Best DIM Supplement

Hormone changes, such as the natural age-related decline in bioavailable testosterone, can significantly affect your mood and physical health.1 2 Because of this, many people seek out ways to boost certain hormones or balance them out. One potential solution that’s been growing in popularity over the past few years is diindolylmethane (DIM) supplements.

Found in cruciferous vegetables, DIM is a phytonutrient that has shown promise in boosting estrogen metabolism, improving prostate health, and potentially reducing cancer risk, among other possible benefits.3 But are DIM supplements right for you? In this guide, we'll help answer that question and identify the best options to consider in 2026.

If you’re in a hurry, check out our summary of recommendations below. For more details, read on to learn how we made our choices.

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

For our guide to the best DIM supplements, our team spent over 80 hours researching the ins and outs of how DIM may benefit a variety of concerns, including menopause symptoms, prostate health, and hormone imbalances. In total, we read through 40+ studies, journals, reviews, and other pieces of scientific literature to bring you the most accurate and up-to-date information. Our team also purchased the market’s top DIM supplements to relay details that could only be gathered through the customer experience.

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

When evaluating DIM supplements, we judged them based on four criteria that consumers often care about the most:

• Effectiveness: Which pick is most likely to help the largest number of people?
• Safety: Do any of our picks pose any health concerns? Do the manufacturers conduct testing? Are the products allergen-free?
• Cost: Out of our top picks, which one is the most cost-effective? Are there any cost-saving opportunities?
• Convenience: Which supplement is the easiest to incorporate into your daily life? Are they easy to order and keep in stock?

Below, we take a closer look at how each one fared, including where certain products stood out.

Effectiveness

Advantage: Nutricost (with Nature’s Way a close runner-up)

At first glance, Nature’s Way DIM-Plus might seem like the most effective option, despite offering just 100mg of DIM per serving. That’s because it uses BioResponse DIM (BR-DIM), a more bioavailable form that has been used in many clinical studies and shown to produce higher blood levels of DIM compared to standard crystalline forms.5

However, Nutricost ultimately earns the advantage by delivering a significantly higher dose — 300mg per serving. While its DIM is less bioavailable, the larger amount helps offset that limitation and may result in a greater overall exposure.

Nutricost also includes BioPerine, a black pepper extract that has been shown to enhance the absorption of certain compounds.6 7 While this effect hasn’t been specifically studied with DIM, it may provide an additional benefit.

In short, Nature’s Way offers a more bioavailable form of DIM, but Nutricost’s higher dose — combined with a potential absorption enhancer — gives it the edge in overall effectiveness.

Safety

Advantage: Thorne

Since the FDA doesn’t regulate supplements like it does prescription medications, it’s up to supplement manufacturers to ensure their products are safe for consumers.4 This is often done by adhering to current Good Manufacturing Practices (GMP), subjecting products to independent third-party testing, or obtaining various safety certifications. Here’s how our top picks compare:

As you can see, only Thorne checks all the boxes for safety. Nature’s Way is a close second, but it doesn’t have TGA and NSF certification the way Thorne does. Nature’s Way does have NSF certification for its GMP compliance, but that’s not the same as the product itself being NSF-certified from testing.

Cost

Advantage: Nutricost DIM Capsules

Both Nutricost and Nature’s Craft are our most cost-effective picks, but the former managed to beat the latter due to a couple of factors, which are illustrated in the chart below.

As you can see, Nutricost offers the lowest up-front cost option ($10) and the highest subscription discount (20%). This, combined with a money-back guarantee on par with most of our other recommendations, is why Nutricost is our best value pick.

In contrast, Thorne and Nature’s Way are among the most expensive options. Thorne only offers a single bottle size, so there’s no lower-cost way to try it, while Nature’s Way’s larger bottle also comes with a relatively high up-front price.

Thorne does offer a 10% subscription discount (which increases to 20% if you subscribe to three or more products), but even with those savings, its per-serving cost remains higher than most competitors. Nature’s Way shows a similar pattern: its per-serving cost stays well above options like Nutricost and Nature’s Craft, even with a subscription.

Convenience

Advantage: Nature’s Craft DIM For Men

Truly, all of our top DIM supplement picks are relatively easy to use, but Nature’s Craft stands out in a few key ways:

• A single bottle of Nature’s Craft DIM For Men provides a four-month supply at one capsule per day. Meanwhile, options like Nature’s Way DIM-Plus provide a 60-day supply when taken as directed. Only Nutricost matches the generous per-bottle serving count of Nature’s Craft.
• Subscriptions from Nature’s Craft can be set anywhere from one to six months. Nutricost offers delivery intervals of 30 days to four months, but Nature’s Craft still provides slightly more flexibility.
• The company also allows customers to pay over time in installments, which adds another layer of convenience for some users.

To be fair, Thorne and Nature’s Way also offer flexible subscription plans, and all of our picks include money-back guarantees, but Nature’s Craft edges ahead with a combination of long supply, flexible delivery options, and added payment flexibility.

The chart below offers a quick reference for how our top DIM picks compare in key ways, such as dosing, price, and servings per bottle.

DIM is the abbreviation for diindolylmethane (or, to be more specific, 3,3'-diindolylmethane), which is a phytonutrient found in cruciferous vegetables, such as cauliflower, Brussels sprouts, cabbage, kale, and broccoli.3 11 This compound is perhaps most well-known for its antiandrogenic and anticancer potential. As explained by the National Cancer Institute, these effects are due to DIM’s apparent abilities to promote estrogen metabolism and cause apoptosis (cell death) in tumors.3 12

Because of these potential effects, DIM is most often supplemented in an effort to improve the following concerns:

• Prostate health
• Menopause symptoms
• Risk of certain cancers
• Hormone imbalances in men

As explained by experts, “DIM alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity.”13

In layman’s terms, this means that DIM changes how estrogen is processed in the body. Certain estrogen by-products may raise the risk of certain cancers, while others don’t. DIM helps influence estrogen to break down into harmless by-products instead. Additionally, DIM can help balance hormones by attaching to the same receptors that estrogen and testosterone do.

Researchers go on to note that lower concentrations of DIM can help protect cells against oxidative stress — an imbalance of free radicals in the body that can lead to chronic inflammation and many long-term health conditions.13 14

“Chronic inflammation (often from poor nutrition, among other causes) produces reactive oxygen species,” explains Dr. Stanford, “which are unstable molecules that lead to oxidative stress. Over time, oxidative stress can cause significant cellular damage and increase the likelihood of inflammation-related health conditions, like Alzheimer's disease, heart disease, autoimmune diseases, and certain cancers.”

Below, we break down promising research on how these properties of DIM (estrogen metabolism modulation and protecting cells against oxidative stress) may benefit various health concerns.

For most healthy adults, DIM appears to be safe and well-tolerated when taken as directed. Most studies using DIM report few to no serious adverse effects. For example:

• Researchers in a 2014 study on DIM for PIN noted, “Good tolerability of DIM-based formulation allows us to recommend it for further clinical trials among men diagnosed with PIN for its efficacy and long-term safety parameters.”29
• In a 2020 systematic review of human trials using DIM, researchers stated, “Systemic toxicity was not observed in all of the human clinical trial studies after ingestion of DIM.”30
• A 2011 animal study found that DIM “seems to have no adverse [effects] on the rat even when given in doses 10x what we propose to be therapeutic.”31

That said, mild side effects, such as headaches and gastrointestinal discomfort, have been reported at higher doses, particularly around 300mg per day.30

While DIM is generally considered safe, emerging research suggests it may interact with hormone-related therapies. A 2025 review examining compounds that influence hormone pathways noted that DIM and similar phytochemicals may alter estrogen signaling, which could theoretically affect the efficacy of hormone replacement therapy (HRT) or other hormone-based treatments.54

Because of this, individuals using HRT or other hormone-modulating therapies should speak with their healthcare provider before supplementing.

How much DIM should I take?

Clinical research on DIM typically uses doses between 100mg and 300mg per day, though the form of DIM matters.30

• Standard (crystalline) DIM: Often used at higher doses (e.g., 200–300mg) due to lower bioavailability
• BioResponse DIM (BR-DIM): A more bioavailable form used in many studies, often at doses around 100–200mg per day, which may achieve similar effects to higher doses of standard DIM5

That said, higher doses don’t necessarily lead to better results. In one tolerability study, increasing BR-DIM beyond 200mg did not significantly improve absorption, and some participants reported side effects at around 300mg.52

Across the products in this guide, doses range from 100mg to 300mg per serving, which aligns well with what’s been studied in human trials. For most people, starting on the lower end and adjusting based on tolerance is a practical approach.

As always, it’s best to speak with your doctor before starting DIM, especially if you’re considering higher doses or using it for hormone-related concerns.

Because of its relatively mild side effects, DIM should be suitable for most healthy adults who aren’t pregnant or breastfeeding. Of course, it’s recommended you speak with your doctor before starting a new supplement, even if you’re perfectly healthy, just to be safe.

As with most supplements, there are specific people who may benefit most from DIM:

• People experiencing mood or vasomotor menopause symptoms (i.e., hot flashes, night sweats)
• Assigned male at birth (AMAB) individuals with high estrogen, low testosterone, or both
• Those concerned about their risk for certain cancers (e.g., prostate, breast, ovarian, cervical, colorectal)
• People lookin to reduce weight gain from menopause
• Those with PIN

However, it’s worth noting that the only potential benefits of DIM supported by a decent amount of research are those for prostate health and the risk of certain cancers. Other possible benefits are largely based on animal or cell studies, anecdotal evidence, or assumptions based on how DIM appears to work.

Who should look elsewhere?

DIM has gained popularity for a range of hormone-related concerns, but not all of the claims you’ll see online are supported by strong evidence. In some cases, expectations may outpace what the research actually shows.

DIM is best viewed as a supportive supplement, not a primary treatment. It tends to work best alongside a broader approach that includes nutrition, lifestyle changes, and — when appropriate — medical guidance.

Best value

Nutricost offers a straightforward, cost-effective DIM supplement. Like Nature’s Craft, the company adds BioPerine, a patented black pepper extract that may be able to improve DIM’s bioavailability.6 There aren’t any studies directly investigating BioPerine’s effects on DIM, but the extract has demonstrated the ability to increase the bioavailability of some substances by up to 200%. Researchers have noted, for example, that when added to curcumin, it increased bioavailability “almost ten-fold.”7

Nutricost’s supplement contains 300mg of DIM per serving, more than any of our other top picks. That’s three times the amount included in Nature’s Way DIM-Plus — an important distinction, since research suggests Nutricost’s form of DIM is only about two-thirds as bioavailable as the branded form found in Nature’s Way (BR-DIM). Even accounting for that difference, the higher dose positions Nutricost to deliver slightly greater overall exposure.

On the subject of manufacturing, Nutricost’s supplements are made in GMP-compliant facilities and undergo third-party testing. On top of that, this one-a-day DIM supplement is also vegetarian and free from major allergens, similar to Thorne’s.

Nutricost DIM Capsules pricing

Nutricost earned the advantage for best value for several reasons:

• A low up-front cost
• The availability of an inexpensive 30-day supply option
• A low cost per serving
• A 20% off subscription discount
• A 60-day money-back guarantee

Here’s how the pricing works out:

For the 120-capsule option, only Nature’s Craft (also $20) matches Nutricost’s price, but it contains 100mg less DIM per serving, and its lower subscription discount (10%) further strengthens Nutricost’s position as the better value. On a per-serving basis, Nutricost costs roughly half as much as Nature’s Way DIM-Plus, making it one of the most cost-efficient options in this guide.

One limitation to keep in mind is shipping: to qualify for free shipping on Nutricost’s website, you’ll need to meet a $59 minimum order, which may require adding additional products.

Best for menopause

Thorne Hormone Advantage, previously known as Thorne DIM Advantage, is similar to Nature’s Craft and Nature’s Way in that it offers additional ingredients besides DIM (pomegranate extract and sulforaphane glucosinolate). However, unlike the competition, Thorne’s supplement does not contain a bioavailability enhancer, so the dose of DIM works independently.

Let’s examine how the other ingredients in Thorne’s supplement may help support people dealing with menopause symptoms:

Add to the above research DIM’s potential to influence estrogen metabolism, and it becomes clear why we chose Thorne Hormone Advantage as the best DIM supplement for menopause.23

Thorne Hormone Advantage pricing

Thorne offers a straightforward subscription model. Customers can save 10% on subscriptions, with the option to increase savings to 20% when subscribing to three or more products.

Here’s how Thorne Hormone Advantage is priced:

• One-time purchase: $51 ($0.85 per serving)
• Subscription (10% off): $46 ($0.77 per serving)

Even with the available discounts, Thorne remains one of the more expensive options in this guide, with a higher cost per serving than most competitors — second only to Nature’s Way. However, the company does offer a 60-day money-back guarantee, which gives customers enough time to assess tolerance and overall experience.

Most bioavailable

Nature’s Way DIM-Plus is the only one of our picks to use BR-DIM, a proprietary form of the compound that “exhibits 50% higher bioavailability” than the typically used crystalline form.5 It’s the form used most often in studies involving DIM, so the majority of the positive research surrounding DIM is on the same BR-DIM that Nature’s Way uses.

Previously, our choice as the most bioavailable DIM supplement was Puritan’s Pride DIM Complex — a product that also used BR-DIM — but that item has been discontinued. Fortunately, Nature’s Way DIM-Plus offers customers the same 100mg BR-DIM dose plus an additional 100mg of a branded spinach, broccoli, and cabbage blend called Protectamins. These cruciferous vegetables are natural sources of DIM precursors, though it’s unclear how much they meaningfully contribute in this form.3

Unlike our other top picks, the recommended dose of DIM-Plus is two capsules per day instead of one. However, Nature’s Way notes that people who want to follow an “intensive use” regimen will have to take different doses. For women, that’s two capsules twice daily (200mg); for men, it’s two capsules four times daily (400mg). It’s worth noting that, even though DIM has a decent safety record, these “intensive use” doses may be too high.30

In a 2008 tolerability study on absorption-enhanced DIM in healthy subjects (men and women), researchers found that BR-DIM is “well tolerated at single doses of up to 200mg, and that increasing the dose to 300mg did not result in an increase in” maximum plasma concentration. Moreover, 300mg of BR-DIM is when some adverse effects (i.e., digestive upset, nausea, vomiting) related to the treatment were reported.52 This isn’t to say that BR-DIM doses higher than 200mg are necessarily dangerous or guaranteed to cause side effects, but it may be best to stick with the lowest effective dose possible. And in the event that you want to titrate up to a higher dose, it’s worth speaking with your doctor first.

But ultimately, Nature’s Way offers a well-dosed BR-DIM supplement that should be safe for most healthy adults when taken at the original recommended dose.

Nature’s Way DIM-Plus pricing

Like our other picks, Nature’s Way sells DIM-Plus as either a one-time purchase or a subscription with a 15% discount. Currently, you can choose from two bottle sizes. The chart below breaks down the pricing details.

As with most of our other picks, excluding Thorne, you’ll need to hit a certain purchase threshold to qualify for free shipping from Nature’s Way. In this case, that threshold is $35 — roughly $15–$25 less than what you need to spend with Nutricost ($59) or Nature’s Craft ($50).

If you’re unhappy with your DIM-Plus purchase, Nature’s Way offers a 45-day satisfaction guarantee that allows returns “for any reason.” While shorter than the 60-day policies from Nutricost and Thorne, it’s a solid return policy.

Best for prostate health

Out of all our picks in this guide, Nature’s Craft DIM For Men contains the largest number of ingredients. At the time of this writing, the ingredients are:

• DIM
• Panax ginseng
• Grape seed extract
• Astragalus root extract
• BioPerine

Since Nature’s Craft is our pick for prostate health, let’s go over how the additional ingredients (save for BioPerine, which we’ve discussed) may help:

These findings, along with DIM’s potential role in prostate cancer, are why we chose Nature’s Craft as our pick for prostate health.15

Nature’s Craft DIM For Men pricing

Nature’s Craft DIM For Men remains one of the more cost-effective options in this guide, with a competitive price per serving. Here’s how the costs break down:

• One-time purchase: $20 ($0.17 per serving)
• Subscription (10% off): $18 ($0.15 per serving)

Nature’s Craft DIM For Men offers strong overall value, especially with its low cost per dose and generous supply. While Nutricost ultimately edges ahead thanks to its higher DIM amount, stronger subscription discount (20%), and the availability of a smaller 30-day option, the two are closely matched for everyday use.

Nature’s Craft has a $50 free-shipping threshold. Depending on your order, you may find yourself just short of that mark — for example, two bottles fall about $10 short — making it tempting to add another bottle to qualify for free delivery. In most cases, though, it’s more economical to simply pay for shipping (around $5) rather than buying more than you need.

Nature’s Craft DIM For Men is also available through retailers like Amazon and iHerb at similar pricing, which may offer more convenient shipping options depending on your preferences.

No matter your reason for investigating DIM supplements, there are multiple alternatives out there that may suit your needs just as well — or maybe even better. DIM’s potential for cancer prevention, improving prostate health, menopause symptom relief, and men’s hormone balance are a few major reasons people seem interested in it, so let’s examine some alternatives dedicated to each of those goals.

For cancer prevention

No supplement can conclusively prevent any form of cancer, but several compounds have shown potential in early research, including:44

• Flaxseed: Contains lignans that have demonstrated anticancer effects in laboratory and some human studies, particularly in hormone-related cancers
• Green tea: Rich in catechins that may help protect cells from damage and are being studied for their role in cancer risk reduction
• Resveratrol: May help protect against cellular damage linked to cancer, though most evidence comes from laboratory and early-stage research

In addition to supplementation with such compounds, you can also make some lifestyle modifications such as:45

• Avoiding tobacco use
• Maintaining good nutrition with clean, whole, unprocessed foods
• Engaging in regular physical activity
• Using sunscreen, especially between the hours of 10 a.m. and 4 p.m.
• Getting regular cancer screenings and conducting self-exams

For prostate health

For prostate health, Dr. Quoc-Dien Trinh, a urological surgeon at the Harvard-affiliated Brigham and Women's Hospital, states, “Research has explored supplements' role in prostate health, suggesting positive results.”46

The supplements that have shown some promise include:46

• Saw palmetto extract: May alleviate some BPH symptoms, though results have been mixed
• Selenium: Might protect against prostate cancer or slow its progression, but findings are inconsistent
• Zinc: May support normal prostate function in those who are deficient, though high doses could increase prostate cancer risk
• Beta-sitosterol: May improve certain BPH symptoms, such as urine flow, particularly when paired with saw palmetto

That being said, Dr. Trinh recommends people rely on healthy eating — such as following a plant-based or Mediterranean diet — over supplements for prostate health.46

Dr. Jennie Stanford, a member of our medical review board, agrees with this recommendation, stating:

“A diet high in ultra-processed foods, which make up the majority of the Western diet, has been shown to increase the risk of many types of cancers. In contrast, prioritizing a diet of whole, clean, antioxidant-rich foods may help prevent certain cancer types and promote optimal hormonal health.”

For menopause symptoms

When it comes to menopause, the available treatments aren’t one-size-fits-all. While one person could benefit greatly from a supplement, someone else may do better with hormone replacement therapy, prescription medications, or another treatment entirely. It all depends on your symptoms, concerns, and unique characteristics.

Some potential options for menopause support include the following:

• Various supplements, such as specialized multivitamins (see our guide to the best menopause supplements for more details)
• Hormone replacement therapy (HRT) from a telehealth company like Winona or Alloy Women's Health
• Prescription treatments for menopausal skin and hair concerns from online dermatologists, such as Musely

For hormone imbalances in men

Depending on whether you’re looking for a way to manage estrogen levels or to support testosterone, there are different approaches to consider.

If high estrogen is your concern, then your best bet as an alternative to DIM may be a prescription medication, like an aromatase inhibitor or a selective estrogen receptor modulator (SERM).47 And some botanicals, like grape seed extract, may act as natural aromatase inhibitors.48

Reducing the fat in your diet may reduce estrogen levels, as well, although the evidence is mixed and suggests small benefits at most.49 Rather, improving body composition is a well-established way to lower elevated estrogen levels. Adipose tissue (or body fat) contributes to estrogen production, particularly in people who are overweight or obese.51 Maintaining a healthy body weight, including optimal lean body mass and fat mass, helps maintain healthy estrogen levels.

If you’re looking to boost testosterone, there are countless T-booster supplements on the market. Many of them are good, but we found nearly all of them to be lacking in one way or another: subclinical doses, dangerous inclusions, missing potentially beneficial ingredients, and so on. Because of this, we worked with experts to create our own: Innerbody Testosterone Support.

You can read more about that supplement and others we found recommendable in our guide to the best testosterone boosters.

Ultimately, though, if you’re concerned about a hormone imbalance, it’s best to speak with your doctor first and get testing done. This can help evaluate potential underlying conditions that need to be addressed. If you don’t want to wait for your doctor to order testing, and you want to bring the results to them, check out our guide to at-home testosterone tests.