Best Urolithin A Supplements

Though increased life expectancy has been the focus of social policies for much of the last century, experts are finding that people’s “healthspans” — the average length of life lived without disease — haven't been able to keep up.1 People may be living longer, but researchers note that the “prevalence of disease has increased markedly” along the way.

Partly due to this realization, more and more research over the past few years has focused on finding ways to lengthen the average healthspan.2 Besides the positive impacts of lifestyle modifications, like eating right and exercising, some experts are investigating pharmacological or supplemental avenues.

One compound that’s recently been in the spotlight is urolithin A (UA), a postbiotic metabolite that’s promoted for its potential to improve mitochondrial health, boost athletic recovery, reduce the signs of skin aging, and more. But are these claims legitimate? And which urolithin A products are worth your investment? In this guide, we’ll break down everything you need to know. But if you’re in a hurry, check out our summary of recommendations below.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

For our guide to the best urolithin A supplements, we spent over 160 hours researching urolithin A, including its optimal dosing, potential benefits, mechanism of action, side effects, and more. Our testers also thoroughly interacted with the companies and products mentioned in this guide, from asking customer support questions and purchasing items to investigating customer account options, getting hands-on with the supplements, and everything in between.

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

When evaluating urolithin A supplements, we considered four key, customer-centric criteria that our team often uses to evaluate similar supplemental products on the market. These four areas include a product’s safety, efficacy, cost, and convenience.

Before delving into the finer details of each category, it’s worth pointing out that all three brands that we chose performed well overall. However, each criterion does have a winner that stood out from the rest for one reason or another.

Let’s see how our top picks fared.

Safety

Winner: Timeline Mitopure

When it comes to supplement safety, it’s important to know that the FDA doesn’t regulate supplements in the same way it does prescription drugs. In the agency’s own words, it does not “have the authority to approve dietary supplements for safety and effectiveness, or to approve their labeling, before the supplements are sold to the public.”3

This means that it’s up to supplement manufacturers to take the necessary steps to ensure consumer safety. Thankfully, all of our top picks come from brands that take safety seriously. The chart below offers a quick overview of each company’s safety measures.

Based on the information in the chart, all of our top picks should be generally safe for most healthy adults. However, Timeline’s Mitopure supplement stands out in a few distinct ways. While Codeage’s product is NSF Certified, which is similarly impressive, Timeline’s NSF Certified for Sport status means that:

• There are no unsafe levels of contaminants
• The supplement contents match what’s listed on the label
• There are no traces of any of the 290 substances banned by major athletic organizations

Additionally, Timeline’s Mitopure received a favorable GRAS review from the FDA in 2018, and it’s the only one of our top picks to have studies conducted on it (over a dozen pieces of research on Mitopure exist at the time of this writing).

Efficacy

Winner: Timeline Mitopure

Based on the scientific research available at the time of this writing, the doses of urolithin A used in all of our picks (500-1,000mg) are clinically relevant. While many trials have found 500mg to be potentially suitable for a wide range of health concerns, other research has found that 1,000mg may be the ideal dose for some needs (e.g., 500mg improved measures of leg strength, while 1,000mg improved aerobic endurance).5

But, out of our picks, only Mitopure has been subjected to multiple studies. In fact, most of the existing clinical research on urolithin A has been conducted using Mitopure.4 This branded form of urolithin A — created by a Swiss life sciences company called Amazentis SA — may improve aerobic endurance, boost leg muscle strength, protect the body against certain age-related conditions, and more.5 6 However, a member of our medical review board, Dr. Matt Segar, MD, points out, “Most human studies of urolithin A and Mitopure were designed and funded by Amazentis. Several authors of the studies are company-affiliated.” This is important to know because, even though this doesn’t completely discredit the research, it does mean that there is potential for bias.

Nonetheless, the possible benefits of urolithin A — Mitopure or not — are mainly due to the potential for the compound to activate a process in the body called “mitophagy” (mitochondrial autophagy). This is when your body breaks down dysfunctional mitochondria and replaces them with new, healthy ones.7 As humans age, mitophagy isn’t activated as often or performed as efficiently, meaning that unhealthy mitochondria can build up and lead to chronic diseases like cancer, dementia, and others.8

Now, besides the extensive research done on Mitopure, our other picks also have some support for their efficacy. For instance, the liposomal delivery of our picks from Perpetua.Life and Codeage may improve the stability and bioavailability of urolithin A (but more research on humans is needed to confirm this).9 And all of our top picks undergo potency analysis to ensure you’re getting the promised dose of urolithin A.

Those potency analyses are particularly important. According to the results of a 2024 study that tested the contents versus the label information of a few urolithin A supplements, “Results showed a significant deviation from the labeled amounts...” with levels of urolithin A ranging from -15.5% to +28.6% of what they should’ve been.10

Cost

Winner: Perpetua.Life Urolithin A Liposomal

If you’ve browsed urolithin A supplements before, you may have noticed that they tend to run on the expensive side. Often, the price of a good-quality urolithin A supplement can hover around $100. Our top picks from Timeline and Codeage fall into this category, but our pick from Perpetua.Life manages to maintain quality and safety for under $60 per bottle (or under $50 with a subscription).

Many inexpensive urolithin A supplements on the market don’t undergo adequate third-party safety testing or potency analysis, but Perpetua.Life’s Urolithin A Liposomal supplement undergoes both. Of course, Perpetua.Life’s product doesn’t contain clinically-tested Mitopure (like Timeline), but it does use liposomal delivery for potentially better bioavailability (like Codeage).5

The chart below breaks down the pricing information for single purchases and 1-month subscriptions of our top picks:

On top of having the lowest single-purchase price and a generous 20% subscription discount, Perpetua.Life’s urolithin A technically comes with another way to reduce costs: easy dose adjustment. Since each 1,000mg dose of this supplement is two capsules, taking only one capsule would still give you 500mg of urolithin A — the same dose that’s been examined the most in research. This would turn each bottle of Perpetua.Life Urolithin A Liposomal capsules into a 2-month supply, lowering your monthly cost to about $30 for single purchases (or a little less than a dollar per dose). Of course, this cost-saving measure only really has potential if 500mg of urolithin A has shown promise for your concern. But, either way, Perpetua.Life still offers an affordable, well-dosed urolithin A supplement.

Pivoting to look at the pricing of Timeline’s Mitopure, its subscriptions can be a bit confusing at first. Basically, even though Timeline’s subscription discount can be the highest of our top picks, it varies based on the length of your subscription. Higher discounts require longer subscriptions, which means paying more initially to save money over time. For instance, the highest possible discount — 32% off — is for the 12-month supply. This option costs $1,020 at checkout, but it lowers your monthly or per-bottle cost to $85. So, if you’re able to pay more, and you know you’ll be taking Mitopure for the foreseeable future, then a longer Timeline subscription could be a worthwhile investment.

But $85 per month is still at least $25 more than what you’d pay with Perpetua.Life, cementing the latter as our best urolithin A pick for those on a budget.

Convenience

Winner: Timeline Mitopure

Convenience can be a somewhat tricky criterion; some may prefer a gummy or drink mix to a capsule, while others could feel that having a generous return policy or guarantee is key. When it comes to our top urolithin A picks, none of them should be particularly inconvenient. Nonetheless, they all have distinct conveniences that they bring to the table, as shown in the chart below.

By offering multiple supplement forms, several subscription options, and a newly added money-back guarantee, Timeline outdoes the competition for convenience. Previously, our winner in this category was Codeage, but with the company putting a temporary pause on subscriptions, it’s no longer the most convenient option.

However, the biggest convenience drawback with Timeline is the lack of subscription customization. If you happen to have a concern that could benefit from 1,000mg of urolithin A, then you’d be taking double the standard 500mg dose — turning a 1-month supply of Mitopure into a half-month one. So, for those customers, Timeline’s subscriptions could be inconvenient. Moreover, Timeline (unlike our other picks) doesn’t allow customers to modify subscriptions in their account; they need to contact customer service to make any adjustments that don’t involve changing their payment method.

For customers who would prefer to take 1,000mg of urolithin A per dose and still receive recurring subscription deliveries, Perpetua.Life may be the better option. However, it’s important to point out that Perpetua.Life’s guarantee and return policies are one and the same, and they only apply to a single bottle. The company even states, “It is advised you not purchase more than one bottle until you're certain our product is right for you.” This is very similar to Codeage’s guarantee, which only applies to your first purchase.

Below, you’ll find a quick reference chart comparing some of the most important details of our top urolithin A supplement picks, such as dosing, safety, returns, and pricing (based on 1-month supplies).

Note: The Timeline information in the chart is based on its Mitopure supplements (the capsules, gummies, and powder). More details on Timeline’s Mito-Biotic Mitopure skincare products can be found under the brand’s dedicated section later in this guide.

When it comes to pill sizes, Perpetua.Life has the smallest of our top picks, while the capsules from Timeline and Codeage are more “standard” sized supplements. Our testers didn’t have issues taking any of these, but individuals who have difficulty swallowing pills may prefer the smaller size of Perpetua.Life’s capsules or even Timeline’s, which have a bit of a “slippery” or almost oily feeling to them that could make them go down a bit easier.

Urolithin A is a bioavailable postbiotic produced by your gut bacteria after you eat certain foods (like berries, pomegranates, pecans, and walnuts) containing the polyphenols ellagitannins or ellagic acid.11 12

Useful postbiotics are a sort of “healthy waste” produced by probiotics after they consume prebiotics.13 When your gut bacteria break down ellagitannins or ellagic acid, urolithin A is what’s left over — or at least that’s what happens for some people. Researchers have found that only around 40% of people are able to produce urolithin A due to differences in individual gut microbiomes.6 Fortunately, other studies have found that the remaining 60% of people can “overcome” that limitation through supplementation.12

Most of the potential benefits of urolithin A are attributed to the compound’s effects on mitophagy.7 This is when your body “cleans up” damaged or excess mitochondria,8 then replaces them with new, healthy ones to maintain mitochondrial homeostasis.14 As you age, the rate and effectiveness of the mitophagy process decrease. When this happens, the gradual buildup of dysfunctional mitochondria can lead to increased inflammation, which is associated with a higher risk of chronic diseases, like cancer or dementia.8 15 So, if urolithin A can kickstart mitophagy, then it may lower your risk for chronic disease, increasing your healthspan and your lifespan.

We cover more about the potential benefits and applications of urolithin A under the “How does urolithin A work?” section.

From what experts currently know about urolithin A, it could be a suitable supplement for any adult — not pregnant or breastfeeding — who’s interested in trying it. Since everyone’s mitophagy process slows down with age, a large population of adults could find some benefit from it.8 Of course, it’s always important to speak with your doctor first before starting a new supplement, just to make sure it’s safe for your unique situation.

Based on the available research, urolithin A may be particularly helpful for people concerned about chronic inflammation, healing an injury, improving athletic performance, or (in the case of topical urolithin A) reducing the signs of skin aging.

Who should look elsewhere?

While urolithin A may be able to promote better mitochondrial health by supporting mitophagy,7 there currently isn’t any research to suggest that the compound could benefit primary or genetic mitochondrial diseases (e.g., Leigh syndrome, Kearns-Sayre syndrome, Leber hereditary optic neuropathy, etc.).16 Some experts suggest that it could be worth investigating whether mitophagy activation could act as a “novel strategy” to treat these diseases, but that research hasn’t been conducted yet.17 18 19 When that happens, we’ll update this information.

Otherwise, urolithin A isn’t suitable for children or anyone taking a medication that may interact with it. (We cover those medications in the following section.)

Urolithin A has demonstrated exceptional safety in the studies conducted on it thus far. According to a 2024 review, “There were no serious adverse events attributed directly to [urolithin A] reported in any of the studies. Observed adverse events such as myalgia and headaches were classified as mild to moderate and assessed as unrelated to the interventions.”20 This means that researchers ultimately determined that the headaches and muscle pain experienced by patients during the studies were not due to urolithin A supplementation.

However, as explained by the Alzheimer’s Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4

Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesn’t necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind. Additionally, skin irritation from polyphenols has been documented in some research, meaning that skincare products containing urolithin A may also have this risk.22

Finally, on the topic of pomegranate, since urolithin A is often derived from compounds of the fruit, it may interact with the same drugs (e.g., those metabolized by cytochrome P450, or CYP450, enzymes).23 24 These include but aren’t limited to:25

• ACE inhibitors
• Blood pressure medications
• Statins (cholesterol-lowering medication)
• Warfarin (blood thinner)
• Sildenafil
• Anticonvulsants
• Sulfonylureas
• Buspirone (an anti-anxiety medication)
• Metformin
• Piracetam (a nootropic drug)
• Theophylline (used in asthma and COPD)

However, Dr. Segar notes, “Many of these interactions are based on mechanistic data, animal data, and isolated case reports.” This means that many of the potential interactions in the list above haven’t been confirmed in human studies.

Nonetheless, it’s recommended that you speak with your doctor before taking urolithin A — even if you’re perfectly healthy and not on any prescription medication. As more human research on the interactions between urolithin A and various medications becomes available, we’ll update this guide accordingly.

As mentioned earlier in this guide, the benefits of urolithin A are mainly attributed to its potential to kickstart mitochondrial autophagy or “mitophagy” — the process of your body clearing out old, dysfunctional mitochondria and replacing them with new, healthy ones.7 8 14

When dysfunctional mitochondria build up, the production of oxidative stress in the body may increase.8 This, in turn, increases the risk of developing various chronic and degenerative diseases, such as cancer, heart disease, kidney disease, Alzheimer’s disease, Parkinson’s disease, rheumatoid arthritis, and more.15

Besides increasing your disease risk, excess oxidative stress can also lead to:

• More visible signs of skin aging (fine lines, wrinkles, etc.)15
• Increased muscle atrophy26
• Reduced muscle force generation26
• Neuroinflammation27

Since urolithin A has the potential to help your body clean out dysfunctional mitochondria by supporting mitophagy, it may also be able to lower your risk of health concerns attributed to oxidative stress — increasing your healthspan and, possibly, your lifespan. This is supported by some of the existing research on the compound.

Let’s go over some key findings. (Note: Most of the clinical research on urolithin A thus far has been done using Mitopure.)4

Best overall, best powdered urolithin A, and best topical urolithin A

The Timeline brand is owned and operated by Amazentis SA, the Swiss life sciences company that developed Mitopure. So, in a way, all Mitopure products bearing the Timeline brand are “straight from the source.” You might occasionally come across other urolithin A products containing Mitopure, but not all of those products are made equal; just because they contain the branded ingredient, it doesn’t mean that it’s the same product (e.g., same capsule, inactive ingredients, etc.) used in Mitopure-focused research. In fact, some non-Timeline Mitopure products we’ve come across even have doses well below what was used in successful studies. For example, the brand Pure Encapsulations offers a complex called Renual that contains Mitopure, but it’s only available in half (250mg) of the smallest dose that has seen positive outcomes in research (500mg).

Now, as mentioned earlier in this guide, Mitopure is the brand of urolithin A used in most clinical research (often in the form of Timeline’s capsules). Because of this, the Alzheimer’s Drug Discovery Foundation has dubbed it “the most well-validated form of urolithin A…”4 This isn’t to say other forms of urolithin A can’t be beneficial, but we do hope to see more research on non-Mitopure urolithin A in the future. As it stands, the current abundance of research focused specifically on Mitopure is a big reason why it won our choice for best overall.

Other reasons for our choice include:

• Timeline’s Mitopure supplements are third-party tested and NSF Certified for Sport.
• In 2018, Amazentis SA received a favorable Generally Recognized As Safe (GRAS) review of Mitopure from the FDA.
• The Mitopure capsules, powder, and gummies from Timeline are free from “the big eight” major allergens (milk, eggs, fish, shellfish, peanuts, tree nuts, soybeans, and wheat).
• Timeline products are produced in facilities that adhere to Good Manufacturing Practices (GMP) standards, along with those for food safety (FSSC 22000),30 quality management (ISO 9001),31 and proper cosmetics manufacturing (ISO 22716).32
• Timeline offers Mitopure as supplements in capsule, powder, and gummy forms or as an ingredient in various skincare products in its Mito-Biotic line.

Continuing with that final point, Timeline is one of the only companies we’ve come across that offers urolithin A as a powder, gummy, or skincare product. There are plenty of urolithin A pills on the market, but the other forms and products are currently difficult — if not impossible — to find elsewhere.

To learn more about Timeline and Mitopure, check out our full Mitopure review.

Timeline Mitopure and Mito-Biotic pricing information

All of the Mitopure supplements and Mito-Biotic skincare products from Timeline are available as either one-time buys or subscriptions, and all purchases made directly through the Timeline website ship for free in the U.S.

First, let’s cover the pricing of the Mitopure supplements. Interestingly, the price doesn’t change depending on the form you purchase; capsules, powder, and gummies all cost the same. Here’s how it all breaks down:

Now, let’s go over the details and pricing of Timeline’s Mito-Biotic skincare products (they all contain a 1% concentration of Mitopure):

Previously, all purchases from Timeline were considered final sale, but the company has recently introduced a 30-day money-back guarantee for its supplements (skincare, unfortunately, isn’t covered). This is the same length as the policies from Codeage and Perpetua.Life, but those companies limit their guarantees to either your first purchase (Codeage) or first bottle (Perpetua.Life).

Best budget urolithin A supplement

Perpetua.Life (also known as Perpetua Life Biotech) is, in the company’s own words, “a research and development firm specializing in longevity.” This focus translates to selling supplements intended to improve your lifespan and healthspan. Perpetua.Life’s flagship product is AEON, a NAD+ longevity complex, but the company has also started branching out and offering supplements with other research-supported ingredients — one of which is urolithin A.

Like our other picks in this guide, Perpetua.Life’s urolithin A supplement is third-party tested for safety and potency. However, this supplement stands out from the rest due to its higher dose; it contains 1,000mg of urolithin A, which is double the amount Timeline and Codeage offer in their supplements.

As we mentioned previously, a dose of 1,000mg (or 1g) may be the ideal dose for some concerns based on a few research studies. Some of the findings include the following:

• In a 2022 trial, subjects taking 1,000mg of urolithin A “exhibited clinically meaningful improvements” in their aerobic endurance and physical performance when compared to subjects who took either 500mg or a placebo.5
• A separate 2022 trial examined the effects of 1,000mg urolithin A versus placebo in older adults after four months of daily supplementation. The authors found that the supplement improved muscle endurance and plasma biomarkers, “suggesting that urolithin A may counteract age-associated muscle decline.”33
• In 2024, researchers assessed the effects of 1g urolithin A (versus placebo) in resistance-trained male athletes. After eight weeks, the urolithin A group demonstrated improved measures of muscle strength and endurance, along with reduced oxidative stress and inflammation response levels.59

With this information in mind, it seems as though a 1,000mg dose of urolithin A may be ideal for athletes or older adults. Of course, more research is needed to confirm or deny this, but the dose does appear promising for those particular groups of people. Thankfully, if you’d prefer to stick with the more widely researched 500mg dose instead, you can just halve the dose of Perpetua.Life’s supplement and only take one capsule.

Perpetua.Life Urolithin A Liposomal pricing and subscriptions

As our choice for those on a budget, Perpetua.Life’s urolithin A is a cost-effective option with a few different cost-saving opportunities. This product can be purchased either one time or on a subscription basis. The prices are as follows:

• One-time purchase: $59.00 ($1.97 per dose)
• Subscription (20% off): $47.20 ($1.57 per dose)

If you’d like to take only 500mg, then subscriptions may be a bit of an inconvenience. Since you’d be doubling the servings, a 1-month subscription shipping interval very well may leave you with a surplus of pills. However, taking only one capsule would mean that your one-time purchase price per month technically drops down to $29.50 — far less than the monthly subscription cost.

Like our other picks, Perpetua.Life has a 30-day money-back guarantee. Unfortunately, the policy is more akin to Codeage’s policy than Timeline’s; it only applies to your first bottle, and no returns or refunds are permitted otherwise.

Best urolithin A complex

Based in Florida, Codeage is a company founded to help people “live better through nutritional supplements.” Though Codeage offers some standard vitamin and mineral supplements, it mainly focuses on specialty options, including — but not limited to — colostrum capsules, leaky gut support, E-sports vitamins (or nootropics), and urolithin A.

As our pick for the best urolithin A complex, Codeage Liposomal Urolithin A doesn’t just contain the eponymous ingredient (at 500mg per dose) but also a few other key ingredients, including:

• Trans-resveratrol: 150mg
• Betaine anhydrous (trimethylglycine): 102.5mg
• Coenzyme Q10: 60mg

Additionally, one of the “other ingredients” worth pointing out is phosphatidylcholine, a phospholipid that may boost brain function, improve fatty liver disease, and more.34 35 However, the phosphatidylcholine is only mentioned on the label as being part of the non-GMO sunflower oil, and there isn’t a dose given, so we can’t fully judge the potential of this ingredient’s inclusion.

Now, pivoting back to the possible benefits of the other active ingredients in Codeage Liposomal Urolithin A, the following breakdown details some research findings.

It’s worth mentioning that, even though the doses of betaine and CoQ10 are on the lower end, the liposomal delivery method may improve their bioavailability. However, we can’t say for sure how much of an improvement there could actually be without more research (particularly human research). As it stands, studies on liposomal CoQ10 seem focused on topical application, and the only liposomal betaine study we could find involves a “novel dual drug-tailed betaine conjugate amphiphile” — not the same type of betaine used in Codeage’s supplement.57 58

All of this to say, Codeage Liposomal Urolithin A is an overall promising supplement for those looking to pair urolithin A with other ingredients that could potentially help improve their healthspan.

Codeage Liposomal Urolithin A pricing details

Unfortunately, Codeage has placed its subscriptions on hold for the time being, so its urolithin A is currently only available as a one-time purchase. Each bottle is $99.99, which is $3.33 per serving.

Like the other options in this guide, Codeage Liposomal Urolithin A ships for free (it meets the company’s $50+ free shipping threshold). And, also like our other picks, Codeage offers a 30-day money-back guarantee. But it’s important to note that the company does not cover return shipping costs, and the guarantee can only be used once per customer and once per household. This means that other people who live with you can’t also take advantage of the guarantee for their own purchase — or, if they’ve already done so for a Codeage product in the past, then you won’t be able to.

Urolithin A supplements and skincare products are far from the only options on the market that may be able to help you reach your health goals, like an improved healthspan, fewer wrinkles, or better mitochondrial health. In the following sections, we cover a few urolithin A alternatives.

NAD+ booster supplements

Similar to urolithin A, increasing your body’s nicotinamide adenine dinucleotide (NAD+) levels may improve the health of your mitochondria.45 But how can you accomplish this?

While you could technically take a supplement containing NAD+ as the primary ingredient, research suggests that its bioavailability isn’t nearly as good as two of its precursors: nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).46

Besides NAD+, NR is also a precursor to NMN.47 And since NMN is “closer” to becoming NAD+ than NR is, some people feel that it’s the better option, but either one should be effective.48 If you’re interested in these supplements, it could be worth trying one of each type (NR or NMN) to see which works better for you.

To learn more about NAD+, its precursors, and the best NAD+ boosting supplements, check out our comprehensive guides:

• Best NMN Supplement in 2025 | The Top 7 Contenders
• Best NR Supplement | We Tested Anti-Aging Solutions [2025]
• Best NAD+ Supplements in 2025: 8 Top Contenders

Our team also created our very own NAD+ supplement, Innerbody Labs NAD+ Support, based on our extensive research and hands-on experience with these products. You can learn more about it in our dedicated review.

Prescription skincare products

If reducing the signs of skin aging is your goal, there are countless prescription skincare products on the market that may suit your needs just as well as — or better than — urolithin A topicals.

Tretinoin, a prescription vitamin A derivative, has been called “the most potent and certainly the most widely investigated retinoid for photoaging therapy” by researchers in a 2006 review.49 And a more recent 2022 review notes that studies on tretinoin “consistently” find it to be “efficacious in improving [the] clinical appearance of photoaging.”50

And many nonprescription ingredients, like niacinamide (for melasma),51 vitamin C (for wrinkles),52 and hyaluronic acid (for dry skin), have demonstrated positive outcomes in studies.53

Some of our favorite online dermatology options that we’ve reviewed are Curology, Agency, Prose, and Musely.

Foods rich in ellagitannins or ellagic acid

If urolithin A sounds like something you’re interested in, but you don’t want to add another supplement to your daily regimen, then eating foods rich in its precursors could be an option.11 While ellagitannins and ellagic acid can be found in an array of fruits and nuts, the pomegranate fruit (and especially pomegranate juice) is often considered to be their best source.54

Unfortunately, this alternative only has the potential to work if you’re part of the roughly 40% or so of people who can produce urolithin A after consuming these polyphenols (this depends on factors like your unique microbiome).6 And, currently, the only way to potentially find out if you’re a producer or not is to apply for the “Mitopure Challenge” offered by Timeline. If you’re accepted, you’ll receive a test kit for submitting a blood sample to Amazentis SA, and your anonymized results will be part of an open-label clinical study (you’ll get your own personal results sent to you, too).

If and when urolithin A producer tests become commercially available, we’ll update this section of our guide.