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ION Gut Health Reviews: Will ION make you healthier and happier?

We tested ION Gut Support to see if the dietary supplement effectively supports physical and mental wellbeing.

Last Updated: May 2, 2022
ION Gut Health Reviews

If the past few years have led to mental distress, depression, or anxiety in your life, you’re not alone. According to the latest data, nearly 50 million Americans experience symptoms of mental illness as of 2022. And while consulting with a physician or therapist should be anyone’s first stop on a path toward recovery, other options may help.

One of these options suggests you can go through the gut to feel better. Scientists and researchers have recently expanded focus on the gut-brain connection, emphasizing the importance of a healthy gut microbiome for better mental health and reduced depression and anxiety.

Could improving your digestive health effectively turn around your mental outlook? We recently tested ION Gut Support, a gut-brain supplement, to see how well it works. Read our full review below for the pros, cons, and details to see if ION’s all-natural digestive elixir may be right for you.

Review Summary


  • Supports healthy digestion
  • All-natural, vegan, gluten-free and glyphosate-free
  • Reduces bloating and diarrhea
  • May promote better mood and stress relief
  • Boosts immunity
  • 60-day money-back guarantee
  • Subscription membership saves 15%


  • Lacks extensive scientific evidence to support benefits
  • Can be expensive to maintain long-term
  • Does not contain probiotics or prebiotics

Bottom line

We recommend ION’s gut health product called Gut Support for individuals seeking to improve digestive function, immunity, and overall mental and physical health. This all-natural supplement is safe for children and adults, and ION even produces a version specifically designed for pets. ION Gut Support takes a holistic approach to digestive health, providing trace minerals and amino acids derived directly from the earth to promote strengthened membranes and heightened cell communication. And all ION products come with a 60-day money-back guarantee to ensure customer satisfaction.

Why you should trust us

Over the past two decades, Innerbody Research has helped tens of millions of readers make more informed decisions involving staying healthy and living healthier lifestyles.

We extensively test each health service or product we review. We try our best to give you, our readers, an unbiased exploration of at-home health options, free of marketing jargon or gimmicks. We evaluate products and services based on their adherence to quality, the latest medical evidence and health standards, and a simple question: would we buy the product or service ourselves if it weren’t part of our job, and would we recommend it to family and friends?

Additionally, like all health-related content on this website, this review was thoroughly vetted by one or more members of our Medical Review Board for accuracy.

What is ION Gut Support?

ION Gut Support is a liquid dietary supplement that supports tight junction (TJ) integrity in the intestinal lining. Tight junctions provide barriers against toxins and inflammatory molecules, supporting immunity and preventing inflammatory disorders and disease.

ION Gut Support is NOT a prebiotic or probiotic supplement. Rather than introducing healthy bacteria into the gut, it works by introducing trace minerals and amino acids in humic extract (derived from ancient soil), which helps strengthen barriers and cell communication in the digestive tract.

This supplement is shelf-stable and comes in a pump bottle, making dosage easy. To take it, you’ll swallow one pump of liquid three times daily, preferably a half-hour before mealtimes. ION Gut Support provides the following benefits, which many consumers experience a short time after beginning the regimen:

  • May help overcome food sensitivities (not allergies), including gluten and dairy intolerance
  • Reduces gas, bloating, and indigestion
  • Helps restore a healthy gut microbiome
  • Minimizes symptoms of irritable bowel syndrome and other digestive disorders
  • Reduces glyphosate damage
  • Supports mental health and immunity

Other products ION offers

ION manufactures four supplements and provides several bundle options for additional savings. In addition to ION Gut Support, you’ll find the following options:

  • ION Skin Support
  • ION Sinus Support
  • ION Gut Support for Pets
  • ION Bundles

We’ll look briefly at ION’s additional products and bundles later in this review.

How the ION gut health product works

Tight junctions are seals between cell walls that form a protective barrier in the lining of the intestines to block toxins from entering the bloodstream while passing through nutrients. These barriers can become degraded over time from exposure to environmental components and chronic conditions, including:

  • Gluten
  • Glyphosate
  • Antibiotics
  • Pathogenic bacteria
  • Crohn’s disease
  • Inflammatory bowel disease (IBD)
  • Type 1 diabetes
  • Celiac disease
  • Nonalcoholic fatty liver disease

ION Gut Support helps restore tight junctions by providing trace minerals and amino acids found in all-natural, soil-derived humic extract. If the thought of drinking water with soil in it three times a day is difficult to swallow, considering the science behind the product may change your mind.

Glyphosate is a synthetic compound used as a broad-spectrum herbicide for killing weeds and grasses that compete with food crops. Developed in the 1970s by Monsanto under the brand name Roundup, glyphosate is one of the most widely used herbicides in the US and is likely found in your diet.

Both glyphosate and gluten act as triggers for the production of the toxin zonulin, which breaks down tight junctions in the digestive tract and may contribute to autoimmune diseases like celiac disease and type 1 diabetes.

Terrahydrite, the primary ingredient in ION Gut Health, contains carbon-based molecules that fight zonulin absorption in the intestines by promoting redox signaling or communication between cells. This signaling helps cells form a protective wall that allows nutrients to pass while blocking toxins. ION Gut Support helps promote balance in the mind and body by fostering this cell communication.

Who would benefit from it and who probably wouldn’t

ION Gut Support is beneficial for adults and children who want to improve their digestive health and immunity. The dosage for adults and children over three years old is one teaspoon three times daily. Children over three can take the supplement in dosages of ¼ teaspoon thrice a day.

ION Gut Support may induce side effects in sensitive individuals, including nausea, headaches, tiredness, and bowel changes. ION suggests starting with ¼ dose for these individuals and gradually building up to the full dosage.

There are no contraindications for ION Gut Support, but the company does recommend maintaining a 30-minute separation between taking the product and certain supplements and medications, including:

  • Thyroid medications
  • Iodine
  • Binder supplements including clay, zeolites, and charcoal

Individuals taking seizure medications or blood thinners should consult with their doctor before taking ION Gut Support.

Price of ION gut health options

You can purchase ION Gut Support in multiple sizes, from a six-day supply to a two-month supply. The greater bulk you buy, the more savings you earn. Additionally, enrolling in the company’s subscription membership earns an additional 15% off purchases (more information below).

  Cost Price per daily serving
Six-day supply (3oz) $16 $2.67
Two-week supply (8oz) $32 $2.29
One-month supply (16oz) $52 $1.73
Two-month supply (32oz) $72 $1.20

HSA, FSA, and health insurance

ION does not accept payments from HSAs, FSAs, or health insurance.

ION Skin Support

ION Skin Support follows the same protocol as ION Gut Support by reinforcing cellular connections and communications and promoting a healthy microbiome. ION has specially designed this product for skin health based on its abilities to:

  • Neutralize free radicals
  • Promote glutathione (antioxidant) production
  • Connect with keratinocytes (skin barrier cells)
  • Balance production of reactive oxygen species (ROS) in response to UV sun exposure
  • Boost immunity
  • Detoxify the body
  • Support lysine production (a precursor of collagen formation)

ION Skin Support comes in a face and body spray that you spritz on twice daily. Its ingredients include:

  • Humic extract
  • Purified water
  • Monomethylsilanetriol
  • Zinc gluconate
  • Copper gluconate
  • Magnesium citrate

Who would benefit from it and who probably wouldn’t

ION Skin Support is beneficial for individuals seeking to improve their skin’s condition and hydration and those trying to protect against damaging UV rays. However, it is not a sunscreen product and should not be used as such.

ION recommends performing a patch test to ensure you are not sensitive to its ingredients before committing to full-body use. This product is inappropriate for children under three years of age, as it contains trace levels of minerals to which they may be sensitive.

Individuals with skin conditions like rosacea, eczema, or vitiligo may want to consult with their dermatologist before using ION Skin Support. Still, ION does not limit its use to individuals with such conditions.

Pricing information

ION Skin Support comes in 3oz and 8oz bottles, with savings earned toward purchasing in bulk or bundles (more information below). It costs:

  • 3oz bottle (one-month supply): $32
  • 8oz bottle (10-week supply): $68

ION Sinus Support

ION Sinus Support contains the same two ingredients as ION Gut Support: humic extract and purified water. This nasal spray promotes strengthened epithelial walls and a diverse microbiome to prevent toxins from entering the nasal lining. It is:

  • Vegan-friendly
  • Glyphosate-free
  • BPA-free

Using the product involves inserting the nozzle into each nostril and pumping 1-3 times as needed.

Who would benefit from it and who probably wouldn’t

ION Sinus Support contains the same ingredients as ION Gut Support and should be safe for adults and children. It is a beneficial product for individuals looking to restore sinus health and their gut microbiome naturally. As with ION Gut Support, it may induce side effects in sensitive individuals and should be administered at least 30 minutes apart from certain supplements and medications, including:

  • Thyroid medications
  • Iodine
  • Binder supplements including clay, zeolites, and charcoal

Individuals taking seizure medications or blood thinners should consult with their doctor before taking ION Sinus Support.

Pricing information

ION Sinus Support comes in 1oz bottles for $16 each. It is also available in bundles and is eligible for subscription savings (more information below).

ION Gut Support for Pets

Those who love our pets want the best for their health, just like we want the best for ourselves and our families. ION Gut Support for Pets provides the same benefits for our furry companions that ION Gut Support offers us. It helps prevent toxins from entering the bloodstream by strengthening the gut lining and allowing for a diverse microbiome.

ION Gut Support for Pets includes three ingredients:

  • Humic extract
  • Purified water
  • Silicon

This supplement can be administered by a feeding syringe (most ideal) or added to your pet’s water. Your pet’s weight will dictate dosage amounts, and ION provides a chart on each label to determine how much to administer daily.

Who would benefit from it and who probably wouldn’t

ION Gut Support for Pets benefits cats and dogs, strengthening their digestive tract lining and supporting improved immunity. It is inappropriate for birds, horses, or other pets for which it has not been tested.

Pricing information

ION Gut Support for Pets comes in 8oz or 16oz bottles. How long each bottle last depends upon your pet’s weight. Again, buying in greater bulk saves you money, and the products are also eligible for subscription service, which saves 15% off orders (more information below). The following are single-purchase prices:

  • 8oz bottle: $32
  • 16oz bottle: $52

ION Bundles

ION offers several bundle options that save you money while combining several of your favorite products. They include:

ION Complete Health Bundle

The Complete Health Bundle provides ION’s three top-sellers for $140, a savings of $32 over the cost of individual purchases. It includes:

  • Gut Support (32oz)
  • Skin Support (8oz)
  • Sinus Support (1oz)

ION Starter Bundle

The Starter Bundle provides the same three best-sellers from ION in smaller sizes for those interested in trying the products out before making a bigger commitment. This $90 bundle includes:

  • Gut Support (16oz)
  • Skin Support (3oz)
  • Sinus Support (1oz)

ION Skincare Bundle

ION’s Skincare Bundle provides its top two sellers for strengthened immunity and collagen production. This pair costs $126 and includes:

  • Gut Support (32oz)
  • Skin Support (8oz)

Subscriptions and shipping

ION offers a free subscription membership plan that earns customers 15% off top-selling products and free US shipping for all orders. This membership also provides perks like a free pump for ION bottles, and it offers easy cancellation and order modifications.

ION provides free shipping on all orders over $40. Orders under $40 cost a flat rate of $7.

Is the ION gut health formula a good value?

ION Gut Support has an entirely different ingredient profile than many supplements for digestive health. Despite this divergence, we’ve prepared the chart below to illustrate the cost comparison of ION alongside significant competitors in the gut support market. As you can see, ION Gut Support falls in the middle range in terms of cost.

Prices below are for one-month supplies and reflect single purchases of each item. These prices do not take into account subscription or bulk savings.

  Cost Price per daily serving
ION Gut Support $52 $1.73
Healthy Gut HCL Guard+ $46 $1.53
Nature M.D. GutConnect 365 $54 $1.80
Bio Complete 3 $69.65 $2.32
Floracil50 $44.95 $1.50

Will ION improve your gut health?

In our testing of ION Gut Support, we found the product to effectively promote better digestion and relief from some symptoms of gluten and dairy intolerance. Overall, it did not have as significant an impact as prebiotic and probiotic supplements we’ve tested in the past. Still, its safety across the board, including use for children and pregnant or nursing women, makes it an excellent value for many.

Privacy considerations

ION collects information about users of its website via cookies and other tracking technologies. The company may use this information for targeted advertising, boosting promotions, and easy site navigation. All payment information is SSL encrypted for protection and security.

How we evaluate health products and services

At Innerbody Research, we customize our evaluation criteria depending on the type and nature of the health-related service or product. In general, we have five broad evaluation areas, including:

Quality: How well does the company deliver its core service(s) or product(s)? How is advanced technology used for accuracy and safety? What evidence of efficacy does the company provide? Are manufacturing standards high-quality?

User-friendly: How intuitive and convenient is the service or product? To what degree is the company interface helpful and understandable?

Value: Are you getting your money’s worth? Are there any hidden costs or charges? Does the company offer discounts?

Privacy: If health data is stored, is it stored securely? Are payments secure? Does the company market your information?

Customer support: With personalized products and services, how well does the company address your individual needs? If a product or service turns out not to work for you, are there satisfaction guarantees or return policies that protect you?