, and the supplement is all-natural. Each ingredient stimulates HGH production in the body and promotes anti-aging, weight loss, and muscle-building properties.

GenF20 Plus includes:

  • Astragalus root extract
  • Colostrum
  • Deer antler velvet
  • GTF chromium
  • L-arginine
  • L-glutamine
  • L-glycine
  • L-isoleucine
  • L-lysine
  • L-ornithine
  • L-tyrosine
  • L-valine
  • Anterior pituitary powder
  • Gamma-aminobutyric acid
  • Phosphatidyl choline

Below, find out how each component helps to facilitate HGH production, among other benefits.

Anterior pituitary powder

Anterior pituitary powder helps the body produce and release more HGH by stimulating the pituitary gland. The anterior pituitary gland produces hormones that impact growth, and this production can slow as we age.

Astragalus root extract

Astragalus root extract can help to boost your metabolism, immune system, and digestion. It has been used in traditional Chinese medicine for hundreds of years and may also help with kidney and lung function.


GenF20 Plus includes bovine colostrum, a milky substance produced close to or a few days after giving birth. This ingredient is said to improve bone density, accelerate healing, and help with aging. Colostrum contains IGF-1, a hormone produced by the body when HGH is released.

Deer antler velvet

Deer antler velvet contains chondroitin, glucosamine, and collagen. It is said to promote joint, skin, and nail health. It also includes IGF-1, a hormone that helps with growth. Some of the claims about the health benefits of this extract are up for debate.

Gamma-aminobutyric acid

Gamma-aminobutyric acid (GABA) stimulates HGH production, improves immune function, and can calm the nervous system. Studies show that it may help with stress and sleep.

GTF chromium

Chromium helps maintain glucose levels, which can impact energy, metabolism, and fat burning. Studies have shown that dietary chromium supplements can improve growth.


L-arginine is an amino acid that helps to increase energy levels and improve exercise performance. Most studies show that arginine can dramatically increase your HGH levels, especially when combined with physical activity.


L-glutamine is an amino acid that helps lower cholesterol and blood pressure and increases energy and metabolism. Studies show that it can help relieve fatigue, especially during intense workouts.


L-glycine is an amino acid that occurs naturally in the body. In studies, L-glycine has been shown to stimulate HGH production in the pituitary gland.


L-isoleucine is an amino acid that can help control blood sugar, boost energy levels, and improve healing. Studies also show that L-isoleucine helps boost the body’s immunity.


L-lysine is an amino acid that does not naturally occur in the body. When combined with L-arginine, L-lysine has been shown in studies to stimulate the release of HGH.


Like L-lysine, L-ornithine works in combination with L-arginine to boost the release of HGH in the body.


L-tyrosine is an amino acid that reduces fatigue and depression and improves metabolism. In studies, it’s been shown to positively impact cognitive issues that can result from stress. There is some question about its safety when taken long-term.


L-valine is an amino acid that does not occur naturally in the body. But, with supplementation, it can positively affect muscle mass and repair.

Phosphatidyl choline

Phosphatidyl choline is an extract that facilitates nutrient absorption, allowing the supplement to enter the bloodstream quickly.

Is GenF20 Plus safe?

Because of its all-natural ingredients, GenF20 Plus is generally safe to take and has no known side effects. In a clinical study performed with the supplement, researchers found that GenF20 Plus was “well-tolerated by all the subjects” with no severe side effects.

GenF20 Plus is also cGMP-certified, an FDA regulation that monitors quality and purity in the manufacture of drugs. This ensures that the supplement is made with high-quality ingredients and in regulated facilities.

As always, it’s essential to check with your doctor before starting any new supplement. Even though GenF20 Plus is generally safe to take, make sure that it’s the best course of action for you before beginning.

How much does GenF20 Plus cost?

Leading Edge Health offers a 67-day money-back guarantee for GenF20 Plus. Try the supplement for 60 days before initiating a return. Even if they’ve been used, you can send back the products for a full refund.

  • 1-month supply: $69.95
  • 2-month supply: $134.95
  • 3-month supply: $199.95 (with free shipping)
  • 4-month supply: $249.95 (with free shipping)
  • 5-month supply: $299.95 (with free shipping)
  • 6-month supply: $349.95 (with free shipping)

When you purchase a monthly supply of GenF20 Plus, you’ll be prompted to add the comparable month’s supply of GenF20 Plus Alpha GPC Oral Spray. The supplement and spray constitute the GenF20 Plus Anti-Aging System. Like the tablet, the spray is taken daily. Alpha GPC is a supplement that has been shown to increase the secretion of growth hormones.

You can opt out of purchasing the spray, but here is the cost breakdown per month:

  • 1 month: $24.98
  • 2 months: $49.95
  • 3 months: $74.93
  • 4 months: $99.90
  • 5 months: $124.88
  • 6 months: $149.85

Placing an order

To purchase GenF20 Plus, follow a few easy steps:

  1. Visit Leading Edge Health and find the GenF20 Plus page. Or, go directly to the GenF20 Plus site.

  2. Choose how many months of product you’d like to order, between 1-6 months.

  3. Enter your personal info and pay using a credit card, debit card, or Paypal.

  4. Orders ship within one business day.

Insider Tip: Buying larger quantities makes sense because of the 67-day money-back guarantee. If you buy a larger quantity, you’ll end up with more of it per dollar as long as you’re happy with the results.

HSA, FSA, and health insurance

You can’t use HSA or FSA funds to purchase GenF20. It’s also not covered under most health insurance plans.

How long does it take to work?

Like any supplement, repeated use of GenF20 Plus provides the best results. Many GenF20 Plus customers report that they began to see changes in energy levels within the first 2-3 weeks.

How long it takes to work depends on many factors. If you already eat a healthy diet and exercise regularly, you may start to see effects on your muscles and weight within a couple of weeks. How much HGH you already have in your system naturally can also impact efficacy. If your HGH is already low, it may take several weeks for you to begin to see the supplement’s effects.

Continue to take the supplement for at least 3 months to see maximum results.

The clinical trial of GenF20 Plus showed that patients over age 40 started seeing increased levels of IGF-1 within 12 weeks. IGF-1 is a hormone released by your liver when HGH increases.

Privacy considerations

Leading Edge Health does not trade or sell your personal information with third parties. Online payments are SSL Secured, and the company follows a strict anti-spam policy. Your order will show on your statement as a charge from or

How we evaluate telemedical services

At Innerbody Research, we customize our evaluation criteria depending on the type and nature of the health service or product. For GenF20 Plus and other health products, we have five areas that we use for our evaluations, including:

Quality: How well does the company deliver its core service(s) to the customer? Is the quality of the product or service high enough that we would recommend it to loved ones without hesitation? Does the company have a high-quality medical review board with oversight? Are their treatment options or products FDA-approved?

Value: Are you getting your money’s worth? Are there any hidden costs or charges? Does the provider offer discounts or free services to our readers?

Customer Support: How well does the company provide information about its product or service? How clearly are options presented?

Privacy: Are all products sent in discreet packaging? Will your data be stored securely? Could your data ever be shared without your permission?

Speed: How fast will you receive your product from the moment you click “buy?” Are the waiting times stated by the company accurate and consistent?