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Rootine Reviews

Rootine uses your DNA to create a specialized vitamin packet that fills your every health need, but does it really work? Find out in our review.

Last Updated: Apr 25, 2022
Rootine Reviews

Multivitamins are a contentious topic among scientific researchers and health experts. Some studies from recent years have shown that, while multivitamins support nearly every vitamin and mineral, they don’t actually help many people. Taking them when you don’t have a deficiency doesn’t affect your risk of heart disease or long-term memory loss, and it’s often more cost-effective to purchase one specialized vitamin.

On the other hand, multivitamins are perfectly safe to take for the long-term — some studies have suggested that taking them up to ten years is fine. But not everyone needs the same dosage, and taking too much of a vitamin or mineral can be as harmful as not having enough (such as iron poisoning). Plus, most supplement companies have a limited range of doses you can take.

Rootine is here to help you fill in the gaps in your nutrition, providing vitamin and mineral supplements your body needs in size-, age-, and sex-appropriate doses. Their AI analyzes everything about your nutritional needs — from your lifestyle choices to your genetics — to create the perfect daily vitamin packet. But how well can they predict what you do and don’t need? We’ve investigated Rootine to help you find out if they’re really the next best thing in vitamins.

Review Summary


  • Personalizes supplement doses to the milligram based on blood and genetic testing
  • Very transparent about their research practices
  • Tube container makes supplements easy to take with you anywhere
  • Rigorously third-party tested with well-certified labs
  • One of the least expensive DNA tests currently available


  • Microbeads are awkward to consume
  • Webpage is difficult to comprehend and navigate
  • Blood tests don’t provide a complete look at your vitamin and mineral levels
  • Blood Vitamin and Blood Mineral Tests must be purchased separately
  • Blood testing unavailable in New York state
  • Not vegan-friendly

Bottom line

Rootine creates hyper-personalized vitamin packets based on your lifestyle, genetics, and current blood vitamin and mineral status. Their core concept has a lot of promise — no other brand makes highly detailed custom vitamin sets that include the vitamins and dosages you need. It’s a tremendous leap forward in vitamin and supplement science, but the company has room to improve. Their microbeads are challenging to consume, and their website is difficult to navigate. But Rootine is a scientifically rooted supplement company worth trying out.

Our Top Picks


Rootine offers personalized vitamins that take into account lifestyle, genetics, and blood vitamin and mineral levels.

Use Rootine vitamins to optimize your health, identify and target nutritional deficiencies. Start customizing your vitamin regimen today.

DNA Test
Reviewed by Innerbody Research
Daily MultiVitamin
Reviewed by Innerbody Research
Reviewed by Innerbody Research

Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions about staying healthy and living healthier lifestyles.

We extensively test each health service or product we review. We try our best to give you, our readers, an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality and the latest medical evidence and health standards. We ask ourselves two simple questions: Would we buy the product or service ourselves if it weren’t part of our job? Would we recommend it to family and friends?

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

What is Rootine?

Rootine is a nutrition company that creates personalized vitamin, mineral, and supplement packets based on your body’s needs. This level of personalization relies on DNA and blood testing and a lifestyle questionnaire to find active and potential vitamin and mineral deficiencies.

Founded in 2018, the company strives to use up-to-date, relevant scientific research to help people reach their full potential. One of their founders has a genetic condition that will “require significant organ transplantation” over time, which propelled him to help create Rootine.

Rootine offers DNA, vitamin, and mineral at-home tests straight from their store (note that vitamins and minerals are two separate tests). After taking their tests, Rootine puts together a special formulation of microbeads — tiny coated pill-like balls — full of up to 20 vitamins and minerals based on your results to help you work at peak nutrient optimization.

How Rootine works

Rootine supplies genetic, vitamin, and mineral tests that you can do from the comfort of your couch. They give you everything you need in one box.

DNA testing

Taking a DNA test can help you and Rootine find nutrients that your body doesn’t absorb or vitamins and minerals it doesn’t metabolize well, meaning you’re predisposed to having a deficiency. Rootine’s test measures more than 50 genetic variants (SNPs) associated with those kinds of vitamin and mineral deficiencies using a saliva swab. To collect your sample, rub the included swab on the inside of your cheek.

SNPs aren’t the same as genes, so don’t expect a complete list of how you’ll absorb every vitamin and mineral. Instead, it looks at things like individual variations on the APOA1 gene to determine how much HDL you make and, therefore, how many omega-3s you should take daily to fill in the gaps.

It takes 2-6 weeks to get your DNA test results back. This might feel long but is on par with most other genetic tests. If you’ve previously taken a DNA test with AncestryDNA or 23andMe, you can upload your results to skip the DNA test. That also cuts your waiting time for analysis down to 1-2 days.

The website doesn’t make it clear if you must take the DNA test in order to get supplements from Rootine. On some pages, it looks like you can order your subscription after taking just the lifestyle test; others say the DNA test is mandatory. We can confirm that you don’t need to take a DNA or blood test to order your first three-month packet. However, the company might require you to take either a DNA or blood test to renew your subscription. Your DNA results are at the core of Rootine’s precision, so they strongly recommend taking their test before ordering your Precision Multivitamins.

Vitamin and mineral testing

If you’re interested in a more accurate picture of your current health needs, Rootine suggests taking their Blood Vitamin and Blood Mineral tests. You can still get meticulously formulated vitamins if you don’t take these tests, but having an accurate snapshot of your current serum levels gives you an even more precise idea of what you need.

Specifically, the Blood Vitamin test looks at the following nutrients:

  • B9 (folate)
  • B12
  • D3
  • hs-CRP
  • Homocysteine

The results guide dosing for vitamins B2, B6, B9, B12, C, D3, alpha-lipoic acid, and omega-3s.

Blood Mineral testing, on the other hand, looks at:

  • Magnesium
  • Copper
  • Zinc
  • Selenium
  • Cadmium
  • Mercury

The results of this test guide your dosing for magnesium, copper, zinc, selenium, vitamin C, and vitamin E.

Both tests are fingerprick tests, meaning you’ll use a lancet to draw a small drop of blood. Both tests take about five days to return your results after they’ve arrived at Rootine’s CLIA-certified laboratory, which is reasonable but on the longer side of average.

If you’ve had some of these measurements taken in the recent past, you can manually type in your information and send it to Rootine. They’ll add it to your file and adjust your microbead dosage with almost no delay.

Other companies lump together vitamin and mineral tests in the category of “micronutrients.” It’s surprising that Rootine doesn’t do the same, especially since the results of a minerals test can alter some of your vitamin doses. Also, on some areas of the website, the vitamin test is just labeled as the “Blood Test,” ignoring the minerals test entirely.

Unlike the DNA test, the vitamin and mineral tests don’t measure every micronutrient Rootine can send to you. However, Rootine is in the process of expanding their blood testing capabilities, so expect to see more variety soon.

Insider Tip: Not sure about paying $200 and then waiting a week for two fingerprick tests? If you have insurance, you can ask your doctor to order these labs using a standard blood draw for faster results and a lower out-of-pocket cost.

Nutrient microbeads

The nutrient microbeads are the pride and joy of Rootine’s service. They provide your custom nutrients efficiently, allowing Rootine to change your dose to the milligram without preparing dozens of large pills. Microbeads are small, hard balls made of three layers:

  • Raw nutrient core
  • Slow-release cellulose matrix
  • Beeswax coating

Most of the microbeads are vegetarian (except for vitamin D3 and omega-3, made from fish oil), but none of them are vegan-friendly because of the beeswax coating. All microbeads are formulated and produced under European Food Safety standards, which are even more stringent than American food safety standards. Rootine is serious about having high standards for sourcing and testing their products, ensuring that every supplier they use is up-to-date on their certifications and uses the contemporary good manufacturing processes (cGMP).

Every batch of microbeads is tested three times:

  • Raw materials are tested on arrival.
  • Finished beads are tested for bacteriology and nutrient activity.
  • Packets are re-tested for microbial contamination, heavy metals, and athletic (non-doping) standards.

All of these tests are done both in-house and by a trusted third party.

Despite looking like Dippin Dots, the nutrient microbeads must be swallowed whole. Rootine states explicitly that they shouldn’t be chewed, crushed, or blended since the outer coating is flavorless, but the inner core isn’t. The “proper” way to eat them is a little confusing and involves holding half a packet on your tongue while drinking water. You can also mix them into something like a smoothie as long as you swallow them without chewing.

How much does Rootine cost?

Since your DNA doesn’t change over time, you only need to purchase one DNA Test kit to have all the information you need. If you want to stay on top of your vitamin and mineral levels or see how your body responds to Rootine’s plan, you can order a subscription for the Blood Vitamin and Blood Mineral Tests, which arrive every three months for 10% off. Plus, if you order two or more tests at a time, you’ll earn another 15% off.

The DNA Test is one of the cheapest, comparable only to 23andMe (which costs $99 for the most basic Ancestry + Traits package). The Blood Vitamin and Blood Mineral Tests aren’t quite as inexpensive but are on par with competitors. And uploading your data is always free.

  One-time purchase Quarterly plan
DNA Test $105  
Blood Vitamin Test $105 $95
Blood Mineral Test $125 $112
DNA + Blood Test Bundle $189  


It takes no more than two weeks to get your Rootine multivitamin microbeads after you place your order, including the time you wait while they create the microbeads. Ordering a DNA test from Rootine tacks on a few extra weeks of waiting for your supplements.

  Processing time Supplement production time Total time
DNA Test 2-6 weeks 1 week 3-7 weeks
DNA Upload 1-2 days 2-3 weeks 2-3.5 weeks

Rootine also recommends uploading your blood test results immediately after uploading your DNA results (if you have them) to avoid any delays in processing time.

Is Rootine a good value?

We think that Rootine is a good value. Taking hyper-personalized vitamins is one of the best approaches for your health and wallet, since taking a supplement that you aren’t deficient in doesn’t do much, leading to wasted money and time. Rootine gives you more vitamins at the same cost as most of their competitors, and while their list of micronutrient supplements isn’t complete yet, they’re off to a great start and are actively working on expanding the list.

A month’s supply of Rootine vitamins costs more than a bottle of multivitamins from the pharmacy, but Rootine’s vitamins are customized to your body’s needs. This means they are inherently a better value.

In terms of tests, their DNA Test is one of the least expensive and tests a decent number of genes. Their Blood Vitamin and Blood Mineral Tests are sold separately, unlike the micronutrient tests of many competitors. This makes them more expensive ($230 for both tests versus an average of $150 from competitors) but not enough to change the value of the rest of Rootine’s services. To save money, you might want to skip ordering the test from Rootine directly and instead opt to upload your information.

Getting started with Rootine

You’ll have to tackle a few tasks before you can hit “purchase.”

  1. Take the lifestyle assessment, which allows you to create an account.

  2. Either upload your DNA results if you’ve had them done before (which takes 1-2 days for analysis before you get any answers) or order a DNA test.

  3. Decide if you want to take the Blood Vitamin or Blood Mineral Test.

If you aren’t interested in ordering their products immediately, it takes a few seconds of maneuvering to get their vitamin and mineral recommendations based on your lifestyle. If you click on the “home” button, a two-column pop-up appears; the left-hand side has information about your recommended supplements (names and dosages). Rootine recommended 20 different supplements to our testers based on the assessment alone.

Lifestyle assessment

Like many personalized supplement programs, you’ll need to take an assessment to initiate services. It isn’t always structured like a typical quiz. For example, it asks questions like “How often do you eat dairy per week?” with answer choices of: “never,” “sometimes,” “regularly,” and “always.” The wording problems weren’t detrimental to our testers’ understanding of the question but did cause a few double-takes.

The assessment asks:

  • What are your top health goals?
  • Personal information (name, assigned sex at birth, birthday, height and weight, email address for account creation)
  • Meat consumption (vegan, vegetarian, paleo, omnivore)
  • How often do you eat: fish, dairy, and gluten?
  • Do you smoke?
  • Daily energy levels without caffeine
  • Daily stress level
  • Average mood (bad, stable, happy, ecstatic)
  • Hours of sleep per night
  • Daily focus and mental clarity
  • Exercise and daily activity level
  • Daily sunlight exposure
  • Have you had a DNA test before? (AncestryDNA and 23andMe)

This assessment unlocks account creation; it asks you to set a password after you’ve finished. Once you’ve generated your account, you’ll be re-routed to the DNA upload page if you answered that you had taken a DNA test before.

You can always retake the assessment if you feel like your answers weren’t accurate or if your lifestyle changes over time.

Creating a personalized formula

After taking the lifestyle assessment and DNA Test – and a Blood Vitamin or Blood Mineral Test if you’re interested in the whole picture – Rootine develops their micronutrient plan for you. No matter what you’re instructed to take, every supplement comes in microbead form.

The supplements that you may receive include:


B2, B6, B9 (folate), B12, C, D3, E


Magnesium, calcium, zinc, manganese, copper, iron, selenium


Phytosterols, alpha-lipoic acid, MSM, CoQ10, omega-3s (at an extra charge)

Your supplements cost $69/month. They’re shipped in three-month sets (90 total packs), but you’re charged $69 every 30 days after your initial purchase.

Since your vitamins and minerals are personalized, Rootine doesn’t accept returns. Cancel your order at least 30 days before your next three-month pack ships if you don’t want to be charged for it. It isn’t the most intuitive payment structure and means you might end up with 90 packs of vitamins you don’t want if you don’t cancel fast enough. However, if you plan on taking a break, you can email Rootine’s customer support team and have your subscription paused at any time.

HSA/FSA and insurance

Rootine doesn’t yet accept HSA, FSA, or insurance as payment, and there are no indications that it’s coming anytime soon.


On every product page, Rootine assures you that they will never sell or share your personal information without your explicit consent. They work exclusively with top-notch laboratories that are all medical-grade and CLIA-certified (a regulation that means they use strong privacy, quality, and accuracy measures). Their labs are also compliant with four major international quality standards.

Your genetic information is stored separately from any information that could identify it as yours. If you ever want to stop using Rootine, you can easily email customer support to get all of your data wiped from their system.

Rootine also offers significant financial privacy. No one in their company ever sees your credit card number, leaving the payment processing with their reliable third-party vendor.

How we evaluate health products and services

At Innerbody Research, we customize our evaluation criteria depending on the type and nature of the health-related service or product. In general, we have five broad evaluation areas, including:

Quality: How well does the company deliver its core service(s) or product(s)? How is advanced technology used for accuracy and safety? What evidence of efficacy does the company provide? Are manufacturing standards high-quality?

User-friendly: How intuitive and convenient is the service or product? To what degree is the company interface helpful and understandable?

Value: Are you getting your money’s worth? Are there any hidden costs or charges? Does the company offer discounts?

Privacy: If health data is stored, is it stored securely? Are payments secure? Does the company market your information?

Customer support: With personalized products and services, how well does the company address your individual needs? If a product or service does not work for you, are there satisfaction guarantees or return policies that protect you?

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