Best Urolithin A Supplements

Though increased life expectancy has been the focus of social policies for much of the last century, experts are finding that people’s “healthspans” — the average length of life lived without disease — haven't been able to keep up.1 People may be living longer, but researchers note that the “prevalence of disease has increased markedly” along the way.

Partly due to this realization, more and more research over the past few years has focused on finding ways to lengthen the average healthspan.2 Besides the positive impacts of lifestyle modifications, like eating right and exercising, some experts are investigating pharmacological or supplemental avenues.

One compound that’s recently been in the spotlight is urolithin A, a postbiotic metabolite that’s promoted for its potential to improve mitochondrial health, boost athletic recovery, reduce the signs of skin aging, and more. But are these claims legitimate? And which urolithin A products are worth your investment? In this guide, we’ll break down everything you need to know. But if you’re in a hurry, check out our summary of recommendations below.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

For our guide to the best urolithin A supplements, we spent over 120 hours researching urolithin A, including its optimal dosing, potential benefits, mechanism of action, side effects, and more. Our testers also thoroughly interacted with the companies and products mentioned in this guide, from asking customer support questions and purchasing items to investigating customer account options, getting hands-on with the supplements, and everything in between.

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

When evaluating urolithin A supplements, we considered four key, customer-centric criteria that our team often uses to evaluate similar supplemental products on the market. These four areas include a product’s safety, efficacy, cost, and convenience.

Before delving into the finer details of each category, it’s worth pointing out that all three brands that we chose performed well overall. However, each criterion does have a winner that stood out from the rest for one reason or another.

Let’s see how our top picks fared.

Safety

Winner: Timeline Mitopure

An important detail we often mention when it comes to supplement safety is the fact that the FDA does not regulate supplements in the same way it does prescription drugs. In the agency’s own words, it does not “have the authority to approve dietary supplements for safety and effectiveness, or to approve their labeling, before the supplements are sold to the public.”3

This means that it’s up to supplement manufacturers to take the necessary steps to ensure consumer safety. Thankfully, all of our top picks come from brands that take safety seriously. The chart below offers a quick overview of each company’s safety measures.

As you can see, though all of our top picks should be generally safe for most healthy adults, Timeline’s Mitopure stands out in a few distinct ways. While Codeage’s product is NSF Certified, which is similarly impressive, Timeline’s NSF Certified for Sport status means that:

• There are no unsafe levels of contaminants
• The supplement contents match what’s listed on the label
• There are no traces of any of the 290 substances banned by major athletic organizations

Additionally, Timeline’s Mitopure received a favorable GRAS review from the FDA in 2018, and it’s the only one of our top picks to have studies conducted on it (over a dozen pieces of research on Mitopure exist at the time of this writing).

Efficacy

Winner: Timeline Mitopure

While all of our urolithin A supplement picks offer the compound at a clinically relevant dose (500mg in each) and should be effective, only Mitopure has been subjected to multiple studies. In fact, most of the existing clinical research on urolithin A has been conducted using Mitopure.4 This branded form of urolithin A may improve aerobic endurance, boost leg muscle strength, protect the body against certain age-related conditions, and more.5 6

These possible benefits are mainly due to the potential for urolithin A — Mitopure or not — to activate a process in the body called “mitophagy” (mitochondrial autophagy). This is when your body breaks down dysfunctional mitochondria and replaces them with new, healthy ones.7 As humans age, mitophagy isn’t activated as often or performed as efficiently, meaning that unhealthy mitochondria can build up and lead to chronic diseases like cancer, dementia, and others.8

Now, besides the extensive research done on Mitopure, our other picks also have some support for their efficacy. For instance, the liposomal delivery of Codeage’s supplement may improve the stability and bioavailability of urolithin A.9 And all of our top picks, including Super Nutrition, undergo potency analysis to ensure you’re getting the promised urolithin A dose.

Those potency analyses are particularly important. According to the results of a 2024 study that tested the contents versus the label information of a few urolithin A supplements, “Results showed a significant deviation from the labeled amounts...” with levels of urolithin A ranging from -15.5% to +28.6% of what they should’ve been.10

Cost

Winner: Super Nutrition Urolithin A

If you’ve browsed urolithin A supplements before, you may have noticed that they tend to run on the expensive side. Often, the price of a good-quality urolithin A supplement can hover around $100. Our top picks from Timeline and Codeage fall into this category, but our pick from Super Nutrition manages to maintain quality and safety for under $40 per bottle.

Many inexpensive urolithin A supplements on the market don’t undergo adequate third-party safety testing or potency analysis, but Super Nutrition Urolithin A undergoes both. Of course, Super Nutrition doesn’t contain clinically-tested Mitopure (like Timeline) or use liposomal delivery for potentially better bioavailability (like Codeage), but it still offers customers a safe, cost-effective, and well-dosed urolithin A supplement.

Here’s how the prices of single purchases and 1-month subscriptions compare between our picks:

It is worth explaining, however, that Super Nutrition’s subscription discount changes after your initial subscription order. At first, it’s 20% off ($31.33), but then it drops to only 10% off ($35.02) on subsequent deliveries. This is still a good price compared to the competition, but it’s always disappointing when companies have discounts that go down with future orders instead of up. In comparison, the discounts from Codeage and Timeline are always the same, and Timeline offers bigger discounts when you choose a longer subscription interval (ranging from 10-32% off).

Convenience

Winner: Codeage Liposomal Urolithin A

Convenience can be a somewhat tricky criterion; some may prefer a gummy or drink mix to a capsule, while others could feel that having a generous return policy or guarantee is key. When it comes to our top urolithin A picks, none of them should be particularly inconvenient. Nonetheless, they all have distinct conveniences that they bring to the table, as shown in the chart below.

While each company has its pros and cons for convenience, we chose Codeage as our winner in this category. This choice was mainly due to the fact that Codeage is the only option to offer any sort of guarantee. In comparison, Timeline and Super Nutrition have stricter policies for returns. The former only allows returns on defective or damaged items, while the latter has a confusing policy that may or “may not” cover your purchase.

It’s also worth explaining the differences between Timeline’s subscription intervals and those from Codeage and Super Nutrition. With Timeline, your subscription options look like this:

• 1-month supply delivered and charged monthly
• 2-month supply delivered and charged every two months
• 4-month supply delivered and charged every four months
• 12-month supply delivered and charged yearly

These subscriptions aren’t customizable, which means that you can’t alter the amount of Mitopure you’re getting per shipment. Now, while most studies on Mitopure found that 500mg (the standard dose) was effective, some research did suggest that 1,000mg could be useful in distinct ways. (A 2022 study found that only the 1,000mg dose boosted subjects’ aerobic endurance.)5 So, there are certainly some cases in which a person may wish to take double the suggested dose — four capsules per day instead of two. And for those customers, Timeline’s subscriptions could be inconvenient. Moreover, Timeline — unlike our other picks — doesn’t allow customers to modify subscriptions in their account; they need to contact customer service to make any adjustments that don’t involve changing their payment method.

In comparison, the interval and product quantity can be adjusted for subscriptions to both Super Nutrition’s and Codeage’s products. For example, when ordering from Codeage, you could get two bottles of its Liposomal Urolithin A each month, five bottles every three months, or whatever other setup fits your regimen.

Below, you’ll find a quick reference chart comparing some of the most important details of our top urolithin A supplement picks.

Note: The Timeline information in the chart below is based on its Mitopure supplements (the capsules, gummies, and powder). More details on Timeline’s Mitopure skincare can be found under the brand’s dedicated section later in this review.

And here’s a photo we took comparing the sizes of each brand’s urolithin A capsule.

As you can see, the pills are all very similar in size. If you squint, the Super Nutrition capsule is ever so slightly longer than the other two, and Timeline’s softgel appears a bit wider — but, in both cases, it’s a minute difference. Our testers didn’t have any issues taking these pills, but they did find that Timeline’s softgels were more “slippery,” which could make them easier to swallow.

Urolithin A is a bioavailable postbiotic produced by your gut bacteria after you eat certain foods (like berries, pomegranates, pecans, and walnuts) containing the polyphenols ellagitannins or ellagic acid.11 12

Useful postbiotics are a sort of “healthy waste” produced by probiotics after they consume prebiotics.13 When your gut bacteria break down ellagitannins or ellagic acid, urolithin A is what’s left over — or at least that’s what happens for some people. Researchers have found that only around 40% of people are able to produce urolithin A due to differences in individual gut microbiomes.6 Fortunately, other studies have found that the remaining 60% of people can “overcome” that limitation through supplementation.12

Most of the potential benefits of urolithin A are attributed to the compound’s effects on mitophagy.7 This is when your body “cleans up” damaged or excess mitochondria,8 then replaces them with new, healthy ones to maintain mitochondrial homeostasis.14 As you age, the rate and effectiveness of the mitophagy process decrease. When this happens, the gradual buildup of dysfunctional mitochondria can lead to increased inflammation,8 which is associated with a higher risk of chronic diseases, like cancer or dementia.15 So, if urolithin A can kickstart mitophagy, then it may lower your risk for chronic disease, increasing your healthspan and your lifespan.

We cover more about the potential benefits and applications of urolithin A under the “How does urolithin A work?” section.

From what experts currently know about urolithin A, it could be a suitable supplement for any adult — not pregnant or breastfeeding — who’s interested in trying it. Since everyone’s mitophagy process slows down with age, a large population of adults could find some benefit from it.8 Of course, it’s always important to speak with your doctor first before starting a new supplement, just to make sure it’s safe for your unique situation.

Based on the available research, urolithin A may be particularly helpful for people concerned about chronic inflammation, healing an injury, improving athletic performance, or (in the case of topical urolithin A) reducing the signs of skin aging.

Who should look elsewhere?

While urolithin A may be able to promote better mitochondrial health by supporting mitophagy,7 there currently isn’t any research to suggest that the compound could benefit primary or genetic mitochondrial diseases (e.g., Leigh syndrome, Kearns-Sayre syndrome, Leber hereditary optic neuropathy, etc.).16 Some experts suggest that it could be worth investigating whether mitophagy activation could act as a “novel strategy” to treat these diseases, but that research hasn’t been conducted yet.17 18 19 When that happens, we’ll update this guide accordingly.

Otherwise, urolithin A isn’t suitable for children or anyone taking a medication that may interact with it. (We cover those medications in the following section.)

Urolithin A has demonstrated exceptional safety in the studies conducted on it thus far. According to a 2024 review, “There were no serious adverse events attributed directly to [urolithin A] reported in any of the studies. Observed adverse events such as myalgia and headaches were classified as mild to moderate and assessed as unrelated to the interventions.”20 This means that researchers ultimately determined that the headaches and muscle pain experienced by patients during the studies were not due to urolithin A supplementation.

However, as explained by the Alzheimer’s Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4

Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesn’t necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind. Additionally, skin irritation from polyphenols has been documented in some research, meaning that skincare products containing urolithin A may also have this risk.22

Finally, on the topic of pomegranate, urolithin A may interact with the same drugs that pomegranate does.23 24 These include:25

• ACE inhibitors
• Blood pressure medications
• Statins (cholesterol-lowering medication)
• Warfarin (blood thinner)

In any case, it’s recommended you speak with your doctor before taking urolithin A — even if you’re perfectly healthy and not on any prescription medication.

As mentioned earlier in this guide, the benefits of urolithin A are mainly attributed to its potential to kickstart mitochondrial autophagy or “mitophagy” — the process of your body clearing out old, dysfunctional mitochondria and replacing them with new, healthy ones.7 8 14

When dysfunctional mitochondria build up, the production of oxidative stress in the body may increase.8 This, in turn, increases the risk of developing various chronic and degenerative diseases, such as cancer, heart disease, kidney disease, Alzheimer’s disease, Parkinson’s disease, rheumatoid arthritis, and more.15

Besides increasing your disease risk, excess oxidative stress can also lead to:

• More visible signs of skin aging (fine lines, wrinkles, etc.)15
• Increased muscle atrophy26
• Reduced muscle force generation26
• Neuroinflammation27

Since urolithin A has the potential to help your body clean out dysfunctional mitochondria by supporting mitophagy, it may also be able to lower your risk of health concerns attributed to oxidative stress — increasing your healthspan and, possibly, your lifespan. This is supported by some of the existing research on the compound.

Let’s go over some key findings. (Note: Most of the clinical research on urolithin A thus far has been done using Mitopure.)4

Best overall, best topical urolithin A, best powdered urolithin A

The Timeline brand is owned and operated by Amazentis SA, the Swiss life sciences company that developed Mitopure. So, in a way, all Mitopure products bearing the Timeline brand are “straight from the source.” You might occasionally come across other urolithin A products containing Mitopure, but not all of those products are made equal; just because they contain the branded ingredient, it doesn’t mean that it’s the same product (e.g., same capsule, inactive ingredients, etc.) used in Mitopure-focused research. In fact, some non-Timeline Mitopure products we’ve come across even have doses well below what was used in successful studies. For example, the brand Pure Encapsulations offers a complex called Renual that contains Mitopure, but it’s only available in half (250mg) of the smallest dose that has seen positive outcomes in research (500mg).

Now, as mentioned earlier in this guide, Mitopure is the brand of urolithin A used in most clinical research (often in the form of Timeline’s capsules). Because of this, the Alzheimer’s Drug Discovery Foundation has dubbed it “the most well-validated form of urolithin A…”4 This isn’t to say other forms of urolithin A can’t be beneficial, but we do hope to see more research on non-Mitopure urolithin A in the future. As it stands, the current abundance of research focused specifically on Mitopure is a big reason why it won our choice for best overall.

Other reasons for our choice include:

• Timeline’s Mitopure supplements are third-party tested and NSF Certified for Sport.
• Amazentis SA earned a favorable review of Mitopure from the FDA, and the compound was granted Generally Recognized As Safe (GRAS) status in 2018.
• The Mitopure capsules, powder, and gummies from Timeline are free from “the big eight” major allergens (milk, eggs, fish, shellfish, peanuts, tree nuts, soybeans, and wheat).
• Timeline products are produced in facilities that adhere to Good Manufacturing Practices (GMP) standards, along with those for food safety (FSSC 22000),30 quality management (ISO 9001),31 and proper cosmetics manufacturing (ISO 22716).32
• Timeline offers Mitopure as skincare or as supplements in capsule, powder, and gummy forms.

Continuing with that final point, Timeline is one of the only companies we’ve come across that offers urolithin A as a powder, gummy, or skincare product. There are plenty of urolithin A pills on the market, but the other forms and products are currently difficult — if not impossible — to find elsewhere.

To learn more about Timeline and Mitopure, check out our full Mitopure review.

Timeline Mitopure pricing information

All of the Mitopure products (supplements and skincare) from Timeline are available as either one-time purchases or subscriptions.

First, let’s go over the price of the Mitopure supplements. Interestingly, the price doesn’t change depending on the form you purchase; capsules, powder, and gummies all cost the same. Here’s how it all breaks down:

Now, let’s go over the cost of Timeline’s Mitopure skincare:

Shipping from Timeline is free to U.S. addresses, and those with an HSA/FSA account may be able to use those funds to purchase certain products (or be reimbursed) through Truemed. All purchases from Timeline are considered final sale, but damaged or defective items can be returned within 30 days. In the case of damaged or defective items — like if some of your capsules have split open and leaked, as our testers experienced — Timeline’s policy is a little more forgiving than Super Nutrition’s, the latter of which includes a statement, without additional explanation, that the policy “may not cover” damaged products.

Best budget urolithin A supplement

Super Nutrition is one of ten brands owned and operated by iHerb, a California-based health and wellness company that sells a wide variety of products, from household supplies and pet care items to makeup, skincare, supplements, and more. Though most Super Nutrition brand supplements focus on “traditional” inclusions, such as vitamins, minerals, and probiotics, there are some items with uncommon ingredients like grape seed extract, bergamot, and urolithin A.

While all of our top urolithin A supplement picks undergo third-party testing, only Super Nutrition has its most recent batch-testing results on the product page. The results not only show the results of microbe and heavy metal testing, but also the amount of urolithin A in the sample. In the report available at the time of this writing, the third-party analysis found that a 2-capsule dose contained 526mg of urolithin A. This slightly higher dose than what’s on the label could be a method to safeguard against the supplement losing too much of its potency before the expiration date.33

Super Nutrition Urolithin A pricing and subscriptions

The pricing of Super Nutrition Urolithin A isn’t too complicated, but it’s important to keep in mind that the subscription discount is reduced by half after your first purchase. While that’s disappointing, this urolithin A supplement is still far more affordable than many of its close competitors (at least those that are also high-quality). Here’s how the pricing works out:

• One-time purchase: $38.91 or $1.30 per serving
• Subscription (20% off; initial purchase): $31.13 or $1.04 per serving
• Subscription (10% off; subsequent purchases): $35.02 or $1.17 per serving

Even if you compare a month of Super Nutrition’s supplement at its most expensive ($38.91) to Timeline’s at its least ($85), Super Nutrition is still far less of a financial investment. The same also applies when you compare Super Nutrition’s highest price to Codeage’s lowest ($84.99).

On iHerb, orders over $30 ship for free, meaning that both one-time and subscription purchases of Super Nutrition Urolithin A qualify. But, unfortunately, the iHerb return policy is rather strict, or at least it could be. Though the policy states you have a 90-day window to return iHerb brand products (like those from Super Nutrition), damaged or open products “may not” be covered — even by the satisfaction guarantee. It’s unclear why something “may not” be applicable, so it’s hard to say whether or not your purchase will be returnable. The decision is ultimately up to the company on a case-by-case basis (and customer service confirmed this when we asked for clarification).

Best urolithin A complex

Based in Florida, Codeage is a company founded to help people “live better through nutritional supplements.” Though Codeage offers some standard vitamin and mineral supplements, it mainly focuses on specialty options, including — but not limited to — colostrum capsules, leaky gut support, E-sports vitamins (or nootropics), and urolithin A.

As our pick for best urolithin A complex, Codeage Liposomal Urolithin A doesn’t just contain the eponymous ingredient (at 500mg per dose) but also a few other key inclusions, including:

• Trans-resveratrol: 150mg
• Betaine anhydrous (trimethylglycine): 102.5mg
• Coenzyme Q10: 60mg

Additionally, one of the “other ingredients” worth pointing out is phosphatidylcholine, a phospholipid that may boost brain function, improve fatty liver disease, and more.34 35 However, the phosphatidylcholine is only mentioned on the label as being part of the non-GMO sunflower oil, and there isn’t a dose given, so we can’t fully judge the potential of this ingredient’s inclusion.

Now, pivoting back to the possible benefits of the other active ingredients in Codeage Liposomal Urolithin A, the following breakdown details some research findings.

It’s worth mentioning that, even though the doses of betaine and CoQ10 are on the lower end, the liposomal delivery method may improve their bioavailability. However, we can’t say for sure how much of an improvement there could actually be without more research. As it stands, studies on liposomal CoQ10 seem focused on topical application, and the only liposomal betaine study we could find involves a “novel dual drug-tailed betaine conjugate amphiphile” — not the same type of betaine used in Codeage’s supplement.57 58

All of this to say Codeage Liposomal Urolithin A is an overall promising supplement for those looking to pair urolithin A with other ingredients that could potentially help improve their healthspan.

Codeage Liposomal Urolithin A pricing details

Codeage has the most straightforward pricing of our top picks. There are only two options to choose from: a one-time purchase and a subscription (with a discount that always remains the same, unlike Super Nutrition’s). The prices are as follows:

• One-time purchase: $99.99 or $3.33 per serving
• Subscription (15% off): $84.99 or $2.83 per serving

Like the other options in this guide, Codeage Liposomal Urolithin A ships for free. However, unlike those picks, Codeage offers a 30-day money-back guarantee on your first purchase. But it’s important to note that the company does not cover return shipping costs, and the guarantee can only be used once per customer and once per household. This means that other people who live with you can’t also take advantage of the guarantee for their own purchase — or, if they’ve already done so for a Codeage product in the past, then you won’t be able to.

Urolithin A supplements and skincare products are far from the only options on the market that may be able to help you reach your health goals, like an improved healthspan, fewer wrinkles, or better mitochondrial health. In the following sections, we cover a few urolithin A alternatives.

NAD+ booster supplements

Similar to urolithin A, increasing your body’s nicotinamide adenine dinucleotide (NAD+) levels may improve the health of your mitochondria.45 But how can you accomplish this?

While you could technically take a supplement containing NAD+ as the primary ingredient, research suggests that its bioavailability isn’t nearly as good as two of its precursors: nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).46

Besides NAD+, NR is also a precursor to NMN.47 And since NMN is “closer” to becoming NAD+ than NR is, some people feel that it’s the better option, but either one should be effective.48 If you’re interested in these supplements, it could be worth trying one of each type (NR or NMN) to see which works better for you.

To learn more about NAD+, its precursors, and the best NAD+ boosting supplements, check out our comprehensive guides:

• Best NMN Supplement in 2025 | The Top 7 Contenders
• Best NR Supplement | We Tested Anti-Aging Solutions [2025]
• Best NAD+ Supplements in 2025: 8 Top Contenders

Prescription skincare products

If reducing the signs of skin aging is your goal, there are countless prescription skincare products on the market that may suit your needs just as well as — or better than — urolithin A topicals.

Tretinoin, a prescription vitamin A derivative, has been called “the most potent and certainly the most widely investigated retinoid for photoaging therapy” by researchers in a 2006 review.49 And a more recent 2022 review notes that studies on tretinoin “consistently” find it to be “efficacious in improving [the] clinical appearance of photoaging.”50

And many nonprescription ingredients, like niacinamide (for melasma),51 vitamin C (for wrinkles),52 and hyaluronic acid (for dry skin) have demonstrated positive outcomes in studies.53

Some of our favorite online dermatology options that we’ve reviewed are Curology, Agency, Prose, and Musely.

Foods rich in ellagitannins or ellagic acid

If urolithin A sounds like something you’re interested in, but you don’t want to add another supplement to your daily regimen, then eating foods rich in its precursors could be an option.11 While ellagitannins and ellagic acid can be found in an array of fruits and nuts, the pomegranate fruit (and especially pomegranate juice) is often considered to be their best source.54

Unfortunately, this alternative only has the potential to work if you’re part of the 40% of people who can produce urolithin A after consuming these polyphenols.6 And, currently, the only way to potentially find out if you’re a producer or not is to apply for the “Mitopure Challenge” offered by Timeline. If you’re accepted, you’ll receive a test kit for submitting a blood sample to Amazentis SA, and your anonymized results will be part of an open-label clinical study (you’ll get your own personal results sent to you, too).

If and when urolithin A producer tests become commercially available, we’ll update this section of our guide accordingly.