Best Digestive Enzymes Supplement

Digestive discomfort is incredibly common. In a large national survey, more than half of U.S. adults reported weekly digestive symptoms like bloating, gas, and abdominal pain.1 With numbers like that, it’s no surprise that many people start looking for anything that might help their bodies break down food more easily.

Digestive enzyme supplements have become a popular go-to, promising relief from feeling overly full or heavy after meals, or like food just isn’t moving the way it should. But enzymes aren’t a cure-all. While research shows they can be genuinely helpful in specific situations — lactase for people with lactose intolerance, for example — benefits often depend on matching the right enzyme to the right digestive issue.2 Because formulas vary widely in strength and purpose, choosing the right one can feel more confusing than the symptoms you’re trying to fix.

This guide walks you through what digestive enzymes can and can’t do, who’s most likely to benefit, and which supplements stood out to us for quality, transparency, and real-world usefulness.

If you’re pressed for time, here’s a summary of our recommendations.

Digestive enzyme supplements generally fall into two groups:

• Multi-enzyme blends, which combine several enzymes to assist with digestion across many food types
• Targeted single-enzyme products, which are often designed to support a specific intolerance such as to lactose, fructose, or histamine

To make it easier to scan the landscape, we’ve organized our recommendations into two sets that correspond to the two supplement types.

Our top pick for most people is a multi-enzyme blend. That’s because it offers the broadest, most versatile support for everyday meals.

Multi-enzyme blends for general digestive support

These formulas include multiple enzymes, sometimes alongside probiotics, and are designed to support improved digestion of a wide range of foods.

• Best for most people: Triquetra Flora Digest
• Best for high-fat meals: Pure Encapsulations Pancreatic Enzyme Formula
• Best for vegetarian diets: Doctor’s Best Digestive Enzymes
• Best for GLP-1 support: Triquetra Flora Digest

Targeted single-enzyme formulas for known intolerances

These supplements can help if you have the specific intolerance they’re designed to address.

• Best for lactose intolerance: Natural Factors Lactase Enzyme
• Best for gas from beans and vegetables: Solaray Bean Enzyme
• Best for protein digestion: Source Naturals Bromelain
• Best for fructose malabsorption: Intoleran Fructase
• Best for histamine intolerance: Life Extension Food Sensitivity Relief (DAO)

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lives.

Our investigation into digestive enzyme supplements began by examining how these enzymes function in the body and where supplementation can make a meaningful difference. We analyzed dozens of peer-reviewed studies, clinical trials, and expert reviews to understand which enzymes — from lactase to multi-enzyme blends — have the strongest evidence behind them.

From there, we evaluated the supplement landscape to identify products that align with research-backed doses, appropriate enzyme strengths, and high standards of quality and transparency. We paid close attention to safety practices, allergen disclosures, third-party testing, capsule design, and cost. We also purchased several of the most promising enzyme formulas ourselves to better assess factors like packaging, ease of use, and the overall customer experience.

As with all health-related content on this website, this guide was thoroughly vetted by one or more members of our Medical Review Board for accuracy and will continue to be monitored for updates by our editorial team.

Identifying the market’s best digestive enzyme supplements meant evaluating each product on the same factors most people consider before adding a supplement to their routine:

• Effectiveness
• Safety
• Cost
• Convenience

These four pillars guided our process.

In the sections ahead, we explain how our top picks performed in these areas and where certain products stood out. All selections met a high standard overall; when we highlight an advantage, we simply mean that the product showed a particular strength in that category — not that others fell short.

Effectiveness

Advantage: Triquetra Flora Digest

Digestive enzyme effectiveness depends heavily on what’s causing the discomfort. People often react to different parts of a meal, which is why the best product for one person may not work for another. One person might digest dairy easily, another might struggle with even a small amount of ice cream, and a third might feel discomfort only after high-fat meals.

If you know your exact trigger, a single-enzyme formula can work exceptionally well. But many people don’t have a single, consistent culprit. Instead, they experience a more general pattern of post-meal heaviness, bloating, or delayed stomach emptying — the kind of symptoms often grouped under functional dyspepsia.

In these cases, multi-enzyme blends have the strongest supporting evidence, with two placebo-controlled studies on functional dyspepsia finding that they significantly improved pain, bloating, fullness, and overall quality of life.7 8

Triquetra Flora Digest aligns closely with such research. It provides:

• Coverage for all major mixed-meal triggers — protein, fat, starches, dairy, and high-FODMAP carbohydrates (FODMAPs are fermentable carbs some people struggle to digest)
• Supportive additions such as Saccharomyces boulardii, a well-studied probiotic yeast, and Bacillus subtilis DE111, a branded, clinically studied spore-forming probiotic strain that survives digestion well9 70
• ButyraGen, a postbiotic that supports your gut's natural production of butyrate, a short-chain fatty acid that nourishes the intestinal lining and supports overall gut barrier health10

This combination makes Triquetra one of the strongest broad-spectrum options for general indigestion, post-meal heaviness, functional-dyspepsia-type symptoms, or slowed gastric emptying related to GLP-1 medications (drugs that mimic a gut hormone to help control blood sugar and appetite, often by slowing stomach emptying). It’s an “everyday digestion” formula rather than a product aimed at only one food type.

That said, a single-enzyme strategy can still be highly effective — especially if you know your exact trigger and want a targeted, adjustable dose. In such situations, Natural Factors Lactase Enzyme is a strong choice for dairy intolerance, while Solaray Bean Enzyme is better suited for gas caused by beans.2 3

Safety

Advantage: Natural Factors Lactase Enzyme

Safety in digestive enzyme supplements comes down to two essentials:

• The safety of the ingredients themselves
• The quality of the manufacturing and testing behind the product

From there, simplicity becomes a practical advantage. Single-ingredient formulas introduce fewer variables into the digestive tract, making them easier to tolerate and easier to adjust if you’re sensitive to new supplements. Multi-enzyme blends are still safe for most people, but they naturally add more components to evaluate.

Among the products in this guide, Natural Factors Lactase Enzyme edges out the others for safety. Lactase is one of the best-studied digestive enzymes, with decades of clinical use and a strong safety record in both adults and children.11

In a randomized, double-blind lactose-challenge study, a 9,000 FCC dose significantly reduced hydrogen breath levels — a common marker of malabsorbed carbohydrate — and improved symptoms without notable adverse effects.2 (FCC stands for “Food Chemicals Codex,” an independent standard that defines enzyme activity units and ensures consistent enzyme strength across products.) Natural Factors delivers this same clinically supported dose in a minimalist capsule with very few excipients. The company also performs third-party testing through ISURA, whose ISO 9001–certified and ISO 17025–accredited labs provide a strong independent check on Natural Factors’ manufacturing quality.

Other products in this guide also offer solid safety profiles, but Natural Factors' simple formula, strong clinical safety data, and rigorous manufacturing standards hand it the lead in this category.

Cost

Advantage: Doctor’s Best Digestive Enzymes

Comparing the cost of digestive enzymes is more nuanced than it looks. Different formulas tackle different digestive problems, and some of the enzymes involved — especially those used for specific intolerances — are more expensive to produce than the basic proteases and amylases found in many broad-spectrum blends. On top of that, the bottle price is only part of the equation; bottle size, serving counts, shipping costs, and subscription discounts all affect the true monthly expense.

The chart below compares our top contenders:

From this information, a few things become clear:

• Doctor’s Best offers the lowest cost for a broad-spectrum enzyme blend. At $0.29 per serving (or $0.27 with a subscription), it delivers one of the most comprehensive digestive enzyme profiles among our picks at a price none of the other multi-enzyme formulas match.
• Source Naturals and Solaray are inexpensive but narrower in scope. Source Naturals Bromelain is the cheapest option overall, and Solaray Bean Enzyme becomes very affordable with a subscription, but both target specific digestion problems — protein digestion and gas from beans and cruciferous vegetables, respectively — rather than offering full-spectrum coverage.
• Some enzymes cost more than others. Intoleran Fructase uses XI for fructose malabsorption, and it’s the only product in this guide that includes this enzyme. Despite being a single-focus formula, it’s the most expensive per serving on the list.
• Triquetra Flora Digest sits midrange but doesn’t beat Doctor’s Best on cost. Its enzyme–probiotic combination may appeal to some readers, but even with subscription savings, its per-serving cost is highert.

Taken together, Doctor’s Best strikes the strongest balance between price, serving count, and breadth of formula. You’re getting a full 90-serving bottle, a well-rounded enzyme blend that covers proteins, fats, carbohydrates, and fiber, and a per-serving cost that significantly undercuts comparable broad-spectrum options.

Convenience

Advantage: Life Extension Food Sensitivity Relief (DAO)

Convenience matters more with digestive enzymes than with many other supplement categories. People often try enzymes to address very specific digestion issues, and not every formula works the same for every person. That means return policies and customer support can make a meaningful difference when you’re figuring out which product your body responds to.

All of the capsule-based products in this guide are straightforward to take, but Life Extension stands out for a couple of practical reasons:

• Generous satisfaction guarantee: Life Extension offers a 12-month satisfaction guarantee, the longest of any brand in this guide. That means if the product doesn’t work for you, you can get your money back — it’s that simple. When return policies are offered at all, most competitors provide only 30 days (like Triquetra) or maybe 60 days (like Solaray). With digestive enzymes — where personal response varies widely and some formulas serve narrow needs, like diamine oxidase (DAO) for histamine intolerance — that extended return window provides meaningful peace of mind.
• Flexible subscription options: Life Extension lets customers choose delivery intervals of 1–12 months, pause shipments, or cancel anytime. Subscriptions ship free and include a discount, making it easy to stay stocked without overcommitting.

Because digestive enzymes can be hit-or-miss depending on your underlying symptoms, Life Extension’s unmatched return window and user-friendly subscription system make it the most convenient option overall. For anyone still determining which enzyme profile works best, that level of flexibility makes a real difference.

The chart below offers a quick reference of how our top picks compare across major areas, including servings, pricing, return policies, and testing.

Digestive enzymes are proteins your body uses to break food down into smaller, absorbable pieces.12 They act as tiny biochemical tools, each one designed to unlock a specific type of nutrient. Without them, even the most nutritious meal would move through your gut largely unused.

Your body makes most of the enzymes you need.13 They work together from the moment food enters your mouth until it reaches your small intestine, where most digestion takes place.14

Here’s a brief overview of the process:

As digestion unfolds, your body depends on three primary classes of enzymes to handle the workload:

• Amylases, which target carbohydrates and starches
• Proteases, which manage proteins
• Lipases, which deal with fats

Though these form the core groups, each includes various subtypes — like salivary or pancreatic amylase for carbs, or lactase and sucrase for certain sugars — that collaborate to transform meals into nutrients ready for absorption.15

Digestive enzyme supplements aim to support your body's natural breakdown of food by providing extra enzymes that target specific nutrients, potentially easing issues like bloating, gas, and discomfort after meals. They work by mimicking or boosting the enzymes your digestive system already uses, helping to chop large food molecules into smaller, absorbable pieces. Think of them as reinforcements for a process that's usually efficient but can sometimes lag due to factors like age, diet, stress, and certain medical conditions.12 14

However, results can vary widely: what helps one person might not make a difference for another, depending on the underlying cause of their symptoms. For instance, if your indigestion stems from a food intolerance, a targeted enzyme might shine, but for broader gut issues like irritable bowel syndrome (IBS), supplements alone may fall short.18

Below, we break down some common enzymes found in supplements:

Digestive enzymes and gluten sensitivity

Gluten is one area where digestive enzymes sound appealing but carry real risks if they’re misunderstood. For people with celiac disease (CD) or non-celiac wheat sensitivity (NCWS), the current gold standard is still strict avoidance of gluten-containing grains, not enzyme therapy. Even as new non-dietary therapies are explored, reviews emphasize that no pill has replaced a gluten-free diet in routine care.45

OTC “gluten-digesting” products often contain DPP-IV–like proteases (enzymes similar to dipeptidyl peptidase-4, which clip certain protein fragments) and are marketed as being capable of breaking down gluten. But a 2017 review of commercially available glutenases found that several products failed to adequately degrade the toxic gluten peptides, leaving immunogenic sequences intact.46 The authors concluded these products could be a potential hazard in celiac disease because they might encourage people to relax their gluten-free diet without actually preventing intestinal injury.

Similarly, a 2020 review of non-dietary therapies for CD and NCWS notes that enzyme strategies are still investigational and should not be used as a license to eat gluten.45

For most healthy adults, digestive enzyme supplements appear to be well tolerated in the short term, especially when taken as directed.41 Clinical trials of multi-enzyme blends for functional dyspepsia — a common cause of post-meal fullness and upper-abdominal discomfort — have found significant symptom improvements with no increase in adverse events compared with placebo.7 8 A broader review of digestive enzyme therapy in GI diseases also concludes that these products generally have a favorable safety profile when used appropriately, while emphasizing that high-quality data on OTC digestive enzyme blends is still limited.14 21

Single-enzyme products such as lactase, alpha-galactosidase, and XI likewise show good tolerability in randomized trials, with side-effect rates similar to placebo and only occasional mild GI symptoms like gas or cramping.2 3 4 11 40 That said, not every formula is the same. Enzymes can come from fungal, microbial, plant (e.g., bromelain, papain), or animal sources, and multi-enzyme blends introduce more variables. Long-term daily use of high-dose OTC blends hasn’t been studied as rigorously as short-term, targeted use, so it’s worth approaching them as a trial tool rather than something you automatically take forever.

Possible side effects

Most side effects reported in clinical trials and reviews are uncommon and mild, but they’re still important to know about.14 21 Potential reactions include:

• Digestive changes, such as gas, bloating, softer stools, and (less often) constipation as your gut adjusts
• Abdominal discomfort or nausea, particularly with higher doses or if taken on an empty stomach

If you notice new or worsening symptoms — particularly significant abdominal pain, blood in the stool, black stools, weight loss, or persistent vomiting — it’s important to stop the supplement and talk with a healthcare professional rather than assume a different enzyme will fix the problem.

Overall, digestive enzyme supplements have a strong short-term safety record in studies of both targeted single enzymes and multi-enzyme blends. But like most supplements, they’re not completely risk-free, and long-term data — especially for complex formulas — is still limited.

Digestive enzyme supplements are best suited for adults who regularly experience post-meal bloating, gas, heaviness, or incomplete digestion despite a relatively balanced diet. Their primary role is to help break down macronutrients and specific food components that the body may struggle to handle on its own, reducing fermentation in the gut and improving nutrient absorption. While they’re not a cure for underlying GI disorders, clinical evidence and real-world use suggest they can provide meaningful relief in targeted situations.

More specifically, the following groups tend to benefit most from consistent, appropriately matched use:

Who are they not for?

Digestive enzymes can help in specific situations, but they’re not a stand-in for medical evaluation, a license to eat anything, or a cure-all for chronic gut issues. The following groups, in particular, should be cautious or adjust expectations:

Best for most people and best for GLP-1 support

Founded in 2010, Triquetra Health is a U.S.-based supplement company built around plant-forward nutrition. The company emphasizes ingredient sourcing and transparency: its products are made in GMP-certified facilities and undergo third-party testing for purity and potency, and Triquetra highlights key testing partners on its site.

Each Flora Digest capsule delivers 450mg of a broad-spectrum digestive enzyme blend, including 1 billion colony-forming units (CFU) of probiotics and 100mg of ButyraGen (a postbiotic).

The other carbohydrate- and fiber-targeting enzymes (such as cellulase, xylanase, and pectinase) don’t have clear, dose-specific human data, but they mechanistically make sense to include in a digestive enzyme blend.27 28 30

Where the formula looks lighter is in its microbiome extras:

• Probiotic blend: Each capsule provides 1 billion CFU total — 500 million S. boulardii and 500 million Bacillus subtilis DE111. Clinical trials typically have used 5–10 times higher doses of S. boulardii and 2–10 times higher doses of DE111 than Flora Digest provides per serving.8 9
• Postbiotic (ButyraGen): Flora Digest includes 100mg of ButyraGen, a branded tributyrin-based postbiotic. A recent trial used 200mg per day, twice the amount in a serving of this formula.10

Altogether, Flora Digest is best viewed as a strong enzyme formula with “background” probiotic and postbiotic support. It’s a sensible option for people who want broad help with mixed meals or GLP-1–related sluggish digestion.

Pricing, subscriptions, and shipping

Here’s how Flora Digest’s costs break down:

You can choose deliveries every 30, 45, 60, or 90 days, which makes it fairly easy to line up a bottle with daily or as-needed use.

The downside is shipping. Direct orders under $75 typically come with a noticeable fee (shipping to the Southwest U.S. came in around $8), which pushes up the true per-capsule cost for single bottles. At the time of writing, subscriptions have unlocked free shipping, but that’s promotion-dependent. Without that promotion, free standard shipping reliably kicks in only once your cart hits $75.

Refunds and guarantees

Triquetra backs Flora Digest with a 30-day money-back guarantee on direct purchases. For a category where “your mileage may vary” is the norm, a month is usually enough to see whether your post-meal bloating or upper-abdominal discomfort actually improves with regular use.

However, that window is shorter than the 60- or 100-day guarantees offered by Doctor’s Best and Intoleran, respectively. Additionally, if you buy Flora Digest through Amazon, you’ll need to start any return or replacement in Amazon’s system. Because Amazon limits returns on some supplement products, your request may ultimately get routed back to Triquetra. In those cases, the company will still honor its 30-day money-back guarantee, but you’ll have to complete that initial Amazon step before Triquetra will issue the refund.

Best for high-fat meals

Founded in 1991, Pure Encapsulations has built its brand around minimalist, hypoallergenic formulas. Its products are made in NSF-GMP–registered facilities and undergo both in-house and independent lab testing for identity, potency, and contaminants (including heavy metals, solvents, and pesticides).

Each capsule of Pancreatic Enzyme Formula contains a porcine-derived pancreatin blend standardized to 17,500 USP units of lipase (about three times greater than Triquetra), along with supporting amylase and protease. The high lipase content is the main attraction here: lipase is the enzyme your pancreas uses to digest fats, and several small crossover trials suggest that supplementing lipase or pancrelipase around very high-fat meals can reduce post-meal fullness, bloating, gas, and upper-abdominal discomfort compared with placebo.6 55

Unlike some basic digestive enzyme blends, this formula uses an acid-resistant capsule so more lipase survives stomach acid and reaches the small intestine, where fat digestion actually happens.56 That makes Pancreatic Enzyme Formula closer to a “lite PERT-style” product — PERT being “prescription pancreatic enzyme replacement for diagnosed insufficiency” — than a general multi-enzyme for every meal.57

For readers whose symptoms clearly flare with high-fat meals (think pizza night, burgers, fried foods, or rich restaurant dishes), this product offers a targeted way to test whether fat-focused enzyme support helps. It isn’t a substitute for prescription pancreatic enzyme replacement in diagnosed exocrine pancreatic insufficiency, and anyone with significant or persistent symptoms should work with a clinician first. But for otherwise healthy adults who consistently feel heavy, bloated, or overfull after fat-dense meals, a high-lipase formula like this is a reasonable experiment.

Pricing, subscriptions, and shipping

Here’s how Pure Encapsulations’ costs break down for Pancreatic Enzyme Formula:

Creating a free Pure Encapsulations account unlocks free standard shipping, which helps offset the higher per-bottle price compared with more basic enzyme blends.

For readers comparing directly with our “best for most people” pick, Triquetra Flora Digest, Pure Encapsulations is noticeably pricier per capsule — about $0.66 at regular pricing, or roughly one-third more per serving. The gap narrows if you look at enzyme strength, though: each Pancreatic Enzyme Formula capsule delivers roughly three times as much lipase as a serving of Triquetra Flora Digest, so you’re paying more per capsule but getting substantially more fat-digesting power in return, which may matter most for readers whose symptoms flare after rich, high-fat meals.

Refunds and guarantees

Pure Encapsulations’ return policy is on the stricter side for this guide. The company guarantees quality, purity, and potency through the expiration date, but:

• Only unopened, unused products in their original factory-sealed packaging are eligible for return.
• You need preauthorization within 30 days of receiving the product, and the warehouse must receive the return within 14 days of authorization.
• Returns may be subject to a 15% processing fee, and shipping costs aren’t reimbursed unless the return is due to a company error.

So unlike Triquetra, Doctor’s Best, or Life Extension, there is no money-back guarantee. Considering digestive enzymes are a “results may vary” type of supplement, the buyer assumes more risk here than with other competitors.

Best for vegetarian diets

Based in Tustin, California, Doctor’s Best has been producing science-supported supplements since 1990. The company manufactures its products in cGMP-compliant facilities and uses third-party testing to verify quality, with many formulas offered in non-GMO, gluten-free, or vegetarian options.

Doctor’s Best Digestive Enzymes stands out in this guide as a fully vegetarian, budget-friendly multi-enzyme blend that works especially well for people eating plant-forward diets. Each veggie capsule provides 450mg of a broad-spectrum mix, including:

These ingredients, together, make Doctor’s Best Digestive Enzymes a strong match for readers who:

• Eat a vegetarian or mostly plant-based diet
• Struggle with gas, bloating, or overfullness after large servings of beans, vegetables, and whole grains
• Want a broad-spectrum, vegetarian-friendly blend at a lower price point

Pricing, subscriptions, and shipping

Here’s how Doctor’s Best’s costs break down based on current direct pricing for a 90-capsule bottle:

• One-time price: $25.99
• Subscription (5% off): $24.69

Shipping on the Doctor’s Best website is typically around $5 for orders under $30, with free shipping once your cart total reaches $30. In practice, that means a single bottle on a one-time order may incur a shipping fee, while combining two bottles or adding another product usually pushes you past the free-shipping threshold. (Third-party retailers like Amazon or iHerb sometimes offer lower prices or bundled shipping, which may be worth checking as well.)

Cost-wise, this makes Doctor’s Best one of the most affordable broad-spectrum vegetarian blends in the guide. Even when you account for Triquetra’s subscription savings, Doctor’s Best is still noticeably cheaper per capsule.

Refunds and guarantees

Doctor’s Best backs direct purchases with a satisfaction guarantee: customers have 60 days from the purchase date to submit a request if they’re not satisfied.

You’ll need to contact the company through its online form and provide proof of purchase, and the guarantee applies only to original U.S. end users buying from authorized sellers. Compared with some of the more generous policies in this guide (like Intoleran’s 100-day window), 60 days is moderate. But for a product you might use daily with meals, two months is usually enough time to see whether it measurably improves bloating, gas, or post-meal discomfort.

Best for lactose intolerance

Founded in British Columbia, Natural Factors is a family-owned supplement company with many ingredients coming from its own 2,000-acre organic farm. From there, ingredients move into in-house manufacturing and independent testing: Natural Factors highlights ISURA certification, which screens finished products for upwards of 800 contaminants (including pesticides, solvents, and heavy metals).

Each Natural Factors Lactase Enzyme capsule contains 9,000 FCC of lactase — a fungal (Aspergillus-derived) enzyme that helps break down lactose into glucose and galactose, making dairy easier to tolerate.11 Regulators and researchers often cite around 4,500 FCC of lactase per lactose-containing meal as a typical effective dose, with some studies using 9,000–10,000 FCC units for heavier lactose loads.53 A double-blind crossover trial using Aspergillus oryzae lactase found that a 9,000 FCC capsule taken before a 25g lactose challenge significantly reduced hydrogen breath levels and GI symptoms versus placebo and outperformed a lower 3,300 FCC dose.54 Natural Factors essentially matches that higher, better-performing dose in a single capsule.

The flip side is that Natural Factors doesn’t try to be all things at once. There are no added probiotics or fiber-digesting enzymes here. If your symptoms are more general — or you also struggle with beans or high-fat meals — one of the broader blends in this guide (like Triquetra) will likely be a better fit.

Pricing, subscriptions, and shipping

Here’s how Natural Factors’ pricing shakes out for a 60-capsule bottle:

• One-time price: $21.95
• Subscription (10% off): $19.76
• Lowest cost per serving: $0.33

That per-capsule cost is higher than some generic lactase tablets, but you’re getting a product with a full 9,000 FCC clinical-strength dose and extensive third-party testing, which helps justify the premium.

The main drawback is shipping. Orders placed directly with Natural Factors typically incur a noticeable fee on carts under $50 (around $15 to the Southwest U.S. in our test order), though shipping becomes more reasonable once you bundle products together.

Refunds and guarantees

Natural Factors offers a 45-day satisfaction guarantee on purchases made through its website. You’ll need to contact customer service to initiate a return, refunds typically exclude shipping costs, and returns of opened products are reviewed on a case-by-case basis. That policy is more consumer-friendly than brands like Pure Encapsulations, which doesn’t offer a money-back guarantee, but less generous than Life Extension’s full one-year refund period.

Best for gas from beans and cruciferous vegetables

Founded in 1973, Solaray is a long-standing U.S. supplement brand that emphasizes responsible global sourcing and in-house quality control. Its products are made in GMP-certified facilities, and Solaray’s Utah lab holds ISO 17025 accreditation, an international standard for testing laboratories.

Each Solaray Bean Enzyme capsule supplies 20mg of alpha-galactosidase, providing 300 GalU of activity. Alpha-galactosidase breaks down complex carbohydrates (oligosaccharides) found in legumes, whole grains, and cruciferous vegetables into simpler sugars, which can reduce the undigested leftovers that feed gas-producing gut bacteria.23

Randomized trials using alpha-galactosidase with bean-heavy test meals typically fall in the 300–1,200 unit range and show reductions in gas, breath hydrogen, or bloating compared with placebo.3 Solaray sits at the bottom of that studied range with 300 GalU per capsule, which should be adequate for smaller servings of beans or mixed dishes. For very large bean-heavy meals, some readers may find that taking multiple capsules better approximates the higher experimental doses.

Pricing, subscriptions, and shipping

Here’s how the pricing looks for a 60-capsule bottle of Solaray Bean Enzyme:

• One-time price: $14.99
• Subscription (20% off): $11.99
• Lowest cost per serving: $0.20

That makes Solaray one of the most affordable targeted bean- and veggie-focused enzyme options in the guide, especially when you factor in the 20% savings available on subscriptions, which you can set to renew every 30, 60, or 90 days.

The main catch is shipping. Solaray offers complimentary shipping on orders of $50 or more, so a single $14.99 bottle ordered directly usually carries a shipping fee (around $5). Readers who want to try Bean Enzyme on its own may find better overall value through third-party retailers like iHerb or Amazon, which sometimes offer lower free-shipping thresholds.

Refunds and guarantees

Solaray backs its products with a 60-day satisfaction guarantee. If a Solaray supplement doesn’t work for you, the company will issue a refund for purchases made through Solaray.com or authorized partners like Amazon, as long as you’re within 60 days of purchase. For U.S. customers, orders under $50 typically don’t need to be shipped back; Solaray processes the refund and asks you to donate or share any remaining product with someone who might benefit.

That policy is more generous than brands that limit returns to unopened bottles (like Pure Encapsulations) or 30 days (like Triquetra), and it fits Bean Enzyme’s “your mileage may vary” use case. Not everyone’s indigestion is driven by the specific oligosaccharides that alpha-galactosidase targets, so a clear 60-day window gives readers time to see whether their bean- and veggie-related bloating actually improves in everyday life.

Best for protein digestion

Founded in 1982 in California, Source Naturals is an early player in the integrative supplement space. As the name implies, the company leans on natural, non-synthetic ingredients where possible. It formulates and manufactures its products in the U.S. under cGMP standards, with in-house testing of both raw materials and finished products.

Each Source Naturals Bromelain capsule provides 500mg of bromelain standardized to 2,000 GDU per gram, which works out to roughly 1,000 GDU of proteolytic activity per serving. Bromelain is a protein-digesting enzyme derived from pineapple. Reviews note that it “primarily acts as a proteolytic enzyme,” supporting the breakdown and absorption of dietary proteins in the GI tract, and that it remains active over a relatively wide pH range, allowing it to function in both the stomach and the small intestine.5 25

You can use it in two main ways:

Pricing, subscriptions, and shipping

Source Naturals carries bromelain on its own site, but availability isn’t always consistent. It’s also stocked by retailers such as Amazon, iHerb, and Vitacost, with Amazon offering the lowest price at the time of writing.

For autoshipping, discounts vary by retailer. Amazon, for example, offers about a 5% discount on recurring deliveries. When available on the Source Naturals website, the brand offers a 15% subscription discount with delivery options every 30 or 90 days.

Refunds and guarantees

When purchased directly from Source Naturals, returns follow the company’s standard 30-day policy. New, unopened items in their original packaging are eligible for a full refund within 30 days of purchase, though customers are responsible for return shipping.

Because availability on the brand’s site can fluctuate — including periods when this product is out of stock — some customers may end up purchasing Source Naturals Bromelain through retailers like Amazon, iHerb, or Vitacost. Refund windows through these sellers vary: Amazon usually offers 30-day returns for supplements, while other retailers set their own timelines and rules for opened versus unopened items.

Best for fructose malabsorption

Founded in the Netherlands in 2008, Intoleran focuses almost exclusively on digestive enzymes for specific food intolerances — lactose, fructose, FODMAP mixes, and starch/sucrose. The products are developed by an in-house dietitian team and formulated with minimal excipients. Many of their supplements, including Fructase, are certified Low FODMAP by Monash University, which independently assesses FODMAP content in compliant products.

Each Fructase capsule provides 7,500 units of XI, an enzyme that converts free fructose to glucose in the small intestine. By shifting toward a roughly 1:1 ratio of glucose and fructose, more sugar can be absorbed in the small intestine rather than spilling into the colon, where it would otherwise feed gas-producing bacteria and trigger symptoms like bloating or loose stools in people with fructose malabsorption.

A randomized, double-blind, placebo-controlled crossover study in adults with fructose malabsorption tested XI during standardized fructose challenges. The enzyme significantly reduced breath hydrogen and improved gastrointestinal symptoms compared with placebo, supporting its use as a mealtime tool.4 Reviews of dietary fructose intolerance and FODMAP management now highlight XI as a promising adjunct for people who don’t get full relief from diet changes alone.2 Still, as with all digestive enzymes, results vary, and some people who take XI don’t see meaningful symptom relief.

Pricing, subscriptions, and shipping

Here’s how the pricing for a 36-serving bottle of Intoleran Fructase looks:

• Price: $34.99
• Cost per serving: $0.97

There’s no way to subscribe or receive a discount on recurring orders. That makes Fructase one of the priciest per-capsule options in this guide, especially if you regularly need two or three capsules with higher-fructose meals.

On the plus side, Intoleran offers free standard shipping throughout the U.S., with delivery in about 2–5 business days, which helps soften the impact of the high bottle price.

Refunds and guarantees

Intoleran backs Fructase with a 100-day satisfaction guarantee: if you try the product and don’t experience relief, you can request your money back within roughly three months of purchase. That window is considerably longer than the 30- and 60-day policies from Triquetra and Doctor’s Best, respectively, and fits well with the trial-and-error nature of fructose-related symptoms.

Fructase may be good if you:

• Have already spoken with a clinician about persistent GI issues
• Want to experiment with adding fruits, juices, or occasional sweets back into your diet

In those cases, Fructase offers a structured way to test whether targeted fructose support meaningfully changes day-to-day comfort — with relatively low financial risk if it doesn’t. The only company in this guide that offers a longer guarantee period is Life Extension, which provides a full year.

Best for histamine intolerance

Founded in 1980 and based in Fort Lauderdale, Florida, Life Extension is one of the most established supplement brands in the U.S. All products are made in NSF-registered, GMP-compliant facilities and undergo independent third-party testing for purity and potency.

Each Food Sensitivity Relief capsule contains 4.3mg of dehydrated pea sprout powder, standardized to provide 20,000 histamine-degrading units (HDU) of vegetarian DAO activity in a delayed-release vegetarian capsule. DAO is the main enzyme responsible for breaking down extracellular histamine in the gut; low DAO activity has been documented in a subset of patients with suspected histamine intolerance.60 By supporting histamine metabolism before it can build up and reach sensitive tissues, supplemental DAO aims to reduce occasional symptoms like bloating, cramping, loose stools, flushing, or headaches after eating histamine-rich items (e.g., wine, aged cheese, cured meats, or fermented foods).

In a randomized, double-blind, placebo-controlled trial of 100 patients with episodic migraine and DAO deficiency, DAO supplementation before meals modestly reduced the mean duration of migraine attacks.59 The authors concluded that one month of DAO supplementation showed a positive trend, while calling for longer and larger studies. Life Extension’s DAO capsule is designed to deliver a similar level of DAO activity to the dose used in that trial.

Pricing, subscriptions, and shipping

Here’s how Food Sensitivity Relief’s pricing breaks down for a 60-serving bottle:

• One-time price: $25.65
• Subscription (9% off): $23.40
• Cost per serving (one-time): $0.43

Subscriptions can be scheduled at any interval from 1 to 12 months, allowing you to easily match deliveries to your regimen. Autoship orders and purchases over $50 ship free, while smaller one-time orders incur a flat $5.50 shipping fee in the U.S.

Refunds and guarantees

Life Extension backs Food Sensitivity Relief with one of the most generous refund policies in the supplement industry: a 365-day money-back guarantee that applies even to opened bottles. If you try the product for several weeks or months and don’t see a meaningful difference in your post-meal comfort, you can request a full refund within a year of purchase. No other supplement company in this guide comes close to that length (Intoleran is the next longest, with 100 days).

For a niche, trial-and-error category like histamine intolerance, that long runway is a real advantage. It lets readers experiment with DAO under real-world conditions — ideally alongside guidance from a clinician — with relatively low financial risk if it doesn’t move the needle.

Digestive enzyme supplements are one way to approach post-meal bloating, gas, or heaviness — especially when you can match a specific enzyme to a specific trigger. But they’re not the only option. For many people, supporting the gut microbiome and adjusting diet patterns can make as much or more of a difference than adding extra enzymes.

Diet

Diet can play a big role in day-to-day indigestion. Changing how and what you eat can often ease symptoms and reduce how hard your GI tract has to work.

• Smaller, more frequent meals instead of large, high-fat feasts can reduce post-meal fullness and reflux by lowering pressure on the lower esophageal sphincter and allowing the stomach to empty more efficiently. Clinical guidelines for gastroesophageal reflux disease (GERD) consistently include smaller meals and earlier cutoffs for evening eating among first-line lifestyle strategies.67
• Adjusting FODMAP load (e.g., temporarily lowering certain fermentable carbs under professional guidance) can relieve gas, bloating, and abdominal pain in many people with IBS. Randomized trials of low-FODMAP diets show significantly greater improvements in global IBS symptoms compared with standard dietary advice.68
• Choosing lower-lactose or lactose-free dairy (such as lactose-free milk, yogurt, and hard cheeses) can be more effective — and easier to sustain — than taking lactase with every meal for some people with lactose intolerance. Reviews and clinical guidance emphasize dietary lactose reduction as first-line management, with lactase supplements as an adjunct when needed.11 22
• Limiting alcohol and ultra-processed, high-fat foods can meaningfully reduce heartburn and reflux. Clinical guidance notes that these foods can delay stomach emptying and relax the lower esophageal sphincter, making reflux more likely.69

For many, starting with these diet and lifestyle shifts — and layering in prebiotics or probiotics as needed — may make more sense than relying indefinitely on digestive enzyme supplements, especially in the absence of a clearly documented enzyme deficiency.