Best Urolithin A Supplements

Though increased life expectancy has been the focus of social policies for much of the last century, experts are finding that people’s “healthspans” — the average length of life lived without being impacted by disease — haven't been able to keep up.1 People may be living longer, but researchers note that the “prevalence of disease has increased markedly” along the way.

Partly due to this realization, more and more research over the past few years has focused on finding ways to lengthen the average healthspan.2 Besides the positive influence of lifestyle modifications, like eating right and exercising, some experts are investigating pharmacological or supplemental avenues.

One compound that’s recently been in the spotlight is urolithin A (UA), a postbiotic metabolite that’s promoted for its potential to improve mitochondrial health, boost athletic recovery, reduce the signs of skin aging, and more. But are these claims legitimate? And which urolithin A products are worth your investment? In this guide, we’ll break down everything you need to know. But if you’re in a hurry, check out our summary of recommendations below.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

For this guide to the best urolithin A supplements, we spent over 1,160 hours researching urolithin A, including its optimal dosing, potential benefits, mechanism of action, side effects, and more. Our testers also thoroughly interacted with the companies and products mentioned in this guide, from asking customer support questions and purchasing items to investigating customer account options, getting hands-on with the supplements, and everything in between.

Our product development team also did the necessary research to create what is the most likely UA supplement to help a wide range of people seeking this compound’s benefits. It isn’t the best choice for everyone, but for a majority of people, our independent evaluation is that this is likely the most effective UA supplement on the market. Where other options seem superior, we’ll be sure to point out alternatives.

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

We considered four key, customer-centric criteria that our team often uses to evaluate similar supplemental products on the market. These four areas include a product’s efficacy, safety, cost, and convenience.

Before delving into the finer details of each category, it’s worth pointing out that all the brands we chose performed well overall. However, each criterion does have one that stood out from the rest for one reason or another.

Let’s see how our top picks fared.

Safety

Winner: Timeline Mitopure

When it comes to supplement safety, it’s important to know that the FDA doesn’t regulate supplements in the same way it does prescription drugs. In the agency’s own words, it does not “have the authority to approve dietary supplements for safety and effectiveness, or to approve their labeling, before the supplements are sold to the public.”3

This means that it’s up to supplement manufacturers to take the necessary steps to ensure consumer safety. Thankfully, all of our top picks come from brands that take safety seriously. The chart below offers a quick overview of each company’s safety measures.

Based on the information in the chart, all of our top picks should be generally safe for most healthy adults. However, Timeline’s Mitopure supplement stands out in a few distinct ways. While Codeage’s product is NSF Certified, which is similarly impressive, Timeline’s NSF Certified for Sport status means that:

• There are no unsafe levels of contaminants
• The supplement contents match what’s listed on the label
• There are no traces of any of the 290 substances banned by major athletic organizations

Additionally, Timeline’s Mitopure received a favorable GRAS review from the FDA in 2018, and it’s the only one of our top picks to have studies conducted on it (over a dozen pieces of research on Mitopure exist at the time of this writing).

POTENCY NOTE: Those potency analyses in the third-party tests are particularly important. According to the results of a 2024 study that tested the contents versus the label information of a few urolithin A supplements, “Results showed a significant deviation from the labeled amounts...” with levels of urolithin A ranging from -15.5% to +28.6% of what they should’ve been.10

Efficacy

Winner: Innerbody Labs CoQ10 Advanced with Urolithin A

Most urolithin A supplements on the market offer either 500mg or 1,000mg per dose, and it might be easy to assume that 1,000mg would be the better of the two doses, as it’s twice as much. However, a close examination of the research available to date doesn’t bear this out. In fact, 500mg and 1,000mg perform nearly identically in most instances, with only marginal gains from doubling the dose that often don’t rise to statistical significance.

What’s more, a head-to-head study comparing 500mg and 1,000mg revealed that only the 500mg dose effectively spurred mitophagy, the process of clearing out dead and dysfunctional mitochondria that is central to UA’s potential to improve human health.5 7 As humans age, mitophagy isn’t activated as often or performed as efficiently, meaning that unhealthy mitochondria can build up and lead to chronic diseases like cancer, dementia, and others.8

How 1,000mg is able to provide comparable downstream benefits to 500mg without encouraging mitophagy is somewhat unclear, and more research is definitely needed to further explore this, but it’s one of the reasons we don’t elevate urolithin A supplements with bioavailability enhancers toward the top of our efficacy rankings.

Take, for example, the liposomal delivery of our picks from Perpetua.Life and Codeage. These may improve the stability and bioavailability of urolithin A (though more research on humans is needed to confirm this).9 But pushing a 1,000mg dose like the one from Perpetua.Life even further might not actually yield increased effect if we’re already seeing a 500mg dose outperform a 1,000mg dose in a key area.

Innerbody Labs offers that 500mg urolithin A dose, but it also includes a clinically relevant dose of coenzyme Q10 (CoQ10), another key component of mitochondrial health. CoQ10 serves as a critical antioxidant to limit mitochondrial oxidative stress and as an electron shuttle between proton pumps in the electron transport chain (ETC), the main source of your body’s energy. It can both increase the effect of certain UA benefits (like athletic performance) and impart a series of its own anti-aging benefits.60 These include improved cardiovascular health, blood sugar control, pain and inflammation management, and more.61 Codeage also includes CoQ10 in its urolithin A supplement, but at half the dose and nearly twice the cost.

Cost

Winner: Perpetua.Life Urolithin A Liposomal

If you’ve browsed urolithin A supplements before, you may have noticed that they tend to run on the expensive side. Often, the price of a good-quality urolithin A supplement can hover around $100. Our top picks from Timeline and Codeage fall into this category, but our pick from Perpetua.Life manages to maintain quality and safety for under $60 per bottle (or under $50 with a subscription).

Many inexpensive urolithin A supplements on the market don’t undergo adequate third-party safety testing or potency analysis, but Perpetua.Life’s Urolithin A Liposomal supplement undergoes both. Of course, Perpetua.Life’s product doesn’t contain clinically-tested Mitopure (like Timeline), but it does use liposomal delivery for potentially better bioavailability (like Codeage).5

The chart below breaks down the pricing information for single purchases and 1-month subscriptions of our top picks:

On top of having the lowest single-purchase price and a generous 20% subscription discount, Perpetua.Life’s urolithin A technically comes with another way to reduce costs: easy dose adjustment. Since each 1,000mg dose of this supplement is two capsules, taking only one capsule would still give you 500mg of UA — the same dose that’s been examined the most in research. This would turn each bottle of Perpetua.Life Urolithin A Liposomal capsules into a 2-month supply, lowering your monthly cost to about $30 for single purchases (or a little less than a dollar per dose).

You can also tell from the chart above that Innerbody Labs offers better value at its lowest cost per bottle — when you sign up for an extended 6-month shipping frequency. That price brings your cost per dose down to just $0.23 more than Perpetua.Life, while adding in a clinically optimal dose of CoQ10. Only Codeage has a comparable combination, and it costs nearly twice as much per dose.

Pivoting to look at the pricing of Timeline’s Mitopure, its subscriptions can be a bit confusing at first. Basically, even though Timeline’s subscription discount can be the highest of our top picks, it varies based on the length of your subscription. Higher discounts require longer subscriptions, which means paying more initially to save money over time. For instance, the highest possible discount — 32% off — is for the 12-month supply. This option costs $1,020 at checkout, but it lowers your monthly or per-bottle cost to $85. So, if you’re able to pay more, and you know you’ll be taking Mitopure for the foreseeable future, then a longer Timeline subscription could be a worthwhile investment.

But $85 per month is still at least $25 more than what you’d pay with Perpetua.Life, cementing the latter as our best urolithin A pick for those on a tight budget.

Convenience

Winner: Innerbody Labs

Convenience can be a somewhat tricky criterion; some may prefer a gummy or drink mix to a capsule, while others could feel that having a generous return policy or guarantee is key. When it comes to the best urolithin A options we’ve identified, none of them should be particularly inconvenient. Nonetheless, they all have distinct conveniences that they bring to the table, as shown in the chart below.

By offering multiple supplement forms, several subscription options, and a newly added money-back guarantee, Timeline should win the competition for convenience.

However, the biggest convenience drawback with Timeline is that its capsules occasionally arrive with some damage to them. It happened to us in testing, and we’ve seen similar reports elsewhere online. And, since capsules are the only form of urolithin A with significant research support, having that messy of an issue is a huge inconvenience (for images of the broken capsules, see our Timeline section below). Moreover, Timeline (unlike our other picks) doesn’t allow customers to modify subscriptions in their account; they need to contact customer service to make any adjustments that don’t involve changing their payment method.

So, for the multiple shipment sizes available through Innerbody Labs, and for its combining two clinically optimized doses of urolithin A and CoQ10, respectively, into one durable capsule for improved mitochondrial support, we give it the edge.

Below, you’ll find a quick reference chart comparing some of the most important details of our top recommendations, such as dosing, safety, returns, and pricing (based on 1-month supplies).

Note: The Timeline information in the chart is based on its Mitopure supplements (the capsules, gummies, and powder). More details on Timeline’s Mito-Biotic Mitopure skincare products can be found under the brand’s dedicated section later in this guide.

When it comes to pill sizes, Perpetua.Life has the smallest of our top picks, while the capsules from Timeline and Codeage are more “standard” sized supplements. Our testers didn’t have issues taking any of these, but individuals who have difficulty swallowing pills may prefer the smaller size of Perpetua.Life’s capsules or even Timeline’s, which have a bit of a “slippery” or almost oily feeling to them that could make them go down a bit easier.

Urolithin A is a bioavailable postbiotic produced by your gut bacteria after you eat certain foods (like berries, pomegranates, pecans, and walnuts) containing the polyphenols ellagitannins or ellagic acid.11 12

Useful postbiotics are a sort of “healthy waste” produced by probiotics after they consume prebiotics.13 When your gut bacteria break down ellagitannins or ellagic acid, urolithin A is what’s left over — or at least that’s what happens for some people. Researchers have found that only around 40% of people are able to produce urolithin A due to differences in individual gut microbiomes.6 Fortunately, other studies have found that the remaining 60% of people can “overcome” that limitation through supplementation.12

Most of the potential benefits of urolithin A are attributed to the compound’s effects on mitophagy.7 This is when your body “cleans up” damaged or excess mitochondria,8 then replaces them with new, healthy ones to maintain mitochondrial homeostasis.14 As you age, the rate and effectiveness of the mitophagy process decrease. When this happens, the gradual buildup of dysfunctional mitochondria can lead to increased inflammation, which is associated with a higher risk of chronic diseases, like cancer or dementia.8 15 So, if urolithin A can optimize mitophagy, then it may lower your risk for chronic disease, increasing your healthspan and your lifespan.

We cover more about the potential benefits and applications of urolithin A under the “How does urolithin A work?” section.

Since everyone’s mitophagy process slows down with age, a large population of adults could find some benefit from urolithin A.8 This is even more important when you consider that a majority of the population lack the specific microbial composition in their guts to effectively produce urolithin A from ellagic acids derived from food. In fact, research indicates that no more than 40% of the population has this ability.6

To make matters worse, there’s no microbiome test or other measure that can determine your ability to produce urolithin A outside of participating in a study that measures it specifically. So, your odds of being in the camp that can’t make it are worse than a coin toss. Supplementation is a reliable way to ensure you have the necessary urolithin A to drive mitophagy. Of course, it’s always important to speak with your doctor first before starting a new supplement, just to make sure it’s safe for your unique situation.

Based on the available research into urolithin A’s downstream effects, it may be particularly helpful for people concerned about chronic inflammation, healing an injury, improving athletic performance, or (in the case of topical urolithin A) reducing the signs of skin aging.28 23 29

Who should look elsewhere?

While urolithin A may be able to promote better mitochondrial health by supporting mitophagy,7 there currently isn’t any research to suggest that the compound could benefit primary or genetic mitochondrial diseases (e.g., Leigh syndrome, Kearns-Sayre syndrome, Leber hereditary optic neuropathy, etc.).16 Some experts suggest that it could be worth investigating whether mitophagy activation could act as a “novel strategy” to treat these diseases, but that research hasn’t been conducted yet.17 18 19 When that happens, we’ll update this information.

There’s been some chatter online about urolithin A’s potential to treat osteoarthritis or improve joint cartilage. At this point, that research has only been conducted in vitro and in animal models.62 The results are promising, but they’ll need to be replicated in human studies before we could recommend urolithin A for those purposes. That said, if those mouse studies are intriguing enough for you, you could look to Innerbody Labs CoQ10 Advanced with Urolithin A as a smart choice, as CoQ10 has a lot of positive pain research behind it that’s been conducted in humans.63

It’s also important to note that urolithin A isn’t a fountain of youth or a bulwark against poor lifestyle choices. Otherwise, urolithin A isn’t suitable for children or anyone taking a medication that may interact with it. (We cover those medications in the following section.)

Urolithin A has demonstrated good safety in the studies conducted on it thus far. According to a 2024 review, “There were no serious adverse events attributed directly to [urolithin A] reported in any of the studies. Observed adverse events such as myalgia and headaches were classified as mild to moderate and assessed as unrelated to the interventions.”20 This means that researchers ultimately determined that the headaches and muscle pain experienced by patients during the studies were not due to urolithin A supplementation.

However, as explained by the Alzheimer’s Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4

Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesn’t necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind. Additionally, skin irritation from polyphenols has been documented in some research, meaning that skincare products containing urolithin A may also have this risk.22

Since urolithin A is often derived from compounds of the fruit, it may interact with the same drugs (e.g., those metabolized by cytochrome P450, or CYP450, enzymes).23 24 These include but aren’t limited to:25

• ACE inhibitors
• Blood pressure medications
• Statins (cholesterol-lowering medication)
• Warfarin (blood thinner)
• Sildenafil
• Anticonvulsants
• Sulfonylureas
• Buspirone (an anti-anxiety medication)
• Metformin
• Piracetam (a nootropic drug)
• Theophylline (used in asthma and COPD)

However, Dr. Segar notes, “Many of these interactions are based on mechanistic data, animal data, and isolated case reports.” This means that many of the potential interactions in the list above haven’t been confirmed in human studies.

Nonetheless, it’s recommended that you speak with your doctor before taking urolithin A — even if you’re perfectly healthy and not on any prescription medication. There’s also insufficient data on how urolithin A could affect anyone pregnant or breastfeeding, so it’s best to avoid it or at least talk to your doctor if that applies to you. As more human research on the interactions between urolithin A and various medications and conditions becomes available, we’ll update this guide accordingly.

As mentioned earlier in this guide, the benefits of urolithin A are mainly attributed to its potential to kickstart mitochondrial autophagy or “mitophagy” — the process of your body clearing out old, dysfunctional mitochondria and replacing them with new, healthy ones.7 8 14

When dysfunctional mitochondria build up, the production of oxidative stress in the body may increase.8 This, in turn, increases the risk of developing various chronic and degenerative diseases, such as cancer, heart disease, kidney disease, Alzheimer’s disease, Parkinson’s disease, rheumatoid arthritis, and more.15

Besides increasing your disease risk, excess oxidative stress can also lead to:

• More visible signs of skin aging (fine lines, wrinkles, etc.)15
• Increased muscle atrophy26
• Reduced muscle force generation26
• Neuroinflammation27

Since urolithin A has the potential to help your body clean out dysfunctional mitochondria by supporting mitophagy, it may also be able to lower your risk of health concerns attributed to oxidative stress — increasing your healthspan and, possibly, your lifespan. This is supported by some of the existing research on the compound.

Let’s go over some key findings. (Note: Most of the clinical research on urolithin A thus far has been done using Mitopure.)4

It’s also important to note that, as a member of our medical review board, Dr. Matt Segar, MD, points out, “Most human studies of urolithin A and Mitopure were designed and funded by Amazentis. Several authors of the studies are company-affiliated.” This is important to know because, even though this doesn’t completely discredit the research, it does mean that there is potential for bias.

Urolithin A form factor: softgels vs. capsules

Urolithin A is available from some companies as a softgel and from others as a capsule. In softgel form, the ingredient is included as a liquid in a carrier oil, whereas capsule delivery provides a dry powder. There are some advantages and disadvantages to each approach, but we prefer to see urolithin A delivered as a softgel.

The simple fact is that the vast majority of published, peer-reviewed clinical scientific research on urolithin A uses softgels as the delivery method. One or two studies use encapsulated powder, but that’s it. The rest of the literature relies on softgels, so we’ve only included urolithin A in our guide from companies that do the same.

The only compelling reason for consumers to reach for a capsule instead of a softgel is that many softgels are made using bovine gelatin, which is unsuitable for vegans, vegetarians, and others who prefer to avoid animal products. But every urolithin A provider in this guide uses vegetarian-friendly softgels that address this problem without resorting to a less scientifically supported delivery method.

Best overall

Innerbody Labs call this “CoQ10 Advanced with Urolithin A”, but it could’ve just as appropriately been called “Urolithin A Advanced with CoQ10”. Everything from the urolithin A dose to the softgel delivery and carrier oil makes this as much a urolithin A supplement, which is just one reason it’s our top pick here.

While urolithin A has performed well in its early studies, its ability to prime the system by spurring mitophagy is only part of the puzzle. Once that cellular landscape is optimized, an ingredient like CoQ10 — an antioxidant that helps the body convert food into energy and fight against free radicals — can come in and introduce additional potential benefits, provided it’s dosed properly.41

The lion’s share of CoQ10’s benefits start in the mitochondria, where it drives the production of adenosine triphosphate (ATP), your body’s energy currency.70 ATP fuels everything from muscle contraction and intracellular signaling to neurotransmission and even DNA and RNA synthesis.71

So, urolithin A primes cells to perform their best by ensuring their mitochondria are healthy, while CoQ10 protects them from oxidative stress and manages the fuel they need to perform their most important tasks.

Here’s a look at the formula:

• Urolithin A: 500mg
• CoQ10 (as ubiquinone): 200mg
• Selenium: 25mcg

It’s the inclusion of CoQ10 and selenium that separates Innerbody Labs from the likes of Timeline and Perpetua.Life. And its clinically ideal CoQ10 dose and the low cost for this specific combination separate Innerbody Labs from a similar product by Codeage. Codeage includes TMG and resveratrol, but its TMG dose is about one-fifth what we’d recommend (it’s about one-fifth what Innerbody Labs includes in its NAD+ Support supplement). And the resveratrol dose is fine, but the potential efficacy of that supplement is notoriously hard to pin down, with mountains of contradictory evidence out there and many potential benefits that haven’t yet been illustrated in human studies.64

The big issue with Codeage is that its CoQ10 dose is only 60mg. Our review of the clinical evidence points toward 100-200mg as the optimal dose range, with doses much lower or much higher than that exhibiting weaker effects along something called a U-shaped curve.65 At 200mg, CoQ10 has been shown, among other things, to:66 67 68 69

• Lower blood pressure
• Improve HDL cholesterol
• Regulate blood sugar
• Reduce statin-induced muscle pain
• Improve sperm characteristics

We have not seen sufficient evidence that CoQ10 can reliably do any of these things at just 60mg. In choosing 200mg, Innerbody Labs opted for a dose with a superior scientific rationale.

Innerbody Labs pricing

A cost comparison with the rest of the market favors Innerbody Labs, where you can combine bulk and subscription discounts to take up to 25% off a price that’s already below Codeage and Timeline. Only Perpetua.Life can offer a lower per-dose cost, and its supplement doesn’t include CoQ10 or selenium.

Here’s how that pricing works out:

Innerbody Labs ships for free in the U.S. on orders over $50, which is any level of its CoQ10 advanced with Urolithin A. There’s also a 30-day money-back guarantee, which we’ve found to be pretty standard for the urolithin A space. International shipping is still limited, though, and free shipping does not apply there.

Best powdered urolithin A and best topical urolithin A

The Timeline brand is owned and operated by Amazentis SA, the Swiss life sciences company that developed Mitopure. You might occasionally come across other urolithin A products containing Mitopure, but some non-Timeline Mitopure products we’ve come across have doses well below what was used in successful studies. For example, the brand Pure Encapsulations offers a complex called Renual that contains Mitopure, but it’s only available in half (250mg) of the dose that has seen positive outcomes in research (500mg).

Timeline is also one the most expensive standalone urolithin A product we’ve encountered. The company justifies this is a few ways:

• Timeline’s Mitopure supplements are third-party tested and NSF Certified for Sport.
• In 2018, Amazentis SA received a favorable Generally Recognized As Safe (GRAS) review of Mitopure from the FDA.
• The Mitopure capsules, powder, and gummies from Timeline are free from “the big eight” major allergens (milk, eggs, fish, shellfish, peanuts, tree nuts, soybeans, and wheat).
• Timeline products are produced in facilities that adhere to Good Manufacturing Practices (GMP) standards, along with those for food safety (FSSC 22000),30 quality management (ISO 9001),31 and proper cosmetics manufacturing (ISO 22716).32
• Timeline offers Mitopure as supplements in capsule, powder, and gummy forms or as an ingredient in various skincare products in its Mito-Biotic line. No other major player in the urolithin A space offers a topical option, even though there’s some promising evidence supporting its use as such.29

The thing is, other companies can claim at least a few of these points, as well. Innerbody Labs, for instance, is also third-party tested. And it provides those test results on its product pages, which Timeline does not.

Of greater interest to some may be that Timeline is one of the only companies we’ve come across that offers urolithin A as a powder, gummy, or skincare product. There are plenty of urolithin A pills on the market, but the other forms and products are currently difficult — if not impossible — to find elsewhere.

To learn more about Timeline and Mitopure, check out our full Mitopure review.

Timeline Mitopure and Mito-Biotic pricing information

All of the Mitopure supplements and Mito-Biotic skincare products from Timeline are available as either one-time buys or subscriptions, and all purchases made directly through the Timeline website ship for free in the U.S.

First, let’s cover the pricing of the Mitopure supplements. Interestingly, the price doesn’t change depending on the form you purchase; capsules, powder, and gummies all cost the same. Here’s how it all breaks down:

Now, let’s go over the details and pricing of Timeline’s Mito-Biotic skincare products (they all contain a 1% concentration of Mitopure). Timeline used to offer these on a subscription basis with a 20% discount, but now you can only get them as one-time purchases, typically in one of two sizes.:

Previously, all purchases from Timeline were considered final sale, but the company has recently introduced a 30-day money-back guarantee for its supplements (skincare, unfortunately, isn’t covered). This is the same length as the policies from Codeage, Innerbody Labs, and Perpetua.Life.

Best budget urolithin A supplement

Perpetua.Life (also known as Perpetua Life Biotech) is, in the company’s own words, “a research and development firm specializing in longevity.” This focus translates to selling supplements intended to improve your lifespan and healthspan. Perpetua.Life’s flagship product is AEON, a NAD+ longevity complex, but the company has also started branching out and offering supplements with other research-supported ingredients — one of which is urolithin A.

The big draw with Perpetua.Life’s Urolithin A is its price, though you make some sacrifices to attain those savings. For example, like our other picks in this guide, Perpetua.Life’s urolithin A supplement is third-party, but the extent of that testing is limited to potency. The results confirm a hair over 988mg per 2-capsule serving, but there’s no information about heavy metals, pesticides, microbial contamination, or other parameters we prefer to see in thorough third-party tests. That extra testing is more expensive, and by opting out of those tests, Perpetua.Life keeps its costs down and lowers its price for consumers.

Perpetua.Life also stands out from the pack due to its higher suggested dose; it contains 1,000mg of urolithin A, which is double the amount Timeline, Innerbody Labs, and Codeage suggest in their supplements.

As we mentioned previously, a dose of 1,000mg (or 1g) may be the ideal dose for some concerns based on a few research studies. Some of the findings include the following:

• In a 2022 trial, subjects taking 1,000mg of urolithin A “exhibited clinically meaningful improvements” in their aerobic endurance and physical performance when compared to subjects who took either 500mg or a placebo.5
• A separate 2022 trial examined the effects of 1,000mg urolithin A versus placebo in older adults after four months of daily supplementation. The authors found that the supplement improved muscle endurance and plasma biomarkers, “suggesting that urolithin A may counteract age-associated muscle decline.”33
• In 2024, researchers assessed the effects of 1g urolithin A (versus placebo) in resistance-trained male athletes. After eight weeks, the urolithin A group demonstrated improved measures of muscle strength and endurance, along with reduced oxidative stress and inflammation response levels.59

That said, as we mentioned above, another study showed 500mg outperformed 1,000mg in genetic expressions of mitochondrial health, implying that a lower dose may be more effective at providing urolithin A’s most notable anti-aging benefits. With that in mind, Perpetua.Life could become an even better value, as you could halve your dose, taking one capsule at a time, and have your bottle last two months instead of one.

Perpetua.Life Urolithin A Liposomal pricing and subscriptions

As our choice for those on a budget, Perpetua.Life’s urolithin A is a cost-effective option with a few different cost-saving opportunities. This product can be purchased either one time or on a subscription basis. The prices are as follows:

• One-time purchase: $59.00 ($1.97 per dose)
• Subscription (20% off): $47.20 ($1.57 per dose)

If you’d like to take only 500mg, then subscriptions may be a bit of an inconvenience. Since you’d be doubling the servings, a 1-month subscription shipping interval very well may leave you with a surplus of pills. However, taking only one capsule would mean that your one-time purchase price per month technically drops down to $29.50 — far less than the monthly subscription cost.

Like our other picks, Perpetua.Life has a 30-day money-back guarantee. Unfortunately, the policy is more akin to Codeage’s policy than Timeline’s; it only applies to your first bottle, and no returns or refunds are permitted otherwise.

Codeage Liposomal Urolithin A doesn’t just contain the eponymous ingredient (at 500mg per dose) but also a few other key ingredients, including:

• Trans-resveratrol: 150mg
• Betaine anhydrous (trimethylglycine): 102.5mg
• Coenzyme Q10: 60mg

Additionally, one of the “other ingredients” worth pointing out is phosphatidylcholine, a phospholipid that may boost brain function, improve fatty liver disease, and more.34 35 However, the phosphatidylcholine is only mentioned on the label as being part of the non-GMO sunflower oil, and there isn’t a dose given, so we can’t fully judge the potential of this ingredient’s inclusion.

Now, pivoting back to the possible benefits of the other active ingredients in Codeage Liposomal Urolithin A, the following breakdown details some research findings.

Even though the doses of betaine and CoQ10 are on the lower end, the liposomal delivery method may improve their bioavailability. However, we can’t say for sure how much of an improvement there could actually be without more research (particularly human research). As it stands, studies on liposomal CoQ10 seem focused on topical application, and the only liposomal betaine study we could find involves a “novel dual drug-tailed betaine conjugate amphiphile” — not the same type of betaine used in Codeage’s supplement.57 58

And when you consider the 200mg CoQ10 dose in the less expensive option from Innerbody Labs, you can see why Codeage failed to earn a spot in our Summary of Recommendations at the top of the page. It’s simply too expensive compared to better supplements on the market.

Codeage Liposomal Urolithin A pricing details

Unfortunately, Codeage has placed its subscriptions on hold for the time being, so its urolithin A is currently only available as a one-time purchase. Each bottle is $99.99, which is $3.33 per serving.

Like the other options in this guide, Codeage Liposomal Urolithin A ships for free (it meets the company’s $50+ free shipping threshold). And, also like our other picks, Codeage offers a 30-day money-back guarantee. But it’s important to note that the company does not cover return shipping costs, and the guarantee can only be used once per customer and once per household. This means that other people who live with you can’t also take advantage of the guarantee for their own purchase — or, if they’ve already done so for a Codeage product in the past, then you won’t be able to.

Urolithin A supplements and skincare products are far from the only options on the market that may be able to help you reach your health goals, like an improved healthspan, fewer wrinkles, or better mitochondrial health. In the following sections, we cover a few urolithin A alternatives.

NAD+ booster supplements

Similar to urolithin A, increasing your body’s nicotinamide adenine dinucleotide (NAD+) levels may improve the health of your mitochondria.45 But how can you accomplish this?

While you could technically take a supplement containing NAD+ as the primary ingredient, research suggests that its bioavailability isn’t nearly as good as two of its precursors: nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).46

Besides NAD+, NR is also a precursor to NMN.47 And since NMN is “closer” to becoming NAD+ than NR is, some people feel that it’s the better option, but either one should be effective.48 If you’re interested in these supplements, it could be worth trying one of each type (NR or NMN) to see which works better for you.

To learn more about NAD+, its precursors, and the best NAD+ boosting supplements, check out our comprehensive guides:

• Best NMN Supplement in 2026 | The Top 7 Contenders
• Best NR Supplement | We Tested Anti-Aging Solutions [2026]
• Best NAD+ Supplements in 2026: 8 Top Contenders

Our team also created our very own NAD+ supplement, Innerbody Labs NAD+ Support, based on our extensive research and hands-on experience with these products. You can learn more about it in our dedicated review.

Prescription skincare products

If reducing the signs of skin aging is your goal, there are countless prescription skincare products on the market that may suit your needs just as well as — or better than — urolithin A topicals.

Tretinoin, a prescription vitamin A derivative, has been called “the most potent and certainly the most widely investigated retinoid for photoaging therapy” by researchers in a 2006 review.49 And a more recent 2022 review notes that studies on tretinoin “consistently” find it to be “efficacious in improving [the] clinical appearance of photoaging.”50

And many nonprescription ingredients, like niacinamide (for melasma),51 vitamin C (for wrinkles),52 and hyaluronic acid (for dry skin), have demonstrated positive outcomes in studies.53

Some of our favorite online dermatology options that we’ve reviewed are Curology, Agency, Prose, and Musely.

Foods rich in ellagitannins or ellagic acid

If urolithin A sounds like something you’re interested in, but you don’t want to add another supplement to your daily regimen, then eating foods rich in its precursors could be an option.11 While ellagitannins and ellagic acid can be found in an array of fruits and nuts, the pomegranate fruit (and especially pomegranate juice) is often considered to be their best source.54

Unfortunately, this alternative only has the potential to work if you’re part of the roughly 40% or so of people who can produce urolithin A after consuming these polyphenols (this depends on factors like your unique microbiome).6