The Best Quercetin Supplement

For many people, immune and allergy symptoms aren’t limited to a few weeks in the spring. Congestion, itchy eyes, sinus pressure, and general inflammation can linger for months — sometimes year-round — especially during periods of stress, travel, or illness.1

One option that often comes up in these conversations is quercetin — a plant-based compound commonly used to support immune balance and inflammatory control.2 It’s been studied for its role in allergy symptoms, cardiovascular health, metabolism, and cellular aging — making it one of the more versatile flavonoids in nutrition research.3 4 5 6 While some claims around quercetin are overstated, there’s credible evidence that it can provide meaningful support when used consistently and appropriately.

With so many quercetin supplements available — each using different forms, doses, and combinations — knowing which ones are worth considering isn’t always obvious. This guide explains what quercetin is, how it may help, and which supplements perform best based on current research.

If you’re looking for a quick answer, here are our top picks:

Over the past two decades, Innerbody Research has helped tens of millions of readers make informed decisions about their health and wellness.

Our team thoroughly evaluates every product and service we review — including the quercetin supplements in this guide. We examined how quercetin functions in the body and reviewed dozens of clinical studies and research reviews exploring its role in immune balance, inflammation, allergy symptoms, cardiovascular health, and related areas.

Alongside this research, we evaluated the leading quercetin supplements on the market, comparing their formulations, dosages, and quality against available scientific evidence. We also purchased and reviewed several of the most promising supplements ourselves to assess factors like packaging, labeling clarity, ease of use, and overall value.

As with all health-related content on our site, this guide has been reviewed by members of our Medical Review Board for accuracy and will be updated as new research and products emerge.

Identifying the market’s best quercetin supplements meant evaluating each product across the same factors most people consider before adding a supplement to their routine:

• Effectiveness
• Safety
• Cost
• Convenience

These four pillars guided our evaluation.

In the sections that follow, we explain how each of our top quercetin picks performed in these areas — and where certain brands stood out. All of our selections met a high standard overall; when we highlight an “advantage,” it doesn’t mean other products fell short, only that a supplement demonstrated a distinct strength in that category.

Effectiveness

Advantage: Bestvite Quercetin

To evaluate effectiveness, we looked at how closely each supplement aligned with the doses and forms of quercetin that have actually produced results in human research. Across randomized trials and meta-analyses, quercetin has been studied for a range of outcomes — including inflammation, blood pressure, cholesterol levels, and immune-related markers.2

When you step back and look across that research, a few dosing patterns show up again and again:

• Inflammation: Doses of 500mg per day or higher, taken for 6–10 weeks, are associated with modest reductions in C-reactive protein (CRP), a marker of systemic inflammation.7 8
• Blood pressure: Doses above 500mg per day, taken for 8 weeks or longer, are linked to small but statistically significant reductions in systolic and diastolic blood pressure.4 9
• Cardiovascular markers: Doses ranging from 100–500mg per day for 8–12 weeks may improve total and LDL cholesterol, with some evidence suggesting greater LDL reductions at higher doses.7 9
• Allergy symptoms: Direct human evidence is more limited, but one small randomized trial using 200mg per day reported improvements in allergic rhinitis symptoms.10

Taken together, this body of evidence points to 500mg per day as a practical threshold for measurable effects across multiple outcomes.

With that in mind, we gave Bestvite Quercetin the effectiveness advantage. It delivers 500mg of standard quercetin — formally known as quercetin aglycone — per capsule, closely matching the dose most often used in clinical trials and meta-analyses. That makes it an easy fit for people looking to align supplementation with what’s actually been studied.

However, it’s worth noting that quercetin has relatively low oral bioavailability.11 To address this, some manufacturers use newer delivery technologies designed to improve absorption. One example is quercetin phytosome, which binds quercetin to phospholipids — fat-like molecules that help transport compounds across cell membranes — an approach used in products like Nootropics Depot Quercetin Phytosome. Pharmacokinetic studies show that these formulations can significantly increase blood quercetin levels.12 However, because most outcome-based human trials use standard quercetin, the clearest case for effectiveness still rests with what’s been studied the most: 500mg per day of quercetin aglycone, which Bestvite delivers.

Safety

Advantage: Bestvite Quercetin

Quercetin is generally well-tolerated in healthy adults. Human clinical trials and safety reviews have reported no serious adverse effects at doses ranging from 200mg to 1,000mg per day, taken for periods of up to 12 weeks.13 14 When side effects do occur, they tend to be mild and temporary — most often digestive discomfort at higher doses. That said, research on long-term daily use beyond several months is limited, which makes conservative dosing a sensible approach.

Beyond dosing and duration, product quality also matters for safety. Because dietary supplements are not pre-approved by the FDA, manufacturing quality played a central role in our safety assessment. We evaluated products using the following criteria:

• GMP-compliant manufacturing
• Independent third-party testing
• Clear allergen disclosure

Here’s how our top recommendations compare based on those factors:

All of our top picks meet baseline safety standards and are manufactured in GMP-compliant facilities. However, Bestvite Quercetin stands out for its combination of quality control and formulation simplicity. Bestvite manufactures in NSF-GMP certified facilities and uses ISO-certified third-party laboratories for testing. This supports consistent purity and potency in a single-ingredient formula that uses standard quercetin.

Other brands bring different strengths. Nootropics Depot and ProHealth Longevity, for example, both publish third-party test results directly on their product pages — a transparency practice we value. That said, there are tradeoffs. ProHealth Longevity’s formula includes bromelain, which can be a concern for people with pineapple sensitivities. Nootropics Depot uses a phytosome delivery system designed to increase absorption; while pharmacokinetic studies show higher blood quercetin levels with this approach, long-term safety data and outcome-based human trials are more limited compared with standard quercetin, which has been evaluated across a much broader clinical literature.12 13

Taken together, Bestvite’s use of a well-studied quercetin form, combined with solid manufacturing practices and minimal allergen risk, makes it the most conservative and broadly appropriate choice from a safety perspective.

Cost

Advantage: Bestvite Quercetin

If you’re looking for a quercetin supplement that delivers strong value without unnecessary complexity, Bestvite Quercetin is hard to beat.

Each Bestvite capsule contains 500mg of quercetin aglycone, which aligns with the amount often studied in clinical research.7 8 9 A 120-capsule bottle — a four-month supply at one capsule per day — costs about $23.99 one-time or $22.79 with a subscription. That works out to $0.20 per 500mg serving and includes free shipping, making Bestvite one of the most affordable options for daily quercetin supplementation.

The other supplements in this guide take different approaches — by using specialized delivery forms or including additional ingredients — and that affects cost. Below is a clear breakdown of how these products compare per serving:

Compared with Bestvite’s simple, daily-use formula, other products may be worthwhile depending on your goals — for example, if you prioritize enhanced absorption technologies or additional active ingredients. But when the goal is straightforward, evidence-aligned daily quercetin at the lowest cost per serving, Bestvite comes out ahead.

Convenience

Advantage: Bestvite Quercetin

Convenience with quercetin mostly comes down to two things:

• How easy it is to take consistently
• How much flexibility you have if it doesn’t work out

On both fronts, Bestvite Quercetin performs well. The dosing is simple — one capsule per day — which makes it easy to build into a routine without thinking about timing, stacking, or multiple pills. That simplicity matters for a supplement that’s taken daily for the long term.

Bestvite also stands out for its generous return policy. The company offers a 60-day satisfaction guarantee, allowing customers to return products for a replacement, exchange, or refund if they’re not satisfied. That’s a longer window than many supplement brands offer and provides meaningful peace of mind if quercetin turns out not to be the right fit.

Other products do well in this area too, but with tradeoffs. For example, ProHealth Longevity Quercetin Bromelain Complex actually offers an even longer 100-day guarantee, which is excellent. However, its three-tablet serving makes daily use a bit more cumbersome, especially for people who prefer to keep pill counts low.

Taken together, Bestvite’s combination of once-daily dosing and a clear, consumer-friendly return window makes it the most convenient option for most people — especially those looking to try quercetin with minimal commitment and hassle.

Below is a side-by-side look at the key features of each quercetin supplement featured in our guide:

Quercetin is a naturally occurring plant compound in a family called flavonoids, which are part of a broader group known as polyphenols.3 Polyphenols help plants manage environmental stress — such as UV exposure and oxidative damage — and many of those same properties appear to be biologically active in humans.15

As a flavonol, quercetin has a structure that allows it to neutralize reactive oxygen species and interact with enzymes and signaling molecules involved in inflammation and cellular stress. Research shows quercetin can affect:16

• Inflammatory signaling molecules (such as cytokines)
• Enzymes involved in oxidative stress
• Mast cell activity related to histamine release

These effects help explain why quercetin is frequently discussed in the context of seasonal allergies and immune support.3

Where quercetin comes from

Quercetin is found naturally in plant foods, with onions being one of the most commonly cited and concentrated sources. In foods, it’s typically bound to sugar molecules (called glycosides), which affects how it’s absorbed and processed in the gut. Onion-derived quercetin glucosides, for example, appear to be relatively well absorbed compared to some other food sources.3

Even so, total dietary intake is modest. Most people consume about 5–40mg of quercetin per day from food, depending on diet — far less than the amounts typically studied in quercetin supplements.17

After you take a quercetin supplement, it’s absorbed in the small intestine and then quickly metabolized into several related forms that circulate in the bloodstream.18 19 These circulating forms are quercetin molecules that have been modified by the body (for example, by attaching sulfate or glucuronide groups), which makes them easier to transport in blood and deliver to tissues.

That distinction matters because quercetin doesn’t behave like a typical antioxidant that simply “soaks up” free radicals. Instead, most of its effects in humans appear to come from how it influences cellular signaling systems involved in inflammation, immune reactivity, and oxidative stress.20 21 These signaling effects help explain why quercetin shows benefits in some areas — like allergy symptoms and blood pressure — while having more subtle or variable effects in others.

Quercetin absorption and bioavailability

One of the main limitations of quercetin supplements is absorption. Quercetin has naturally low oral bioavailability, meaning only a small portion of what you swallow reaches circulation in forms the body can use.13 36 This is partly because quercetin doesn’t dissolve well in water and partly because it’s rapidly broken down and modified by the gut and liver soon after intake.18 19

There are a couple of strategies commonly used to help improve absorption:

Quercetin dosage

Human studies on quercetin have tested a wide range of daily doses, most often between 200mg and 1,000mg per day, typically taken for 6–12 weeks.7 8 13 14 When you look across that research, a fairly consistent pattern shows up: doses around 500mg per day are where measurable effects most often occur.

To put that into context, different outcomes tend to cluster around similar dose ranges:

• Inflammation: Meta-analyses of randomized trials show that quercetin doses at or above 500mg daily are associated with modest reductions in CRP.7 8 Lower doses are sometimes helpful, but results are less consistent.
• Blood pressure: In pooled analyses, quercetin supplementation lowered systolic and diastolic blood pressure most reliably in studies using 500mg per day or more, particularly in adults with elevated baseline blood pressure.4 9
• Cardiometabolic markers: For cholesterol and fasting blood glucose, effective doses again tend to cluster around 500mg per day, with benefits showing up more clearly in metabolically at-risk adults.7 9

At the lower end of the range, one small randomized trial reported improvements in allergic rhinitis symptoms using 200mg per day.10 While encouraging, broader human evidence for allergy outcomes remains more limited than it is for inflammation and blood pressure.

It’s also worth noting that most outcome-based human trials use plain quercetin, rather than lipid-based or phytosome delivery systems. For that reason, 500mg per day of standard quercetin serves as a practical reference point when trying to align supplementation with what’s been studied most extensively. Enhanced-absorption formulations may achieve higher blood levels at lower doses, but long-term outcome data using those forms are still limited.37

Finally, there’s currently no official recommended daily intake for quercetin, and long-term safety data beyond several months of use remain limited.

Quercetin supplements are generally considered safe for most healthy adults when used at doses studied in human trials. A comprehensive safety review examining quercetin as a dietary supplement found no serious adverse effects in studies using doses ranging from 200mg to 1,000mg per day, taken for periods of up to 12 weeks.13

Across randomized trials and meta-analyses, reported side effects are uncommon and usually mild. When they do occur, they most often involve digestive discomfort — such as nausea or stomach upset — particularly at higher doses.13 These effects are typically temporary and can often be minimized by taking quercetin with food.

That said, certain groups may want to use extra caution. As with any supplement, it’s wise to speak with a healthcare professional before starting quercetin if you fall into one of the following categories:

Overall, quercetin has a favorable short-term safety profile when used within evidence-based dose ranges. Sticking to 200–500mg per day, or up to 1,000mg per day for limited periods, keeps intake within the amounts most commonly studied in human research.

Quercetin supplements are best suited for adults looking to support immune balance, histamine response, vascular health, and inflammation control. Its benefits stem less from acting as a simple antioxidant and more from how it influences cellular signaling pathways involved in oxidative stress, immune reactivity, and endothelial function — mechanisms that show up across allergy, cardiovascular, and metabolic research.3 4 7 9

More specifically, the following groups are most likely to benefit from consistent use:

Who are they not for?

Quercetin is a well-studied flavonoid with real, measurable effects — but it isn’t a cure-all. Its benefits are modest, context-dependent, and gradual, and they’re most pronounced alongside lifestyle fundamentals like diet, sleep, and stress management. People in the following groups may want to reconsider supplementation or adjust their expectations before adding quercetin to their routine:

Quercetin works best as a supportive tool, not a shortcut — complementing a healthy diet, consistent sleep, and evidence-based medical care rather than replacing them.

Best for everyday health

Founded in 2006, Bestvite is a U.S.-based supplement company that focuses on keeping formulas simple and affordable without cutting corners on manufacturing. Its products are made in NSF-GMP certified facilities and verified by ISO-certified third-party laboratories — a level of quality control that isn’t always guaranteed in the budget supplement space.

Each Bestvite Quercetin capsule delivers 500mg in the standard aglycone form — the version used in most human studies examining antioxidant, anti-inflammatory, and metabolic effects.7 8 9 In clinical research, daily intakes in the 500–1,000mg range have been linked to reductions in oxidative stress markers and modest improvements in inflammatory signaling, vascular function, and exercise recovery when taken consistently.2 29 44

That said, it’s important to talk about absorption. Quercetin aglycone isn’t the most bioavailable form out there. Enhanced options — such as phytosome-bound quercetin — can raise blood levels more efficiently.37 That said, the bulk of human evidence supporting quercetin’s benefits relies on this same aglycone form, suggesting that higher doses (500–1,000mg) can still produce meaningful biological effects despite lower absorption.7 8 9

Pricing, subscriptions, and shipping

At $23.99 for 120 capsules — a full four-month supply at the 500mg daily dose — Bestvite is one of the most affordable ways to supplement with quercetin. A larger 240-capsule bottle is available, but the per-capsule savings are modest. Bestvite also offers a 5% subscription discount, which helps a bit, though it’s less aggressive than the introductory discounts offered by some competitors, such as Qualia’s 50% first-order promotion.

Bestvite’s pricing breaks down as follows:

Refunds and guarantees

Bestvite offers a 60-day money-back guarantee, which gives most people enough time to assess tolerance. While this doesn’t match the longer 100-day policies offered by brands like ProHealth Longevity, it does align well with the shorter timelines used in many quercetin studies, where changes in inflammatory or cardiovascular markers were observed within 4-8 weeks.7 8 9

Combined with free U.S. shipping and a low upfront cost, the policy keeps the risk relatively low for first-time users.

Best for high absorption

One of the main ways Nootropics Depot distinguishes itself is through its commitment to testing transparency. Every batch of every supplement undergoes both in-house analysis and independent third-party testing, with COAs made publicly available. That level of documentation remains uncommon in the supplement industry and has helped the brand build a strong reputation among consumers.

For its quercetin formula, Nootropics Depot uses Quercefit, a branded phospholipid-bound quercetin phytosome designed to improve absorption. In human pharmacokinetic research, quercetin phytosome has been shown to produce substantially higher plasma quercetin levels than quercetin aglycone at equivalent doses.37 Importantly, Quercefit isn’t just a theoretical upgrade. This same branded form has been used in multiple human studies — including clinical research examining immune and metabolic outcomes — demonstrating that it reaches circulation at biologically meaningful levels.42 45 However, these outcome studies were not designed as direct head-to-head comparisons with quercetin aglycone.

Compared with standard quercetin products, Nootropics Depot’s offering is best suited for readers who prioritize absorption efficiency and testing transparency over the lowest possible cost per milligram.

Pricing, subscriptions, and shipping

Unlike some competitors, Nootropics Depot does not offer a subscription program for its quercetin phytosome. Any savings come from purchasing larger bottle sizes rather than recurring discounts. Pricing breaks down as follows:

Additionally, only orders above $50 qualify for free U.S. shipping. Otherwise, shipping is the highest among the products in this guide (approximately $10.50 to the U.S. Southwest).

Refunds and guarantees

Nootropics Depot accepts returns within 30 days, but only for unopened products. In practice, this means there is no money-back guarantee once a bottle has been opened.

This is the most restrictive return policy among the products featured in this guide. For comparison, Bestvite offers a 60-day money-back guarantee, while ProHealth Longevity and Qualia provide return windows of up to 100 days.

Best quercetin with bromelain for immune support

Founded in 1988 and based in Carpinteria, California, ProHealth Longevity is best known for supplements focused on healthy aging, as the name implies. Its Quercetin Bromelain Complex is part of that portfolio, pairing ingredients commonly studied together for immune-related support.

A full daily serving delivers:

• Quercetin: 1,000mg
• Vitamin C: 600mg
• Bromelain: 300mg

This trio gained attention during the COVID-19 era, when quercetin was often paired with vitamin C and bromelain — and sometimes zinc — in immune-focused clinical research.39 46 47 ProHealth’s formula closely reflects the quercetin dose range and combination approach used in those studies.

At 1,000mg per day, quercetin is provided at the upper end of doses commonly used in short-term human research. That level reflects how quercetin was used in several COVID-era trials, where the goal was to raise circulating quercetin levels during periods of heightened immune demand.

While results across these trials were mixed, some studies and observational data reported symptom relief in people taking quercetin-based combinations. Given the overlapping roles these ingredients play in antioxidant activity, inflammation signaling, and immune response, the overall rationale for combining them is biologically plausible.

In addition to their individual roles, bromelain and vitamin C are often paired with quercetin to help address its naturally low bioavailability. Bromelain is thought to support quercetin absorption by improving intestinal permeability, while vitamin C may offer complementary antioxidant support by protecting quercetin from oxidation.39 53 While direct human evidence for large absorption gains is limited, the combination is mechanistically sensible and helps explain why this trio appeared together in several COVID-era clinical trials.

Given that 1,000mg sits at the upper end of quercetin doses used in research, some readers may wonder whether taking fewer tablets still makes sense. Outside of short-term immune-support situations, taking one or two tablets still provides quercetin, vitamin C, and bromelain in amounts that overlap with ranges studied for antioxidant, inflammatory, and immune-related effects, while reducing the likelihood of gastrointestinal discomfort for routine use.9 48 50

Pricing, subscriptions, and shipping

A 100-tablet bottle (33 servings) of Quercetin Bromelain Complex costs $25.35 as a one-time purchase or $22.82 with a subscription. Subscription intervals of 33, 66, or 99 days align neatly with different intake patterns, whether you take one, two, or the full three tablets per day.

Shipping costs $4.99 unless your order reaches the free shipping threshold of $30. Within this guide, that places ProHealth Longevity in the middle of the pack for shipping costs: Nootropics Depot and Qualia both charge more, while Bestvite offers free shipping on its quercetin products.

Refunds and guarantees

ProHealth offers a 100-day satisfaction guarantee on vitamins and supplements, allowing customers to return the unused portion for a refund or store credit (shipping is non-refundable). This is a long window that gives most people ample time to assess tolerance and perceived benefits — even at lower daily tablet counts.

Among the products featured in this guide, Qualia is the only other brand that matches ProHealth’s 100-day guarantee.

Best senolytic formula

Qualia Senolytic is the outlier in this guide — not because it uses quercetin in a radically different form, but because it uses quercetin on a very different schedule. Instead of a daily capsule meant for steady, long-term use, Qualia adopts what researchers often describe as a “hit-and-run” approach: a higher-dose pulse taken infrequently, rather than smaller doses taken every day.54

To understand why this matters, it helps to look at quercetin’s role in cellular senescence research. Senescent cells are older, damaged cells that stop dividing but continue to release inflammatory signals, contributing to tissue dysfunction over time.33 Quercetin has been studied for its potential senolytic activity, both on its own and in combination with dasatinib, a prescription cancer drug used experimentally in senescence research.32 34 35

The rationale behind the hit-and-run strategy comes down to timing. Cells don’t become senescent overnight; the process appears to unfold over weeks, with laboratory models suggesting timelines on the order of six weeks.32 Because of that, taking high doses of senolytic candidates every day may offer little added benefit once existing senescent cells have been addressed — while increasing the likelihood of side effects.

Instead, the hit-and-run model aims to allow senescent cells to accumulate gradually, then periodically target them with a short, high-dose intervention. Conceptually, it’s less about constant pressure and more about periodic reset — intervening at intervals that better match the biology of senescent cell formation, rather than trying to suppress the process continuously.32 55

This approach extends beyond quercetin alone. Qualia Senolytic’s formula combines multiple polyphenols and plant extracts that are frequently discussed in senescence and inflammation research, including:

• Fisetin: 1,400mg
• Quercetin: 750mg
• Curcumin extract: 400mg
• Olive leaf extract: 250mg
• Soybean seed extract: 200mg
• Luteolin: 150mg
• Milk thistle extract: 125mg
• Piper longum root extract: 50mg
• Senactiv: 50mg

It’s also worth noting that the quercetin used here is a phytosome form, which has been shown to achieve substantially higher absorption than standard quercetin — estimates in human pharmacokinetic studies suggest increases on the order of 10–20 times higher.12

Taken together, Qualia Senolytic isn’t designed for daily antioxidant support or routine inflammation management. It’s built for readers specifically interested in the senolytic pulse-dosing concept, where quercetin plays a supporting role in a broader, intermittently dosed formula.

Pricing, subscriptions, and shipping

Each box of Qualia Senolytic contains two servings, intended to be taken on consecutive days once per month. Pricing is structured around one-time purchases or subscriptions, with a steep discount applied to the first subscription order.

Shipping is $9, and there is no free shipping threshold. Subscription deliveries are limited to a four-week interval, which aligns with the intended two-day-per-month dosing schedule.

Refunds and guarantees

Qualia offers a 100-day money-back guarantee, which is generous compared with most supplement brands. The only other product in this guide with a comparable return window is ProHealth Longevity.

One important limitation applies: the guarantee covers one unit of product, even if multiple boxes were delivered during the guarantee period.

If quercetin isn't right for you due to cost or sensitivities — or if you want to build a stack around similar pathways — several well-studied nutrients overlap with quercetin’s primary roles in antioxidant defense, inflammation regulation, and immune support.

Dietary sources of quercetin

Supplementation isn’t the only way to support the pathways quercetin influences. Quercetin is one of the most abundant flavonoids in the human diet, and higher dietary intake has been associated with improved antioxidant status and markers of cardiovascular health in observational studies.59

Foods particularly rich in quercetin and related flavonoids include:59 60

• Onions (especially red and yellow onions)
• Apples (with the skin)
• Capers
• Berries (such as blueberries and cranberries)
• Leafy greens like kale and spinach
• Broccoli and other cruciferous vegetables
• Green and black tea

Eating a diet rich in flavonoid-containing fruits and vegetables can help support antioxidant defenses and inflammatory balance, whether or not you choose to supplement with quercetin directly.